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The map label for this gene is wecB [H]

Identifier: 148642913

GI number: 148642913

Start: 809707

End: 811029

Strand: Reverse

Name: wecB [H]

Synonym: Msm_0853

Alternate gene names: 148642913

Gene position: 811029-809707 (Counterclockwise)

Preceding gene: 148642915

Following gene: 148642912

Centisome position: 43.76

GC content: 31.52

Gene sequence:

>1323_bases
ATGAAAATAGCTATTATACTTGGAACTAGGCCGGAAATTATTAAAATGGCTCCAATTATTGATGAAATTGAAAAGCGAGG
TATAACTTCCTGTCTTATTCATACTGGCCAACATTATGATAAAGAAATGTCGGATAATTTCTTTAAAGACTTGGAAATCA
AATCTCCAGATTATAATATTCACGTTGGTTCTGGTTCCCATGGAAAACAAACTGGTTTGATGATGCAGGGTATCGAAGAA
GTTTTGCTTGATGAAAAACCGGATATAGTTCTTGTTCAGGGAGATACAAATGCAGTTCTTGCAGGAGCACTGGTGGCTTC
TAAATTACATATTGCTGTTGGACATGTTGAAGCGGGACTCAGATCATTTGATATTACGATGCCTGAAGAATTAAATAGGA
TGGCTGCAGATGCCTGTTCTTTAATGTATTTTATTCCGACTGAAGAATCTGCAATTAATCTTTTAGCTGAAGGAATTTCA
AGAAAAAAACTATTTATTACAGGAAATACTGTAGTTGATGCCTGTTTCAGGCATTTGGAAATAGCAAACAAAGCGGGAAT
TCAGGAAGAGTCTTTGGCTAACTTGGACATTGAAAATATGGATAATATTTTAACTTTGACTATGCATAGGGCAGAAAATG
TTGATGATAAGGAAAGGTTAATAAATATTATTTCTTCTTTAAAAGAACTTAAAGACATGAATATTATTTTTCCGATTCAT
CCAAGAACTAAAAAGACTTTGGAGAACTTTAATTTATTTGATGAATTAAATGAATTGGACAATGTCCATATTATTAAACC
GTTGGGATATTTGGACTTTTTAATTTTAACTTCACATTCTACTTTAATTTTAACAGATTCCGGAGGTCTTCAGGAAGAAG
CAATTACTTTGGATGTTCCTGTTTTAACTTTAAGGTATAATACTGAAAGGCCTGAAACAGTCAGTGCAGGGGGAAATATT
TTGGTGGGAGCTAATAAAAATAATATTTTAGAAAACGCTGAAAAGATTCTCAATGATGAAGAATTTGCAAATAAAATGAA
AAATGCTAAAAATCCTTATGGAAAAGGGGATGCAGCTATTAAAACTATTGATGCAATCGAAGAAGCATATAATAATGGTT
TATTGGATATTAAAGCCCCTGAAAATATAATGTCATCATTTGACCGTAAAATGATAAAAATTAATGAAGATGTTTCTGTT
AAGGAATTTGAAGAAAATGAAAATGCATTAGTGCATATGGTTTTTGATGGTGAAAAAATGATTTTCCCATTGAATAATTT
AAATTTAAAAGGTATGATGATTACTTATGATGTCTATCAATGA

Upstream 100 bases:

>100_bases
GTCATAATAATCACCCCAATGTGTATTAGTAGAAGTTTATACTATTTAAATAACCAACATTTATTATTCATGATTAACTA
ATTTTATATAGGTCGATAAA

Downstream 100 bases:

>100_bases
TGATTCAATTTTACTGTTCGAATATTTTACAGCTTCCGGTGAAAAAGATAAATGTATTATTTCAGAAGCAGAAGCTTTAA
TATTTTCACTTTTAGATGAT

Product: UDP-N-acetylglucosamine 2-epimerase, WecB

Products: NA

Alternate protein names: UDP-GlcNAc-2-epimerase [H]

Number of amino acids: Translated: 440; Mature: 440

Protein sequence:

>440_residues
MKIAIILGTRPEIIKMAPIIDEIEKRGITSCLIHTGQHYDKEMSDNFFKDLEIKSPDYNIHVGSGSHGKQTGLMMQGIEE
VLLDEKPDIVLVQGDTNAVLAGALVASKLHIAVGHVEAGLRSFDITMPEELNRMAADACSLMYFIPTEESAINLLAEGIS
RKKLFITGNTVVDACFRHLEIANKAGIQEESLANLDIENMDNILTLTMHRAENVDDKERLINIISSLKELKDMNIIFPIH
PRTKKTLENFNLFDELNELDNVHIIKPLGYLDFLILTSHSTLILTDSGGLQEEAITLDVPVLTLRYNTERPETVSAGGNI
LVGANKNNILENAEKILNDEEFANKMKNAKNPYGKGDAAIKTIDAIEEAYNNGLLDIKAPENIMSSFDRKMIKINEDVSV
KEFEENENALVHMVFDGEKMIFPLNNLNLKGMMITYDVYQ

Sequences:

>Translated_440_residues
MKIAIILGTRPEIIKMAPIIDEIEKRGITSCLIHTGQHYDKEMSDNFFKDLEIKSPDYNIHVGSGSHGKQTGLMMQGIEE
VLLDEKPDIVLVQGDTNAVLAGALVASKLHIAVGHVEAGLRSFDITMPEELNRMAADACSLMYFIPTEESAINLLAEGIS
RKKLFITGNTVVDACFRHLEIANKAGIQEESLANLDIENMDNILTLTMHRAENVDDKERLINIISSLKELKDMNIIFPIH
PRTKKTLENFNLFDELNELDNVHIIKPLGYLDFLILTSHSTLILTDSGGLQEEAITLDVPVLTLRYNTERPETVSAGGNI
LVGANKNNILENAEKILNDEEFANKMKNAKNPYGKGDAAIKTIDAIEEAYNNGLLDIKAPENIMSSFDRKMIKINEDVSV
KEFEENENALVHMVFDGEKMIFPLNNLNLKGMMITYDVYQ
>Mature_440_residues
MKIAIILGTRPEIIKMAPIIDEIEKRGITSCLIHTGQHYDKEMSDNFFKDLEIKSPDYNIHVGSGSHGKQTGLMMQGIEE
VLLDEKPDIVLVQGDTNAVLAGALVASKLHIAVGHVEAGLRSFDITMPEELNRMAADACSLMYFIPTEESAINLLAEGIS
RKKLFITGNTVVDACFRHLEIANKAGIQEESLANLDIENMDNILTLTMHRAENVDDKERLINIISSLKELKDMNIIFPIH
PRTKKTLENFNLFDELNELDNVHIIKPLGYLDFLILTSHSTLILTDSGGLQEEAITLDVPVLTLRYNTERPETVSAGGNI
LVGANKNNILENAEKILNDEEFANKMKNAKNPYGKGDAAIKTIDAIEEAYNNGLLDIKAPENIMSSFDRKMIKINEDVSV
KEFEENENALVHMVFDGEKMIFPLNNLNLKGMMITYDVYQ

Specific function: Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) to produce UDP-N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues [H]

COG id: COG0381

COG function: function code M; UDP-N-acetylglucosamine 2-epimerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-N-acetylglucosamine 2-epimerase family [H]

Homologues:

Organism=Escherichia coli, GI48994967, Length=378, Percent_Identity=37.8306878306878, Blast_Score=219, Evalue=3e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003331 [H]

Pfam domain/function: PF02350 Epimerase_2 [H]

EC number: =5.1.3.14 [H]

Molecular weight: Translated: 49155; Mature: 49155

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAIILGTRPEIIKMAPIIDEIEKRGITSCLIHTGQHYDKEMSDNFFKDLEIKSPDYNI
CEEEEEECCCCCCEEHHHHHHHHHHCCCCEEEHHCCCCCCHHHHCCHHHCCEECCCCCEE
HVGSGSHGKQTGLMMQGIEEVLLDEKPDIVLVQGDTNAVLAGALVASKLHIAVGHVEAGL
EECCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHEEEEEHHHHCC
RSFDITMPEELNRMAADACSLMYFIPTEESAINLLAEGISRKKLFITGNTVVDACFRHLE
CEECCCCHHHHHHHHHHHEEEEEEECCCHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHH
IANKAGIQEESLANLDIENMDNILTLTMHRAENVDDKERLINIISSLKELKDMNIIFPIH
HHHHCCCCHHHHCCCCHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCEEEEECC
PRTKKTLENFNLFDELNELDNVHIIKPLGYLDFLILTSHSTLILTDSGGLQEEAITLDVP
CCHHHHHHHCCHHHHHHHCCCEEEEECCCHHEEEEEECCCEEEEECCCCCCCCEEEEECE
VLTLRYNTERPETVSAGGNILVGANKNNILENAEKILNDEEFANKMKNAKNPYGKGDAAI
EEEEEECCCCCCEECCCCCEEEECCCCHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCHHH
KTIDAIEEAYNNGLLDIKAPENIMSSFDRKMIKINEDVSVKEFEENENALVHMVFDGEKM
HHHHHHHHHHCCCEEEEECCHHHHHHHCCEEEEECCCCCHHHHCCCCCEEEEEEECCCEE
IFPLNNLNLKGMMITYDVYQ
EEECCCCCEEEEEEEEEECC
>Mature Secondary Structure
MKIAIILGTRPEIIKMAPIIDEIEKRGITSCLIHTGQHYDKEMSDNFFKDLEIKSPDYNI
CEEEEEECCCCCCEEHHHHHHHHHHCCCCEEEHHCCCCCCHHHHCCHHHCCEECCCCCEE
HVGSGSHGKQTGLMMQGIEEVLLDEKPDIVLVQGDTNAVLAGALVASKLHIAVGHVEAGL
EECCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHEEEEEHHHHCC
RSFDITMPEELNRMAADACSLMYFIPTEESAINLLAEGISRKKLFITGNTVVDACFRHLE
CEECCCCHHHHHHHHHHHEEEEEEECCCHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHH
IANKAGIQEESLANLDIENMDNILTLTMHRAENVDDKERLINIISSLKELKDMNIIFPIH
HHHHCCCCHHHHCCCCHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCEEEEECC
PRTKKTLENFNLFDELNELDNVHIIKPLGYLDFLILTSHSTLILTDSGGLQEEAITLDVP
CCHHHHHHHCCHHHHHHHCCCEEEEECCCHHEEEEEECCCEEEEECCCCCCCCEEEEECE
VLTLRYNTERPETVSAGGNILVGANKNNILENAEKILNDEEFANKMKNAKNPYGKGDAAI
EEEEEECCCCCCEECCCCCEEEECCCCHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCHHH
KTIDAIEEAYNNGLLDIKAPENIMSSFDRKMIKINEDVSVKEFEENENALVHMVFDGEKM
HHHHHHHHHHCCCEEEEECCHHHHHHHCCEEEEECCCCCHHHHCCCCCEEEEEEECCCEE
IFPLNNLNLKGMMITYDVYQ
EEECCCCCEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]