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The map label for this gene is mfnA

Identifier: 148643047

GI number: 148643047

Start: 946481

End: 947638

Strand: Reverse

Name: mfnA

Synonym: Msm_0987

Alternate gene names: 148643047

Gene position: 947638-946481 (Counterclockwise)

Preceding gene: 148643048

Following gene: 148643046

Centisome position: 51.14

GC content: 32.56

Gene sequence:

>1158_bases
ATGGAAGATAAACCAATATCTAAAAAAGACATACTTAAAGAATTAAATGAAATCCAATCAAAAGACCATAAATATAGTGA
TGGTAGAATATTAGGTTCTATGTGTACAGAAGCACATCCATTTGCTAAAGAAGTTTATTGTAAATTTTTAGATTCTAATT
TGGGAGATCCTGGTCTTTTTAAAGGAACAAAATATATTGAAAATGAAGTTATAAAATCTATTGGTGAATTATTATCGATT
AGTGAACCTTATGGAAATATTGTAACTGGTGGTACTGAAGCTAATATCATGGCGATGAGGGCAGCAAGAAATCATGCCCG
AAAATATAAGGGAATTAAAGAAGGAGAAATCATAATTCCGGATTCTGCTCATTTCTCATTTAAAAAAGCTGCAGATATGA
TGAATTTAAAAATTATTGAAGCTAAACTGGATGAAAATTACAAAATCGATGTTGATTCAGTTAAAGAAAATATTTCCGAT
AATACTGTGGCTATTGTAGCTATTGCAGGAACTACTGAATTGGGTTTGGTTGATCCTATTGAAGAATTGTCTGAAATAGC
TTATGAAAATAATATTTACTTCCATGTTGACGCGGCATTTGGAGGTTTTTCAATACCATTTTTAAGAAAAATTGGTTATG
AATTTCCGCCTTTTGATTTTTCATTACCGGGGGTATGTTCAATTACTGTTGATCCTCATAAAATGGGTTTGGCACCAATT
CCTGCCGGAGGAATTCTGTTTAGAAAAAAAGAGTATCTGGAAGTGATGGCTGTTGATTCTCCATATCTGACTGTTAAAAC
ACAATCTACAATTGTTGGAACTCGTTCAGGAGCAGCTTCTGCAGCTACTTATGCAATCATGAAATATCTTGGAAACGAAG
GCTATGAAAAGCTTGCAGGAAACTTGATGGATAATACTCATTATTTTAAAGAAGGTCTGGAAAAAATAGGTTATGATGTT
GTTGTAGAACCTGAATTGAACATTGTAGCATTTAATCATCCGGATATGGAAGCTCATGATTTGGCTGATAAACTGGAAGA
TTTGGGATGGAGAGTTTCAGTAGCTAAATGTCCTATAGCTATTCGTGTAGTTTTAATGAATCATATCACTAAACAGCATT
TGACTGATTTATTGGATGATTTAACAGAAATTTATTAA

Upstream 100 bases:

>100_bases
AGCTGAGAAAAAAATTATTCTTGATGCTGCTCGCAAATCTCAAGAATAAATTTTATTTTCTTTTTTATTTTTTTTAAATA
TCACCTTATAAGGTTGTACT

Downstream 100 bases:

>100_bases
TTTTTTTGTTTCTGCTCTTTTTTTTAGAATATATAATTAAGTATAAATATGGATTATACATAATTAATTATCAACGGAGG
TTTGGTAATTATGTGTACTG

Product: L-tyrosine decarboxylase

Products: NA

Alternate protein names: TDC

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MEDKPISKKDILKELNEIQSKDHKYSDGRILGSMCTEAHPFAKEVYCKFLDSNLGDPGLFKGTKYIENEVIKSIGELLSI
SEPYGNIVTGGTEANIMAMRAARNHARKYKGIKEGEIIIPDSAHFSFKKAADMMNLKIIEAKLDENYKIDVDSVKENISD
NTVAIVAIAGTTELGLVDPIEELSEIAYENNIYFHVDAAFGGFSIPFLRKIGYEFPPFDFSLPGVCSITVDPHKMGLAPI
PAGGILFRKKEYLEVMAVDSPYLTVKTQSTIVGTRSGAASAATYAIMKYLGNEGYEKLAGNLMDNTHYFKEGLEKIGYDV
VVEPELNIVAFNHPDMEAHDLADKLEDLGWRVSVAKCPIAIRVVLMNHITKQHLTDLLDDLTEIY

Sequences:

>Translated_385_residues
MEDKPISKKDILKELNEIQSKDHKYSDGRILGSMCTEAHPFAKEVYCKFLDSNLGDPGLFKGTKYIENEVIKSIGELLSI
SEPYGNIVTGGTEANIMAMRAARNHARKYKGIKEGEIIIPDSAHFSFKKAADMMNLKIIEAKLDENYKIDVDSVKENISD
NTVAIVAIAGTTELGLVDPIEELSEIAYENNIYFHVDAAFGGFSIPFLRKIGYEFPPFDFSLPGVCSITVDPHKMGLAPI
PAGGILFRKKEYLEVMAVDSPYLTVKTQSTIVGTRSGAASAATYAIMKYLGNEGYEKLAGNLMDNTHYFKEGLEKIGYDV
VVEPELNIVAFNHPDMEAHDLADKLEDLGWRVSVAKCPIAIRVVLMNHITKQHLTDLLDDLTEIY
>Mature_385_residues
MEDKPISKKDILKELNEIQSKDHKYSDGRILGSMCTEAHPFAKEVYCKFLDSNLGDPGLFKGTKYIENEVIKSIGELLSI
SEPYGNIVTGGTEANIMAMRAARNHARKYKGIKEGEIIIPDSAHFSFKKAADMMNLKIIEAKLDENYKIDVDSVKENISD
NTVAIVAIAGTTELGLVDPIEELSEIAYENNIYFHVDAAFGGFSIPFLRKIGYEFPPFDFSLPGVCSITVDPHKMGLAPI
PAGGILFRKKEYLEVMAVDSPYLTVKTQSTIVGTRSGAASAATYAIMKYLGNEGYEKLAGNLMDNTHYFKEGLEKIGYDV
VVEPELNIVAFNHPDMEAHDLADKLEDLGWRVSVAKCPIAIRVVLMNHITKQHLTDLLDDLTEIY

Specific function: Specifically catalyzes the decarboxylation of L-tyrosine to produce tyramine

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family. Archaeal L-tyrosine decarboxylase subfamily

Homologues:

Organism=Homo sapiens, GI31982936, Length=397, Percent_Identity=30.9823677581864, Blast_Score=195, Evalue=5e-50,
Organism=Homo sapiens, GI197383062, Length=295, Percent_Identity=24.7457627118644, Blast_Score=72, Evalue=7e-13,
Organism=Escherichia coli, GI1789934, Length=367, Percent_Identity=24.7956403269755, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1787769, Length=367, Percent_Identity=24.7956403269755, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17543922, Length=397, Percent_Identity=29.4710327455919, Blast_Score=181, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI17557272, Length=356, Percent_Identity=31.1797752808989, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI25148342, Length=329, Percent_Identity=31.0030395136778, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI71993062, Length=351, Percent_Identity=23.9316239316239, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17555682, Length=351, Percent_Identity=23.9316239316239, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71993058, Length=268, Percent_Identity=25, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320500, Length=394, Percent_Identity=28.1725888324873, Blast_Score=160, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6323905, Length=283, Percent_Identity=23.321554770318, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21355963, Length=386, Percent_Identity=30.8290155440415, Blast_Score=192, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24654344, Length=386, Percent_Identity=30.8290155440415, Blast_Score=192, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24657193, Length=296, Percent_Identity=24.6621621621622, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24657185, Length=296, Percent_Identity=24.6621621621622, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24657188, Length=296, Percent_Identity=24.6621621621622, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MFNA_METS3 (A5ULW4)

Other databases:

- EMBL:   CP000678
- RefSeq:   YP_001273560.1
- ProteinModelPortal:   A5ULW4
- SMR:   A5ULW4
- STRING:   A5ULW4
- GeneID:   5216971
- GenomeReviews:   CP000678_GR
- KEGG:   msi:Msm_0987
- eggNOG:   arNOG04425
- HOGENOM:   HBG497871
- OMA:   ILGSMCT
- ProtClustDB:   PRK13520
- HAMAP:   MF_01610
- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR021115
- InterPro:   IPR020931
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11999
- TIGRFAMs:   TIGR03812

Pfam domain/function: PF00282 Pyridoxal_deC; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =4.1.1.25

Molecular weight: Translated: 42725; Mature: 42725

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS00392 DDC_GAD_HDC_YDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDKPISKKDILKELNEIQSKDHKYSDGRILGSMCTEAHPFAKEVYCKFLDSNLGDPGLF
CCCCCCCHHHHHHHHHHHHHCCCCCCCCEEHHHHHCCCCHHHHHHHHHHHHCCCCCCCCC
KGTKYIENEVIKSIGELLSISEPYGNIVTGGTEANIMAMRAARNHARKYKGIKEGEIIIP
CCHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHCCCCCCCEEEC
DSAHFSFKKAADMMNLKIIEAKLDENYKIDVDSVKENISDNTVAIVAIAGTTELGLVDPI
CCCCCCHHHHHHHHCEEEEEEECCCCCEEEHHHHHCCCCCCEEEEEEEECCCCCCCCCHH
EELSEIAYENNIYFHVDAAFGGFSIPFLRKIGYEFPPFDFSLPGVCSITVDPHKMGLAPI
HHHHHHHHCCCEEEEEECCCCCCCCHHHHHCCCCCCCCCCCCCCEEEEEECHHHCCCCCC
PAGGILFRKKEYLEVMAVDSPYLTVKTQSTIVGTRSGAASAATYAIMKYLGNEGYEKLAG
CCCCEEEEHHHHEEEEEECCCEEEEEECCEEEECCCCCHHHHHHHHHHHHCCCCHHHHHH
NLMDNTHYFKEGLEKIGYDVVVEPELNIVAFNHPDMEAHDLADKLEDLGWRVSVAKCPIA
HHHCCHHHHHHHHHHCCCCEEECCCCCEEEECCCCCHHHHHHHHHHHCCCEEEEECCCHH
IRVVLMNHITKQHLTDLLDDLTEIY
HHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEDKPISKKDILKELNEIQSKDHKYSDGRILGSMCTEAHPFAKEVYCKFLDSNLGDPGLF
CCCCCCCHHHHHHHHHHHHHCCCCCCCCEEHHHHHCCCCHHHHHHHHHHHHCCCCCCCCC
KGTKYIENEVIKSIGELLSISEPYGNIVTGGTEANIMAMRAARNHARKYKGIKEGEIIIP
CCHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHCCCCCCCEEEC
DSAHFSFKKAADMMNLKIIEAKLDENYKIDVDSVKENISDNTVAIVAIAGTTELGLVDPI
CCCCCCHHHHHHHHCEEEEEEECCCCCEEEHHHHHCCCCCCEEEEEEEECCCCCCCCCHH
EELSEIAYENNIYFHVDAAFGGFSIPFLRKIGYEFPPFDFSLPGVCSITVDPHKMGLAPI
HHHHHHHHCCCEEEEEECCCCCCCCHHHHHCCCCCCCCCCCCCCEEEEEECHHHCCCCCC
PAGGILFRKKEYLEVMAVDSPYLTVKTQSTIVGTRSGAASAATYAIMKYLGNEGYEKLAG
CCCCEEEEHHHHEEEEEECCCEEEEEECCEEEECCCCCHHHHHHHHHHHHCCCCHHHHHH
NLMDNTHYFKEGLEKIGYDVVVEPELNIVAFNHPDMEAHDLADKLEDLGWRVSVAKCPIA
HHHCCHHHHHHHHHHCCCCEEECCCCCEEEECCCCCHHHHHHHHHHHCCCEEEEECCCHH
IRVVLMNHITKQHLTDLLDDLTEIY
HHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA