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The map label for this gene is moeA [C]

Identifier: 148643010

GI number: 148643010

Start: 911720

End: 912949

Strand: Reverse

Name: moeA [C]

Synonym: Msm_0950

Alternate gene names: 148643010

Gene position: 912949-911720 (Counterclockwise)

Preceding gene: 148643013

Following gene: 148643009

Centisome position: 49.26

GC content: 34.47

Gene sequence:

>1230_bases
ATGGGAACTGAATTTTTAAAAATTAAAGAATCCGAAGATGCTTTAGAAATTATTCAAAACTTATTTGATAAATATTACAC
TCTTCAAAGTGAAGAGATTGCTGTTGAAGATGCATACGGCAGAGTACTTTCTGGTGATGTGTACAGTAGGATGGATTTTC
CTCCATTTGATAAAGCTTTAAAAGATGGTTTTGCAATTCTTTCACAGGACAGTTTTGGAGCTAGTGAAGAGTCTCCAAAG
ACTTTGGAAGTTATTGATTTTTTAGAGGCAGGTTCAACAACGGATAAGATTGTTGAAGAAGGCAAATGTGTTGAAATAAG
TACTGGTGCAGCTATGCCTGAAGGGGCAGATGCAGTTGTAATGGTTGAATACTGTGAAAAAATGGATTCTGCAGTTAATA
TCTTGACTACTGTTACTCCTACTCAGGATGTAGCTAAAAAAGGTTCTGATACTGAAGAATCCAAATTAATTTTAAAGAAA
GGTGATGTTTTAACTCCTGGTAAAATTGGTGTTTTACTTTCTCAGGGATTTGAAACAATTGAAGTTTATAAAAAACCTAC
TGTTGGGGTCATATCAACCGGAAATGAAATTACTCTTCAGGGCAATGAATTGCCGTACGGTAAAATTTATGATGTCAATG
GAAACATGATTAAAAATGATGCAATATCCTGTGGAGCTGATGCTAAGTTTTTAGGAACTGTTAAGGATAATTATGATCAA
CTTAAAGCTAAAATTCAGGAATCTTTAGATGATGTGGATATTTTAATCGGATCTGGAGGAACTTCTGCAGGTCTGGGAGA
TGTAATGAAACATGTTTTGGATGAACTGGGTCAGGTTTATATTCATGGAATTTCTGTCCAGCCTGGAAAACCTACTATTG
TGGGTATTGTAGATGGTAAAATTGTTATTGGATTGCCTGGAAATCCGGTATCTGCTTTAATGATATTTAATGCATTTGTA
GCTCCTCCTTTAACAAAATTGGCAGGTATTGACAAAAATTTCGAAAAAAGTGTAGTTAAAGGTAAACTAACCAGAAGAAT
ACATTCTCCAGTGGGTAGGATGCAGTATCAGTTAGTAAAAGTTGACGGTGAAGATATCCAACCGATATTTAAAGACTCTG
GAGCTATATTTTCTTTATCTACTGCTGACGGTTATGTTAAAGTTCCAAAATCTGTTGAACTTCTTGATGAAGGAGAAGAA
GTTGAGGTATATTTATTTAACATAAATTAA

Upstream 100 bases:

>100_bases
CCATCAATATAGTTTATATTTTCCATTTGGTTGATGATAAATTAAACTATTTATATATTACTTTTATTAATATATTAATG
TATTCATTAAAGGGGATAAT

Downstream 100 bases:

>100_bases
AAATATTAAATAAAAAAAGGTGAATCAAATGCAAATTCAAGATAAAATTATTCCTGATCAAAAAATAGCTGTTATTAATT
ATAAAGGTCCAATTTCTGAT

Product: molybdopterin biosynthesis protein, MoeA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 409; Mature: 408

Protein sequence:

>409_residues
MGTEFLKIKESEDALEIIQNLFDKYYTLQSEEIAVEDAYGRVLSGDVYSRMDFPPFDKALKDGFAILSQDSFGASEESPK
TLEVIDFLEAGSTTDKIVEEGKCVEISTGAAMPEGADAVVMVEYCEKMDSAVNILTTVTPTQDVAKKGSDTEESKLILKK
GDVLTPGKIGVLLSQGFETIEVYKKPTVGVISTGNEITLQGNELPYGKIYDVNGNMIKNDAISCGADAKFLGTVKDNYDQ
LKAKIQESLDDVDILIGSGGTSAGLGDVMKHVLDELGQVYIHGISVQPGKPTIVGIVDGKIVIGLPGNPVSALMIFNAFV
APPLTKLAGIDKNFEKSVVKGKLTRRIHSPVGRMQYQLVKVDGEDIQPIFKDSGAIFSLSTADGYVKVPKSVELLDEGEE
VEVYLFNIN

Sequences:

>Translated_409_residues
MGTEFLKIKESEDALEIIQNLFDKYYTLQSEEIAVEDAYGRVLSGDVYSRMDFPPFDKALKDGFAILSQDSFGASEESPK
TLEVIDFLEAGSTTDKIVEEGKCVEISTGAAMPEGADAVVMVEYCEKMDSAVNILTTVTPTQDVAKKGSDTEESKLILKK
GDVLTPGKIGVLLSQGFETIEVYKKPTVGVISTGNEITLQGNELPYGKIYDVNGNMIKNDAISCGADAKFLGTVKDNYDQ
LKAKIQESLDDVDILIGSGGTSAGLGDVMKHVLDELGQVYIHGISVQPGKPTIVGIVDGKIVIGLPGNPVSALMIFNAFV
APPLTKLAGIDKNFEKSVVKGKLTRRIHSPVGRMQYQLVKVDGEDIQPIFKDSGAIFSLSTADGYVKVPKSVELLDEGEE
VEVYLFNIN
>Mature_408_residues
GTEFLKIKESEDALEIIQNLFDKYYTLQSEEIAVEDAYGRVLSGDVYSRMDFPPFDKALKDGFAILSQDSFGASEESPKT
LEVIDFLEAGSTTDKIVEEGKCVEISTGAAMPEGADAVVMVEYCEKMDSAVNILTTVTPTQDVAKKGSDTEESKLILKKG
DVLTPGKIGVLLSQGFETIEVYKKPTVGVISTGNEITLQGNELPYGKIYDVNGNMIKNDAISCGADAKFLGTVKDNYDQL
KAKIQESLDDVDILIGSGGTSAGLGDVMKHVLDELGQVYIHGISVQPGKPTIVGIVDGKIVIGLPGNPVSALMIFNAFVA
PPLTKLAGIDKNFEKSVVKGKLTRRIHSPVGRMQYQLVKVDGEDIQPIFKDSGAIFSLSTADGYVKVPKSVELLDEGEEV
EVYLFNIN

Specific function: Involved In The Biosynthesis Of A Demolybdo-Cofactor (Molybdopterin), Necessary For Molybdo-Enzymes. Seems To Be Involved In A Step Of Activation Of Molybdenum In The Form Of Thiomolybdenum. [C]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=402, Percent_Identity=32.5870646766169, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI66932975, Length=402, Percent_Identity=32.5870646766169, Blast_Score=184, Evalue=1e-46,
Organism=Escherichia coli, GI1787049, Length=327, Percent_Identity=33.0275229357798, Blast_Score=182, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI25147659, Length=318, Percent_Identity=33.3333333333333, Blast_Score=148, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI17562606, Length=315, Percent_Identity=26.984126984127, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17136978, Length=292, Percent_Identity=32.1917808219178, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24638841, Length=292, Percent_Identity=32.1917808219178, Blast_Score=129, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 44142; Mature: 44011

Theoretical pI: Translated: 4.32; Mature: 4.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTEFLKIKESEDALEIIQNLFDKYYTLQSEEIAVEDAYGRVLSGDVYSRMDFPPFDKAL
CCCCEEEEECCCHHHHHHHHHHHHHEECCCCCEEEEHHCCCEECCCHHHCCCCCCHHHHH
KDGFAILSQDSFGASEESPKTLEVIDFLEAGSTTDKIVEEGKCVEISTGAAMPEGADAVV
HCCEEEEECCCCCCCCCCCCHHHHHHHHHCCCCHHHHHCCCCEEEEECCCCCCCCCCEEE
MVEYCEKMDSAVNILTTVTPTQDVAKKGSDTEESKLILKKGDVLTPGKIGVLLSQGFETI
EHHHHHHHHHHHEEEEECCCCHHHHHCCCCCHHHEEEEECCCEECCCHHHHHHHCCCCEE
EVYKKPTVGVISTGNEITLQGNELPYGKIYDVNGNMIKNDAISCGADAKFLGTVKDNYDQ
EEECCCCEEEEECCCEEEEECCCCCCCEEEECCCCEEECCCCCCCCCCEEEECHHCCHHH
LKAKIQESLDDVDILIGSGGTSAGLGDVMKHVLDELGQVYIHGISVQPGKPTIVGIVDGK
HHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCEEEEEEEECCCCCEEEEEECCE
IVIGLPGNPVSALMIFNAFVAPPLTKLAGIDKNFEKSVVKGKLTRRIHSPVGRMQYQLVK
EEEECCCCCHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHEEEEEEE
VDGEDIQPIFKDSGAIFSLSTADGYVKVPKSVELLDEGEEVEVYLFNIN
ECCCCCCHHHCCCCCEEEEECCCCEEECCCCCHHHCCCCEEEEEEEECC
>Mature Secondary Structure 
GTEFLKIKESEDALEIIQNLFDKYYTLQSEEIAVEDAYGRVLSGDVYSRMDFPPFDKAL
CCCEEEEECCCHHHHHHHHHHHHHEECCCCCEEEEHHCCCEECCCHHHCCCCCCHHHHH
KDGFAILSQDSFGASEESPKTLEVIDFLEAGSTTDKIVEEGKCVEISTGAAMPEGADAVV
HCCEEEEECCCCCCCCCCCCHHHHHHHHHCCCCHHHHHCCCCEEEEECCCCCCCCCCEEE
MVEYCEKMDSAVNILTTVTPTQDVAKKGSDTEESKLILKKGDVLTPGKIGVLLSQGFETI
EHHHHHHHHHHHEEEEECCCCHHHHHCCCCCHHHEEEEECCCEECCCHHHHHHHCCCCEE
EVYKKPTVGVISTGNEITLQGNELPYGKIYDVNGNMIKNDAISCGADAKFLGTVKDNYDQ
EEECCCCEEEEECCCEEEEECCCCCCCEEEECCCCEEECCCCCCCCCCEEEECHHCCHHH
LKAKIQESLDDVDILIGSGGTSAGLGDVMKHVLDELGQVYIHGISVQPGKPTIVGIVDGK
HHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCEEEEEEEECCCCCEEEEEECCE
IVIGLPGNPVSALMIFNAFVAPPLTKLAGIDKNFEKSVVKGKLTRRIHSPVGRMQYQLVK
EEEECCCCCHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHEEEEEEE
VDGEDIQPIFKDSGAIFSLSTADGYVKVPKSVELLDEGEEVEVYLFNIN
ECCCCCCHHHCCCCCEEEEECCCCEEECCCCCHHHCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]