Click here to switch to the map view.

The map label for this gene is pth [H]

Identifier: 148642665

GI number: 148642665

Start: 576503

End: 576841

Strand: Reverse

Name: pth [H]

Synonym: Msm_0605

Alternate gene names: 148642665

Gene position: 576841-576503 (Counterclockwise)

Preceding gene: 148642668

Following gene: 148642664

Centisome position: 31.13

GC content: 33.63

Gene sequence:

>339_bases
ATGAAACAAGTGATGGTTGTAAGAAGAGATTTAAAAATGGGCAAGGGAAAAATTGCTGCTCAATGTTGTCATGGTTCTAT
AGGTTCATATAAAAGAACAGATTCTAAATTAATTAAAAAATGGGAATCTGACGGTTATGCTAAGGTAGTTTGTAAAGTGG
ATTCTTTGGAAGAATTATTGGACCTTAAAAAGGAAGCCGATAAAAACAATGTTTCTAATTATTTGGTAGTTGATGCTGGA
AGGACTCAGTTACCTACATCAACCACAACAGTTTTGGGCATTGGGCCTGATGAAGATGAAATAATGGATAAGATAACTGG
GGATTTAAAACTTTTATGA

Upstream 100 bases:

>100_bases
TTTTTTTCACTTAAAATAGTAATAATCTATATAAACATTATAAGTATTATACTTTATTGGAGCTAAAATTATTTAAGTGG
ACACATAGAAAAATGTGTGT

Downstream 100 bases:

>100_bases
GTTTTATTTAATTTAATGATAGCTAGTTTTAATTAAACACATAGTAAATTAGGTTGGAGATATCATTATCAAACAGGTTG
TTAAAATTGGGGGAAGTTTA

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH [H]

Number of amino acids: Translated: 112; Mature: 112

Protein sequence:

>112_residues
MKQVMVVRRDLKMGKGKIAAQCCHGSIGSYKRTDSKLIKKWESDGYAKVVCKVDSLEELLDLKKEADKNNVSNYLVVDAG
RTQLPTSTTTVLGIGPDEDEIMDKITGDLKLL

Sequences:

>Translated_112_residues
MKQVMVVRRDLKMGKGKIAAQCCHGSIGSYKRTDSKLIKKWESDGYAKVVCKVDSLEELLDLKKEADKNNVSNYLVVDAG
RTQLPTSTTTVLGIGPDEDEIMDKITGDLKLL
>Mature_112_residues
MKQVMVVRRDLKMGKGKIAAQCCHGSIGSYKRTDSKLIKKWESDGYAKVVCKVDSLEELLDLKKEADKNNVSNYLVVDAG
RTQLPTSTTTVLGIGPDEDEIMDKITGDLKLL

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG1990

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH2 family [H]

Homologues:

Organism=Homo sapiens, GI7706351, Length=113, Percent_Identity=46.9026548672566, Blast_Score=105, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI17558188, Length=116, Percent_Identity=43.1034482758621, Blast_Score=82, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6319414, Length=120, Percent_Identity=35.8333333333333, Blast_Score=88, Evalue=3e-19,
Organism=Drosophila melanogaster, GI281376919, Length=115, Percent_Identity=48.695652173913, Blast_Score=118, Evalue=8e-28,
Organism=Drosophila melanogaster, GI24644665, Length=115, Percent_Identity=48.695652173913, Blast_Score=118, Evalue=8e-28,
Organism=Drosophila melanogaster, GI24646438, Length=117, Percent_Identity=44.4444444444444, Blast_Score=103, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002833 [H]

Pfam domain/function: PF01981 PTH2 [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 12389; Mature: 12389

Theoretical pI: Translated: 8.47; Mature: 8.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQVMVVRRDLKMGKGKIAAQCCHGSIGSYKRTDSKLIKKWESDGYAKVVCKVDSLEELL
CCCHHHHHHHHHCCCCHHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEEEEEHHHHHHHH
DLKKEADKNNVSNYLVVDAGRTQLPTSTTTVLGIGPDEDEIMDKITGDLKLL
HHHHHCCCCCCCCEEEEECCCCCCCCCCEEEEEECCCHHHHHHHHCCCEECC
>Mature Secondary Structure
MKQVMVVRRDLKMGKGKIAAQCCHGSIGSYKRTDSKLIKKWESDGYAKVVCKVDSLEELL
CCCHHHHHHHHHCCCCHHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEEEEEHHHHHHHH
DLKKEADKNNVSNYLVVDAGRTQLPTSTTTVLGIGPDEDEIMDKITGDLKLL
HHHHHCCCCCCCCEEEEECCCCCCCCCCEEEEEECCCHHHHHHHHCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]