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The map label for this gene is ksgA [H]

Identifier: 148652714

GI number: 148652714

Start: 1079786

End: 1080676

Strand: Direct

Name: ksgA [H]

Synonym: PsycPRwf_0907

Alternate gene names: 148652714

Gene position: 1079786-1080676 (Clockwise)

Preceding gene: 148652713

Following gene: 148652715

Centisome position: 36.25

GC content: 46.8

Gene sequence:

>891_bases
ATGACGCAATCAGACATTACAAAACATCCGTTACACAATACCCTGCAGCGGGCAGCCAAGCACCAGCCTCGCAAACGCTT
TGGGCAAAACTTCTTGCATGATGCCAGTATTATCAGTGAAATTGTTGACGCTATTGGGCTTAATCGTGATGATAACTTGG
TTGAGATTGGACCAGGGATGGGCGCTTTAACTGAGCCGCTGCTAGAGCAAGTTGATGCGATGACCGTCATTGAGCTTGAT
CGTGACTTGGCAGGCAGTTTACGCATCCGTATTGGGGCCAACAGTCATCCAAATTTCACCATCGTGAATGCCAATGCGAT
GCAATTTGATTACCATAGCTTGTATGATGCTGACAGTGAAACTCCAAAAAAACTGCGTGTGGTCGGTAACTTGCCCTACA
ATATCTCAACGCCCTTGTTGTTCACCTTGCTTGAGTATGCCGATATTATTGAAGACATGCATTTTATGCTACAAAAAGAG
GTGGTGGAGCGCATTACCGCAGAAGTGGGCAGTAAAATATATGGCCGTTTATCGGTAATTATGCAGTATTTTTGTGACAC
CCAATATTTATTAACGGTACCCAGAGGTGCCTTTAATCCGCCACCAAAAGTGACCAGTGCTGTGTTCCGTCTGCGCCCAC
ATCAGGTGAAGCCGGTGCAAGCTGACGATGAAAAACTGTTCGCTTTGGTGGTGCGCGAAACCTTTAATCATCGCCGCAAA
ACCTTGCGTGCTATTTTTAAACAGTCCTCACTCATGCCCACGTTGACCGATGAGGATCTGGCGAGCATAGGCATTGATGG
CAATGCGCGTCCTGAAACTTTGGATGTGAATGATTTTGTGGCGCTCAGTAACTTGGTGATTGCTAAGCAAGCAGAGCAAG
AGCAGCTGTAG

Upstream 100 bases:

>100_bases
TCACAGCAGAAGTAAGCTGAGCTTTTTAGCCACAAGCTCACGCTTTAGCACTGCAAATTATGCTACACTAAATCCTTTTT
TAATTGATAAATATCGACTT

Downstream 100 bases:

>100_bases
GCTGGCTGATAGATGCTTATCGTGTTTTATGTCTAATAAACAAGCGGTTCACAGAGTGTCTGCTATAAAAACTCACCTGC
AATAAGAGTAAATACTATCA

Product: dimethyladenosine transferase

Products: NA

Alternate protein names: 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase; 16S rRNA dimethyladenosine transferase; 16S rRNA dimethylase; S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase [H]

Number of amino acids: Translated: 296; Mature: 295

Protein sequence:

>296_residues
MTQSDITKHPLHNTLQRAAKHQPRKRFGQNFLHDASIISEIVDAIGLNRDDNLVEIGPGMGALTEPLLEQVDAMTVIELD
RDLAGSLRIRIGANSHPNFTIVNANAMQFDYHSLYDADSETPKKLRVVGNLPYNISTPLLFTLLEYADIIEDMHFMLQKE
VVERITAEVGSKIYGRLSVIMQYFCDTQYLLTVPRGAFNPPPKVTSAVFRLRPHQVKPVQADDEKLFALVVRETFNHRRK
TLRAIFKQSSLMPTLTDEDLASIGIDGNARPETLDVNDFVALSNLVIAKQAEQEQL

Sequences:

>Translated_296_residues
MTQSDITKHPLHNTLQRAAKHQPRKRFGQNFLHDASIISEIVDAIGLNRDDNLVEIGPGMGALTEPLLEQVDAMTVIELD
RDLAGSLRIRIGANSHPNFTIVNANAMQFDYHSLYDADSETPKKLRVVGNLPYNISTPLLFTLLEYADIIEDMHFMLQKE
VVERITAEVGSKIYGRLSVIMQYFCDTQYLLTVPRGAFNPPPKVTSAVFRLRPHQVKPVQADDEKLFALVVRETFNHRRK
TLRAIFKQSSLMPTLTDEDLASIGIDGNARPETLDVNDFVALSNLVIAKQAEQEQL
>Mature_295_residues
TQSDITKHPLHNTLQRAAKHQPRKRFGQNFLHDASIISEIVDAIGLNRDDNLVEIGPGMGALTEPLLEQVDAMTVIELDR
DLAGSLRIRIGANSHPNFTIVNANAMQFDYHSLYDADSETPKKLRVVGNLPYNISTPLLFTLLEYADIIEDMHFMLQKEV
VERITAEVGSKIYGRLSVIMQYFCDTQYLLTVPRGAFNPPPKVTSAVFRLRPHQVKPVQADDEKLFALVVRETFNHRRKT
LRAIFKQSSLMPTLTDEDLASIGIDGNARPETLDVNDFVALSNLVIAKQAEQEQL

Specific function: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits [H]

COG id: COG0030

COG function: function code J; Dimethyladenosine transferase (rRNA methylation)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily [H]

Homologues:

Organism=Homo sapiens, GI156415992, Length=293, Percent_Identity=30.3754266211604, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI7657198, Length=252, Percent_Identity=31.3492063492063, Blast_Score=117, Evalue=1e-26,
Organism=Escherichia coli, GI1786236, Length=274, Percent_Identity=47.4452554744526, Blast_Score=238, Evalue=4e-64,
Organism=Caenorhabditis elegans, GI25146882, Length=280, Percent_Identity=30, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI25141369, Length=284, Percent_Identity=24.2957746478873, Blast_Score=85, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6324989, Length=230, Percent_Identity=30, Blast_Score=100, Evalue=2e-22,
Organism=Drosophila melanogaster, GI21358017, Length=249, Percent_Identity=31.7269076305221, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI21357273, Length=298, Percent_Identity=28.5234899328859, Blast_Score=96, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023165
- InterPro:   IPR020596
- InterPro:   IPR001737
- InterPro:   IPR020598
- InterPro:   IPR011530 [H]

Pfam domain/function: PF00398 RrnaAD [H]

EC number: =2.1.1.182 [H]

Molecular weight: Translated: 33320; Mature: 33188

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS01131 RRNA_A_DIMETH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQSDITKHPLHNTLQRAAKHQPRKRFGQNFLHDASIISEIVDAIGLNRDDNLVEIGPGM
CCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCC
GALTEPLLEQVDAMTVIELDRDLAGSLRIRIGANSHPNFTIVNANAMQFDYHSLYDADSE
CHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCEEEEECCEEEECHHHHHCCCCC
TPKKLRVVGNLPYNISTPLLFTLLEYADIIEDMHFMLQKEVVERITAEVGSKIYGRLSVI
CCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MQYFCDTQYLLTVPRGAFNPPPKVTSAVFRLRPHQVKPVQADDEKLFALVVRETFNHRRK
HHHHCCCCEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
TLRAIFKQSSLMPTLTDEDLASIGIDGNARPETLDVNDFVALSNLVIAKQAEQEQL
HHHHHHHHHCCCCCCCCCHHHHCCCCCCCCCCEECCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TQSDITKHPLHNTLQRAAKHQPRKRFGQNFLHDASIISEIVDAIGLNRDDNLVEIGPGM
CCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCC
GALTEPLLEQVDAMTVIELDRDLAGSLRIRIGANSHPNFTIVNANAMQFDYHSLYDADSE
CHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCEEEEECCEEEECHHHHHCCCCC
TPKKLRVVGNLPYNISTPLLFTLLEYADIIEDMHFMLQKEVVERITAEVGSKIYGRLSVI
CCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MQYFCDTQYLLTVPRGAFNPPPKVTSAVFRLRPHQVKPVQADDEKLFALVVRETFNHRRK
HHHHCCCCEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
TLRAIFKQSSLMPTLTDEDLASIGIDGNARPETLDVNDFVALSNLVIAKQAEQEQL
HHHHHHHHHCCCCCCCCCHHHHCCCCCCCCCCEECCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA