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The map label for this gene is pyrD [H]

Identifier: 148643104

GI number: 148643104

Start: 1006822

End: 1007733

Strand: Reverse

Name: pyrD [H]

Synonym: Msm_1044

Alternate gene names: 148643104

Gene position: 1007733-1006822 (Counterclockwise)

Preceding gene: 148643105

Following gene: 148643103

Centisome position: 54.38

GC content: 34.98

Gene sequence:

>912_bases
ATGTTGAGGACAAATGTTTGTGGAGTTGAATTTAGAAATCCTTTAATGTTGGCTGCAGGAGTTATGGGAAGTAATGCTTC
TTCCATGAATTGGATTTTAAAATCCGGTGCAGCAGGTGTTGTTTCTAAATCTTTTTCTTTAGAACCGAATCCGGGATATG
CAAATCCTACAACTGTAGGTGTTGAATGCGGCATTATCAATGCTATCGGTCTTTCAAATCCCGGTGCAGAAAACTTTAAA
GAGGAACTTAAAAGAATTGACAGGAAAGGAAATGTTTCAATAGCTTCAATTTACGGGGCAACTCCTGAAGAATTTAGCAA
GTTAGTTTTGGAAATTGAAGATTATGTTGATATGATTGAGTTGAATATTTCATGTCCTCATGCTATGGAAGGTTATGGTG
CATCCATAGGTCAGGATGCTAATTTAACTCATAAAATTGTTAGTGCTGCTAAAGATAGTGCAAATAAACCAGTAATAGCT
AAACTAACTCCAAATGTTACTGATATTGTTGAAATAGCTGTGGCAGCTCAGGATGCAGGAGCAGATGCATTGACTTTAAT
TAATTCATTAGGTCCTGGAATGAAAATCAATATTGATGTTGCAAGACCTGTTTTATCAAATAAGTTTGGCGGAATGAGCG
GTAAGGCTATAAAACCAATAGCTCTTCGTAATGTTTATACTGTTTATGATAATGTAGATATTCCAATTATTGGTGTTGGA
GGTATTTCAAACTTTGAAGATGTTGTTGAATTTTTATTTGCTGGAGCTAGGGCAGTTCAAATTGGTACTTCTATTATGGA
TGAGGGTGTAGAAGTATTTGGCAAAATCAACAAAGATTTAGAAGAATTTATGAATAAAAAAGGTTATGAATCTATTGATG
AAATGATTGGCCTTGCACATGAGGAGTTGTAA

Upstream 100 bases:

>100_bases
ATCGTGAATTGATTAAGAAATATGAAGAAAAACTTGATTAAAAATGTATAAATGTTTTATAATACATAATTAATATCATA
TAAAAATTTTTGGTGTAATC

Downstream 100 bases:

>100_bases
TTTATGAATGATGTTCCACAAATTGTTGAAATTAATGAAATAATTGAAGAGACTCCAACAATTAAAACTTTTGTCTTTGA
TTGGGATATGGATAAGTTCG

Product: dihydroorotate dehydrogenase 1B

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MLRTNVCGVEFRNPLMLAAGVMGSNASSMNWILKSGAAGVVSKSFSLEPNPGYANPTTVGVECGIINAIGLSNPGAENFK
EELKRIDRKGNVSIASIYGATPEEFSKLVLEIEDYVDMIELNISCPHAMEGYGASIGQDANLTHKIVSAAKDSANKPVIA
KLTPNVTDIVEIAVAAQDAGADALTLINSLGPGMKINIDVARPVLSNKFGGMSGKAIKPIALRNVYTVYDNVDIPIIGVG
GISNFEDVVEFLFAGARAVQIGTSIMDEGVEVFGKINKDLEEFMNKKGYESIDEMIGLAHEEL

Sequences:

>Translated_303_residues
MLRTNVCGVEFRNPLMLAAGVMGSNASSMNWILKSGAAGVVSKSFSLEPNPGYANPTTVGVECGIINAIGLSNPGAENFK
EELKRIDRKGNVSIASIYGATPEEFSKLVLEIEDYVDMIELNISCPHAMEGYGASIGQDANLTHKIVSAAKDSANKPVIA
KLTPNVTDIVEIAVAAQDAGADALTLINSLGPGMKINIDVARPVLSNKFGGMSGKAIKPIALRNVYTVYDNVDIPIIGVG
GISNFEDVVEFLFAGARAVQIGTSIMDEGVEVFGKINKDLEEFMNKKGYESIDEMIGLAHEEL
>Mature_303_residues
MLRTNVCGVEFRNPLMLAAGVMGSNASSMNWILKSGAAGVVSKSFSLEPNPGYANPTTVGVECGIINAIGLSNPGAENFK
EELKRIDRKGNVSIASIYGATPEEFSKLVLEIEDYVDMIELNISCPHAMEGYGASIGQDANLTHKIVSAAKDSANKPVIA
KLTPNVTDIVEIAVAAQDAGADALTLINSLGPGMKINIDVARPVLSNKFGGMSGKAIKPIALRNVYTVYDNVDIPIIGVG
GISNFEDVVEFLFAGARAVQIGTSIMDEGVEVFGKINKDLEEFMNKKGYESIDEMIGLAHEEL

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=313, Percent_Identity=30.9904153354633, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI45006951, Length=331, Percent_Identity=25.0755287009063, Blast_Score=92, Evalue=6e-19,
Organism=Escherichia coli, GI87082059, Length=321, Percent_Identity=33.3333333333333, Blast_Score=159, Evalue=2e-40,
Organism=Escherichia coli, GI1787177, Length=301, Percent_Identity=26.578073089701, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71984108, Length=317, Percent_Identity=29.6529968454259, Blast_Score=126, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17509475, Length=331, Percent_Identity=25.3776435045317, Blast_Score=85, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6322633, Length=312, Percent_Identity=31.4102564102564, Blast_Score=132, Evalue=9e-32,
Organism=Drosophila melanogaster, GI24640763, Length=291, Percent_Identity=33.6769759450172, Blast_Score=135, Evalue=3e-32,
Organism=Drosophila melanogaster, GI18858217, Length=291, Percent_Identity=33.6769759450172, Blast_Score=135, Evalue=3e-32,
Organism=Drosophila melanogaster, GI281361352, Length=322, Percent_Identity=23.9130434782609, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI17137316, Length=322, Percent_Identity=23.9130434782609, Blast_Score=68, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.3.1 [H]

Molecular weight: Translated: 32155; Mature: 32155

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: PS00014 ER_TARGET ; PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRTNVCGVEFRNPLMLAAGVMGSNASSMNWILKSGAAGVVSKSFSLEPNPGYANPTTVG
CCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHCCCCCHHCCCCCCCCCCCCCCCCEEE
VECGIINAIGLSNPGAENFKEELKRIDRKGNVSIASIYGATPEEFSKLVLEIEDYVDMIE
EEECEEEECCCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHEEEE
LNISCPHAMEGYGASIGQDANLTHKIVSAAKDSANKPVIAKLTPNVTDIVEIAVAAQDAG
EECCCCCHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHCCCC
ADALTLINSLGPGMKINIDVARPVLSNKFGGMSGKAIKPIALRNVYTVYDNVDIPIIGVG
CHHHHHHHHCCCCEEEEEEECCHHHHHCCCCCCCCCCCCCHHHHEEEEECCCCEEEEEEC
GISNFEDVVEFLFAGARAVQIGTSIMDEGVEVFGKINKDLEEFMNKKGYESIDEMIGLAH
CCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
EEL
HCC
>Mature Secondary Structure
MLRTNVCGVEFRNPLMLAAGVMGSNASSMNWILKSGAAGVVSKSFSLEPNPGYANPTTVG
CCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHCCCCCHHCCCCCCCCCCCCCCCCEEE
VECGIINAIGLSNPGAENFKEELKRIDRKGNVSIASIYGATPEEFSKLVLEIEDYVDMIE
EEECEEEECCCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHEEEE
LNISCPHAMEGYGASIGQDANLTHKIVSAAKDSANKPVIAKLTPNVTDIVEIAVAAQDAG
EECCCCCHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHCCCC
ADALTLINSLGPGMKINIDVARPVLSNKFGGMSGKAIKPIALRNVYTVYDNVDIPIIGVG
CHHHHHHHHCCCCEEEEEEECCHHHHHCCCCCCCCCCCCCHHHHEEEEECCCCEEEEEEC
GISNFEDVVEFLFAGARAVQIGTSIMDEGVEVFGKINKDLEEFMNKKGYESIDEMIGLAH
CCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
EEL
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]