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The map label for this gene is eif2g [H]

Identifier: 148642260

GI number: 148642260

Start: 191640

End: 192854

Strand: Reverse

Name: eif2g [H]

Synonym: Msm_0200

Alternate gene names: 148642260

Gene position: 192854-191640 (Counterclockwise)

Preceding gene: 148642261

Following gene: 148642259

Centisome position: 10.41

GC content: 35.47

Gene sequence:

>1215_bases
GTGAACATACAGTCAGATGTAAACATAGGTTTAGTTGGTCATGTGGATCACGGTAAGACTACTCTTACCAAAGCATTATC
AGGAATATGGACTGATACTCACAGTGAAGAAACAAAAAGAGGTATTTCAATTCGTTTAGGTTATGCAGACATTGAATTCA
GAAAATGTCCAGATTGTGATGAACCTATGTGTTATACTACTTCTAAAACTTGTGAAAACTGTGGAAGCGAGACAGAATTA
GTTAGAAAAGTATCATTTGTTGATGCTCCAGGTCACGAAACCTTAATGGCGACTATGTTATCTGGTGCTGCAATAATGGA
TGGTGCAGTTTTAGTAATTGCTGCAAATGAATATTGCCCACAACCACAAACTAAAGAACACTTAATGGCTCTTGATGTTA
TTGGTGTTAAAGATGTTATTGTAGTTCAAAATAAAATTGATATTGTTTCAAAAGAAAGAGCTATTGAAAGTTATCATGAA
ATTAAAGAATTTGTAAAAGGTACTTGTGCAGAAGATGCTCCAATTATACCTGTATCTGCTCAGCAAGGAGCAAATATGGA
TATTTTAATTGAAGCTATGCTTAAAAGAATCCAACCGCCAGAAAGAAGTTTGGATAAAACTCCTTTAATGCATGTTGCAA
GATCTTTTGATATTAACAAACCTGGTTCCGGCGCTGCTAAAATCAAAGGTGGAGTTATTGGCGGAACTTTAGTTCAGGGT
ACTTTTAAGCTTGGAGACACTATTGAAATAAGGCCGGGAATTACAAATAACAATAAAAGAATAACCTTGAAATCCGAAAT
TATTGGTCTTGAAGCTAATGGAAAAGACGTTGAAGAAATAGGTCCCGGAGGACTTATTGGTGTAGCTACAAAATTAGACC
CTTCATTAACTAAAGCTGATTCATTATCAGGTTCTGTTGCTGGAGCAGTAGATACATTACCTGATGTTTTAGATAGTTTT
ACAATGGAAGCACATTTACTTGACAGAGTAGTAGGTACAAAAGAAGAACGTGATGTAGCTCCAATTAAACTTAAAGAACC
TTTAATGATTAATTGTGGTACTACAACAACTATTGGTGTTGTTACTTCTACTAAGAAAAAGAATATTGAAGTTGCTCTTA
AATTGCCTGTTTGTGCCAGTCCCGGAACTAGGGTAGCTTTAAGCCGTAGAGTGGGAGCTCGTTGGAGATTAATTGGTTAT
GGAATTATTATATAG

Upstream 100 bases:

>100_bases
TCTTGGTGTTGGCGATGAAGAGGAAGAAGAATAGTTTTACTATTTTTCTTATTTTAACTTTTAAGTTAAATTTAAAATTA
TAATAAAAAGGTGGTTATCT

Downstream 100 bases:

>100_bases
AGGGAAATAATGGAGTCTAAAGAAGTTGTGATTGATACCAATTTTTTTATGGTTCCTTTTCAATTTAACGTCGATATAAT
CGATGAACTTGAAAAAGCAC

Product: translation initiation factor IF-2 subunit gamma

Products: NA

Alternate protein names: aIF2-gamma; eIF-2-gamma [H]

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MNIQSDVNIGLVGHVDHGKTTLTKALSGIWTDTHSEETKRGISIRLGYADIEFRKCPDCDEPMCYTTSKTCENCGSETEL
VRKVSFVDAPGHETLMATMLSGAAIMDGAVLVIAANEYCPQPQTKEHLMALDVIGVKDVIVVQNKIDIVSKERAIESYHE
IKEFVKGTCAEDAPIIPVSAQQGANMDILIEAMLKRIQPPERSLDKTPLMHVARSFDINKPGSGAAKIKGGVIGGTLVQG
TFKLGDTIEIRPGITNNNKRITLKSEIIGLEANGKDVEEIGPGGLIGVATKLDPSLTKADSLSGSVAGAVDTLPDVLDSF
TMEAHLLDRVVGTKEERDVAPIKLKEPLMINCGTTTTIGVVTSTKKKNIEVALKLPVCASPGTRVALSRRVGARWRLIGY
GIII

Sequences:

>Translated_404_residues
MNIQSDVNIGLVGHVDHGKTTLTKALSGIWTDTHSEETKRGISIRLGYADIEFRKCPDCDEPMCYTTSKTCENCGSETEL
VRKVSFVDAPGHETLMATMLSGAAIMDGAVLVIAANEYCPQPQTKEHLMALDVIGVKDVIVVQNKIDIVSKERAIESYHE
IKEFVKGTCAEDAPIIPVSAQQGANMDILIEAMLKRIQPPERSLDKTPLMHVARSFDINKPGSGAAKIKGGVIGGTLVQG
TFKLGDTIEIRPGITNNNKRITLKSEIIGLEANGKDVEEIGPGGLIGVATKLDPSLTKADSLSGSVAGAVDTLPDVLDSF
TMEAHLLDRVVGTKEERDVAPIKLKEPLMINCGTTTTIGVVTSTKKKNIEVALKLPVCASPGTRVALSRRVGARWRLIGY
GIII
>Mature_404_residues
MNIQSDVNIGLVGHVDHGKTTLTKALSGIWTDTHSEETKRGISIRLGYADIEFRKCPDCDEPMCYTTSKTCENCGSETEL
VRKVSFVDAPGHETLMATMLSGAAIMDGAVLVIAANEYCPQPQTKEHLMALDVIGVKDVIVVQNKIDIVSKERAIESYHE
IKEFVKGTCAEDAPIIPVSAQQGANMDILIEAMLKRIQPPERSLDKTPLMHVARSFDINKPGSGAAKIKGGVIGGTLVQG
TFKLGDTIEIRPGITNNNKRITLKSEIIGLEANGKDVEEIGPGGLIGVATKLDPSLTKADSLSGSVAGAVDTLPDVLDSF
TMEAHLLDRVVGTKEERDVAPIKLKEPLMINCGTTTTIGVVTSTKKKNIEVALKLPVCASPGTRVALSRRVGARWRLIGY
GIII

Specific function: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA [H]

COG id: COG5257

COG function: function code J; Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. EIF2G subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503507, Length=427, Percent_Identity=44.2622950819672, Blast_Score=358, Evalue=3e-99,
Organism=Homo sapiens, GI34147630, Length=314, Percent_Identity=30.2547770700637, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI54607086, Length=268, Percent_Identity=30.9701492537313, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI223555963, Length=324, Percent_Identity=25.9259259259259, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI5729864, Length=324, Percent_Identity=25.9259259259259, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI194097354, Length=330, Percent_Identity=25.1515151515152, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI194018522, Length=322, Percent_Identity=25.4658385093168, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI194018520, Length=330, Percent_Identity=25.1515151515152, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI46094014, Length=324, Percent_Identity=25.9259259259259, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI4503475, Length=391, Percent_Identity=25.0639386189258, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI4503471, Length=391, Percent_Identity=25.3196930946292, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI2367247, Length=400, Percent_Identity=28, Blast_Score=114, Evalue=8e-27,
Organism=Escherichia coli, GI1790412, Length=313, Percent_Identity=30.0319488817891, Blast_Score=101, Evalue=8e-23,
Organism=Escherichia coli, GI1789737, Length=313, Percent_Identity=30.0319488817891, Blast_Score=101, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI17509919, Length=421, Percent_Identity=43.4679334916865, Blast_Score=354, Evalue=4e-98,
Organism=Caenorhabditis elegans, GI17556456, Length=312, Percent_Identity=30.7692307692308, Blast_Score=114, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI25141371, Length=291, Percent_Identity=31.2714776632302, Blast_Score=104, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI17506081, Length=269, Percent_Identity=27.1375464684015, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17552884, Length=349, Percent_Identity=25.7879656160458, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17569207, Length=349, Percent_Identity=25.7879656160458, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI115532067, Length=196, Percent_Identity=28.0612244897959, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI115532065, Length=196, Percent_Identity=28.0612244897959, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320863, Length=423, Percent_Identity=43.9716312056738, Blast_Score=355, Evalue=5e-99,
Organism=Saccharomyces cerevisiae, GI6324761, Length=308, Percent_Identity=32.1428571428571, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6325337, Length=350, Percent_Identity=24.2857142857143, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6319594, Length=350, Percent_Identity=24.2857142857143, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24647046, Length=422, Percent_Identity=44.3127962085308, Blast_Score=370, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24647048, Length=422, Percent_Identity=44.3127962085308, Blast_Score=369, Evalue=1e-102,
Organism=Drosophila melanogaster, GI281363316, Length=292, Percent_Identity=31.5068493150685, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI17864358, Length=292, Percent_Identity=31.5068493150685, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI19922690, Length=254, Percent_Identity=32.2834645669291, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI19921738, Length=246, Percent_Identity=31.7073170731707, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI45553807, Length=381, Percent_Identity=25.9842519685039, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI45553816, Length=381, Percent_Identity=25.9842519685039, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24651721, Length=381, Percent_Identity=25.9842519685039, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI17864154, Length=381, Percent_Identity=25.9842519685039, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI45550900, Length=276, Percent_Identity=27.1739130434783, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000795
- InterPro:   IPR022424
- InterPro:   IPR015256
- InterPro:   IPR009001
- InterPro:   IPR004161
- InterPro:   IPR009000 [H]

Pfam domain/function: PF09173 eIF2_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: NA

Molecular weight: Translated: 43335; Mature: 43335

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIQSDVNIGLVGHVDHGKTTLTKALSGIWTDTHSEETKRGISIRLGYADIEFRKCPDCD
CCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCHHHHCCCEEEEEEEEEEECCCCCCC
EPMCYTTSKTCENCGSETELVRKVSFVDAPGHETLMATMLSGAAIMDGAVLVIAANEYCP
CCEEEECCHHHHHCCCHHHHHHHHHEECCCCHHHHHHHHHCCCCEECCEEEEEECCCCCC
QPQTKEHLMALDVIGVKDVIVVQNKIDIVSKERAIESYHEIKEFVKGTCAEDAPIIPVSA
CCCCHHHEEEEEEECCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECC
QQGANMDILIEAMLKRIQPPERSLDKTPLMHVARSFDINKPGSGAAKIKGGVIGGTLVQG
CCCCCHHHHHHHHHHHCCCCHHCCCCCHHHHHHHHCCCCCCCCCCEEECCCEEECEEEEE
TFKLGDTIEIRPGITNNNKRITLKSEIIGLEANGKDVEEIGPGGLIGVATKLDPSLTKAD
EEECCCEEEECCCCCCCCCEEEEEHHEEEEECCCCCHHHCCCCCEEEEEECCCCCHHHHH
SLSGSVAGAVDTLPDVLDSFTMEAHLLDRVVGTKEERDVAPIKLKEPLMINCGTTTTIGV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCEEEECCCCEEEEE
VTSTKKKNIEVALKLPVCASPGTRVALSRRVGARWRLIGYGIII
EECCCCCCEEEEEEECEECCCCCEEEEECCCCCEEEEEEEEEEC
>Mature Secondary Structure
MNIQSDVNIGLVGHVDHGKTTLTKALSGIWTDTHSEETKRGISIRLGYADIEFRKCPDCD
CCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCHHHHCCCEEEEEEEEEEECCCCCCC
EPMCYTTSKTCENCGSETELVRKVSFVDAPGHETLMATMLSGAAIMDGAVLVIAANEYCP
CCEEEECCHHHHHCCCHHHHHHHHHEECCCCHHHHHHHHHCCCCEECCEEEEEECCCCCC
QPQTKEHLMALDVIGVKDVIVVQNKIDIVSKERAIESYHEIKEFVKGTCAEDAPIIPVSA
CCCCHHHEEEEEEECCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECC
QQGANMDILIEAMLKRIQPPERSLDKTPLMHVARSFDINKPGSGAAKIKGGVIGGTLVQG
CCCCCHHHHHHHHHHHCCCCHHCCCCCHHHHHHHHCCCCCCCCCCEEECCCEEECEEEEE
TFKLGDTIEIRPGITNNNKRITLKSEIIGLEANGKDVEEIGPGGLIGVATKLDPSLTKAD
EEECCCEEEECCCCCCCCCEEEEEHHEEEEECCCCCHHHCCCCCEEEEEECCCCCHHHHH
SLSGSVAGAVDTLPDVLDSFTMEAHLLDRVVGTKEERDVAPIKLKEPLMINCGTTTTIGV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCEEEECCCCEEEEE
VTSTKKKNIEVALKLPVCASPGTRVALSRRVGARWRLIGYGIII
EECCCCCCEEEEEEECEECCCCCEEEEECCCCCEEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]