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The map label for this gene is argH [H]

Identifier: 148642252

GI number: 148642252

Start: 187429

End: 188814

Strand: Reverse

Name: argH [H]

Synonym: Msm_0192

Alternate gene names: 148642252

Gene position: 188814-187429 (Counterclockwise)

Preceding gene: 148642253

Following gene: 148642249

Centisome position: 10.19

GC content: 33.62

Gene sequence:

>1386_bases
ATGACTGATGAAGCCGCTGAATATACTTCATCACTTGAATTTGATAAAATTATTTTTGAAGCTGATATTAAAACCAATTT
TGCACATACTTTGATGTTAAAAGAAGAAAATATTATTGATGATGAAATAGCAGATAATATTTTAGGTGCTCTTGACCAGT
TAAAAGAAGATGGCTATAATGAGCTTGTTTTCGACCCTTCTGTTGAAGATATTCACATGGCTATTGAAAATTATGTTACT
GATAAAATAGGTCCAACTGCAGGTTTTATGCATACAGCCAAATCACGTAACGACCAGGTAGCTACTGATGTCAGACTGGT
TCTTCGTGATAAAATTACCGAAACCCAAATCGGTATTTTGGAATTTATGGAAGGGCTGGTTGAAAAAGCAGGTGAGCATT
TGGAAACTGTTTTTATAGGTTATACTCATCTTCAGCATGCACAGCCAATTACAATAGCTCATCATTTGATGGCTCATGTA
CAGGCACTTAAAAGAGATTATGAACGTTTGGAAGATACTTATAAACGTGTCAATTTAAATCCTTTAGGTTCAGCAGCTAT
GACTACAACCAGTTTCCCGATCAACAGACAGTTAACCACTGATTTGCTTGGTTTTGATGCTTATCTTGAAAACTCAATGG
ATGGTGTTTCTTCAAGGGATTTCATTTCAGAAACAGTTTTTGATTTATCTGCATTATGTACAACATTATCCAAAATCTGT
GAAGAACTTATTTTATGGAGTACTTATGAATTCGGTATTATAGAAATGGCTGATGAATATTCATCTACATCATCTATTAT
GCCTCAAAAGAAAAATCCTGATGTTGCTGAACTTGCAAGAGCAAAATCAACAATTGTCAACGGTGAACTTGTAACTATTT
TAACTATTTTAAAAGCAATTCCTTACACCTATAATAGAGACTTGCAGGAAATCACTCCTCACTTATGGAATGCAGTTAAA
GTAACTCAAGACACTTTATCAATAGTTACAAAAATGTTGCTTTCTGTTAAATTTAAGGAAGACAGATGTTTGGAGTTAGC
CGGAACTAATTTTGCTACAGCTACTGATTTGGCAGATATTATGGTTCGTGAAAAACAGATTCCATTTAGGACAGCTCATA
AAATTGTAGGCAGAATAGTCAATGAAGCTACTGCCAGCGGATTAAAAGAAGCAGACATTACATCAGAATATATTGATGAT
ATAGCTTCAGAACTTGGTTTTGAAAAATTAGGTCTTGAAGATGATTTGGTTCAGAAAGCTTTAAATCCTTTAGAAAATGT
TAAAATGAGAACTGTTCCGGGTGGTCCTTCTCCTGCTATGGTTGAAATAGCTAGAGACAATATTAAAGAATTTTTAAATG
AAGAATTTGAGAAAAAAGGAATTTAA

Upstream 100 bases:

>100_bases
AAAAAGATTAAACAATCTTTTTTTTAACTATTTTTTTTATAAAATTTATTTTTAAGAAGGGAGTCTTGTGAATTTAAGAA
GTGGTAGACTTAAAACAGAA

Downstream 100 bases:

>100_bases
TCCTTTTCCAATTCTTCATCTTCATCTGTGTTTTCTTGAGGATGTTTTTGTGATTCAAGATAGGCTTCACGTATTTCCTC
AGATAACTCCTCATTACCTT

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MTDEAAEYTSSLEFDKIIFEADIKTNFAHTLMLKEENIIDDEIADNILGALDQLKEDGYNELVFDPSVEDIHMAIENYVT
DKIGPTAGFMHTAKSRNDQVATDVRLVLRDKITETQIGILEFMEGLVEKAGEHLETVFIGYTHLQHAQPITIAHHLMAHV
QALKRDYERLEDTYKRVNLNPLGSAAMTTTSFPINRQLTTDLLGFDAYLENSMDGVSSRDFISETVFDLSALCTTLSKIC
EELILWSTYEFGIIEMADEYSSTSSIMPQKKNPDVAELARAKSTIVNGELVTILTILKAIPYTYNRDLQEITPHLWNAVK
VTQDTLSIVTKMLLSVKFKEDRCLELAGTNFATATDLADIMVREKQIPFRTAHKIVGRIVNEATASGLKEADITSEYIDD
IASELGFEKLGLEDDLVQKALNPLENVKMRTVPGGPSPAMVEIARDNIKEFLNEEFEKKGI

Sequences:

>Translated_461_residues
MTDEAAEYTSSLEFDKIIFEADIKTNFAHTLMLKEENIIDDEIADNILGALDQLKEDGYNELVFDPSVEDIHMAIENYVT
DKIGPTAGFMHTAKSRNDQVATDVRLVLRDKITETQIGILEFMEGLVEKAGEHLETVFIGYTHLQHAQPITIAHHLMAHV
QALKRDYERLEDTYKRVNLNPLGSAAMTTTSFPINRQLTTDLLGFDAYLENSMDGVSSRDFISETVFDLSALCTTLSKIC
EELILWSTYEFGIIEMADEYSSTSSIMPQKKNPDVAELARAKSTIVNGELVTILTILKAIPYTYNRDLQEITPHLWNAVK
VTQDTLSIVTKMLLSVKFKEDRCLELAGTNFATATDLADIMVREKQIPFRTAHKIVGRIVNEATASGLKEADITSEYIDD
IASELGFEKLGLEDDLVQKALNPLENVKMRTVPGGPSPAMVEIARDNIKEFLNEEFEKKGI
>Mature_460_residues
TDEAAEYTSSLEFDKIIFEADIKTNFAHTLMLKEENIIDDEIADNILGALDQLKEDGYNELVFDPSVEDIHMAIENYVTD
KIGPTAGFMHTAKSRNDQVATDVRLVLRDKITETQIGILEFMEGLVEKAGEHLETVFIGYTHLQHAQPITIAHHLMAHVQ
ALKRDYERLEDTYKRVNLNPLGSAAMTTTSFPINRQLTTDLLGFDAYLENSMDGVSSRDFISETVFDLSALCTTLSKICE
ELILWSTYEFGIIEMADEYSSTSSIMPQKKNPDVAELARAKSTIVNGELVTILTILKAIPYTYNRDLQEITPHLWNAVKV
TQDTLSIVTKMLLSVKFKEDRCLELAGTNFATATDLADIMVREKQIPFRTAHKIVGRIVNEATASGLKEADITSEYIDDI
ASELGFEKLGLEDDLVQKALNPLENVKMRTVPGGPSPAMVEIARDNIKEFLNEEFEKKGI

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=383, Percent_Identity=37.0757180156658, Blast_Score=260, Evalue=2e-69,
Organism=Homo sapiens, GI68303542, Length=383, Percent_Identity=37.0757180156658, Blast_Score=260, Evalue=2e-69,
Organism=Homo sapiens, GI68303547, Length=386, Percent_Identity=36.0103626943005, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI68303549, Length=383, Percent_Identity=33.9425587467363, Blast_Score=220, Evalue=2e-57,
Organism=Escherichia coli, GI1790398, Length=440, Percent_Identity=36.1363636363636, Blast_Score=272, Evalue=3e-74,
Organism=Saccharomyces cerevisiae, GI6321806, Length=450, Percent_Identity=36.2222222222222, Blast_Score=254, Evalue=1e-68,
Organism=Drosophila melanogaster, GI221473854, Length=393, Percent_Identity=35.1145038167939, Blast_Score=236, Evalue=2e-62,
Organism=Drosophila melanogaster, GI78706858, Length=393, Percent_Identity=35.1145038167939, Blast_Score=236, Evalue=2e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 51684; Mature: 51553

Theoretical pI: Translated: 4.40; Mature: 4.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDEAAEYTSSLEFDKIIFEADIKTNFAHTLMLKEENIIDDEIADNILGALDQLKEDGYN
CCCCHHHHHHCCCHHHHEEEECCCCCHHHEEEEECCCCCHHHHHHHHHHHHHHHHHCCCC
ELVFDPSVEDIHMAIENYVTDKIGPTAGFMHTAKSRNDQVATDVRLVLRDKITETQIGIL
CEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
EFMEGLVEKAGEHLETVFIGYTHLQHAQPITIAHHLMAHVQALKRDYERLEDTYKRVNLN
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PLGSAAMTTTSFPINRQLTTDLLGFDAYLENSMDGVSSRDFISETVFDLSALCTTLSKIC
CCCCHHHEECCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
EELILWSTYEFGIIEMADEYSSTSSIMPQKKNPDVAELARAKSTIVNGELVTILTILKAI
HHHHHHCCCCCCHHHHHHHHCCHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHC
PYTYNRDLQEITPHLWNAVKVTQDTLSIVTKMLLSVKFKEDRCLELAGTNFATATDLADI
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCHHHHHHHHH
MVREKQIPFRTAHKIVGRIVNEATASGLKEADITSEYIDDIASELGFEKLGLEDDLVQKA
HHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHH
LNPLENVKMRTVPGGPSPAMVEIARDNIKEFLNEEFEKKGI
HCHHHCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TDEAAEYTSSLEFDKIIFEADIKTNFAHTLMLKEENIIDDEIADNILGALDQLKEDGYN
CCCHHHHHHCCCHHHHEEEECCCCCHHHEEEEECCCCCHHHHHHHHHHHHHHHHHCCCC
ELVFDPSVEDIHMAIENYVTDKIGPTAGFMHTAKSRNDQVATDVRLVLRDKITETQIGIL
CEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
EFMEGLVEKAGEHLETVFIGYTHLQHAQPITIAHHLMAHVQALKRDYERLEDTYKRVNLN
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PLGSAAMTTTSFPINRQLTTDLLGFDAYLENSMDGVSSRDFISETVFDLSALCTTLSKIC
CCCCHHHEECCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
EELILWSTYEFGIIEMADEYSSTSSIMPQKKNPDVAELARAKSTIVNGELVTILTILKAI
HHHHHHCCCCCCHHHHHHHHCCHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHC
PYTYNRDLQEITPHLWNAVKVTQDTLSIVTKMLLSVKFKEDRCLELAGTNFATATDLADI
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCHHHHHHHHH
MVREKQIPFRTAHKIVGRIVNEATASGLKEADITSEYIDDIASELGFEKLGLEDDLVQKA
HHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHH
LNPLENVKMRTVPGGPSPAMVEIARDNIKEFLNEEFEKKGI
HCHHHCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]