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The map label for this gene is cbh [H]

Identifier: 148643046

GI number: 148643046

Start: 945440

End: 946390

Strand: Reverse

Name: cbh [H]

Synonym: Msm_0986

Alternate gene names: 148643046

Gene position: 946390-945440 (Counterclockwise)

Preceding gene: 148643047

Following gene: 148643041

Centisome position: 51.07

GC content: 33.75

Gene sequence:

>951_bases
ATGTGTACTGCTGCAAATTATTTAACAAAATGCCATTATTTTGGCCGTAATTTTGACTATGAAATTTCATATAATGAAAG
AGTAACGATAACTCCTAGAAACTATCCTTTAATATTCAGGGATACTGAGGACATTGAAAATCATTATGGGATTATTGGCA
TAGCTGCAGGTATTGATGAATATCCTTTGTATTATGATGCATGTAATGAGAAAGGATTAGCTATGGGGGGATTAAACTTT
CCGGATTACTGTGACTACAAACCACTAGATAAATCTAAAGTTAACATAGCTTCTTTTGAGATTATTCCATATATATTATC
TCAAGCAAAAACCATCAGTGATGCCGAAAGGTTATTGGAAAACTTAAATATTTCAGATGAGAAATTTTCCGCCCAGTTGC
CTCCATCTCCACTTCATTGGATTATTTCAGATAGGAATGCTTCAATTGTTGTAGAGGTTGTAGAGGAAGGACTGGATATT
TATGATAATCCTGTAGGAGTTTTAACAAACAACCCTCCTTTTGATAAACAGCTATTTAATTTAAATAATTATATGGCATT
ATCAAACAGAACGCCTGAAAATACCTTTGGAGGCAATTTGGATTTGGCAACTTATAGTCGGGGAATGGGTTCAATTGGTC
TTCCGGGGGATGTTTCTTCACAGTCCCGTTTTGTAAAAGCAGCTTTTGTTAAAGAAAATTCCGTTTCCGGAGATTCTGAA
AAAGAAAGTGTGTCTCAGTTTTTCCATATTCTGGCATCTGTTGAACAGCAAAAAGGATGTACGTTAGTGGAAGAACCTGA
TAAATTTGAGTATACTATTTATTCAGACTGTTACAATACAGATAAGGGAATATTGTATTATAAAACATATGATGGTCCTC
AAACATCTGTTAATATACATGATGAGGATTTGGAAACCAATCAGTTAATTAATTTTGAGTTGGTTGATTAA

Upstream 100 bases:

>100_bases
AATTTATTAATTTTTTTGTTTCTGCTCTTTTTTTTAGAATATATAATTAAGTATAAATATGGATTATACATAATTAATTA
TCAACGGAGGTTTGGTAATT

Downstream 100 bases:

>100_bases
AAAATAGTTTATGGGTGTTGTTTGTATAACAACACCTGCAATAATTTAATTGATGTCTTCTACATACATTAAAGGATAAT
TTAACTCTTCAATAAATTCT

Product: conjugated bile salt acid hydrolase (CBAH)

Products: NA

Alternate protein names: Bile salt hydrolase; Conjugated bile acid hydrolase; CBAH [H]

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MCTAANYLTKCHYFGRNFDYEISYNERVTITPRNYPLIFRDTEDIENHYGIIGIAAGIDEYPLYYDACNEKGLAMGGLNF
PDYCDYKPLDKSKVNIASFEIIPYILSQAKTISDAERLLENLNISDEKFSAQLPPSPLHWIISDRNASIVVEVVEEGLDI
YDNPVGVLTNNPPFDKQLFNLNNYMALSNRTPENTFGGNLDLATYSRGMGSIGLPGDVSSQSRFVKAAFVKENSVSGDSE
KESVSQFFHILASVEQQKGCTLVEEPDKFEYTIYSDCYNTDKGILYYKTYDGPQTSVNIHDEDLETNQLINFELVD

Sequences:

>Translated_316_residues
MCTAANYLTKCHYFGRNFDYEISYNERVTITPRNYPLIFRDTEDIENHYGIIGIAAGIDEYPLYYDACNEKGLAMGGLNF
PDYCDYKPLDKSKVNIASFEIIPYILSQAKTISDAERLLENLNISDEKFSAQLPPSPLHWIISDRNASIVVEVVEEGLDI
YDNPVGVLTNNPPFDKQLFNLNNYMALSNRTPENTFGGNLDLATYSRGMGSIGLPGDVSSQSRFVKAAFVKENSVSGDSE
KESVSQFFHILASVEQQKGCTLVEEPDKFEYTIYSDCYNTDKGILYYKTYDGPQTSVNIHDEDLETNQLINFELVD
>Mature_316_residues
MCTAANYLTKCHYFGRNFDYEISYNERVTITPRNYPLIFRDTEDIENHYGIIGIAAGIDEYPLYYDACNEKGLAMGGLNF
PDYCDYKPLDKSKVNIASFEIIPYILSQAKTISDAERLLENLNISDEKFSAQLPPSPLHWIISDRNASIVVEVVEEGLDI
YDNPVGVLTNNPPFDKQLFNLNNYMALSNRTPENTFGGNLDLATYSRGMGSIGLPGDVSSQSRFVKAAFVKENSVSGDSE
KESVSQFFHILASVEQQKGCTLVEEPDKFEYTIYSDCYNTDKGILYYKTYDGPQTSVNIHDEDLETNQLINFELVD

Specific function: The enzyme catalyzes the degradation of conjugated bile acids in the mammalian gut [H]

COG id: COG3049

COG function: function code M; Penicillin V acylase and related amidases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C59 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003199 [H]

Pfam domain/function: PF02275 CBAH [H]

EC number: =3.5.1.24 [H]

Molecular weight: Translated: 35689; Mature: 35689

Theoretical pI: Translated: 4.19; Mature: 4.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCTAANYLTKCHYFGRNFDYEISYNERVTITPRNYPLIFRDTEDIENHYGIIGIAAGIDE
CCCHHHHHHHHHHCCCCCEEEEECCCEEEECCCCCEEEEECCHHHHHCCCEEEEECCCCC
YPLYYDACNEKGLAMGGLNFPDYCDYKPLDKSKVNIASFEIIPYILSQAKTISDAERLLE
CCEEEECCCCCCCEECCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHH
NLNISDEKFSAQLPPSPLHWIISDRNASIVVEVVEEGLDIYDNPVGVLTNNPPFDKQLFN
HCCCCCHHEECCCCCCCEEEEEECCCCEEEEEEHHCCCCCCCCCEEEEECCCCCCHHHHC
LNNYMALSNRTPENTFGGNLDLATYSRGMGSIGLPGDVSSQSRFVKAAFVKENSVSGDSE
CCCEEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCHHEEEEEEEECCCCCCCCH
KESVSQFFHILASVEQQKGCTLVEEPDKFEYTIYSDCYNTDKGILYYKTYDGPQTSVNIH
HHHHHHHHHHHHHHHHHCCCEEEECCCCEEEEEEECCCCCCCCEEEEEECCCCCCEEEEE
DEDLETNQLINFELVD
CCCCCCCEEEEEEECC
>Mature Secondary Structure
MCTAANYLTKCHYFGRNFDYEISYNERVTITPRNYPLIFRDTEDIENHYGIIGIAAGIDE
CCCHHHHHHHHHHCCCCCEEEEECCCEEEECCCCCEEEEECCHHHHHCCCEEEEECCCCC
YPLYYDACNEKGLAMGGLNFPDYCDYKPLDKSKVNIASFEIIPYILSQAKTISDAERLLE
CCEEEECCCCCCCEECCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHH
NLNISDEKFSAQLPPSPLHWIISDRNASIVVEVVEEGLDIYDNPVGVLTNNPPFDKQLFN
HCCCCCHHEECCCCCCCEEEEEECCCCEEEEEEHHCCCCCCCCCEEEEECCCCCCHHHHC
LNNYMALSNRTPENTFGGNLDLATYSRGMGSIGLPGDVSSQSRFVKAAFVKENSVSGDSE
CCCEEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCHHEEEEEEEECCCCCCCCH
KESVSQFFHILASVEQQKGCTLVEEPDKFEYTIYSDCYNTDKGILYYKTYDGPQTSVNIH
HHHHHHHHHHHHHHHHHCCCEEEECCCCEEEEEEECCCCCCCCEEEEEECCCCCCEEEEE
DEDLETNQLINFELVD
CCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1476424; 12566566 [H]