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The map label for this gene is 148642301

Identifier: 148642301

GI number: 148642301

Start: 227343

End: 228131

Strand: Reverse

Name: 148642301

Synonym: Msm_0241

Alternate gene names: NA

Gene position: 228131-227343 (Counterclockwise)

Preceding gene: 148642302

Following gene: 148642294

Centisome position: 12.31

GC content: 34.6

Gene sequence:

>789_bases
ATGGTTGATATTGTACCTGAAATTACAAAGGAAAGTATAATTAATCTTGCTGTCAATGATAAAAGGGAAGATGGCAGGGA
ACTTGATGAATACAGGGATATTTCTATTGAAACTGATGTGATATCCAAAGCTGAAGGTTCTGCAAGAGTTAAAATAGGAG
ATACTCAGGTTATTGTTGGTATTAAACCGCAAATTGGTGCACCATTTCCGGATACTCCGGATTTGGGAGTTTTAATGACT
AACTGTGAAATGCTGCCAATGGCTGATCCTACTTTTGAACCTGGACCACCAAGTGAAGATTCAATTGAACTTGCACGTGT
TGTTGACAGGGGAATTCGTGAAAGTGAACTTGTTGATTTGGATAAGTTATGTGTTGAAGAAGGCAAACATGTTTGGATGT
TATTTATAGATTTGCATATTATAGATAACTGTGGAAATCTTTTTGATGCCTGTGAACTTGCTGTAATGGCTGCTCTAAAA
AGTACCAAATTACCTTCTGCAAGTATTGCTGATGATGAAGTTGTACTTGACCATGAAAACACTATAGATTTACCTATCAA
TAATGAAGTGGCTATGTGTACTTTTGTTAAAATAGGGGATAAATTGATTTTAGACCCTACTTTAAATGAAGAAAAAGTAG
CTAGTGCTCGTTTAAATGTAGGTGTTACTAAAGATGGTAATATTTGCGCTATGCAGAAAGGTGGAATTTCACCGTTAACA
AAAGAAGACATATTTTACTGTGTTGATAAAGCAGTTTCAAAAACAAAAGAATTAGTTGAATATCTTTAA

Upstream 100 bases:

>100_bases
GAAGAAGCAATTAATTTAGCTATGGAAGGATGCAGGAAAGTAAATGAAATCCAAAAAGAAGCTTTAATGAAAAAATATTC
TGCTGAGATGAGTGATTAAT

Downstream 100 bases:

>100_bases
ACGTCTGATGGACGATTAAGATTTCTAAATTCTTTTTTTAATAATTTTTTATTGTCTATTAATATAAATTTCGCATCTAT
TTTTTCTATTAATCCCTTAA

Product: exosome complex RNA-binding protein Rrp42

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 262; Mature: 262

Protein sequence:

>262_residues
MVDIVPEITKESIINLAVNDKREDGRELDEYRDISIETDVISKAEGSARVKIGDTQVIVGIKPQIGAPFPDTPDLGVLMT
NCEMLPMADPTFEPGPPSEDSIELARVVDRGIRESELVDLDKLCVEEGKHVWMLFIDLHIIDNCGNLFDACELAVMAALK
STKLPSASIADDEVVLDHENTIDLPINNEVAMCTFVKIGDKLILDPTLNEEKVASARLNVGVTKDGNICAMQKGGISPLT
KEDIFYCVDKAVSKTKELVEYL

Sequences:

>Translated_262_residues
MVDIVPEITKESIINLAVNDKREDGRELDEYRDISIETDVISKAEGSARVKIGDTQVIVGIKPQIGAPFPDTPDLGVLMT
NCEMLPMADPTFEPGPPSEDSIELARVVDRGIRESELVDLDKLCVEEGKHVWMLFIDLHIIDNCGNLFDACELAVMAALK
STKLPSASIADDEVVLDHENTIDLPINNEVAMCTFVKIGDKLILDPTLNEEKVASARLNVGVTKDGNICAMQKGGISPLT
KEDIFYCVDKAVSKTKELVEYL
>Mature_262_residues
MVDIVPEITKESIINLAVNDKREDGRELDEYRDISIETDVISKAEGSARVKIGDTQVIVGIKPQIGAPFPDTPDLGVLMT
NCEMLPMADPTFEPGPPSEDSIELARVVDRGIRESELVDLDKLCVEEGKHVWMLFIDLHIIDNCGNLFDACELAVMAALK
STKLPSASIADDEVVLDHENTIDLPINNEVAMCTFVKIGDKLILDPTLNEEKVASARLNVGVTKDGNICAMQKGGISPLT
KEDIFYCVDKAVSKTKELVEYL

Specific function: Probably involved in the 3'->5' degradation of a variety of RNA species (Potential) [H]

COG id: COG2123

COG function: function code J; RNase PH-related exoribonuclease

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase PH family [H]

Homologues:

Organism=Homo sapiens, GI31415882, Length=242, Percent_Identity=35.9504132231405, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI189083688, Length=248, Percent_Identity=35.4838709677419, Blast_Score=147, Evalue=8e-36,
Organism=Homo sapiens, GI77812672, Length=248, Percent_Identity=31.8548387096774, Blast_Score=117, Evalue=7e-27,
Organism=Homo sapiens, GI77812670, Length=248, Percent_Identity=31.8548387096774, Blast_Score=117, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI25144570, Length=243, Percent_Identity=27.9835390946502, Blast_Score=109, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6320486, Length=264, Percent_Identity=27.2727272727273, Blast_Score=108, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24642649, Length=262, Percent_Identity=27.8625954198473, Blast_Score=110, Evalue=6e-25,
Organism=Drosophila melanogaster, GI28573444, Length=214, Percent_Identity=33.6448598130841, Blast_Score=110, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001247
- InterPro:   IPR015847
- InterPro:   IPR020869
- InterPro:   IPR020568 [H]

Pfam domain/function: PF01138 RNase_PH; PF03725 RNase_PH_C [H]

EC number: 3.1.13.-

Molecular weight: Translated: 28728; Mature: 28728

Theoretical pI: Translated: 4.15; Mature: 4.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDIVPEITKESIINLAVNDKREDGRELDEYRDISIETDVISKAEGSARVKIGDTQVIVG
CCCCCCHHHHHHEEEEEECCCCCCCHHHHHHHCCEEEHHHHHCCCCCEEEEECCEEEEEE
IKPQIGAPFPDTPDLGVLMTNCEMLPMADPTFEPGPPSEDSIELARVVDRGIRESELVDL
ECCCCCCCCCCCCCCEEEEECCEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHH
DKLCVEEGKHVWMLFIDLHIIDNCGNLFDACELAVMAALKSTKLPSASIADDEVVLDHEN
HHHHHHCCCEEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCC
TIDLPINNEVAMCTFVKIGDKLILDPTLNEEKVASARLNVGVTKDGNICAMQKGGISPLT
EEECCCCCCEEEEEEEECCCEEEECCCCCHHHHHHHHEEEEECCCCCEEEEECCCCCCCC
KEDIFYCVDKAVSKTKELVEYL
HHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MVDIVPEITKESIINLAVNDKREDGRELDEYRDISIETDVISKAEGSARVKIGDTQVIVG
CCCCCCHHHHHHEEEEEECCCCCCCHHHHHHHCCEEEHHHHHCCCCCEEEEECCEEEEEE
IKPQIGAPFPDTPDLGVLMTNCEMLPMADPTFEPGPPSEDSIELARVVDRGIRESELVDL
ECCCCCCCCCCCCCCEEEEECCEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHH
DKLCVEEGKHVWMLFIDLHIIDNCGNLFDACELAVMAALKSTKLPSASIADDEVVLDHEN
HHHHHHCCCEEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCC
TIDLPINNEVAMCTFVKIGDKLILDPTLNEEKVASARLNVGVTKDGNICAMQKGGISPLT
EEECCCCCCEEEEEEEECCCEEEECCCCCHHHHHHHHEEEEECCCCCEEEEECCCCCCCC
KEDIFYCVDKAVSKTKELVEYL
HHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]