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The map label for this gene is folP-A [H]

Identifier: 148652348

GI number: 148652348

Start: 640968

End: 641879

Strand: Direct

Name: folP-A [H]

Synonym: PsycPRwf_0536

Alternate gene names: 148652348

Gene position: 640968-641879 (Clockwise)

Preceding gene: 148652347

Following gene: 148652349

Centisome position: 21.52

GC content: 47.59

Gene sequence:

>912_bases
ATGCAACTACATTGTCTTCCTAATATTAAAATTAAAGCGCCTTTATCTACCAAGCCAGGTATCGCTAGCGGCTATAAACA
GCTAGACTTGTCTGAGCCTCAAGTAATGGGTATTTTGAATGTGACCCCTGACTCGTTTTCTGATGGTGGGCAGTTTAATA
ATATCGAGTCGGCTATACGGCACTGTGAACGCATGATTCAAGAGGGTGCCACTATTATTGATATCGGCGGAGAATCAACT
CGGCCAAATGCCAGTCCAGTGAGCGAAGAAGAAGAATGCGCGCGCGTAGTGCCTGTGGTTGCAGCGATTCGTGAACGCTT
CGGTGATAAGCTGTGGCTGTCTATTGATACCAGCTCACCGACAGTGATTGAACAGGCGGTGCACGCGGGTGCTGACATCT
GGAATGATGTGCGAGCATTGACTCGGGAGGGCGCACTTGAGATGGCGGCCAAGCTCGATATCCCTGTGGTACTGATGCAC
ATGCGCGGTGAACCTACTACCATGAATGCCAAAGCCCATTATCAAGATGTGATCAGTGAAGTACTTGCTGAGCTTAAGGT
ACGAATTGAGGCAGCTCAGCAAGCTGGCGTAAAAGCACATAATCTCATTATTGATCCAGGCTTCGGCTTTGCTAAAGAGT
ATGAGCACCACAAGCGGTTATTAAATCATATGTCGCAGTTGCATCAATTGCAGTTGCCCATCTTATTCGGTGTCTCACGT
AAGCGCTTTTTAGGTCAGGTGCTGACCCATACCGGCCTCGGTATCTTTGATGATCATATGGCAACTGATAGAGATGGCGT
GGGTATGGTTGCAGCATTATTAGCAGTACAGCAAGGCGCTAGTATTATACGCACTCATAATGTCAGATTAAGCGTAGAGG
GTCTGGCTTTGTGGCAGCAATTGAGCCAATAA

Upstream 100 bases:

>100_bases
GGCCTTTTTTTATGCGCCGCCACCGGGCGACATATCTGTTAGAATAGCGGATGAAATCTATGGAGTATTTGCCAAAATAA
TTATAAACAGATGAGCCATT

Downstream 100 bases:

>100_bases
CAATACATTATAAATTTTAAAACCGTACTACCTCAAAGCATTGGCTTTTATCGCTATATTATTTTTATTTTTTTTACTTA
GTTAGGAGTGTCTTATGAGC

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MQLHCLPNIKIKAPLSTKPGIASGYKQLDLSEPQVMGILNVTPDSFSDGGQFNNIESAIRHCERMIQEGATIIDIGGEST
RPNASPVSEEEECARVVPVVAAIRERFGDKLWLSIDTSSPTVIEQAVHAGADIWNDVRALTREGALEMAAKLDIPVVLMH
MRGEPTTMNAKAHYQDVISEVLAELKVRIEAAQQAGVKAHNLIIDPGFGFAKEYEHHKRLLNHMSQLHQLQLPILFGVSR
KRFLGQVLTHTGLGIFDDHMATDRDGVGMVAALLAVQQGASIIRTHNVRLSVEGLALWQQLSQ

Sequences:

>Translated_303_residues
MQLHCLPNIKIKAPLSTKPGIASGYKQLDLSEPQVMGILNVTPDSFSDGGQFNNIESAIRHCERMIQEGATIIDIGGEST
RPNASPVSEEEECARVVPVVAAIRERFGDKLWLSIDTSSPTVIEQAVHAGADIWNDVRALTREGALEMAAKLDIPVVLMH
MRGEPTTMNAKAHYQDVISEVLAELKVRIEAAQQAGVKAHNLIIDPGFGFAKEYEHHKRLLNHMSQLHQLQLPILFGVSR
KRFLGQVLTHTGLGIFDDHMATDRDGVGMVAALLAVQQGASIIRTHNVRLSVEGLALWQQLSQ
>Mature_303_residues
MQLHCLPNIKIKAPLSTKPGIASGYKQLDLSEPQVMGILNVTPDSFSDGGQFNNIESAIRHCERMIQEGATIIDIGGEST
RPNASPVSEEEECARVVPVVAAIRERFGDKLWLSIDTSSPTVIEQAVHAGADIWNDVRALTREGALEMAAKLDIPVVLMH
MRGEPTTMNAKAHYQDVISEVLAELKVRIEAAQQAGVKAHNLIIDPGFGFAKEYEHHKRLLNHMSQLHQLQLPILFGVSR
KRFLGQVLTHTGLGIFDDHMATDRDGVGMVAALLAVQQGASIIRTHNVRLSVEGLALWQQLSQ

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=268, Percent_Identity=48.5074626865672, Blast_Score=254, Evalue=5e-69,
Organism=Saccharomyces cerevisiae, GI6324073, Length=326, Percent_Identity=30.6748466257669, Blast_Score=140, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 33237; Mature: 33237

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLHCLPNIKIKAPLSTKPGIASGYKQLDLSEPQVMGILNVTPDSFSDGGQFNNIESAIR
CEEEECCCCEEECCCCCCCCCCCCCHHCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHH
HCERMIQEGATIIDIGGESTRPNASPVSEEEECARVVPVVAAIRERFGDKLWLSIDTSSP
HHHHHHHCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCC
TVIEQAVHAGADIWNDVRALTREGALEMAAKLDIPVVLMHMRGEPTTMNAKAHYQDVISE
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHH
VLAELKVRIEAAQQAGVKAHNLIIDPGFGFAKEYEHHKRLLNHMSQLHQLQLPILFGVSR
HHHHHHHHHHHHHHCCCEEHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCHHHCCCHH
KRFLGQVLTHTGLGIFDDHMATDRDGVGMVAALLAVQQGASIIRTHNVRLSVEGLALWQQ
HHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEECCEEEEEHHHHHHHH
LSQ
HCC
>Mature Secondary Structure
MQLHCLPNIKIKAPLSTKPGIASGYKQLDLSEPQVMGILNVTPDSFSDGGQFNNIESAIR
CEEEECCCCEEECCCCCCCCCCCCCHHCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHH
HCERMIQEGATIIDIGGESTRPNASPVSEEEECARVVPVVAAIRERFGDKLWLSIDTSSP
HHHHHHHCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCC
TVIEQAVHAGADIWNDVRALTREGALEMAAKLDIPVVLMHMRGEPTTMNAKAHYQDVISE
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHH
VLAELKVRIEAAQQAGVKAHNLIIDPGFGFAKEYEHHKRLLNHMSQLHQLQLPILFGVSR
HHHHHHHHHHHHHHCCCEEHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCHHHCCCHH
KRFLGQVLTHTGLGIFDDHMATDRDGVGMVAALLAVQQGASIIRTHNVRLSVEGLALWQQ
HHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEECCEEEEEHHHHHHHH
LSQ
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]