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The map label for this gene is tmk

Identifier: 148642580

GI number: 148642580

Start: 491647

End: 492225

Strand: Reverse

Name: tmk

Synonym: Msm_0520

Alternate gene names: 148642580

Gene position: 492225-491647 (Counterclockwise)

Preceding gene: 148642586

Following gene: 148642579

Centisome position: 26.56

GC content: 32.64

Gene sequence:

>579_bases
ATGTACATTGTTTTTGAGGGAATTGATGGTGCAGGTAAATCTACTCAGATTAACCTGTTAAAAGATTGGCTGGATCAGAA
TGGTTTTGATGTTGAAACAGTTGTGGAACCGACAGATTCTGAAGTCGGTAAGTTAATTAGAAAAATACTGCAAAGACCGG
ATGCAACAACTGACAGAATTCAAAAAACATTAGGTCTACTATTTGCAGCAGACAGGATGCTTATTATGGATAAACTTAAT
GATGATTCTAAAGTTATTTTAAGTGACCGCTCTTTTATTTCTAGTTTAGCTTATCAGGAACCTGCAGAATGGATTGAACA
GATTAATAAATATGCTAAAGAACCTGATCTGGTTTTACTTTTAGATGTGGATGTTAAAACTTCTGTAAATCGATGCTCTA
AAGAAGACGAATTTGAAAATGAGGAATTTTTAAGTAAAGTCAAAGCTAATTATTTGGATTTAATCAGCAATTTCAATCAT
GAAATAATTGATGCAAGTACTGGAGTAAATAAAGTATCAACAGATATTAAAAAAGCTGTAGCTCCGTATATGGGTATTTG
TCCTGATTGTATTAGGTGA

Upstream 100 bases:

>100_bases
GTAAAATAGGTATTTATTAAATAGCTGTTTTGCTTTTTGTTTTAATGAAACATTGAAAAAATAGTTAAAGTTTAATATAG
TTTAATTCAAATTTAAAATT

Downstream 100 bases:

>100_bases
TATTATGAGCGAAGTCTTAAACAATGTAGTAAATGTAATAAGTGGTTTGGATGGTGTTTTGGAAGTAAGGCAACTTTCCA
ATGATGATATTTTAAAGATA

Product: thymidylate kinase, Tmk

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 192; Mature: 192

Protein sequence:

>192_residues
MYIVFEGIDGAGKSTQINLLKDWLDQNGFDVETVVEPTDSEVGKLIRKILQRPDATTDRIQKTLGLLFAADRMLIMDKLN
DDSKVILSDRSFISSLAYQEPAEWIEQINKYAKEPDLVLLLDVDVKTSVNRCSKEDEFENEEFLSKVKANYLDLISNFNH
EIIDASTGVNKVSTDIKKAVAPYMGICPDCIR

Sequences:

>Translated_192_residues
MYIVFEGIDGAGKSTQINLLKDWLDQNGFDVETVVEPTDSEVGKLIRKILQRPDATTDRIQKTLGLLFAADRMLIMDKLN
DDSKVILSDRSFISSLAYQEPAEWIEQINKYAKEPDLVLLLDVDVKTSVNRCSKEDEFENEEFLSKVKANYLDLISNFNH
EIIDASTGVNKVSTDIKKAVAPYMGICPDCIR
>Mature_192_residues
MYIVFEGIDGAGKSTQINLLKDWLDQNGFDVETVVEPTDSEVGKLIRKILQRPDATTDRIQKTLGLLFAADRMLIMDKLN
DDSKVILSDRSFISSLAYQEPAEWIEQINKYAKEPDLVLLLDVDVKTSVNRCSKEDEFENEEFLSKVKANYLDLISNFNH
EIIDASTGVNKVSTDIKKAVAPYMGICPDCIR

Specific function: Phosphorylation Of Dtmp To Form Dtdp In Both De Novo And Salvage Pathways Of Dttp Synthesis. [C]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Homo sapiens, GI42544174, Length=188, Percent_Identity=30.8510638297872, Blast_Score=72, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_METS3 (A5UKJ7)

Other databases:

- EMBL:   CP000678
- RefSeq:   YP_001273093.1
- ProteinModelPortal:   A5UKJ7
- SMR:   A5UKJ7
- STRING:   A5UKJ7
- GeneID:   5216955
- GenomeReviews:   CP000678_GR
- KEGG:   msi:Msm_0520
- eggNOG:   arNOG06813
- HOGENOM:   HBG626009
- OMA:   ETAIARI
- ProtClustDB:   CLSK798266
- HAMAP:   MF_00165
- InterPro:   IPR018095
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 21696; Mature: 21696

Theoretical pI: Translated: 4.38; Mature: 4.38

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYIVFEGIDGAGKSTQINLLKDWLDQNGFDVETVVEPTDSEVGKLIRKILQRPDATTDRI
CEEEEECCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCHHHH
QKTLGLLFAADRMLIMDKLNDDSKVILSDRSFISSLAYQEPAEWIEQINKYAKEPDLVLL
HHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEE
LDVDVKTSVNRCSKEDEFENEEFLSKVKANYLDLISNFNHEIIDASTGVNKVSTDIKKAV
EECCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHH
APYMGICPDCIR
HHHHCCCHHHCC
>Mature Secondary Structure
MYIVFEGIDGAGKSTQINLLKDWLDQNGFDVETVVEPTDSEVGKLIRKILQRPDATTDRI
CEEEEECCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCHHHH
QKTLGLLFAADRMLIMDKLNDDSKVILSDRSFISSLAYQEPAEWIEQINKYAKEPDLVLL
HHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEE
LDVDVKTSVNRCSKEDEFENEEFLSKVKANYLDLISNFNHEIIDASTGVNKVSTDIKKAV
EECCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHH
APYMGICPDCIR
HHHHCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA