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The map label for this gene is pyrE [H]

Identifier: 148652333

GI number: 148652333

Start: 623311

End: 623985

Strand: Direct

Name: pyrE [H]

Synonym: PsycPRwf_0521

Alternate gene names: 148652333

Gene position: 623311-623985 (Clockwise)

Preceding gene: 148652332

Following gene: 148652334

Centisome position: 20.92

GC content: 44.74

Gene sequence:

>675_bases
ATGGCAGTTTCTCCTTCTATTTCTAATTTTTCTAGCAGTGCTTTTATTGAGCTTGCTTTGTCTAATGAAGTGTTAAAGTT
TGGTGAATATGTGCTTAAATCAGGCCGTATTAGTCCTTATTTCTTTAATGCAGGTTTACTGTCCACAGGAGAGATGTTGT
CATTATTGGCCAATGGTTATGCCGAAGCTTTAGCTCAGCAAGTAAAGGTGTCGGGTAGCGATGAGCTGGTTATCTTTGGC
GCCGCTTATAAAGGCATTCCTTTTGTGGCAGCCACTGCACAAGCCCTATGGAATAATCATGGCATTAACGCACACTGGGG
TTACAATCGTAAAGAGGCCAAAGATCATGGTGAAGGCGGCAACTTAGTGGGTGCAGATGTGAATGGCAAAGCGGTATGGG
TGCTAGATGATGTCATCACTGCTGGCACAGCAATGCGAGAGGTTGTCGATATTTTGGATGCTGCCGGTGCCACAGTGGCC
GGTATTCTTGTGGCGCTTGATCGCAAAGAGCGTGGCCAAAATGAGCAATCTGCGATTCAAGAGCTGGCAGAGAACTTAAA
AGTTCCTGTACAAGCTTTGGTTAATATAGATGATATTATTGATTATGTGGCCAAAAAGGGTGAGGAAACGCAGTTGGCCA
AAATGCGTCATTACCGTGAGCAGTACGGCGTATAA

Upstream 100 bases:

>100_bases
ACAGGTTTTTGGCCTATCTTTTACCAAGCTTTAGCCTAAGTTTGGTTGGTGGCTTGATATAACGTCACTTTACTTTTTAT
TTATTTAAATAGGACTTTTC

Downstream 100 bases:

>100_bases
ATGGAGTGGGGCTTAAGTCAGCTAAACTTGTAAAAATGAAGCCTAGCCATCACCCTAACTATAATCATCTTATCTTTGTC
AGTTGCTGACAGTCATAACG

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase [H]

Number of amino acids: Translated: 224; Mature: 223

Protein sequence:

>224_residues
MAVSPSISNFSSSAFIELALSNEVLKFGEYVLKSGRISPYFFNAGLLSTGEMLSLLANGYAEALAQQVKVSGSDELVIFG
AAYKGIPFVAATAQALWNNHGINAHWGYNRKEAKDHGEGGNLVGADVNGKAVWVLDDVITAGTAMREVVDILDAAGATVA
GILVALDRKERGQNEQSAIQELAENLKVPVQALVNIDDIIDYVAKKGEETQLAKMRHYREQYGV

Sequences:

>Translated_224_residues
MAVSPSISNFSSSAFIELALSNEVLKFGEYVLKSGRISPYFFNAGLLSTGEMLSLLANGYAEALAQQVKVSGSDELVIFG
AAYKGIPFVAATAQALWNNHGINAHWGYNRKEAKDHGEGGNLVGADVNGKAVWVLDDVITAGTAMREVVDILDAAGATVA
GILVALDRKERGQNEQSAIQELAENLKVPVQALVNIDDIIDYVAKKGEETQLAKMRHYREQYGV
>Mature_223_residues
AVSPSISNFSSSAFIELALSNEVLKFGEYVLKSGRISPYFFNAGLLSTGEMLSLLANGYAEALAQQVKVSGSDELVIFGA
AYKGIPFVAATAQALWNNHGINAHWGYNRKEAKDHGEGGNLVGADVNGKAVWVLDDVITAGTAMREVVDILDAAGATVAG
ILVALDRKERGQNEQSAIQELAENLKVPVQALVNIDDIIDYVAKKGEETQLAKMRHYREQYGV

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) [H]

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507835, Length=157, Percent_Identity=29.2993630573248, Blast_Score=68, Evalue=5e-12,
Organism=Escherichia coli, GI1790073, Length=211, Percent_Identity=53.5545023696682, Blast_Score=220, Evalue=7e-59,
Organism=Saccharomyces cerevisiae, GI6323530, Length=216, Percent_Identity=42.1296296296296, Blast_Score=162, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6323927, Length=219, Percent_Identity=39.2694063926941, Blast_Score=159, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004467
- InterPro:   IPR023031
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.10 [H]

Molecular weight: Translated: 24059; Mature: 23928

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVSPSISNFSSSAFIELALSNEVLKFGEYVLKSGRISPYFFNAGLLSTGEMLSLLANGY
CCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHH
AEALAQQVKVSGSDELVIFGAAYKGIPFVAATAQALWNNHGINAHWGYNRKEAKDHGEGG
HHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCCC
NLVGADVNGKAVWVLDDVITAGTAMREVVDILDAAGATVAGILVALDRKERGQNEQSAIQ
CEEECCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHCCCCHHHHHH
ELAENLKVPVQALVNIDDIIDYVAKKGEETQLAKMRHYREQYGV
HHHHHCCCHHHHHHCHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AVSPSISNFSSSAFIELALSNEVLKFGEYVLKSGRISPYFFNAGLLSTGEMLSLLANGY
CCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHH
AEALAQQVKVSGSDELVIFGAAYKGIPFVAATAQALWNNHGINAHWGYNRKEAKDHGEGG
HHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCCC
NLVGADVNGKAVWVLDDVITAGTAMREVVDILDAAGATVAGILVALDRKERGQNEQSAIQ
CEEECCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHCCCCHHHHHH
ELAENLKVPVQALVNIDDIIDYVAKKGEETQLAKMRHYREQYGV
HHHHHCCCHHHHHHCHHHHHHHHHCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA