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The map label for this gene is atpA

Identifier: 148642495

GI number: 148642495

Start: 415903

End: 417657

Strand: Reverse

Name: atpA

Synonym: Msm_0435

Alternate gene names: 148642495

Gene position: 417657-415903 (Counterclockwise)

Preceding gene: 148642496

Following gene: 148642494

Centisome position: 22.54

GC content: 38.58

Gene sequence:

>1755_bases
ATGATTATCGAAGGAAAAATTATTAAAATTGCTGGGCCTGTTATTATCGCGGATGGTATGAGAGGAGCTCAGATGTATGA
AATGGTTAGAGTAGGTGAACAAAAGCTCATTGGGGAAATTATTGAGCTTGAAGGTGACACCGCTACCATTCAAGTATATG
AAGAAACAGCTGGTATTCAACCAGGTGAAGTAGTTGAAAGTACTGGAGGTCCATTGTCTGTAGAACTTGGTCCTGGTGTA
ATGGGTTCCATTTTTGATGGTATTCAAAGGCCTTTAGAACTCATCAGAGAAGAATCTGGTGATTTCATTGCTAGGGGAGT
AGATGCAGAATCTATCAGTAAAGAGAAAAAATGGACATTCAAACCAGTAGCTAAAGTTGGAGACAAAGTTAAAGGTGGAG
ATGTTCTTGGTGAAGTACAAGAAACTTCTGCAGTTTTACAAAAAATATTAGTTCCTCCAATGATTGAAGGTGAATTAACA
AGCATTGCTTCTGAAGGTGAATACACAGTATTAGAAGACATTGCTGAAGTTGCAACTGATAAAGGTGACGAAAAAATCCA
AATGCTTCAAAAATGGCCTGTAAGGAAAGGACGTCCATATGTGGATAAATTGGACCCTGATGTACCTCTTGTAACTGGTC
AAAGAGCACAAGATACTTTCTTTTCAGTAGCTAAAGGTGGAGCAGCAGCTATTCCAGGTCCTTTCGGATCAGGTAAAACT
GTTACCCAACAGCAATTAGCTAAATGGGCAGACGCAGATATTGTTATTTATATTGGATGTGGAGAACGTGGTAACGAAAT
GACTGAAGTACTTACTGAATTCCCATACCTTGATGACCCTAAAACTGGAAACCCATTAATGGACAGAACTGTTCTTATTG
CAAACACTTCAAACATGCCGGTAGCAGCTCGTGAAGCATGTGTATACACAGGTATTACTATTGCTGAATATTACCGTGAC
CAAGGTTACGATGTAGCACTTATGGCTGATTCAACCTCAAGATGGGCTGAAGCTATGAGGGAGATTTCCGGAAGACTTGA
AGAAATGCCTGGGGAAGAAGGTTACCCTGCATACTTAGCATCCAGACTTGCTCAATTCTATGAAAGAGCAGGAAGAGTAA
ACACTATTGGTACTACTTCTGATGTAGCTTCCATTACTGTTGTTGGTGCTGTATCACCTCCTGGTGGGGACTTATCTGAA
CCTGTTACTCAGAACACTTTACGTATCTGTAAAGTATTTTGGGCTTTAGATGCATCTCTTGCAGATAAACGTCACTTCCC
TTCAATTGACTGGTTACAAAGTTATTCTTTATATGTAGACAGTATTGAAGGCTGGTGGGCTGAAAATGTAGCTGCTGATT
GGAGAGAAACTCGTGATCAAGCTATGATTTTATTACAAAAAGAATCAGAACTTCAAGAAATTGTACAATTAGTTGGTCCT
GATGCATTACCTGAAGCTGACCAAGCTACTTTAGAAACTACTCGTATGTTAAGAGAAGATTTCTTACAACAAAATGCATT
TGATGACATTGATACATATTGTCCACCTGTCAAACAATACAATATGTTAAAAACTATTTTATTATTCCATAAAGAAGCTC
TTGCAGCTGTTGGCAGGGGAGTTCCTATTCAAAACATAGTAGCATTACCTGTTAAAGAAGAAATTGGTAAAATGAAATAC
ATTCCACAAGACGAATTTGCAGCTAAATGTGAAGAAATTCAAGCAGCTATTACTAAACAATGCAGTGAGGCTTAA

Upstream 100 bases:

>100_bases
CAATGATAATTGAGATACCTGATAAAGACGGGTCCTCTGAAGGATCATCTGATCAAATGGCAGATCTCATCAAAAGAGTT
ATTGGGGTAGAGATGGTTAA

Downstream 100 bases:

>100_bases
ATATGAACACAAATATTAAAACAAGAGAATATACTACAATCTCCGAAGTCTCCGGTCCTTTAATGGTTGTTGAAGGTGTA
GAAGGCGTAGGTTACAACGA

Product: V-type ATP synthase subunit A

Products: NA

Alternate protein names: V-ATPase subunit A

Number of amino acids: Translated: 584; Mature: 584

Protein sequence:

>584_residues
MIIEGKIIKIAGPVIIADGMRGAQMYEMVRVGEQKLIGEIIELEGDTATIQVYEETAGIQPGEVVESTGGPLSVELGPGV
MGSIFDGIQRPLELIREESGDFIARGVDAESISKEKKWTFKPVAKVGDKVKGGDVLGEVQETSAVLQKILVPPMIEGELT
SIASEGEYTVLEDIAEVATDKGDEKIQMLQKWPVRKGRPYVDKLDPDVPLVTGQRAQDTFFSVAKGGAAAIPGPFGSGKT
VTQQQLAKWADADIVIYIGCGERGNEMTEVLTEFPYLDDPKTGNPLMDRTVLIANTSNMPVAAREACVYTGITIAEYYRD
QGYDVALMADSTSRWAEAMREISGRLEEMPGEEGYPAYLASRLAQFYERAGRVNTIGTTSDVASITVVGAVSPPGGDLSE
PVTQNTLRICKVFWALDASLADKRHFPSIDWLQSYSLYVDSIEGWWAENVAADWRETRDQAMILLQKESELQEIVQLVGP
DALPEADQATLETTRMLREDFLQQNAFDDIDTYCPPVKQYNMLKTILLFHKEALAAVGRGVPIQNIVALPVKEEIGKMKY
IPQDEFAAKCEEIQAAITKQCSEA

Sequences:

>Translated_584_residues
MIIEGKIIKIAGPVIIADGMRGAQMYEMVRVGEQKLIGEIIELEGDTATIQVYEETAGIQPGEVVESTGGPLSVELGPGV
MGSIFDGIQRPLELIREESGDFIARGVDAESISKEKKWTFKPVAKVGDKVKGGDVLGEVQETSAVLQKILVPPMIEGELT
SIASEGEYTVLEDIAEVATDKGDEKIQMLQKWPVRKGRPYVDKLDPDVPLVTGQRAQDTFFSVAKGGAAAIPGPFGSGKT
VTQQQLAKWADADIVIYIGCGERGNEMTEVLTEFPYLDDPKTGNPLMDRTVLIANTSNMPVAAREACVYTGITIAEYYRD
QGYDVALMADSTSRWAEAMREISGRLEEMPGEEGYPAYLASRLAQFYERAGRVNTIGTTSDVASITVVGAVSPPGGDLSE
PVTQNTLRICKVFWALDASLADKRHFPSIDWLQSYSLYVDSIEGWWAENVAADWRETRDQAMILLQKESELQEIVQLVGP
DALPEADQATLETTRMLREDFLQQNAFDDIDTYCPPVKQYNMLKTILLFHKEALAAVGRGVPIQNIVALPVKEEIGKMKY
IPQDEFAAKCEEIQAAITKQCSEA
>Mature_584_residues
MIIEGKIIKIAGPVIIADGMRGAQMYEMVRVGEQKLIGEIIELEGDTATIQVYEETAGIQPGEVVESTGGPLSVELGPGV
MGSIFDGIQRPLELIREESGDFIARGVDAESISKEKKWTFKPVAKVGDKVKGGDVLGEVQETSAVLQKILVPPMIEGELT
SIASEGEYTVLEDIAEVATDKGDEKIQMLQKWPVRKGRPYVDKLDPDVPLVTGQRAQDTFFSVAKGGAAAIPGPFGSGKT
VTQQQLAKWADADIVIYIGCGERGNEMTEVLTEFPYLDDPKTGNPLMDRTVLIANTSNMPVAAREACVYTGITIAEYYRD
QGYDVALMADSTSRWAEAMREISGRLEEMPGEEGYPAYLASRLAQFYERAGRVNTIGTTSDVASITVVGAVSPPGGDLSE
PVTQNTLRICKVFWALDASLADKRHFPSIDWLQSYSLYVDSIEGWWAENVAADWRETRDQAMILLQKESELQEIVQLVGP
DALPEADQATLETTRMLREDFLQQNAFDDIDTYCPPVKQYNMLKTILLFHKEALAAVGRGVPIQNIVALPVKEEIGKMKY
IPQDEFAAKCEEIQAAITKQCSEA

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit

COG id: COG1155

COG function: function code C; Archaeal/vacuolar-type H+-ATPase subunit A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family

Homologues:

Organism=Homo sapiens, GI19913424, Length=562, Percent_Identity=50.5338078291815, Blast_Score=575, Evalue=1e-164,
Organism=Homo sapiens, GI32189394, Length=306, Percent_Identity=31.6993464052288, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI19913426, Length=260, Percent_Identity=27.3076923076923, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI19913428, Length=228, Percent_Identity=28.5087719298246, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI50345984, Length=235, Percent_Identity=25.531914893617, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI4757810, Length=235, Percent_Identity=25.531914893617, Blast_Score=70, Evalue=6e-12,
Organism=Escherichia coli, GI1790170, Length=322, Percent_Identity=28.5714285714286, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1788251, Length=303, Percent_Identity=28.0528052805281, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1790172, Length=243, Percent_Identity=26.7489711934156, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17565854, Length=562, Percent_Identity=51.6014234875445, Blast_Score=578, Evalue=1e-165,
Organism=Caenorhabditis elegans, GI25144756, Length=303, Percent_Identity=31.3531353135314, Blast_Score=115, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI17510931, Length=320, Percent_Identity=27.8125, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17570191, Length=234, Percent_Identity=28.2051282051282, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71988080, Length=241, Percent_Identity=26.1410788381743, Blast_Score=76, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI71988063, Length=241, Percent_Identity=26.1410788381743, Blast_Score=75, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI71988074, Length=249, Percent_Identity=25.7028112449799, Blast_Score=75, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6320016, Length=305, Percent_Identity=49.1803278688525, Blast_Score=316, Evalue=7e-87,
Organism=Saccharomyces cerevisiae, GI6322581, Length=314, Percent_Identity=30.5732484076433, Blast_Score=117, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6319603, Length=256, Percent_Identity=27.734375, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6319370, Length=317, Percent_Identity=23.0283911671924, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24583988, Length=561, Percent_Identity=51.3368983957219, Blast_Score=581, Evalue=1e-166,
Organism=Drosophila melanogaster, GI24583986, Length=561, Percent_Identity=51.3368983957219, Blast_Score=581, Evalue=1e-166,
Organism=Drosophila melanogaster, GI24583984, Length=561, Percent_Identity=51.3368983957219, Blast_Score=581, Evalue=1e-166,
Organism=Drosophila melanogaster, GI20129479, Length=538, Percent_Identity=52.4163568773234, Blast_Score=578, Evalue=1e-165,
Organism=Drosophila melanogaster, GI24583992, Length=561, Percent_Identity=50.9803921568627, Blast_Score=575, Evalue=1e-164,
Organism=Drosophila melanogaster, GI24638766, Length=306, Percent_Identity=32.0261437908497, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI28574560, Length=305, Percent_Identity=31.8032786885246, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI281361666, Length=228, Percent_Identity=27.6315789473684, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24646341, Length=228, Percent_Identity=27.6315789473684, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI17136796, Length=228, Percent_Identity=27.6315789473684, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24658560, Length=236, Percent_Identity=25.4237288135593, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: 10836 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 8,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): VATA_METS3 (A5UKB2)

Other databases:

- EMBL:   CP000678
- RefSeq:   YP_001273008.1
- ProteinModelPortal:   A5UKB2
- SMR:   A5UKB2
- STRING:   A5UKB2
- GeneID:   5215809
- GenomeReviews:   CP000678_GR
- KEGG:   msi:Msm_0435
- eggNOG:   arNOG04086
- HOGENOM:   HBG288114
- OMA:   NTIRESM
- ProtClustDB:   PRK04192
- HAMAP:   MF_00309
- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR005726
- InterPro:   IPR003593
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100
- InterPro:   IPR022878
- SMART:   SM00382
- TIGRFAMs:   TIGR01043

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N; SSF47917 ATPase_a/b_C; SSF50615 ATPase_a/b_N

EC number: =3.6.3.14

Molecular weight: Translated: 64005; Mature: 64005

Theoretical pI: Translated: 4.26; Mature: 4.26

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIEGKIIKIAGPVIIADGMRGAQMYEMVRVGEQKLIGEIIELEGDTATIQVYEETAGIQ
CCCCCEEEEEECCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHCCCC
PGEVVESTGGPLSVELGPGVMGSIFDGIQRPLELIREESGDFIARGVDAESISKEKKWTF
CCHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHCCCCCCCC
KPVAKVGDKVKGGDVLGEVQETSAVLQKILVPPMIEGELTSIASEGEYTVLEDIAEVATD
CHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCHHHHHHHHHHHHC
KGDEKIQMLQKWPVRKGRPYVDKLDPDVPLVTGQRAQDTFFSVAKGGAAAIPGPFGSGKT
CCHHHHHHHHHCCCCCCCCCHHHCCCCCCEECCCCHHHHHHHHHCCCCCCCCCCCCCCCC
VTQQQLAKWADADIVIYIGCGERGNEMTEVLTEFPYLDDPKTGNPLMDRTVLIANTSNMP
HHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCC
VAAREACVYTGITIAEYYRDQGYDVALMADSTSRWAEAMREISGRLEEMPGEEGYPAYLA
CHHHHHHHHCCCHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
SRLAQFYERAGRVNTIGTTSDVASITVVGAVSPPGGDLSEPVTQNTLRICKVFWALDASL
HHHHHHHHHCCCCEECCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
ADKRHFPSIDWLQSYSLYVDSIEGWWAENVAADWRETRDQAMILLQKESELQEIVQLVGP
HHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHEEEEECHHHHHHHHHHHCC
DALPEADQATLETTRMLREDFLQQNAFDDIDTYCPPVKQYNMLKTILLFHKEALAAVGRG
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCC
VPIQNIVALPVKEEIGKMKYIPQDEFAAKCEEIQAAITKQCSEA
CCHHHEEECCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIIEGKIIKIAGPVIIADGMRGAQMYEMVRVGEQKLIGEIIELEGDTATIQVYEETAGIQ
CCCCCEEEEEECCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHCCCC
PGEVVESTGGPLSVELGPGVMGSIFDGIQRPLELIREESGDFIARGVDAESISKEKKWTF
CCHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHCCCCCCCC
KPVAKVGDKVKGGDVLGEVQETSAVLQKILVPPMIEGELTSIASEGEYTVLEDIAEVATD
CHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCHHHHHHHHHHHHC
KGDEKIQMLQKWPVRKGRPYVDKLDPDVPLVTGQRAQDTFFSVAKGGAAAIPGPFGSGKT
CCHHHHHHHHHCCCCCCCCCHHHCCCCCCEECCCCHHHHHHHHHCCCCCCCCCCCCCCCC
VTQQQLAKWADADIVIYIGCGERGNEMTEVLTEFPYLDDPKTGNPLMDRTVLIANTSNMP
HHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCC
VAAREACVYTGITIAEYYRDQGYDVALMADSTSRWAEAMREISGRLEEMPGEEGYPAYLA
CHHHHHHHHCCCHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
SRLAQFYERAGRVNTIGTTSDVASITVVGAVSPPGGDLSEPVTQNTLRICKVFWALDASL
HHHHHHHHHCCCCEECCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
ADKRHFPSIDWLQSYSLYVDSIEGWWAENVAADWRETRDQAMILLQKESELQEIVQLVGP
HHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHEEEEECHHHHHHHHHHHCC
DALPEADQATLETTRMLREDFLQQNAFDDIDTYCPPVKQYNMLKTILLFHKEALAAVGRG
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCC
VPIQNIVALPVKEEIGKMKYIPQDEFAAKCEEIQAAITKQCSEA
CCHHHEEECCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA