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The map label for this gene is mre11 [H]

Identifier: 148642181

GI number: 148642181

Start: 118493

End: 119716

Strand: Reverse

Name: mre11 [H]

Synonym: Msm_0121

Alternate gene names: 148642181

Gene position: 119716-118493 (Counterclockwise)

Preceding gene: 148642182

Following gene: 148642180

Centisome position: 6.46

GC content: 30.64

Gene sequence:

>1224_bases
ATGAAATTTGCACATTTGGCAGATACTCATTTAGGTTATAGACAGTTCGGATTGCTTGAACGGGAAAAAGACTTTTATGA
AGTATTTGATAAAATTATAGATAAAATAATCGAAGAAAAGGTCGATTTTGTAATACATAGTGGAGATTTATTTGATTCAG
CAAGACCGTCACCAAGTGCTCTTTTAGCTTTTCAAAAAGGTTTGCTTAAACTGAAAGGTGCAGGAATACCAATGTATGCA
ATTGCAGGAAATCATGATATTGTAAACCGTAACGGAGCTATACCTCCTCAAGTTTTATTTAAAAAATTTGGTTTAAAGTT
AATAAGCCCTATTAATACAAATTATATGCATGATGATGTTTTTATTGCAGGACTGCCTTTTTATCCTGCTTCCCAAAACA
AAAATCTTAAAAGCAAATTAGATGAATTATCTAAAAAAGCAGAAAATCACGAAAAATCTATTCTTGTTTTACATCAGGGA
ATTGACAAATATTTTAATCTACAGTATGAATTGGAAATTGGTGATATTCCCGATAATTTTGATTATTATGCATTAGGCCA
CATTCATAATTATATCTGTGATGATTTTGGTAATGGAAAACTCGTTTATCCAGGTTCAACTGAAACCTGGAATGTTAGTG
AGTTAATAGACCTTAAAAAGAATGGTAAAGGTTTTATTGTAGTTGATTTAGACGGACCGAAAATGAATGTTAAAAGAGTT
GCTATGGATATTCCCCGTGAATTTATTGTAAAAACAATTGATTATAGAAATTTAGGCGCTGAAATAGATTCCATTAAAAA
TACAATAAAAGATTTTGATAAACGGCCTATTTTAAATCTTAAAATTAACAATATAGATTCAAACCTAGGTGAAATCTATG
AATTCATTAATAGGGAACTTGGTGATTTGGCATTAATGATTAGACCTACATTCAATGTACTTGATAGGGAAGTGGATGTT
GATGCCATAATTAATGATGAAAATGCTTTACGTCCTAAAGAGCTTTTAATCGATGAATTAAAGGAATATGACAGTGAAGA
CGTTAATAATTTAGCTGTTGAATTATATGATTTGCTTTCAAAAAATAAAACAGAGGAATCTGAGGACTTGATTAGGCAGT
TTTTCAATGAAAAATACAATATTATACGTGATGATTCCGGTGAGGAAATAACTGAAAACAAAGCTGAAGACGGTCAGGTA
AGATTTAGTGGGGCTATTCAATGA

Upstream 100 bases:

>100_bases
TACCATAGTATTAAATATATTATTAACTATATAATTAATTGTTAAATGCTTTAATTTTAGAGTGTTTATTGGTTATATAA
AAATTTTAAAAGGTAATATA

Downstream 100 bases:

>100_bases
TTTTTACAAAATTAACATTAAACAATTTCAAATCCTATGGTCATGAAGTTATTAAGTTTGGTGATGGGATTACAGTTATT
GTAGGGGAAAATGGTGCTGG

Product: DNA repair exonuclease Rad32

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MKFAHLADTHLGYRQFGLLEREKDFYEVFDKIIDKIIEEKVDFVIHSGDLFDSARPSPSALLAFQKGLLKLKGAGIPMYA
IAGNHDIVNRNGAIPPQVLFKKFGLKLISPINTNYMHDDVFIAGLPFYPASQNKNLKSKLDELSKKAENHEKSILVLHQG
IDKYFNLQYELEIGDIPDNFDYYALGHIHNYICDDFGNGKLVYPGSTETWNVSELIDLKKNGKGFIVVDLDGPKMNVKRV
AMDIPREFIVKTIDYRNLGAEIDSIKNTIKDFDKRPILNLKINNIDSNLGEIYEFINRELGDLALMIRPTFNVLDREVDV
DAIINDENALRPKELLIDELKEYDSEDVNNLAVELYDLLSKNKTEESEDLIRQFFNEKYNIIRDDSGEEITENKAEDGQV
RFSGAIQ

Sequences:

>Translated_407_residues
MKFAHLADTHLGYRQFGLLEREKDFYEVFDKIIDKIIEEKVDFVIHSGDLFDSARPSPSALLAFQKGLLKLKGAGIPMYA
IAGNHDIVNRNGAIPPQVLFKKFGLKLISPINTNYMHDDVFIAGLPFYPASQNKNLKSKLDELSKKAENHEKSILVLHQG
IDKYFNLQYELEIGDIPDNFDYYALGHIHNYICDDFGNGKLVYPGSTETWNVSELIDLKKNGKGFIVVDLDGPKMNVKRV
AMDIPREFIVKTIDYRNLGAEIDSIKNTIKDFDKRPILNLKINNIDSNLGEIYEFINRELGDLALMIRPTFNVLDREVDV
DAIINDENALRPKELLIDELKEYDSEDVNNLAVELYDLLSKNKTEESEDLIRQFFNEKYNIIRDDSGEEITENKAEDGQV
RFSGAIQ
>Mature_407_residues
MKFAHLADTHLGYRQFGLLEREKDFYEVFDKIIDKIIEEKVDFVIHSGDLFDSARPSPSALLAFQKGLLKLKGAGIPMYA
IAGNHDIVNRNGAIPPQVLFKKFGLKLISPINTNYMHDDVFIAGLPFYPASQNKNLKSKLDELSKKAENHEKSILVLHQG
IDKYFNLQYELEIGDIPDNFDYYALGHIHNYICDDFGNGKLVYPGSTETWNVSELIDLKKNGKGFIVVDLDGPKMNVKRV
AMDIPREFIVKTIDYRNLGAEIDSIKNTIKDFDKRPILNLKINNIDSNLGEIYEFINRELGDLALMIRPTFNVLDREVDV
DAIINDENALRPKELLIDELKEYDSEDVNNLAVELYDLLSKNKTEESEDLIRQFFNEKYNIIRDDSGEEITENKAEDGQV
RFSGAIQ

Specific function: Involved in DNA double-strand break repair (DSBR). The rad50/mre11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific 3'-5' exonuclease activity [H]

COG id: COG0420

COG function: function code L; DNA repair exonuclease

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MRE11/RAD32 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004843 [H]

Pfam domain/function: PF00149 Metallophos [H]

EC number: NA

Molecular weight: Translated: 46545; Mature: 46545

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFAHLADTHLGYRQFGLLEREKDFYEVFDKIIDKIIEEKVDFVIHSGDLFDSARPSPSA
CCCCHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCCCCCCHHH
LLAFQKGLLKLKGAGIPMYAIAGNHDIVNRNGAIPPQVLFKKFGLKLISPINTNYMHDDV
HHHHHHHHHEECCCCCEEEEEECCCCEECCCCCCCHHHHHHHHCHHEECCCCCCCEECCE
FIAGLPFYPASQNKNLKSKLDELSKKAENHEKSILVLHQGIDKYFNLQYELEIGDIPDNF
EEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCHHHCCEEEEEEECCCCCCC
DYYALGHIHNYICDDFGNGKLVYPGSTETWNVSELIDLKKNGKGFIVVDLDGPKMNVKRV
CEEEHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCHHHH
AMDIPREFIVKTIDYRNLGAEIDSIKNTIKDFDKRPILNLKINNIDSNLGEIYEFINREL
HHHCCHHHHHHHHCHHHCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHH
GDLALMIRPTFNVLDREVDVDAIINDENALRPKELLIDELKEYDSEDVNNLAVELYDLLS
CCEEEEEECCHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
KNKTEESEDLIRQFFNEKYNIIRDDSGEEITENKAEDGQVRFSGAIQ
CCCCCHHHHHHHHHHCCCCCEEECCCCCHHHCCCCCCCEEEEECCCC
>Mature Secondary Structure
MKFAHLADTHLGYRQFGLLEREKDFYEVFDKIIDKIIEEKVDFVIHSGDLFDSARPSPSA
CCCCHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCCCCCCHHH
LLAFQKGLLKLKGAGIPMYAIAGNHDIVNRNGAIPPQVLFKKFGLKLISPINTNYMHDDV
HHHHHHHHHEECCCCCEEEEEECCCCEECCCCCCCHHHHHHHHCHHEECCCCCCCEECCE
FIAGLPFYPASQNKNLKSKLDELSKKAENHEKSILVLHQGIDKYFNLQYELEIGDIPDNF
EEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCHHHCCEEEEEEECCCCCCC
DYYALGHIHNYICDDFGNGKLVYPGSTETWNVSELIDLKKNGKGFIVVDLDGPKMNVKRV
CEEEHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCHHHH
AMDIPREFIVKTIDYRNLGAEIDSIKNTIKDFDKRPILNLKINNIDSNLGEIYEFINREL
HHHCCHHHHHHHHCHHHCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHH
GDLALMIRPTFNVLDREVDVDAIINDENALRPKELLIDELKEYDSEDVNNLAVELYDLLS
CCEEEEEECCHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
KNKTEESEDLIRQFFNEKYNIIRDDSGEEITENKAEDGQVRFSGAIQ
CCCCCHHHHHHHHHHCCCCCEEECCCCCHHHCCCCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA