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The map label for this gene is 148642864

Identifier: 148642864

GI number: 148642864

Start: 764597

End: 765526

Strand: Reverse

Name: 148642864

Synonym: Msm_0804

Alternate gene names: NA

Gene position: 765526-764597 (Counterclockwise)

Preceding gene: 148642865

Following gene: 148642863

Centisome position: 41.31

GC content: 35.48

Gene sequence:

>930_bases
ATGAAAACACTTGAATGGGAAGATAATAAATTAAAGCTTATTGATCAAACAAAACTTCCAGATGAATTGACTTATGTTTA
TTGTAATGATTATAAGGAAGTTATTGTAGCTATTAAGGACATGATTGTTAGGGGAGCTCCAGCTATTGGAGTTGCAGCAG
CTTTTGGAATGGCATTGGCTGATTTGCATGGTGAAGATTTAGATAATGCTGCAGATGAAATTAAAGCAGCAAGACCAACA
GCTATCAATTTATTTTGGGCAGTTGACAGGGTTTTAAATAGTGATGACCCATTGGAAGAAGCTTTAACCATGTATAAAGA
AGATATTGATACTAATTTAGCTATTGGGAGATATGGTGCCGAAATAATTGAGGATGGAGATACTGTTTTAACACATTGTA
ATGCTGGAGCACTGGCCTGTGTTGATTATGGTACTGCTTTAGGTGTTATTCGTTCTGCATTCCATCAGGGAAAAAATATT
AATGTAATATGTGATGAAACACGTCCAAGAGGTCAAGGAGCCAGATTAAGTGTTTGGGAAATGCAGCAGGAAAACATTCC
AGTCAAATTAATTCCTGATGTGGCTTCAGGTTATTTGATGTCTCAATACAAAATTAATAAAGTTGTAATTGGTGCAGATA
GGATAGCTAAAGGTGGTGTTGTAAATAAAATAGGCTCTTTAATGGTTGCTTTAGCAGCTAAACATTTCCATGTTCCATTT
TATGTAGCTGCTCCATTATCTACTTTTGACATGGATGCTTCTGTATTTGACACTGAAATTGAAGAAAGAGACGGCGATGA
GGTAAGATATTATGGCGGATGTAGGATTTGTCCTAAGGGAACTGAAGTTATTAATCCTGCATTTGATATTGTGCCAAAGG
AGCTTATTACTGGTATTATAACTGAAAATGGAATTATTGATCCAATTTAG

Upstream 100 bases:

>100_bases
TATATTTTTAATTAATGGATTTAAATTAGAAACTAACGGGGAATTATGCTTTTCCTTTTTTTAAAGATTTATTATTTCTA
ATTAACAGAAGGTATTATTT

Downstream 100 bases:

>100_bases
GTGATTGATATTAATGAAAAATTTTCACAAAAGCATGTTATTTTGTTCAGCATACTTTTAGCATTGGCTTTTGTTGTAAT
TTTTGGATTTGGGGCAGTAA

Product: translation initiation factor aIF-2B, alpha subunit

Products: NA

Alternate protein names: M1Pi; MTR-1-P isomerase; MTNA-like protein; aMTNA; S-methyl-5-thioribose-1-phosphate isomerase [H]

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MKTLEWEDNKLKLIDQTKLPDELTYVYCNDYKEVIVAIKDMIVRGAPAIGVAAAFGMALADLHGEDLDNAADEIKAARPT
AINLFWAVDRVLNSDDPLEEALTMYKEDIDTNLAIGRYGAEIIEDGDTVLTHCNAGALACVDYGTALGVIRSAFHQGKNI
NVICDETRPRGQGARLSVWEMQQENIPVKLIPDVASGYLMSQYKINKVVIGADRIAKGGVVNKIGSLMVALAAKHFHVPF
YVAAPLSTFDMDASVFDTEIEERDGDEVRYYGGCRICPKGTEVINPAFDIVPKELITGIITENGIIDPI

Sequences:

>Translated_309_residues
MKTLEWEDNKLKLIDQTKLPDELTYVYCNDYKEVIVAIKDMIVRGAPAIGVAAAFGMALADLHGEDLDNAADEIKAARPT
AINLFWAVDRVLNSDDPLEEALTMYKEDIDTNLAIGRYGAEIIEDGDTVLTHCNAGALACVDYGTALGVIRSAFHQGKNI
NVICDETRPRGQGARLSVWEMQQENIPVKLIPDVASGYLMSQYKINKVVIGADRIAKGGVVNKIGSLMVALAAKHFHVPF
YVAAPLSTFDMDASVFDTEIEERDGDEVRYYGGCRICPKGTEVINPAFDIVPKELITGIITENGIIDPI
>Mature_309_residues
MKTLEWEDNKLKLIDQTKLPDELTYVYCNDYKEVIVAIKDMIVRGAPAIGVAAAFGMALADLHGEDLDNAADEIKAARPT
AINLFWAVDRVLNSDDPLEEALTMYKEDIDTNLAIGRYGAEIIEDGDTVLTHCNAGALACVDYGTALGVIRSAFHQGKNI
NVICDETRPRGQGARLSVWEMQQENIPVKLIPDVASGYLMSQYKINKVVIGADRIAKGGVVNKIGSLMVALAAKHFHVPF
YVAAPLSTFDMDASVFDTEIEERDGDEVRYYGGCRICPKGTEVINPAFDIVPKELITGIITENGIIDPI

Specific function: Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) [H]

COG id: COG0182

COG function: function code J; Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily [H]

Homologues:

Organism=Homo sapiens, GI72534748, Length=345, Percent_Identity=37.3913043478261, Blast_Score=193, Evalue=1e-49,
Organism=Homo sapiens, GI23943880, Length=329, Percent_Identity=32.8267477203647, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI4503503, Length=192, Percent_Identity=28.6458333333333, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17557462, Length=333, Percent_Identity=32.4324324324324, Blast_Score=164, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI17557123, Length=163, Percent_Identity=30.6748466257669, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6325375, Length=386, Percent_Identity=31.6062176165803, Blast_Score=146, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6322878, Length=204, Percent_Identity=27.4509803921569, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21357667, Length=350, Percent_Identity=38, Blast_Score=208, Evalue=3e-54,
Organism=Drosophila melanogaster, GI24651647, Length=350, Percent_Identity=38, Blast_Score=208, Evalue=3e-54,
Organism=Drosophila melanogaster, GI18543295, Length=221, Percent_Identity=27.6018099547511, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000649
- InterPro:   IPR005251
- InterPro:   IPR011559 [H]

Pfam domain/function: PF01008 IF-2B [H]

EC number: =5.3.1.23 [H]

Molecular weight: Translated: 33808; Mature: 33808

Theoretical pI: Translated: 4.38; Mature: 4.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTLEWEDNKLKLIDQTKLPDELTYVYCNDYKEVIVAIKDMIVRGAPAIGVAAAFGMALA
CCCCCCCCCEEEEEECCCCCCCEEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
DLHGEDLDNAADEIKAARPTAINLFWAVDRVLNSDDPLEEALTMYKEDIDTNLAIGRYGA
HCCCCCCHHHHHHHHCCCCCEEHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEHHHCH
EIIEDGDTVLTHCNAGALACVDYGTALGVIRSAFHQGKNINVICDETRPRGQGARLSVWE
HHHCCCCEEEEECCCCEEEEHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEE
MQQENIPVKLIPDVASGYLMSQYKINKVVIGADRIAKGGVVNKIGSLMVALAAKHFHVPF
HHHCCCCEEEECCHHCCCEEEEEEEEEEEEECCHHHCCCHHHHHHHHHHHHHHHHCCCCE
YVAAPLSTFDMDASVFDTEIEERDGDEVRYYGGCRICPKGTEVINPAFDIVPKELITGII
EEECCCCCCCCCCHHHHCHHHHCCCCEEEEECCEEECCCCCHHCCCHHHHCHHHHHHHHH
TENGIIDPI
CCCCCCCCC
>Mature Secondary Structure
MKTLEWEDNKLKLIDQTKLPDELTYVYCNDYKEVIVAIKDMIVRGAPAIGVAAAFGMALA
CCCCCCCCCEEEEEECCCCCCCEEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
DLHGEDLDNAADEIKAARPTAINLFWAVDRVLNSDDPLEEALTMYKEDIDTNLAIGRYGA
HCCCCCCHHHHHHHHCCCCCEEHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEHHHCH
EIIEDGDTVLTHCNAGALACVDYGTALGVIRSAFHQGKNINVICDETRPRGQGARLSVWE
HHHCCCCEEEEECCCCEEEEHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEE
MQQENIPVKLIPDVASGYLMSQYKINKVVIGADRIAKGGVVNKIGSLMVALAAKHFHVPF
HHHCCCCEEEECCHHCCCEEEEEEEEEEEEECCHHHCCCHHHHHHHHHHHHHHHHCCCCE
YVAAPLSTFDMDASVFDTEIEERDGDEVRYYGGCRICPKGTEVINPAFDIVPKELITGII
EEECCCCCCCCCCHHHHCHHHHCCCCEEEEECCEEECCCCCHHCCCHHHHCHHHHHHHHH
TENGIIDPI
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]