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The map label for this gene is nadC [H]

Identifier: 148642551

GI number: 148642551

Start: 465608

End: 466438

Strand: Reverse

Name: nadC [H]

Synonym: Msm_0491

Alternate gene names: 148642551

Gene position: 466438-465608 (Counterclockwise)

Preceding gene: 148642555

Following gene: 148642550

Centisome position: 25.17

GC content: 31.77

Gene sequence:

>831_bases
TTGGATAGAATAATTGAATACATGCTTGAAGAAGATGAAGGTTTTGGAGATATTACATCTGAAGCAGTAGTTGATGAAGA
TAAAACTGTAACTGCTCATATTATTTCTAAAGATGAAGGTATTTTGGCAGGTATTGATATCATTAAGGAAATGTTTGAGT
CTAAAAATGTCCAAGTAATTTTTAACTTAAAAGATGGAACTAAAATAGCTAAAAATGATTTGTTAATGTGTTTAAAAGGT
GATGCAAGGACAATATTGTTGCTTGAACGTTCTGCACTAAATCTGCTCATGAGAATGAGTGGTGTAGCCAGTGCCGCTGA
CTATTATGTTAATTTGGTAAATGATTATGATGTAATAATTGCAGGAACACGTAAAACACTGCCAGCTATTGGAAAATTCG
ATAAACAGGCATTAAAAATAGGCGGTGTAGATACACACAGATTCTCCCTTGATGATATGGTGTTGATTAAGGATAATCAC
ATAGCCAGTGTTGGAACTCCTTTGGAAACACTTTTAAAAGCTAAAGAAAATGTTAGCTTTTCTAAAAAAATTGAAATAGA
AGTTGAATCCCTAAAAGATGCGGTTGATTGTGTTGAAAATAAAGCAGATATTGTAATGTTGGATAACATGTCTCCTAAAG
AAGTTGAAGAAGTTTTAGAAGAGTTAATCAAATTAAATATTCGTGACAATTCTTTAATTGAAGTTTCTGGAGGAATCACT
GCTGAAAATATTGTGGATTATGCTAAATTGGGAATTGATATAATTTCTCTTGGTGCTCTGACTCATTCAAGCAGAAGTTT
AAACTTTTCTTTAAGAATACTAGAGGATTAA

Upstream 100 bases:

>100_bases
CTGCTGAAGATGTTCCTAAAAATGTAATTTCCATTTAATCACTTATATTAATTATAATAAAAATATATATCAACATATAA
TTTAAAATTTTGGTGATTTT

Downstream 100 bases:

>100_bases
AGAATGTCTGTTGTAAATAAGTTCAACCAAAAAGCTAAAGAATATGATAGTGAAAGAAGAGCTTTAATACCATGTTTTGA
TGATTTTTATGGAATAGCTA

Product: nicotinate-nucleotide pyrophosphorylase (carboxylating), NadC

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 276; Mature: 276

Protein sequence:

>276_residues
MDRIIEYMLEEDEGFGDITSEAVVDEDKTVTAHIISKDEGILAGIDIIKEMFESKNVQVIFNLKDGTKIAKNDLLMCLKG
DARTILLLERSALNLLMRMSGVASAADYYVNLVNDYDVIIAGTRKTLPAIGKFDKQALKIGGVDTHRFSLDDMVLIKDNH
IASVGTPLETLLKAKENVSFSKKIEIEVESLKDAVDCVENKADIVMLDNMSPKEVEEVLEELIKLNIRDNSLIEVSGGIT
AENIVDYAKLGIDIISLGALTHSSRSLNFSLRILED

Sequences:

>Translated_276_residues
MDRIIEYMLEEDEGFGDITSEAVVDEDKTVTAHIISKDEGILAGIDIIKEMFESKNVQVIFNLKDGTKIAKNDLLMCLKG
DARTILLLERSALNLLMRMSGVASAADYYVNLVNDYDVIIAGTRKTLPAIGKFDKQALKIGGVDTHRFSLDDMVLIKDNH
IASVGTPLETLLKAKENVSFSKKIEIEVESLKDAVDCVENKADIVMLDNMSPKEVEEVLEELIKLNIRDNSLIEVSGGIT
AENIVDYAKLGIDIISLGALTHSSRSLNFSLRILED
>Mature_276_residues
MDRIIEYMLEEDEGFGDITSEAVVDEDKTVTAHIISKDEGILAGIDIIKEMFESKNVQVIFNLKDGTKIAKNDLLMCLKG
DARTILLLERSALNLLMRMSGVASAADYYVNLVNDYDVIIAGTRKTLPAIGKFDKQALKIGGVDTHRFSLDDMVLIKDNH
IASVGTPLETLLKAKENVSFSKKIEIEVESLKDAVDCVENKADIVMLDNMSPKEVEEVLEELIKLNIRDNSLIEVSGGIT
AENIVDYAKLGIDIISLGALTHSSRSLNFSLRILED

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=273, Percent_Identity=34.0659340659341, Blast_Score=157, Evalue=1e-38,
Organism=Escherichia coli, GI1786299, Length=260, Percent_Identity=35, Blast_Score=133, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6321162, Length=251, Percent_Identity=35.0597609561753, Blast_Score=156, Evalue=4e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 30491; Mature: 30491

Theoretical pI: Translated: 4.37; Mature: 4.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRIIEYMLEEDEGFGDITSEAVVDEDKTVTAHIISKDEGILAGIDIIKEMFESKNVQVI
CHHHHHHHHHCCCCCCCCCCHHHCCCCCEEEEEEEECCCCEEHHHHHHHHHHCCCCEEEE
FNLKDGTKIAKNDLLMCLKGDARTILLLERSALNLLMRMSGVASAADYYVNLVNDYDVII
EEECCCCEECCCCEEEEEECCCEEEEEEEHHHHHHHHHHHCCCHHHHHEEEEECCCEEEE
AGTRKTLPAIGKFDKQALKIGGVDTHRFSLDDMVLIKDNHIASVGTPLETLLKAKENVSF
ECCCCCCCHHCCCCHHHEEECCCCCEEECCCCEEEEECCCEEECCCHHHHHHHHHCCCCC
SKKIEIEVESLKDAVDCVENKADIVMLDNMSPKEVEEVLEELIKLNIRDNSLIEVSGGIT
CEEEEEEHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCC
AENIVDYAKLGIDIISLGALTHSSRSLNFSLRILED
HHHHHHHHHHCCEEEEECCEECCCCCEEEEEEEECC
>Mature Secondary Structure
MDRIIEYMLEEDEGFGDITSEAVVDEDKTVTAHIISKDEGILAGIDIIKEMFESKNVQVI
CHHHHHHHHHCCCCCCCCCCHHHCCCCCEEEEEEEECCCCEEHHHHHHHHHHCCCCEEEE
FNLKDGTKIAKNDLLMCLKGDARTILLLERSALNLLMRMSGVASAADYYVNLVNDYDVII
EEECCCCEECCCCEEEEEECCCEEEEEEEHHHHHHHHHHHCCCHHHHHEEEEECCCEEEE
AGTRKTLPAIGKFDKQALKIGGVDTHRFSLDDMVLIKDNHIASVGTPLETLLKAKENVSF
ECCCCCCCHHCCCCHHHEEECCCCCEEECCCCEEEEECCCEEECCCHHHHHHHHHCCCCC
SKKIEIEVESLKDAVDCVENKADIVMLDNMSPKEVEEVLEELIKLNIRDNSLIEVSGGIT
CEEEEEEHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCC
AENIVDYAKLGIDIISLGALTHSSRSLNFSLRILED
HHHHHHHHHHCCEEEEECCEECCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]