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The map label for this gene is pyrE [H]

Identifier: 148642881

GI number: 148642881

Start: 778928

End: 779452

Strand: Reverse

Name: pyrE [H]

Synonym: Msm_0821

Alternate gene names: 148642881

Gene position: 779452-778928 (Counterclockwise)

Preceding gene: 148642882

Following gene: 148642876

Centisome position: 42.06

GC content: 31.81

Gene sequence:

>525_bases
ATGATTACTAAAGAATATTTAATTAATTTATTAAAAGAAAATGGTGTTTTCTTAAAAGGGGACTTTACATTATCTTCCGG
TAAAAAAAGTGATTATTACATAAACATGAAAAAGGCTATTACTGATCCTGAAATCCTGTCAACAATAGCTAAACTAATCA
CAAAATCTATTAGTGAAGATAATATTGATAAAGTAGCAGGTCCTGCACTTGGGGCGGTTCCAATAGCTACTGCAGTTTCT
CTCGAATCTGAAATTCCTTTGTTAATGATTAGAAAAGAGAAAAAAGGTTATGGGACTTCCAAACTTATTGAAGGTGAATT
AAACGAAGGTGATGATGTCATTGTTGTAGAAGATGTTACAACTACTGGAGGATCATTACTTAAAGCTATTAAAGCTATTC
AAGACAATGGAGGTAGTGTAAAAAGAGCTTTTGTTGTTGTTGATAGGCAGGAAGGAGCTATTGAAGCTTTTGATAGTGAA
GGTGTTAAATTAGAACCTTTAATAACTGTTGACGAATTTTTCTAA

Upstream 100 bases:

>100_bases
AGCTGGAGGGGAAAATGTTGTTCCTAGTGAACTTGTAAAAGTTATTGGGGATAAAATTTTACTTAAAAGTGATGATGATA
TTTAAATTTTGGTTATTTAG

Downstream 100 bases:

>100_bases
TTAAAAAAAGATGATGAATGGTTAAGTTCATCATTTTAAAATTTTTATTTTTTTGCATGGAATACTAGATGGGGAAATTC
ATCTATTATGATGTTGGATG

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase [H]

Number of amino acids: Translated: 174; Mature: 174

Protein sequence:

>174_residues
MITKEYLINLLKENGVFLKGDFTLSSGKKSDYYINMKKAITDPEILSTIAKLITKSISEDNIDKVAGPALGAVPIATAVS
LESEIPLLMIRKEKKGYGTSKLIEGELNEGDDVIVVEDVTTTGGSLLKAIKAIQDNGGSVKRAFVVVDRQEGAIEAFDSE
GVKLEPLITVDEFF

Sequences:

>Translated_174_residues
MITKEYLINLLKENGVFLKGDFTLSSGKKSDYYINMKKAITDPEILSTIAKLITKSISEDNIDKVAGPALGAVPIATAVS
LESEIPLLMIRKEKKGYGTSKLIEGELNEGDDVIVVEDVTTTGGSLLKAIKAIQDNGGSVKRAFVVVDRQEGAIEAFDSE
GVKLEPLITVDEFF
>Mature_174_residues
MITKEYLINLLKENGVFLKGDFTLSSGKKSDYYINMKKAITDPEILSTIAKLITKSISEDNIDKVAGPALGAVPIATAVS
LESEIPLLMIRKEKKGYGTSKLIEGELNEGDDVIVVEDVTTTGGSLLKAIKAIQDNGGSVKRAFVVVDRQEGAIEAFDSE
GVKLEPLITVDEFF

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) [H]

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507835, Length=170, Percent_Identity=33.5294117647059, Blast_Score=116, Evalue=9e-27,
Organism=Escherichia coli, GI1790073, Length=140, Percent_Identity=32.8571428571429, Blast_Score=67, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17508631, Length=166, Percent_Identity=34.3373493975904, Blast_Score=103, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17554964, Length=168, Percent_Identity=36.3095238095238, Blast_Score=100, Evalue=4e-22,
Organism=Drosophila melanogaster, GI17933654, Length=162, Percent_Identity=36.4197530864198, Blast_Score=102, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004467
- InterPro:   IPR023031
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.10 [H]

Molecular weight: Translated: 18811; Mature: 18811

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITKEYLINLLKENGVFLKGDFTLSSGKKSDYYINMKKAITDPEILSTIAKLITKSISED
CCCHHHHHHHHHCCCEEEEEEEEECCCCCCCEEEEEHHHCCCHHHHHHHHHHHHHHCCCC
NIDKVAGPALGAVPIATAVSLESEIPLLMIRKEKKGYGTSKLIEGELNEGDDVIVVEDVT
CHHHHCCCCCCCHHHHHEEECCCCCCEEEEEECCCCCCCCEEEECCCCCCCCEEEEEECC
TTGGSLLKAIKAIQDNGGSVKRAFVVVDRQEGAIEAFDSEGVKLEPLITVDEFF
CCCHHHHHHHHHHHCCCCCEEEEEEEEECCCCCEEEECCCCCEEEEEEECCCCC
>Mature Secondary Structure
MITKEYLINLLKENGVFLKGDFTLSSGKKSDYYINMKKAITDPEILSTIAKLITKSISED
CCCHHHHHHHHHCCCEEEEEEEEECCCCCCCEEEEEHHHCCCHHHHHHHHHHHHHHCCCC
NIDKVAGPALGAVPIATAVSLESEIPLLMIRKEKKGYGTSKLIEGELNEGDDVIVVEDVT
CHHHHCCCCCCCHHHHHEEECCCCCCEEEEEECCCCCCCCEEEECCCCCCCCEEEEEECC
TTGGSLLKAIKAIQDNGGSVKRAFVVVDRQEGAIEAFDSEGVKLEPLITVDEFF
CCCHHHHHHHHHHHCCCCCEEEEEEEEECCCCCEEEECCCCCEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA