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The map label for this gene is ilvI [H]

Identifier: 148652421

GI number: 148652421

Start: 732673

End: 734472

Strand: Direct

Name: ilvI [H]

Synonym: PsycPRwf_0609

Alternate gene names: 148652421

Gene position: 732673-734472 (Clockwise)

Preceding gene: 148652420

Following gene: 148652422

Centisome position: 24.59

GC content: 47.83

Gene sequence:

>1800_bases
ATGACAGGGCACACTCAGACAGCGCACGCGGCCATTAATTTTGGCAAAAAGCGTGAACTTTTAGAAAATGGCGATGGGCC
AATCATGCTCTCTGGTGGCGAAATGCTGGTCCAGGCCTTAATTGATCAGGGCGTTGAGTATATTTTTGGTTATCCAGGTG
GTGCGGTATTGCACATTTATGATGCCATATTTAAGCAAGATGCCATTGAGCATTTACTGGTGCGTCATGAGCAAGCCGCT
GGTCACATGGCGGATGCTTATTCTCGCAGAACGGGCAAAACAGGTGTGGTATTGGCCACATCAGGCCCTGGCGCTACCAA
CACCGTCACTGCTATTGCCACCGCGTTTATGGATTCTATCCCTATGGTGGTCATCTCCGGTCAGGTGCCTAAGTACTTAA
TCGGTGACGATGCTTTCCAAGAAACAGACATGGTGGGCGTGTCTCGTCCGATCGTAAAACACAGTTTCCAAGTGCGCCAT
GCCAGCGAAATACCCGGTATTATCAAAAAAGCATTTTATATTGCAGAGTCTGGCCGTCCAGGTCCTGTGGTCATCGATAT
TCCCAAAGACACCACTGCGCCGCATGAAAAATATGAATACAACTATCCTGATTCAGTCAGCATGCGCTCCTATCAGCCTT
CAGTAAAAGGCCACAGTGGTCAGATTAAAAAAGCCATTGAGACTTTATTAGGCGCCAAACGCCCCATCTTATATTCAGGC
GGCGGCGTGATTATTGGTAATGCTCACAAAGAGCTGACCGAGCTTGCTCATAAGCTCAACTTACCCGTCACCAATACTTT
AATGGGTTTGGGCGGCTTTCCAGGCTCAGACCGTCAGTTCCTAGGGATGCTGGGTATGCACGGCACTTATGAAGCCAACA
TGACCATGCACCATGCCGATGTTATCTTGGCGGTGGGGGCGCGCTTTGATGACCGCGTGACCAATAATGTTCAGAAATTC
TGTCCAAACGCGACAATCATTCATATTGATATCGATCCGGCCTCTATTTCTAAGACCATCATGGCGGATATTCCTATCGT
TGGTGATGTAAAGTCGGTATTGACCGACATACTTGAGCAGCTAAAAGGCGATGACAAACAGCTAGATCAGCCCGCCTTGC
TTGACTGGTGGTCGCAGATTAATGAATGGCGTAAGCGTCATGGCCTACGTTATGACACCAATACAGATGAAGGCATGAAG
CCGCAAGCTGTGGTTGAAAAATTGTATGAGCTGACTGAGGGTAAAGCGATTATTACCAGTGATGTGGGTCAGCATCAGAT
GTTTGCTGCACTATATTATAAGTATGATGAGCCGCGCCAGTGGTTAAACTCAGGTGGCCTTGGCACCATGGGTGTGGGCT
TGCCATATGCAATGGCAGCCAAATTGGTTGAACCTGAGCGTGATGTGGTGTGTATCACCGGTGAAGGCTCTATTCAGATG
AATATCCAAGAGCTGTCTACTTGCTTCCAGTATGGTTTGCCGGTGAAGATTTTATGCTTAAATAACGCTCAGCTGGGCAT
GGTAAAGCAGTGGCAGGATATGCTCTATGAAGGCCGCCATGCCTCATCTTACATGGAGTCACTACCTGACTTTGTGAAAC
TGGCTGAAAGCTATGGTCACGTTGGTATCAAAATTACCGACCCAGAAAAGCTTGATGAGCAATTGGCTCAAGCCCTTGCC
ATGAAAGATAAATTGGTATTTATTGACGTGTATGTGAACCGTCATGAGCACGTTTATCCAATGCAGGTTGCGGGTCAGTC
GATGCGCGATATGTGGTTATCTAAGGGGGAGCGTACCTAA

Upstream 100 bases:

>100_bases
TGTTAATAATAAAGGCTGATGATAAGGGTGATAAAAGCCTTAATAACATCCCGCAATAACAAAGGTGATGACAGTGACCC
AAACAACCCAAAGCCCTAAC

Downstream 100 bases:

>100_bases
TGCAACAACATCTAATCTCTGTACTAATGGAAAACGAAGCTGGGTCGCTTTCACGCCTTGTTGGATTGTTTTCGCAGCGT
GGCTATAACATCGAGACACT

Product: acetolactate synthase 3 catalytic subunit

Products: NA

Alternate protein names: AHAS-III; ALS-III; Acetohydroxy-acid synthase III large subunit [H]

Number of amino acids: Translated: 599; Mature: 598

Protein sequence:

>599_residues
MTGHTQTAHAAINFGKKRELLENGDGPIMLSGGEMLVQALIDQGVEYIFGYPGGAVLHIYDAIFKQDAIEHLLVRHEQAA
GHMADAYSRRTGKTGVVLATSGPGATNTVTAIATAFMDSIPMVVISGQVPKYLIGDDAFQETDMVGVSRPIVKHSFQVRH
ASEIPGIIKKAFYIAESGRPGPVVIDIPKDTTAPHEKYEYNYPDSVSMRSYQPSVKGHSGQIKKAIETLLGAKRPILYSG
GGVIIGNAHKELTELAHKLNLPVTNTLMGLGGFPGSDRQFLGMLGMHGTYEANMTMHHADVILAVGARFDDRVTNNVQKF
CPNATIIHIDIDPASISKTIMADIPIVGDVKSVLTDILEQLKGDDKQLDQPALLDWWSQINEWRKRHGLRYDTNTDEGMK
PQAVVEKLYELTEGKAIITSDVGQHQMFAALYYKYDEPRQWLNSGGLGTMGVGLPYAMAAKLVEPERDVVCITGEGSIQM
NIQELSTCFQYGLPVKILCLNNAQLGMVKQWQDMLYEGRHASSYMESLPDFVKLAESYGHVGIKITDPEKLDEQLAQALA
MKDKLVFIDVYVNRHEHVYPMQVAGQSMRDMWLSKGERT

Sequences:

>Translated_599_residues
MTGHTQTAHAAINFGKKRELLENGDGPIMLSGGEMLVQALIDQGVEYIFGYPGGAVLHIYDAIFKQDAIEHLLVRHEQAA
GHMADAYSRRTGKTGVVLATSGPGATNTVTAIATAFMDSIPMVVISGQVPKYLIGDDAFQETDMVGVSRPIVKHSFQVRH
ASEIPGIIKKAFYIAESGRPGPVVIDIPKDTTAPHEKYEYNYPDSVSMRSYQPSVKGHSGQIKKAIETLLGAKRPILYSG
GGVIIGNAHKELTELAHKLNLPVTNTLMGLGGFPGSDRQFLGMLGMHGTYEANMTMHHADVILAVGARFDDRVTNNVQKF
CPNATIIHIDIDPASISKTIMADIPIVGDVKSVLTDILEQLKGDDKQLDQPALLDWWSQINEWRKRHGLRYDTNTDEGMK
PQAVVEKLYELTEGKAIITSDVGQHQMFAALYYKYDEPRQWLNSGGLGTMGVGLPYAMAAKLVEPERDVVCITGEGSIQM
NIQELSTCFQYGLPVKILCLNNAQLGMVKQWQDMLYEGRHASSYMESLPDFVKLAESYGHVGIKITDPEKLDEQLAQALA
MKDKLVFIDVYVNRHEHVYPMQVAGQSMRDMWLSKGERT
>Mature_598_residues
TGHTQTAHAAINFGKKRELLENGDGPIMLSGGEMLVQALIDQGVEYIFGYPGGAVLHIYDAIFKQDAIEHLLVRHEQAAG
HMADAYSRRTGKTGVVLATSGPGATNTVTAIATAFMDSIPMVVISGQVPKYLIGDDAFQETDMVGVSRPIVKHSFQVRHA
SEIPGIIKKAFYIAESGRPGPVVIDIPKDTTAPHEKYEYNYPDSVSMRSYQPSVKGHSGQIKKAIETLLGAKRPILYSGG
GVIIGNAHKELTELAHKLNLPVTNTLMGLGGFPGSDRQFLGMLGMHGTYEANMTMHHADVILAVGARFDDRVTNNVQKFC
PNATIIHIDIDPASISKTIMADIPIVGDVKSVLTDILEQLKGDDKQLDQPALLDWWSQINEWRKRHGLRYDTNTDEGMKP
QAVVEKLYELTEGKAIITSDVGQHQMFAALYYKYDEPRQWLNSGGLGTMGVGLPYAMAAKLVEPERDVVCITGEGSIQMN
IQELSTCFQYGLPVKILCLNNAQLGMVKQWQDMLYEGRHASSYMESLPDFVKLAESYGHVGIKITDPEKLDEQLAQALAM
KDKLVFIDVYVNRHEHVYPMQVAGQSMRDMWLSKGERT

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=566, Percent_Identity=27.208480565371, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI21361361, Length=536, Percent_Identity=26.865671641791, Blast_Score=165, Evalue=1e-40,
Organism=Escherichia coli, GI87081685, Length=573, Percent_Identity=63.5253054101222, Blast_Score=780, Evalue=0.0,
Organism=Escherichia coli, GI1790104, Length=563, Percent_Identity=40.8525754884547, Blast_Score=421, Evalue=1e-119,
Organism=Escherichia coli, GI1786717, Length=549, Percent_Identity=33.1511839708561, Blast_Score=310, Evalue=2e-85,
Organism=Escherichia coli, GI1787096, Length=555, Percent_Identity=29.5495495495495, Blast_Score=201, Evalue=9e-53,
Organism=Escherichia coli, GI1788716, Length=578, Percent_Identity=25.9515570934256, Blast_Score=156, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI17531299, Length=599, Percent_Identity=25.3756260434057, Blast_Score=161, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17531301, Length=599, Percent_Identity=25.3756260434057, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17542570, Length=603, Percent_Identity=25.5389718076285, Blast_Score=148, Evalue=7e-36,
Organism=Saccharomyces cerevisiae, GI6323755, Length=587, Percent_Identity=42.4190800681431, Blast_Score=447, Evalue=1e-126,
Organism=Saccharomyces cerevisiae, GI6320816, Length=482, Percent_Identity=26.3485477178423, Blast_Score=128, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6321524, Length=493, Percent_Identity=23.7322515212982, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI19922626, Length=563, Percent_Identity=26.4653641207815, Blast_Score=184, Evalue=2e-46,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012846
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 66060; Mature: 65928

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGHTQTAHAAINFGKKRELLENGDGPIMLSGGEMLVQALIDQGVEYIFGYPGGAVLHIY
CCCCCCHHHHHHCCCHHHHHHHCCCCCEEECCHHHHHHHHHHCCCCEEEECCCCHHHHHH
DAIFKQDAIEHLLVRHEQAAGHMADAYSRRTGKTGVVLATSGPGATNTVTAIATAFMDSI
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHCC
PMVVISGQVPKYLIGDDAFQETDMVGVSRPIVKHSFQVRHASEIPGIIKKAFYIAESGRP
CEEEEECCCCCEEECCCHHHHCCCCCCCCHHHHHHHHHCCHHHCHHHHHHHHHEECCCCC
GPVVIDIPKDTTAPHEKYEYNYPDSVSMRSYQPSVKGHSGQIKKAIETLLGAKRPILYSG
CCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEC
GGVIIGNAHKELTELAHKLNLPVTNTLMGLGGFPGSDRQFLGMLGMHGTYEANMTMHHAD
CCEEEECCHHHHHHHHHHCCCCHHHHHHHCCCCCCCCHHHHHHHCCCCEEECCEEEEECE
VILAVGARFDDRVTNNVQKFCPNATIIHIDIDPASISKTIMADIPIVGDVKSVLTDILEQ
EEEEECCCCCHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHCCCCCCCHHHHHHHHHHH
LKGDDKQLDQPALLDWWSQINEWRKRHGLRYDTNTDEGMKPQAVVEKLYELTEGKAIITS
HCCCCHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEC
DVGQHQMFAALYYKYDEPRQWLNSGGLGTMGVGLPYAMAAKLVEPERDVVCITGEGSIQM
CCCHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCEEEEECCCCEEE
NIQELSTCFQYGLPVKILCLNNAQLGMVKQWQDMLYEGRHASSYMESLPDFVKLAESYGH
EHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCC
VGIKITDPEKLDEQLAQALAMKDKLVFIDVYVNRHEHVYPMQVAGQSMRDMWLSKGERT
EEEEECCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHCHHHHHHHHHCCCCC
>Mature Secondary Structure 
TGHTQTAHAAINFGKKRELLENGDGPIMLSGGEMLVQALIDQGVEYIFGYPGGAVLHIY
CCCCCHHHHHHCCCHHHHHHHCCCCCEEECCHHHHHHHHHHCCCCEEEECCCCHHHHHH
DAIFKQDAIEHLLVRHEQAAGHMADAYSRRTGKTGVVLATSGPGATNTVTAIATAFMDSI
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHCC
PMVVISGQVPKYLIGDDAFQETDMVGVSRPIVKHSFQVRHASEIPGIIKKAFYIAESGRP
CEEEEECCCCCEEECCCHHHHCCCCCCCCHHHHHHHHHCCHHHCHHHHHHHHHEECCCCC
GPVVIDIPKDTTAPHEKYEYNYPDSVSMRSYQPSVKGHSGQIKKAIETLLGAKRPILYSG
CCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEC
GGVIIGNAHKELTELAHKLNLPVTNTLMGLGGFPGSDRQFLGMLGMHGTYEANMTMHHAD
CCEEEECCHHHHHHHHHHCCCCHHHHHHHCCCCCCCCHHHHHHHCCCCEEECCEEEEECE
VILAVGARFDDRVTNNVQKFCPNATIIHIDIDPASISKTIMADIPIVGDVKSVLTDILEQ
EEEEECCCCCHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHCCCCCCCHHHHHHHHHHH
LKGDDKQLDQPALLDWWSQINEWRKRHGLRYDTNTDEGMKPQAVVEKLYELTEGKAIITS
HCCCCHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEC
DVGQHQMFAALYYKYDEPRQWLNSGGLGTMGVGLPYAMAAKLVEPERDVVCITGEGSIQM
CCCHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCEEEEECCCCEEE
NIQELSTCFQYGLPVKILCLNNAQLGMVKQWQDMLYEGRHASSYMESLPDFVKLAESYGH
EHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCC
VGIKITDPEKLDEQLAQALAMKDKLVFIDVYVNRHEHVYPMQVAGQSMRDMWLSKGERT
EEEEECCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6308579; 1630901; 9278503; 3891724; 9298646 [H]