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The map label for this gene is moeB [H]

Identifier: 148652575

GI number: 148652575

Start: 915965

End: 916777

Strand: Direct

Name: moeB [H]

Synonym: PsycPRwf_0766

Alternate gene names: 148652575

Gene position: 915965-916777 (Clockwise)

Preceding gene: 148652573

Following gene: 148652578

Centisome position: 30.75

GC content: 47.97

Gene sequence:

>813_bases
ATGGATATGAATTTAAGCGATGCAGAGCTGATGCGTTATTCACGCCAAATTCTACTTGAAAGCTGGGATATTGAGGCCCA
AGAAAGATTAAAAGCCAGTACGGTAGTGATTTTAGGTGCAGGCGGACTTGGCTGCCCAGTGTCTGAGACTTTGGCACGCG
CAGGTATCGGTGCGATTCATCTTATTGATGATGATGTGATTGAGGCCAGTAACCTACAACGGCAAACCTTATTTACCGCA
GAGGATATTGGGAAAAGTAAGGCCAAAACTGCTTGCCAAGCATTGTCGCACATCAACCCTTTTGTAAAACTCAGTTATGC
CACCGAGCGGTTACAGGCAGATAATGCCAAGCAGCTATTGCTTATTGAGCAAGCCCAAGCGGCAAGCGGCCCTTATTTAT
TGCTAGACTGTACCGATAATTTTAGCGCGCGCGACATATTAAATCGGGTGAGTGTCAAGGAGCGTCTGCCATTGTTATCC
GCCTCAGCCATTGGTATGTCTGGACAATTGGCTTTGTATGAGCCGGCTCAGAAAAGTGGCTGCTATCACTGCGTATTTGG
TGAAACCTTAGGCAGCTTAGAGCAATCAGAAACAAGTGATACCCAGAGCTGTGCCAATTCTGGGGTGCTGGCCAGTACCA
CCACTATTATGGGTAATTTGCAGGCCAATGCCGCCTTACAGTATTTAGGGCGGGGCAAAAACCCGCTGGCAGGTCAGCTG
CTCATCTGGGAGGGTATTCATATGACGCAGCACAAGCTGCATTACCGCCAAGACAAGCAGTGTGAGGTATGTGCCAAGCC
TTATGACATTTAA

Upstream 100 bases:

>100_bases
CAGTTTTTGTAAGGTGTTATAATGGCCCTTTAATCGATAATACATACCCACGGCGTGGGTAAAAAAGAGATCAGATATGG
CACAAGATAAGAGGGGCGCA

Downstream 100 bases:

>100_bases
TAATCGATGTAGTGCTTAACCAGAGGGCTTAAGTCAATCTCTACGCCAAGATTAACCAAGTTCCAGTATTGGCCCGAAAC
CGTACGGTCTATCATCATGG

Product: UBA/THIF-type NAD/FAD binding protein

Products: NA

Alternate protein names: MoaD protein adenylase; Molybdopterin-converting factor subunit 1 adenylase [H]

Number of amino acids: Translated: 270; Mature: 270

Protein sequence:

>270_residues
MDMNLSDAELMRYSRQILLESWDIEAQERLKASTVVILGAGGLGCPVSETLARAGIGAIHLIDDDVIEASNLQRQTLFTA
EDIGKSKAKTACQALSHINPFVKLSYATERLQADNAKQLLLIEQAQAASGPYLLLDCTDNFSARDILNRVSVKERLPLLS
ASAIGMSGQLALYEPAQKSGCYHCVFGETLGSLEQSETSDTQSCANSGVLASTTTIMGNLQANAALQYLGRGKNPLAGQL
LIWEGIHMTQHKLHYRQDKQCEVCAKPYDI

Sequences:

>Translated_270_residues
MDMNLSDAELMRYSRQILLESWDIEAQERLKASTVVILGAGGLGCPVSETLARAGIGAIHLIDDDVIEASNLQRQTLFTA
EDIGKSKAKTACQALSHINPFVKLSYATERLQADNAKQLLLIEQAQAASGPYLLLDCTDNFSARDILNRVSVKERLPLLS
ASAIGMSGQLALYEPAQKSGCYHCVFGETLGSLEQSETSDTQSCANSGVLASTTTIMGNLQANAALQYLGRGKNPLAGQL
LIWEGIHMTQHKLHYRQDKQCEVCAKPYDI
>Mature_270_residues
MDMNLSDAELMRYSRQILLESWDIEAQERLKASTVVILGAGGLGCPVSETLARAGIGAIHLIDDDVIEASNLQRQTLFTA
EDIGKSKAKTACQALSHINPFVKLSYATERLQADNAKQLLLIEQAQAASGPYLLLDCTDNFSARDILNRVSVKERLPLLS
ASAIGMSGQLALYEPAQKSGCYHCVFGETLGSLEQSETSDTQSCANSGVLASTTTIMGNLQANAALQYLGRGKNPLAGQL
LIWEGIHMTQHKLHYRQDKQCEVCAKPYDI

Specific function: Catalyzes the adenylation by ATP of the carboxyl group of the C-terminal glycine of sulfur carrier protein moaD [H]

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hesA/moeB/thiF family [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=244, Percent_Identity=35.655737704918, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI23510338, Length=169, Percent_Identity=30.7692307692308, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI23510340, Length=169, Percent_Identity=30.7692307692308, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI4885649, Length=161, Percent_Identity=29.1925465838509, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI38045942, Length=71, Percent_Identity=46.4788732394366, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI38045944, Length=89, Percent_Identity=40.4494382022472, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI4885585, Length=108, Percent_Identity=30.5555555555556, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI225543285, Length=108, Percent_Identity=30.5555555555556, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI38045948, Length=176, Percent_Identity=30.6818181818182, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI225543288, Length=108, Percent_Identity=30.5555555555556, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1787048, Length=265, Percent_Identity=35.4716981132075, Blast_Score=169, Evalue=1e-43,
Organism=Escherichia coli, GI87082356, Length=261, Percent_Identity=36.7816091954023, Blast_Score=158, Evalue=3e-40,
Organism=Escherichia coli, GI1789177, Length=177, Percent_Identity=26.5536723163842, Blast_Score=66, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17540406, Length=262, Percent_Identity=33.206106870229, Blast_Score=154, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI193203301, Length=167, Percent_Identity=32.9341317365269, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI86565433, Length=169, Percent_Identity=30.7692307692308, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI86565431, Length=169, Percent_Identity=30.7692307692308, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71984476, Length=83, Percent_Identity=42.1686746987952, Blast_Score=67, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6321903, Length=274, Percent_Identity=30.6569343065693, Blast_Score=129, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6320598, Length=165, Percent_Identity=29.6969696969697, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6322639, Length=178, Percent_Identity=29.7752808988764, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6325438, Length=115, Percent_Identity=27.8260869565217, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24582879, Length=262, Percent_Identity=34.3511450381679, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24660640, Length=160, Percent_Identity=34.375, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI28573937, Length=168, Percent_Identity=30.952380952381, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI20129973, Length=78, Percent_Identity=44.8717948717949, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24641311, Length=228, Percent_Identity=29.8245614035088, Blast_Score=68, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR012730
- InterPro:   IPR016040
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00899 ThiF [H]

EC number: NA

Molecular weight: Translated: 29332; Mature: 29332

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDMNLSDAELMRYSRQILLESWDIEAQERLKASTVVILGAGGLGCPVSETLARAGIGAIH
CCCCCCHHHHHHHHHHHHHHCCCCCHHHHHCEEEEEEEECCCCCCCHHHHHHHCCCCEEE
LIDDDVIEASNLQRQTLFTAEDIGKSKAKTACQALSHINPFVKLSYATERLQADNAKQLL
EECCCHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHHCCHHEEEHHHHHHHHCCCCCEEE
LIEQAQAASGPYLLLDCTDNFSARDILNRVSVKERLPLLSASAIGMSGQLALYEPAQKSG
EEEECCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHCCCCCCEEEECCHHHCC
CYHCVFGETLGSLEQSETSDTQSCANSGVLASTTTIMGNLQANAALQYLGRGKNPLAGQL
CEEEEHHHHHHHHHHCCCCHHHHHHCCCCEEEHHHEEECCCHHHHHHHHCCCCCCCCCEE
LIWEGIHMTQHKLHYRQDKQCEVCAKPYDI
EEECCCHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MDMNLSDAELMRYSRQILLESWDIEAQERLKASTVVILGAGGLGCPVSETLARAGIGAIH
CCCCCCHHHHHHHHHHHHHHCCCCCHHHHHCEEEEEEEECCCCCCCHHHHHHHCCCCEEE
LIDDDVIEASNLQRQTLFTAEDIGKSKAKTACQALSHINPFVKLSYATERLQADNAKQLL
EECCCHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHHCCHHEEEHHHHHHHHCCCCCEEE
LIEQAQAASGPYLLLDCTDNFSARDILNRVSVKERLPLLSASAIGMSGQLALYEPAQKSG
EEEECCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHCCCCCCEEEECCHHHCC
CYHCVFGETLGSLEQSETSDTQSCANSGVLASTTTIMGNLQANAALQYLGRGKNPLAGQL
CEEEEHHHHHHHHHHCCCCHHHHHHCCCCEEEHHHEEECCCHHHHHHHHCCCCCCCCCEE
LIWEGIHMTQHKLHYRQDKQCEVCAKPYDI
EEECCCHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503 [H]