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The map label for this gene is mcrA [H]

Identifier: 148643075

GI number: 148643075

Start: 977489

End: 979144

Strand: Reverse

Name: mcrA [H]

Synonym: Msm_1015

Alternate gene names: 148643075

Gene position: 979144-977489 (Counterclockwise)

Preceding gene: 148643076

Following gene: 148643074

Centisome position: 52.84

GC content: 39.67

Gene sequence:

>1656_bases
ATGGCAGATAAAAAATTCTTAGATGCAATGAAAAACAAATTCAGTGAAGGTCCAACTGATAAAAGAACCACTTTCTATAA
CATGGGCGGTTGGAAACAATCTGAAAGAAAAAGCGCATTCGTAAAAGAAGGTAAAGAAATCGCTGAAAAAAGAGGAATTC
CAATGTACAACCCAGACATTGGTACTCCTTTAGGTCAAAGGGCTTTAATGTCTTACCAATTATCTACTACTGATACTTAT
GTAGAAGGTGACGATTTACACTTCATTAACAACGCAGCTATCCAACAAGCTTGGGACGATATTAGAAGAACTGTAATTGT
AGGTTTAAATACTGCTCACAACGTTCTTGAAAAAAGGTTAGGTATTGAAGTAACTCCTGAAACAATCACTGAATACTTAG
AAACTGTAAACCACGCAATGCCTGGTGCAGCAGTAGTTCAAGAACACATGGTAGAAACTGACCCATTAGTAGTACAAGAC
AGTTATGTTAAAGTATTTACTGGTGACGATGAATTAGCTGATGAAATTGATTCAGCATTCGTTTTAGACATCAACAAAGA
GTTCAATGAAGAACAAGCAGCAGCTTTAAAAGAAGAAGTTGGTGGAAGTGTATGGCAAGCTGTAAGAATTCCTGCTATCG
TAGGAAGAGTTTGTGACGGAGGTACTACCTCAAGATGGTCTGCAATGCAAATTGGTATGTCAATGATTTCTGCATACAAC
CAATGTGCTGGTGAAGGAGCTACTGGTGACTTCGCATACGCATCCAAACACGCAGAAGTTATTCACATGGGTACTTACTT
ACCTGTAAGAAGAGCAAGAGCAGAAAACGAGTTAGGTGGAGTTCCATTTGGTTTCATGGCAGATATCTGTCAATCTTCCA
GAGTAAATGCTGACGACCCAGTACGTTCAACCTTAGATGTAGTAGCTTTAGGTGCTGCATTATACGACCAAATTTGGTTA
GGTTCTTACATGTCTGGTGGTGTAGGATTCACTCAATATGCTACTGCAGCATATACTGATGATGTATTAGATGACTTCAC
TTACTATGGTAAAGATTACGTAGAAGACAAATATGGTGGATTAACTGAAGCACCTAATAACATGGACACTGTTCTTGATG
TAGGTTCTGAAGTTTCATTCTACGCATTAGAACAATACGAAGAATACCCAGCTTTACTTGAAACTCACTTCGGTGGATCT
CAAAGGGCTTCTGTTATTTCAGCGGCAGCTGGTTGTTCCACTGCATTCGCTACTGGTAATGCTCAAACTGGTTTAAGTGC
ATGGTACTTAGGTATGTACTTACACAAAGAACAACATTCCAGATTAGGTTTCTACGGATACGATTTACAAGATCAATGTG
GTGCAGCTAACGTATTCTCCATCAGAAATGATGAAGGTTTACCACTCGAAATGAGAGGACCAAACTACCCTAACTACGCA
ATGAACGTAGGTCACCAAGGTGAATACGCTGGTATCGCTCAAGCTCCTCACGCAGCTCGTGGAGATGCTTGGTCTTTCAA
CCCATTAGTTAAAATCGCATTTGCTGATAAAAACTTAGTATTCGACTTCAGTAAACCTCGTGAAGAATTTGCTAAAGGTG
CATTAAGAGAGTTCGAACCATCCGGTGAAAGAACTGTCATCACCCCAGCAAAATAA

Upstream 100 bases:

>100_bases
AAGCATACAAAGATGATACTGAAGCTGTTGAAGTGTTAAAAAACATTCACGTATCCAGATCATTTGGTGCATTCAATCCA
GTTAAAGGATGGGATTAAGT

Downstream 100 bases:

>100_bases
ATTTGAAACAAATAGGTTAAATAGGTGATTTTTCATCTATTTATTCCTTAAATTTAAGTATACCTTAAAATTTTTTAGTA
AAACATTTATATTAATATTG

Product: methyl-coenzyme M reductase, alpha subunit, McrA

Products: NA

Alternate protein names: Coenzyme-B sulfoethylthiotransferase alpha [H]

Number of amino acids: Translated: 551; Mature: 550

Protein sequence:

>551_residues
MADKKFLDAMKNKFSEGPTDKRTTFYNMGGWKQSERKSAFVKEGKEIAEKRGIPMYNPDIGTPLGQRALMSYQLSTTDTY
VEGDDLHFINNAAIQQAWDDIRRTVIVGLNTAHNVLEKRLGIEVTPETITEYLETVNHAMPGAAVVQEHMVETDPLVVQD
SYVKVFTGDDELADEIDSAFVLDINKEFNEEQAAALKEEVGGSVWQAVRIPAIVGRVCDGGTTSRWSAMQIGMSMISAYN
QCAGEGATGDFAYASKHAEVIHMGTYLPVRRARAENELGGVPFGFMADICQSSRVNADDPVRSTLDVVALGAALYDQIWL
GSYMSGGVGFTQYATAAYTDDVLDDFTYYGKDYVEDKYGGLTEAPNNMDTVLDVGSEVSFYALEQYEEYPALLETHFGGS
QRASVISAAAGCSTAFATGNAQTGLSAWYLGMYLHKEQHSRLGFYGYDLQDQCGAANVFSIRNDEGLPLEMRGPNYPNYA
MNVGHQGEYAGIAQAPHAARGDAWSFNPLVKIAFADKNLVFDFSKPREEFAKGALREFEPSGERTVITPAK

Sequences:

>Translated_551_residues
MADKKFLDAMKNKFSEGPTDKRTTFYNMGGWKQSERKSAFVKEGKEIAEKRGIPMYNPDIGTPLGQRALMSYQLSTTDTY
VEGDDLHFINNAAIQQAWDDIRRTVIVGLNTAHNVLEKRLGIEVTPETITEYLETVNHAMPGAAVVQEHMVETDPLVVQD
SYVKVFTGDDELADEIDSAFVLDINKEFNEEQAAALKEEVGGSVWQAVRIPAIVGRVCDGGTTSRWSAMQIGMSMISAYN
QCAGEGATGDFAYASKHAEVIHMGTYLPVRRARAENELGGVPFGFMADICQSSRVNADDPVRSTLDVVALGAALYDQIWL
GSYMSGGVGFTQYATAAYTDDVLDDFTYYGKDYVEDKYGGLTEAPNNMDTVLDVGSEVSFYALEQYEEYPALLETHFGGS
QRASVISAAAGCSTAFATGNAQTGLSAWYLGMYLHKEQHSRLGFYGYDLQDQCGAANVFSIRNDEGLPLEMRGPNYPNYA
MNVGHQGEYAGIAQAPHAARGDAWSFNPLVKIAFADKNLVFDFSKPREEFAKGALREFEPSGERTVITPAK
>Mature_550_residues
ADKKFLDAMKNKFSEGPTDKRTTFYNMGGWKQSERKSAFVKEGKEIAEKRGIPMYNPDIGTPLGQRALMSYQLSTTDTYV
EGDDLHFINNAAIQQAWDDIRRTVIVGLNTAHNVLEKRLGIEVTPETITEYLETVNHAMPGAAVVQEHMVETDPLVVQDS
YVKVFTGDDELADEIDSAFVLDINKEFNEEQAAALKEEVGGSVWQAVRIPAIVGRVCDGGTTSRWSAMQIGMSMISAYNQ
CAGEGATGDFAYASKHAEVIHMGTYLPVRRARAENELGGVPFGFMADICQSSRVNADDPVRSTLDVVALGAALYDQIWLG
SYMSGGVGFTQYATAAYTDDVLDDFTYYGKDYVEDKYGGLTEAPNNMDTVLDVGSEVSFYALEQYEEYPALLETHFGGSQ
RASVISAAAGCSTAFATGNAQTGLSAWYLGMYLHKEQHSRLGFYGYDLQDQCGAANVFSIRNDEGLPLEMRGPNYPNYAM
NVGHQGEYAGIAQAPHAARGDAWSFNPLVKIAFADKNLVFDFSKPREEFAKGALREFEPSGERTVITPAK

Specific function: Reduction of methyl-coenzyme M (2-(methylthio) ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate to methane and an heterodisulfide [H]

COG id: COG4058

COG function: function code H; Methyl coenzyme M reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022681
- InterPro:   IPR016212
- InterPro:   IPR008924
- InterPro:   IPR009047
- InterPro:   IPR003183
- InterPro:   IPR015811
- InterPro:   IPR015823
- InterPro:   IPR009024 [H]

Pfam domain/function: PF02249 MCR_alpha; PF02745 MCR_alpha_N [H]

EC number: =2.8.4.1 [H]

Molecular weight: Translated: 60483; Mature: 60352

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: PS00277 STAPH_STREP_TOXIN_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADKKFLDAMKNKFSEGPTDKRTTFYNMGGWKQSERKSAFVKEGKEIAEKRGIPMYNPDI
CCCHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCC
GTPLGQRALMSYQLSTTDTYVEGDDLHFINNAAIQQAWDDIRRTVIVGLNTAHNVLEKRL
CCCHHHHHHHEEEECCCCCEECCCCEEEEHHHHHHHHHHHHHHEEEEECCHHHHHHHHHC
GIEVTPETITEYLETVNHAMPGAAVVQEHMVETDPLVVQDSYVKVFTGDDELADEIDSAF
CCEECHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEECCEEEEEECCHHHHHHHCCEE
VLDINKEFNEEQAAALKEEVGGSVWQAVRIPAIVGRVCDGGTTSRWSAMQIGMSMISAYN
EEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
QCAGEGATGDFAYASKHAEVIHMGTYLPVRRARAENELGGVPFGFMADICQSSRVNADDP
HHCCCCCCCCCHHHCCCCEEEEECCCCHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCH
VRSTLDVVALGAALYDQIWLGSYMSGGVGFTQYATAAYTDDVLDDFTYYGKDYVEDKYGG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCC
LTEAPNNMDTVLDVGSEVSFYALEQYEEYPALLETHFGGSQRASVISAAAGCSTAFATGN
CCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHEECCC
AQTGLSAWYLGMYLHKEQHSRLGFYGYDLQDQCGAANVFSIRNDEGLPLEMRGPNYPNYA
CCCCHHHHHHHHHHHHHHHCCCCEECCCHHHHCCCCCEEEEECCCCCEEEECCCCCCCHH
MNVGHQGEYAGIAQAPHAARGDAWSFNPLVKIAFADKNLVFDFSKPREEFAKGALREFEP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCEEEECCCCHHHHHHHHHHHCCC
SGERTVITPAK
CCCEEEECCCC
>Mature Secondary Structure 
ADKKFLDAMKNKFSEGPTDKRTTFYNMGGWKQSERKSAFVKEGKEIAEKRGIPMYNPDI
CCHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCC
GTPLGQRALMSYQLSTTDTYVEGDDLHFINNAAIQQAWDDIRRTVIVGLNTAHNVLEKRL
CCCHHHHHHHEEEECCCCCEECCCCEEEEHHHHHHHHHHHHHHEEEEECCHHHHHHHHHC
GIEVTPETITEYLETVNHAMPGAAVVQEHMVETDPLVVQDSYVKVFTGDDELADEIDSAF
CCEECHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEECCEEEEEECCHHHHHHHCCEE
VLDINKEFNEEQAAALKEEVGGSVWQAVRIPAIVGRVCDGGTTSRWSAMQIGMSMISAYN
EEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
QCAGEGATGDFAYASKHAEVIHMGTYLPVRRARAENELGGVPFGFMADICQSSRVNADDP
HHCCCCCCCCCHHHCCCCEEEEECCCCHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCH
VRSTLDVVALGAALYDQIWLGSYMSGGVGFTQYATAAYTDDVLDDFTYYGKDYVEDKYGG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCC
LTEAPNNMDTVLDVGSEVSFYALEQYEEYPALLETHFGGSQRASVISAAAGCSTAFATGN
CCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHEECCC
AQTGLSAWYLGMYLHKEQHSRLGFYGYDLQDQCGAANVFSIRNDEGLPLEMRGPNYPNYA
CCCCHHHHHHHHHHHHHHHCCCCEECCCHHHHCCCCCEEEEECCCCCEEEECCCCCCCHH
MNVGHQGEYAGIAQAPHAARGDAWSFNPLVKIAFADKNLVFDFSKPREEFAKGALREFEP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCEEEECCCCHHHHHHHHHHHCCC
SGERTVITPAK
CCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7929010; 9371463; 2269306 [H]