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The map label for this gene is serA [H]

Identifier: 148652381

GI number: 148652381

Start: 683754

End: 684980

Strand: Direct

Name: serA [H]

Synonym: PsycPRwf_0569

Alternate gene names: 148652381

Gene position: 683754-684980 (Clockwise)

Preceding gene: 148652379

Following gene: 148652382

Centisome position: 22.95

GC content: 45.48

Gene sequence:

>1227_bases
ATGGCATTATCGCTTGAAAAAGATAAGATTCGTTTTTTACTTCTAGAGGGGTTGCACGAGAATTCACTAAAAGTATTAAA
CGATGCTGGCTATACCAACATTGAATATTTATCACACGCGCTAGACCCCGAAGAGTTGGCTGAAAAAATCAAAGACGCCC
ACTTTATTGGCATTCGTTCGCGCACTCAGTTGACCCGTGATATCTTAGAACAAGCGGATAAATTAATTGCCATTGGTTGC
TTCTGCATTGGTACCAACCAAGTGGATCTAGATGCCGCTCGTGAGCTTGGTATTCCTGTCTTTAACGCCCCTTATTCCAA
CACCCGCTCAGTGGCAGAGTTGGTCTTAGCCGAAGCGATTATGTTATATCGTGGTATCCCCGAAAAAAATGCTGTGGTTC
ATCGCGGCGGCTGGGGTAAGTCTGCTAAGAACTCACATGAAGTTCGCGGTAAAGTGATGGGTATCGTGGGCTACGGCTCA
ATCGGCTCACAGTTGTCTGTATTGGCTGAGAGCTTGGGCATGAAAGTCATCTATCATGATGTGGTTACCAAGCTACCCTT
AGGTAATGCCGTTCAGGTTGGCAGCTTAGAGGAATTATTAAACAAAGCAGATATCGTTACCCTGCATGTGCCCGACCTGC
CCAGCACACGTTATATGATGAAAAAAGAGCAGTTTGATCAAATGAAAGAGGGCAGCTATTTTATCAACGCTGCTCGTGGT
ACTTGTGTTGAGATTGATGATCTTGCTGCTGCACTTGAGTCAGGCCGAGTGTTAGGCGCGGCTGTAGACGTGTTCCCTAA
AGAGCCAAAATCAGCAGATGAAGAATTTGAATCACCACTGCGTAAGTTTGATAACGTCATCTTGACGCCTCATATCGGTG
GCTCAACTCAAGAAGCTCAGGCCAATATTGGTCTTGAAGTGGCTGAGAAATTTGTTAAATATTCAGATGCCGGTGATACC
ACCACTTCTGTGAACTTCCCTGAAGTCAGCATTCCAGTCAAAGAAGGCTCGCACCGTTTGCTGCATATTCACAAAAACGT
ACCGGGTGTATTGTCGCAAATTAACTCATCATTCGCGTCAGCGGGCATCAACATTTTAGCCCAAAGCTTGATGACAGAAG
GCGATGTGGGTTATTTGGTAATGGATGTCGACAACCGCAACTCACAAGAAGCGCTCGATAAGCTTAGAGATATTGAAGAG
ACCATTCGCGTTCGCGTCTTGTTCTAA

Upstream 100 bases:

>100_bases
TGCGTTTTGTGACGTTATATTTTAATTCGACGCTTTTTATGATAAAGGGGCACAGTGAGATCACTGCTCCCCATTACCCA
TCCGAAATAAGGGCTAAGAC

Downstream 100 bases:

>100_bases
TCGTCTCGATGACTTGACCTCTGTTAGAAAAAAGCTGGCTGCGGCTGGCTTTTTTTATGCCTGCTGGTTTTACCCGCTTC
ACAAAGGGGCAGGTGTTGTT

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 408; Mature: 407

Protein sequence:

>408_residues
MALSLEKDKIRFLLLEGLHENSLKVLNDAGYTNIEYLSHALDPEELAEKIKDAHFIGIRSRTQLTRDILEQADKLIAIGC
FCIGTNQVDLDAARELGIPVFNAPYSNTRSVAELVLAEAIMLYRGIPEKNAVVHRGGWGKSAKNSHEVRGKVMGIVGYGS
IGSQLSVLAESLGMKVIYHDVVTKLPLGNAVQVGSLEELLNKADIVTLHVPDLPSTRYMMKKEQFDQMKEGSYFINAARG
TCVEIDDLAAALESGRVLGAAVDVFPKEPKSADEEFESPLRKFDNVILTPHIGGSTQEAQANIGLEVAEKFVKYSDAGDT
TTSVNFPEVSIPVKEGSHRLLHIHKNVPGVLSQINSSFASAGINILAQSLMTEGDVGYLVMDVDNRNSQEALDKLRDIEE
TIRVRVLF

Sequences:

>Translated_408_residues
MALSLEKDKIRFLLLEGLHENSLKVLNDAGYTNIEYLSHALDPEELAEKIKDAHFIGIRSRTQLTRDILEQADKLIAIGC
FCIGTNQVDLDAARELGIPVFNAPYSNTRSVAELVLAEAIMLYRGIPEKNAVVHRGGWGKSAKNSHEVRGKVMGIVGYGS
IGSQLSVLAESLGMKVIYHDVVTKLPLGNAVQVGSLEELLNKADIVTLHVPDLPSTRYMMKKEQFDQMKEGSYFINAARG
TCVEIDDLAAALESGRVLGAAVDVFPKEPKSADEEFESPLRKFDNVILTPHIGGSTQEAQANIGLEVAEKFVKYSDAGDT
TTSVNFPEVSIPVKEGSHRLLHIHKNVPGVLSQINSSFASAGINILAQSLMTEGDVGYLVMDVDNRNSQEALDKLRDIEE
TIRVRVLF
>Mature_407_residues
ALSLEKDKIRFLLLEGLHENSLKVLNDAGYTNIEYLSHALDPEELAEKIKDAHFIGIRSRTQLTRDILEQADKLIAIGCF
CIGTNQVDLDAARELGIPVFNAPYSNTRSVAELVLAEAIMLYRGIPEKNAVVHRGGWGKSAKNSHEVRGKVMGIVGYGSI
GSQLSVLAESLGMKVIYHDVVTKLPLGNAVQVGSLEELLNKADIVTLHVPDLPSTRYMMKKEQFDQMKEGSYFINAARGT
CVEIDDLAAALESGRVLGAAVDVFPKEPKSADEEFESPLRKFDNVILTPHIGGSTQEAQANIGLEVAEKFVKYSDAGDTT
TSVNFPEVSIPVKEGSHRLLHIHKNVPGVLSQINSSFASAGINILAQSLMTEGDVGYLVMDVDNRNSQEALDKLRDIEET
IRVRVLF

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=317, Percent_Identity=35.9621451104101, Blast_Score=185, Evalue=6e-47,
Organism=Homo sapiens, GI145580578, Length=312, Percent_Identity=29.4871794871795, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI4557499, Length=312, Percent_Identity=29.4871794871795, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI61743967, Length=281, Percent_Identity=29.1814946619217, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI4557497, Length=281, Percent_Identity=29.1814946619217, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI145580575, Length=246, Percent_Identity=31.3008130081301, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI6912396, Length=276, Percent_Identity=27.1739130434783, Blast_Score=97, Evalue=3e-20,
Organism=Escherichia coli, GI1789279, Length=408, Percent_Identity=59.5588235294118, Blast_Score=496, Evalue=1e-142,
Organism=Escherichia coli, GI87082289, Length=241, Percent_Identity=32.7800829875519, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1787645, Length=254, Percent_Identity=27.5590551181102, Blast_Score=99, Evalue=7e-22,
Organism=Escherichia coli, GI87081824, Length=152, Percent_Identity=31.5789473684211, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1788660, Length=271, Percent_Identity=29.8892988929889, Blast_Score=75, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=261, Percent_Identity=36.7816091954023, Blast_Score=158, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI25147481, Length=261, Percent_Identity=27.9693486590038, Blast_Score=103, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6320925, Length=414, Percent_Identity=47.3429951690821, Blast_Score=386, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6322116, Length=414, Percent_Identity=47.8260869565217, Blast_Score=383, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6324964, Length=317, Percent_Identity=29.3375394321767, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6324055, Length=239, Percent_Identity=26.7782426778243, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6324980, Length=181, Percent_Identity=30.939226519337, Blast_Score=80, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6325144, Length=174, Percent_Identity=32.7586206896552, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI19921140, Length=317, Percent_Identity=30.2839116719243, Blast_Score=148, Evalue=7e-36,
Organism=Drosophila melanogaster, GI24646446, Length=240, Percent_Identity=32.5, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24646448, Length=240, Percent_Identity=32.5, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24646452, Length=240, Percent_Identity=32.5, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24646450, Length=240, Percent_Identity=32.5, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI62472511, Length=240, Percent_Identity=32.5, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI28574286, Length=267, Percent_Identity=28.4644194756554, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24585516, Length=297, Percent_Identity=27.2727272727273, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI28571528, Length=294, Percent_Identity=27.5510204081633, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI45551003, Length=291, Percent_Identity=25.7731958762887, Blast_Score=89, Evalue=8e-18,
Organism=Drosophila melanogaster, GI28574284, Length=291, Percent_Identity=25.7731958762887, Blast_Score=89, Evalue=8e-18,
Organism=Drosophila melanogaster, GI24585514, Length=291, Percent_Identity=25.7731958762887, Blast_Score=88, Evalue=8e-18,
Organism=Drosophila melanogaster, GI28574282, Length=291, Percent_Identity=25.7731958762887, Blast_Score=88, Evalue=8e-18,
Organism=Drosophila melanogaster, GI45552429, Length=291, Percent_Identity=25.7731958762887, Blast_Score=88, Evalue=9e-18,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR010771
- InterPro:   IPR016040
- ProDom:   PD147088 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 44670; Mature: 44538

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALSLEKDKIRFLLLEGLHENSLKVLNDAGYTNIEYLSHALDPEELAEKIKDAHFIGIRS
CCCCCCHHHHHHHEECCCCCCCHHEECCCCCCHHHHHHHCCCHHHHHHHHCCCEEEEECH
RTQLTRDILEQADKLIAIGCFCIGTNQVDLDAARELGIPVFNAPYSNTRSVAELVLAEAI
HHHHHHHHHHHHCCEEEEEEEEEECCCCCHHHHHHCCCCEECCCCCCHHHHHHHHHHHHH
MLYRGIPEKNAVVHRGGWGKSAKNSHEVRGKVMGIVGYGSIGSQLSVLAESLGMKVIYHD
HHHCCCCCCCCEEECCCCCCCCCCCHHCCCEEEEEEECCCCHHHHHHHHHHHCCHHHHHH
VVTKLPLGNAVQVGSLEELLNKADIVTLHVPDLPSTRYMMKKEQFDQMKEGSYFINAARG
HHHHCCCCCCEECCCHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEECCC
TCVEIDDLAAALESGRVLGAAVDVFPKEPKSADEEFESPLRKFDNVILTPHIGGSTQEAQ
CEEEHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHHCCEEEECCCCCCCCHHH
ANIGLEVAEKFVKYSDAGDTTTSVNFPEVSIPVKEGSHRLLHIHKNVPGVLSQINSSFAS
HCCCHHHHHHHHHHCCCCCCCEECCCCEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHH
AGINILAQSLMTEGDVGYLVMDVDNRNSQEALDKLRDIEETIRVRVLF
HHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHEEEEEC
>Mature Secondary Structure 
ALSLEKDKIRFLLLEGLHENSLKVLNDAGYTNIEYLSHALDPEELAEKIKDAHFIGIRS
CCCCCHHHHHHHEECCCCCCCHHEECCCCCCHHHHHHHCCCHHHHHHHHCCCEEEEECH
RTQLTRDILEQADKLIAIGCFCIGTNQVDLDAARELGIPVFNAPYSNTRSVAELVLAEAI
HHHHHHHHHHHHCCEEEEEEEEEECCCCCHHHHHHCCCCEECCCCCCHHHHHHHHHHHHH
MLYRGIPEKNAVVHRGGWGKSAKNSHEVRGKVMGIVGYGSIGSQLSVLAESLGMKVIYHD
HHHCCCCCCCCEEECCCCCCCCCCCHHCCCEEEEEEECCCCHHHHHHHHHHHCCHHHHHH
VVTKLPLGNAVQVGSLEELLNKADIVTLHVPDLPSTRYMMKKEQFDQMKEGSYFINAARG
HHHHCCCCCCEECCCHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEECCC
TCVEIDDLAAALESGRVLGAAVDVFPKEPKSADEEFESPLRKFDNVILTPHIGGSTQEAQ
CEEEHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHHCCEEEECCCCCCCCHHH
ANIGLEVAEKFVKYSDAGDTTTSVNFPEVSIPVKEGSHRLLHIHKNVPGVLSQINSSFAS
HCCCHHHHHHHHHHCCCCCCCEECCCCEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHH
AGINILAQSLMTEGDVGYLVMDVDNRNSQEALDKLRDIEETIRVRVLF
HHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]