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The map label for this gene is wecC [H]

Identifier: 148643363

GI number: 148643363

Start: 1310642

End: 1311880

Strand: Reverse

Name: wecC [H]

Synonym: Msm_1303

Alternate gene names: 148643363

Gene position: 1311880-1310642 (Counterclockwise)

Preceding gene: 148643365

Following gene: 148643361

Centisome position: 70.79

GC content: 33.09

Gene sequence:

>1239_bases
ATGAAAATTTGTATTATTGGACAAGGCTACATCGGATTGCCAACAGCTGCACTTTTTACAAAAAATCACTGTGAAGTTGT
TGGAGTAGATGTTAATGAAAAGGTTGTTGAAACTTTAAATCAGGGAAAAATTCATATTGAAGAACCTGGAATTGGTGAAA
TAATTAAAAAAGCTGTTGAAAAAGGCGTATATTCTGCTTCAACAACACCTGTAAAAGCTGATGCATTTATAATAACTGTG
CCAACACCATACATTGCTGAAAATTACACATGTGATTTAAGTTATGTTATCAGTGCATGTGAATCCATACTTCCTTATTT
GGAAAAAGGAAATACTGTAATTGTTGAATCTACAATAGCTCCAATGTCTATGGATGATTATGTTAAACCTATTTTTGAAA
AAGCCGGTTACACAATAGGAAAAGACTTATACCTTGCCCATTGCCCTGAGAGAGTCCTTCCAGGAAAAATCATGTATGAA
TTAGTACATAATGATCGTATTGTAGGTGGAATAACCCCTGAATGCTCAATTAAAGCCAGTGAAGTTTATGGTCAGTTTGT
TGAAGGTGCATTAATGAAAACAGAAGCAAAAACTGCAGAATTATCCAAATGTATGGAAAATACTTTTAGAGACGTTAACA
TTGCACTAGCTAATGAACTTACAAAAATATGTACTAAAATAGGAGTAAATGCATTGGATGTAATTGAAATGGCAAATAAA
CATCCAAGAGTAAACCTGCACTCACCAGGACCTGGAGTTGGAGGACACTGCCTAGCTATTGACCCTTATTTCATTTATTC
AAAAGCACCGGAATATGCAAAAATAATAAAACTAGCCAGAGACACCAACAACTCAATGCCCGAATTTGTATATGAAAATG
TTAAAAAAATAACACCAAATGGCAAAATAGCAGTTTTAGGAGTTGCATATAAAGGAAACACTGGTGATGACAGGGAAAGT
CCGGCATATGAGATAATAGCTAAATTAAAAGAAGACAACTATGAAATAAGCATCTGTGATCCCCATGTAGCCAATGAAGA
ATATGTTGATTTAAAGCAGGCTACCAAAGATGCAAACCTTATTTTAATATTATGTGACCATGATGAGTTTAAAGACCTTG
ATTACGATTTAATCAAAGAAAACATGGAAAAAGCAATTATATTCGACACTAAAAATATAATAAAAGAAGTACCTGAAGAC
ATTAAGCTTTACAATTATGGAAATTTATTTAGTCTTTAA

Upstream 100 bases:

>100_bases
CATAATTATCCCTATTTTTATTTAATAAAAACTAAATATTATTTATATTAATAAACATAATATATTTAATTATTTGAAAA
ATAAAAGGGGCTTTTTATTT

Downstream 100 bases:

>100_bases
AAACAATAAAAAGAGAAAAAAAGAAAAATTAGAAATCAATTGATTGATCAGGTTCTACTGGATTACCATTCCAAGCTTTT
AAAGTAGTCCATTCTTCAAA

Product: UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: UDP-ManNAc 6-dehydrogenase [H]

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MKICIIGQGYIGLPTAALFTKNHCEVVGVDVNEKVVETLNQGKIHIEEPGIGEIIKKAVEKGVYSASTTPVKADAFIITV
PTPYIAENYTCDLSYVISACESILPYLEKGNTVIVESTIAPMSMDDYVKPIFEKAGYTIGKDLYLAHCPERVLPGKIMYE
LVHNDRIVGGITPECSIKASEVYGQFVEGALMKTEAKTAELSKCMENTFRDVNIALANELTKICTKIGVNALDVIEMANK
HPRVNLHSPGPGVGGHCLAIDPYFIYSKAPEYAKIIKLARDTNNSMPEFVYENVKKITPNGKIAVLGVAYKGNTGDDRES
PAYEIIAKLKEDNYEISICDPHVANEEYVDLKQATKDANLILILCDHDEFKDLDYDLIKENMEKAIIFDTKNIIKEVPED
IKLYNYGNLFSL

Sequences:

>Translated_412_residues
MKICIIGQGYIGLPTAALFTKNHCEVVGVDVNEKVVETLNQGKIHIEEPGIGEIIKKAVEKGVYSASTTPVKADAFIITV
PTPYIAENYTCDLSYVISACESILPYLEKGNTVIVESTIAPMSMDDYVKPIFEKAGYTIGKDLYLAHCPERVLPGKIMYE
LVHNDRIVGGITPECSIKASEVYGQFVEGALMKTEAKTAELSKCMENTFRDVNIALANELTKICTKIGVNALDVIEMANK
HPRVNLHSPGPGVGGHCLAIDPYFIYSKAPEYAKIIKLARDTNNSMPEFVYENVKKITPNGKIAVLGVAYKGNTGDDRES
PAYEIIAKLKEDNYEISICDPHVANEEYVDLKQATKDANLILILCDHDEFKDLDYDLIKENMEKAIIFDTKNIIKEVPED
IKLYNYGNLFSL
>Mature_412_residues
MKICIIGQGYIGLPTAALFTKNHCEVVGVDVNEKVVETLNQGKIHIEEPGIGEIIKKAVEKGVYSASTTPVKADAFIITV
PTPYIAENYTCDLSYVISACESILPYLEKGNTVIVESTIAPMSMDDYVKPIFEKAGYTIGKDLYLAHCPERVLPGKIMYE
LVHNDRIVGGITPECSIKASEVYGQFVEGALMKTEAKTAELSKCMENTFRDVNIALANELTKICTKIGVNALDVIEMANK
HPRVNLHSPGPGVGGHCLAIDPYFIYSKAPEYAKIIKLARDTNNSMPEFVYENVKKITPNGKIAVLGVAYKGNTGDDRES
PAYEIIAKLKEDNYEISICDPHVANEEYVDLKQATKDANLILILCDHDEFKDLDYDLIKENMEKAIIFDTKNIIKEVPED
IKLYNYGNLFSL

Specific function: Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA) [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=455, Percent_Identity=26.1538461538462, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI296040438, Length=350, Percent_Identity=25.4285714285714, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI296040443, Length=448, Percent_Identity=23.4375, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI48994968, Length=426, Percent_Identity=42.2535211267606, Blast_Score=341, Evalue=5e-95,
Organism=Escherichia coli, GI1788340, Length=398, Percent_Identity=26.3819095477387, Blast_Score=94, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17560350, Length=443, Percent_Identity=25.9593679458239, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI17136908, Length=444, Percent_Identity=27.027027027027, Blast_Score=134, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 45648; Mature: 45648

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKICIIGQGYIGLPTAALFTKNHCEVVGVDVNEKVVETLNQGKIHIEEPGIGEIIKKAVE
CEEEEEECCCCCCCHHHHEECCCCEEEEECCCHHHHHHHCCCEEEEECCCHHHHHHHHHH
KGVYSASTTPVKADAFIITVPTPYIAENYTCDLSYVISACESILPYLEKGNTVIVESTIA
CCCCCCCCCCEECCEEEEECCCCHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCC
PMSMDDYVKPIFEKAGYTIGKDLYLAHCPERVLPGKIMYELVHNDRIVGGITPECSIKAS
CCCHHHHHHHHHHHCCCCCCCCEEEECCCCHHCCHHHHHHHHHCCEEEECCCCCCCEEHH
EVYGQFVEGALMKTEAKTAELSKCMENTFRDVNIALANELTKICTKIGVNALDVIEMANK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCC
HPRVNLHSPGPGVGGHCLAIDPYFIYSKAPEYAKIIKLARDTNNSMPEFVYENVKKITPN
CCEEEECCCCCCCCCEEEEECCEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCC
GKIAVLGVAYKGNTGDDRESPAYEIIAKLKEDNYEISICDPHVANEEYVDLKQATKDANL
CCEEEEEEEEECCCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHCCCCCE
ILILCDHDEFKDLDYDLIKENMEKAIIFDTKNIIKEVPEDIKLYNYGNLFSL
EEEEECCCCCCCCCHHHHHHCCCCEEEEECHHHHHHCCHHCEEEECCCCCCC
>Mature Secondary Structure
MKICIIGQGYIGLPTAALFTKNHCEVVGVDVNEKVVETLNQGKIHIEEPGIGEIIKKAVE
CEEEEEECCCCCCCHHHHEECCCCEEEEECCCHHHHHHHCCCEEEEECCCHHHHHHHHHH
KGVYSASTTPVKADAFIITVPTPYIAENYTCDLSYVISACESILPYLEKGNTVIVESTIA
CCCCCCCCCCEECCEEEEECCCCHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCC
PMSMDDYVKPIFEKAGYTIGKDLYLAHCPERVLPGKIMYELVHNDRIVGGITPECSIKAS
CCCHHHHHHHHHHHCCCCCCCCEEEECCCCHHCCHHHHHHHHHCCEEEECCCCCCCEEHH
EVYGQFVEGALMKTEAKTAELSKCMENTFRDVNIALANELTKICTKIGVNALDVIEMANK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCC
HPRVNLHSPGPGVGGHCLAIDPYFIYSKAPEYAKIIKLARDTNNSMPEFVYENVKKITPN
CCEEEECCCCCCCCCEEEEECCEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCC
GKIAVLGVAYKGNTGDDRESPAYEIIAKLKEDNYEISICDPHVANEEYVDLKQATKDANL
CCEEEEEEEEECCCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHCCCCCE
ILILCDHDEFKDLDYDLIKENMEKAIIFDTKNIIKEVPEDIKLYNYGNLFSL
EEEEECCCCCCCCCHHHHHHCCCCEEEEECHHHHHHCCHHCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA