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The map label for this gene is ffh [H]

Identifier: 148652404

GI number: 148652404

Start: 709652

End: 711199

Strand: Direct

Name: ffh [H]

Synonym: PsycPRwf_0592

Alternate gene names: 148652404

Gene position: 709652-711199 (Clockwise)

Preceding gene: 148652402

Following gene: 148652408

Centisome position: 23.82

GC content: 48.58

Gene sequence:

>1548_bases
ATGTTTGATACCTTAACCGAAAGACTCTCTGGCAGCCTGCGTAAGATTTCAGGCTCAGGACAGCTGACCGAAGACAATAT
TAAAGACACGCTGCGTGAAGTGCGTATGGCGCTGCTTGAGGCCGATGTCGCTCTACCTATCACCCGTGACTTCGTTAAGC
GCGTAAAAGAGCAAGCGCTGGGTCAAGAGGTGTTAAAGGAGTTGGCCCCAGGTCAAGCTTTCGTCAAGATTGTCTATGAT
GAATTAACGGAAATGATGGGCAGTGCCAACCAGCAGCTAGAGATGACCGGTAAGCCGCCTGTCGTCTACTTACTGGCTGG
TCTGCAAGGTGCCGGTAAAACCACCACAGCAGGTAAGCTTGCTAAGTACTTACAAGAGCGTCATAAGAAAAAAGTAATGC
TGGTCTCAGCCGACGTTTATCGTCCGGCAGCCATTAAGCAGCTAGAGCAAGTGGCCGCTCAGGTAAACGCTAAGTTTGTA
AACTCAAGCAGTGATGAGAACCCCATTGATATCGCTAAGCGTGCCATCGAAGAGGCCAAGCTGCAGTATCAAGACATCCT
AATTATCGATACCGCAGGTCGCTTGCATATCGATGAAGATATGATGGATGAGATTAAAGCATTGACAGCAGCGGCCAATC
CTTCTGAAACTCTGTTCGTTGTTGACTCAATGACCGGTCAAGATGCGGCCAATACTGCCAAAGCCTTTAATGATGCACTG
CCGCTCACTGGTGTTATCTTAACCAAGACTGATGGTGATGCCCGCGGCGGTGCGGCCTTATCTGTGCGCGCCATTACTGA
CAAGCCCATTAAATTCTTGGGCCGCGGTGAAAAACTCGATGCCCTAGAAGCTTTCCACCCTGAGCGTATCGCTCAGCGTA
TCTTGGGCATGGGTGATGTTCTAAGCTTGGTTGAAGAAGTTGAGCAAAAAATCGACCGTGACAAAGCCGAAAAAATGGCC
AAAAAAATCCAAAAAGGCGGTGAGTTTGACCTTGAGGATTTATTGACTCAGTTCCAACAGATGAAGAATATGGGCGGTAT
GAGTGGCTTCTTAGATAAGATGCCAGGCATGAGCGGAGCAGGTATCAAAGAGGCACTAGAGGAAGCCAAGCCAGAAGAAA
AAGTAAAAGAGATGGAAGCGCTGATTAACTCTATGACCCCTTATGAGCGCAAAAATCCTGATAAGATTAACCCAAGCCGT
AAGCGCCGTATTGCAGCGGGCTCTGGCAAACAAATCCAGGACATCAACCGTTTGCTTAAGCAGCACAAGCAAATGGCAAA
AATGATGAAGATGCTGTCAAAACCTGAAGGCCTAACCAAAATGATGAAAGCGGTTCAAGGCTTAACCGGTATGGGCGGCG
GCGGTGCTCAAGGTGCAGGCGGTCCCTTATTTGGGGGTGGTAACACAGGTGGTAAGCCTGCTCAAGGTGCAGGCGGCATG
CCACCCTTTGGCCTAGATCCGAATAATATGCCAAGCAAAGAAGATATGGAGCGTCAACTGAAAGACTTAGAACAACAGCT
GCCTCCAGACTTCAAAAAACGCTTTTAA

Upstream 100 bases:

>100_bases
GTCTTACTTATTAAGCACTGCCCCAATTGAGCATGACCTGATTTGATTAATTCTTATTTTACAGCCTTAAACTTTATTAA
CAATTTATCGAGAAAACCCT

Downstream 100 bases:

>100_bases
GTCAGTAAAAATACTTTTAACTTGCTTAATCTGCATTAAGGCCAGATCAATCGATCTGGCCTTTTGTTAAGAAGATGAGT
TCTGGCTCAATCAATACGGC

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 515; Mature: 515

Protein sequence:

>515_residues
MFDTLTERLSGSLRKISGSGQLTEDNIKDTLREVRMALLEADVALPITRDFVKRVKEQALGQEVLKELAPGQAFVKIVYD
ELTEMMGSANQQLEMTGKPPVVYLLAGLQGAGKTTTAGKLAKYLQERHKKKVMLVSADVYRPAAIKQLEQVAAQVNAKFV
NSSSDENPIDIAKRAIEEAKLQYQDILIIDTAGRLHIDEDMMDEIKALTAAANPSETLFVVDSMTGQDAANTAKAFNDAL
PLTGVILTKTDGDARGGAALSVRAITDKPIKFLGRGEKLDALEAFHPERIAQRILGMGDVLSLVEEVEQKIDRDKAEKMA
KKIQKGGEFDLEDLLTQFQQMKNMGGMSGFLDKMPGMSGAGIKEALEEAKPEEKVKEMEALINSMTPYERKNPDKINPSR
KRRIAAGSGKQIQDINRLLKQHKQMAKMMKMLSKPEGLTKMMKAVQGLTGMGGGGAQGAGGPLFGGGNTGGKPAQGAGGM
PPFGLDPNNMPSKEDMERQLKDLEQQLPPDFKKRF

Sequences:

>Translated_515_residues
MFDTLTERLSGSLRKISGSGQLTEDNIKDTLREVRMALLEADVALPITRDFVKRVKEQALGQEVLKELAPGQAFVKIVYD
ELTEMMGSANQQLEMTGKPPVVYLLAGLQGAGKTTTAGKLAKYLQERHKKKVMLVSADVYRPAAIKQLEQVAAQVNAKFV
NSSSDENPIDIAKRAIEEAKLQYQDILIIDTAGRLHIDEDMMDEIKALTAAANPSETLFVVDSMTGQDAANTAKAFNDAL
PLTGVILTKTDGDARGGAALSVRAITDKPIKFLGRGEKLDALEAFHPERIAQRILGMGDVLSLVEEVEQKIDRDKAEKMA
KKIQKGGEFDLEDLLTQFQQMKNMGGMSGFLDKMPGMSGAGIKEALEEAKPEEKVKEMEALINSMTPYERKNPDKINPSR
KRRIAAGSGKQIQDINRLLKQHKQMAKMMKMLSKPEGLTKMMKAVQGLTGMGGGGAQGAGGPLFGGGNTGGKPAQGAGGM
PPFGLDPNNMPSKEDMERQLKDLEQQLPPDFKKRF
>Mature_515_residues
MFDTLTERLSGSLRKISGSGQLTEDNIKDTLREVRMALLEADVALPITRDFVKRVKEQALGQEVLKELAPGQAFVKIVYD
ELTEMMGSANQQLEMTGKPPVVYLLAGLQGAGKTTTAGKLAKYLQERHKKKVMLVSADVYRPAAIKQLEQVAAQVNAKFV
NSSSDENPIDIAKRAIEEAKLQYQDILIIDTAGRLHIDEDMMDEIKALTAAANPSETLFVVDSMTGQDAANTAKAFNDAL
PLTGVILTKTDGDARGGAALSVRAITDKPIKFLGRGEKLDALEAFHPERIAQRILGMGDVLSLVEEVEQKIDRDKAEKMA
KKIQKGGEFDLEDLLTQFQQMKNMGGMSGFLDKMPGMSGAGIKEALEEAKPEEKVKEMEALINSMTPYERKNPDKINPSR
KRRIAAGSGKQIQDINRLLKQHKQMAKMMKMLSKPEGLTKMMKAVQGLTGMGGGGAQGAGGPLFGGGNTGGKPAQGAGGM
PPFGLDPNNMPSKEDMERQLKDLEQQLPPDFKKRF

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=441, Percent_Identity=33.1065759637188, Blast_Score=231, Evalue=9e-61,
Organism=Homo sapiens, GI226371618, Length=385, Percent_Identity=34.025974025974, Blast_Score=208, Evalue=8e-54,
Organism=Homo sapiens, GI89061728, Length=165, Percent_Identity=35.1515151515151, Blast_Score=109, Evalue=7e-24,
Organism=Homo sapiens, GI23308697, Length=323, Percent_Identity=24.7678018575851, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI295424842, Length=323, Percent_Identity=24.7678018575851, Blast_Score=95, Evalue=1e-19,
Organism=Escherichia coli, GI1788963, Length=427, Percent_Identity=64.6370023419204, Blast_Score=560, Evalue=1e-160,
Organism=Escherichia coli, GI1789874, Length=265, Percent_Identity=33.5849056603774, Blast_Score=147, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17539958, Length=439, Percent_Identity=31.4350797266515, Blast_Score=225, Evalue=5e-59,
Organism=Caenorhabditis elegans, GI193206261, Length=215, Percent_Identity=30.6976744186047, Blast_Score=95, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6325345, Length=408, Percent_Identity=33.0882352941176, Blast_Score=220, Evalue=4e-58,
Organism=Saccharomyces cerevisiae, GI6320498, Length=313, Percent_Identity=26.517571884984, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI17647949, Length=442, Percent_Identity=31.9004524886878, Blast_Score=212, Evalue=4e-55,
Organism=Drosophila melanogaster, GI24641198, Length=272, Percent_Identity=26.1029411764706, Blast_Score=93, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 56129; Mature: 56129

Theoretical pI: Translated: 9.02; Mature: 9.02

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDTLTERLSGSLRKISGSGQLTEDNIKDTLREVRMALLEADVALPITRDFVKRVKEQAL
CCHHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
GQEVLKELAPGQAFVKIVYDELTEMMGSANQQLEMTGKPPVVYLLAGLQGAGKTTTAGKL
HHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEECCCCCCCCCHHHHH
AKYLQERHKKKVMLVSADVYRPAAIKQLEQVAAQVNAKFVNSSSDENPIDIAKRAIEEAK
HHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
LQYQDILIIDTAGRLHIDEDMMDEIKALTAAANPSETLFVVDSMTGQDAANTAKAFNDAL
HHHHCEEEEECCCCEEECHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHCCC
PLTGVILTKTDGDARGGAALSVRAITDKPIKFLGRGEKLDALEAFHPERIAQRILGMGDV
CCCEEEEECCCCCCCCCCEEEEEECCCCHHHHHCCCCCHHHHHHCCHHHHHHHHHCHHHH
LSLVEEVEQKIDRDKAEKMAKKIQKGGEFDLEDLLTQFQQMKNMGGMSGFLDKMPGMSGA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCCCCC
GIKEALEEAKPEEKVKEMEALINSMTPYERKNPDKINPSRKRRIAAGSGKQIQDINRLLK
CHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHH
QHKQMAKMMKMLSKPEGLTKMMKAVQGLTGMGGGGAQGAGGPLFGGGNTGGKPAQGAGGM
HHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PPFGLDPNNMPSKEDMERQLKDLEQQLPPDFKKRF
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHCC
>Mature Secondary Structure
MFDTLTERLSGSLRKISGSGQLTEDNIKDTLREVRMALLEADVALPITRDFVKRVKEQAL
CCHHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
GQEVLKELAPGQAFVKIVYDELTEMMGSANQQLEMTGKPPVVYLLAGLQGAGKTTTAGKL
HHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEECCCCCCCCCHHHHH
AKYLQERHKKKVMLVSADVYRPAAIKQLEQVAAQVNAKFVNSSSDENPIDIAKRAIEEAK
HHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
LQYQDILIIDTAGRLHIDEDMMDEIKALTAAANPSETLFVVDSMTGQDAANTAKAFNDAL
HHHHCEEEEECCCCEEECHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHCCC
PLTGVILTKTDGDARGGAALSVRAITDKPIKFLGRGEKLDALEAFHPERIAQRILGMGDV
CCCEEEEECCCCCCCCCCEEEEEECCCCHHHHHCCCCCHHHHHHCCHHHHHHHHHCHHHH
LSLVEEVEQKIDRDKAEKMAKKIQKGGEFDLEDLLTQFQQMKNMGGMSGFLDKMPGMSGA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCCCCC
GIKEALEEAKPEEKVKEMEALINSMTPYERKNPDKINPSRKRRIAAGSGKQIQDINRLLK
CHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHH
QHKQMAKMMKMLSKPEGLTKMMKAVQGLTGMGGGGAQGAGGPLFGGGNTGGKPAQGAGGM
HHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PPFGLDPNNMPSKEDMERQLKDLEQQLPPDFKKRF
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]