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The map label for this gene is lon [H]

Identifier: 148381558

GI number: 148381558

Start: 3864003

End: 3865922

Strand: Reverse

Name: lon [H]

Synonym: CBO3621

Alternate gene names: 148381558

Gene position: 3865922-3864003 (Counterclockwise)

Preceding gene: 148381559

Following gene: 148381557

Centisome position: 99.46

GC content: 29.58

Gene sequence:

>1920_bases
GTGAATTCTCATAAATTAGATGAATTACAAGAGGATATAATAAATGAAATAGAACAGGATATTTCAAAGGACATGTCTAT
TGAGTTACAGACAGAGGTTTTATTTGAAATAGTAAAAAAAATAATAAAAGATTCTAATATAAGGGCTAGAGTTGTAAAGT
ATAAATTAGAAAAATATATAAATAGTAACAACCCATATGAAAGGCTATATGCATTAAATAAAATAATAAGTGATGGTAAG
GGGATACAAACAGTACCTACAGATAAGAACGTCATAGAAGTATTAACAGAAACAAATAGATTAATTGTGGAAGTTTTAGC
TAAAAGATATGTTGAAAATAATATAGAAAGAGAAGTAGAACAAGTTTTAATGGAAAAACAAGATAAATATATAGAAGAAG
TAAAGCTTAATATTTTAAAGAAACAAAAAGGACCAGAGAATGCTAAAACCTTAAAAAAATATGCTAATATTCAGGTTCTT
GAGTCTAAAAAATTAACTAATAATATTCAACATTTATTAAGACCAGCTTCTTTTTCAGAAATTATAGGACAGGAAAGACC
TATAAAGTCTCTTTTATCTAAAATAGCGTCCCCGTATCCACAACATATTATACTATATGGACCACCAGGGGTAGGAAAAA
CATCTGCGGCTAGATTAGCTCTAGAAGAAGTAAAAAAGTTAAAATATACACCTTTTTATCAAGAATCTAAATTTGTAGAG
GTAGATGGAACTACTTTAAGATGGGACCCAAGAGAAATTACTAATCCTCTTTTAGGATCAGTACATGATCCTATATACCA
AGGTTCTAAAAGGGATTTAGCAGAAACTGGTATACCAGAGCCTAAGCTAGGCCTAGTTACAGAAGCTCACGGAGGAGTAC
TTTTTATAGATGAAATAGGTGAGTTAGATGACATGCTTCAAAATAAACTTTTGAAGGTTTTAGAAGATAAAAGAGTAGAA
TTTTCATCTTCTTATTATGATCCAGATGATGAAAATACTCCTAAGTATATAAAACACTTATTTGAAAATGGAGCACCAGC
TGATTTTGTTCTTATAGGGGCTACTACTAGGGAACCTTCAGAAATAAATCCAGCACTAAGATCTAGATGTGCGGAAGTGT
TTTTTGAGCCATTATCCTCTAAAGATATTGAAAAAATAGTAATAAATGCCGCAGATAAATTAAATATAATATTAGAAGAT
GGGGTAGCTCAAACTATAAGTAGATATACTATAGAGGGAAGAAAAGCAGTTAATATATTATCAGATGTCTATGGATATGC
TTTATATAAAGATAAAGAATATAAAGAAGGAACAAAACTTAATATAACTATGGATGACTTAGAACAAGTTATATCTATAA
GTAGATTAATTCCATACGACAGAATAGAAAATAAAGAAGAATTAGAAATAGGACATGTATATGGATTAGGTGTAAGTGGA
TATATAGGATCTACTATAGAAATAGAAGCTACTGTATTTAATGCTAAAGATAAAGGTAAAGGCTTTATTAGATTTAATGA
TACAGCAGGAAGTATGGCGAAGGATTCAGTATTTAATGCAACTTCTGTTATAAGAAAAATAACAAAAGAAGATATAAAGG
ATTATGATGTACATGTTAATGCTATAGGTGGTGGGAAAATAGATGGACCATCTGCAGGAGCAGCTATAACAATATGTATT
ATTAGTGCTTTATTAAACAAGCCCATAAAACAGGATATAGCCATAACAGGAGAAATATCTCTTAAAGGAAAGATAAAGCC
TGTTGGAGGCATATTTGAAAAAATATATGGTGCAAGAAGAAAAGGCATAAAAAGGGTAATAATACCTAAGGACAATATGA
AAGATGCTCCTTCAGATATAAAAGATATAGAAATAATATGTATAGATACTATAGAAGAGCTTATGAATATAGTATTTTAG

Upstream 100 bases:

>100_bases
ACTATAAGACAAACAGGAGTTTATGAGGCAGAAATAAAAATTTACCCAGAAGTTTCAACTAAAGTTAAAGTTTCTGTTTT
AGAAGAATAGGAGGAAAATT

Downstream 100 bases:

>100_bases
ATTAAGGAGTACTTAAGGAGAGATGTTTATATGGATGCACCCATAAAAAGTATGCCACAGAGTATAGATGCAGAGCAAAA
TGTATTAGGGGCAATGATTA

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La 2 [H]

Number of amino acids: Translated: 639; Mature: 639

Protein sequence:

>639_residues
MNSHKLDELQEDIINEIEQDISKDMSIELQTEVLFEIVKKIIKDSNIRARVVKYKLEKYINSNNPYERLYALNKIISDGK
GIQTVPTDKNVIEVLTETNRLIVEVLAKRYVENNIEREVEQVLMEKQDKYIEEVKLNILKKQKGPENAKTLKKYANIQVL
ESKKLTNNIQHLLRPASFSEIIGQERPIKSLLSKIASPYPQHIILYGPPGVGKTSAARLALEEVKKLKYTPFYQESKFVE
VDGTTLRWDPREITNPLLGSVHDPIYQGSKRDLAETGIPEPKLGLVTEAHGGVLFIDEIGELDDMLQNKLLKVLEDKRVE
FSSSYYDPDDENTPKYIKHLFENGAPADFVLIGATTREPSEINPALRSRCAEVFFEPLSSKDIEKIVINAADKLNIILED
GVAQTISRYTIEGRKAVNILSDVYGYALYKDKEYKEGTKLNITMDDLEQVISISRLIPYDRIENKEELEIGHVYGLGVSG
YIGSTIEIEATVFNAKDKGKGFIRFNDTAGSMAKDSVFNATSVIRKITKEDIKDYDVHVNAIGGGKIDGPSAGAAITICI
ISALLNKPIKQDIAITGEISLKGKIKPVGGIFEKIYGARRKGIKRVIIPKDNMKDAPSDIKDIEIICIDTIEELMNIVF

Sequences:

>Translated_639_residues
MNSHKLDELQEDIINEIEQDISKDMSIELQTEVLFEIVKKIIKDSNIRARVVKYKLEKYINSNNPYERLYALNKIISDGK
GIQTVPTDKNVIEVLTETNRLIVEVLAKRYVENNIEREVEQVLMEKQDKYIEEVKLNILKKQKGPENAKTLKKYANIQVL
ESKKLTNNIQHLLRPASFSEIIGQERPIKSLLSKIASPYPQHIILYGPPGVGKTSAARLALEEVKKLKYTPFYQESKFVE
VDGTTLRWDPREITNPLLGSVHDPIYQGSKRDLAETGIPEPKLGLVTEAHGGVLFIDEIGELDDMLQNKLLKVLEDKRVE
FSSSYYDPDDENTPKYIKHLFENGAPADFVLIGATTREPSEINPALRSRCAEVFFEPLSSKDIEKIVINAADKLNIILED
GVAQTISRYTIEGRKAVNILSDVYGYALYKDKEYKEGTKLNITMDDLEQVISISRLIPYDRIENKEELEIGHVYGLGVSG
YIGSTIEIEATVFNAKDKGKGFIRFNDTAGSMAKDSVFNATSVIRKITKEDIKDYDVHVNAIGGGKIDGPSAGAAITICI
ISALLNKPIKQDIAITGEISLKGKIKPVGGIFEKIYGARRKGIKRVIIPKDNMKDAPSDIKDIEIICIDTIEELMNIVF
>Mature_639_residues
MNSHKLDELQEDIINEIEQDISKDMSIELQTEVLFEIVKKIIKDSNIRARVVKYKLEKYINSNNPYERLYALNKIISDGK
GIQTVPTDKNVIEVLTETNRLIVEVLAKRYVENNIEREVEQVLMEKQDKYIEEVKLNILKKQKGPENAKTLKKYANIQVL
ESKKLTNNIQHLLRPASFSEIIGQERPIKSLLSKIASPYPQHIILYGPPGVGKTSAARLALEEVKKLKYTPFYQESKFVE
VDGTTLRWDPREITNPLLGSVHDPIYQGSKRDLAETGIPEPKLGLVTEAHGGVLFIDEIGELDDMLQNKLLKVLEDKRVE
FSSSYYDPDDENTPKYIKHLFENGAPADFVLIGATTREPSEINPALRSRCAEVFFEPLSSKDIEKIVINAADKLNIILED
GVAQTISRYTIEGRKAVNILSDVYGYALYKDKEYKEGTKLNITMDDLEQVISISRLIPYDRIENKEELEIGHVYGLGVSG
YIGSTIEIEATVFNAKDKGKGFIRFNDTAGSMAKDSVFNATSVIRKITKEDIKDYDVHVNAIGGGKIDGPSAGAAITICI
ISALLNKPIKQDIAITGEISLKGKIKPVGGIFEKIYGARRKGIKRVIIPKDNMKDAPSDIKDIEIICIDTIEELMNIVF

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG1067

COG function: function code O; Predicted ATP-dependent protease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S16 family [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=508, Percent_Identity=26.3779527559055, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI21396489, Length=185, Percent_Identity=31.3513513513514, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI1786643, Length=482, Percent_Identity=27.1784232365145, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1790850, Length=101, Percent_Identity=34.6534653465347, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1789828, Length=115, Percent_Identity=40.8695652173913, Blast_Score=63, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17556486, Length=483, Percent_Identity=24.223602484472, Blast_Score=102, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI17505831, Length=158, Percent_Identity=38.6075949367089, Blast_Score=88, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6319449, Length=101, Percent_Identity=37.6237623762376, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI221513036, Length=487, Percent_Identity=26.694045174538, Blast_Score=100, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24666867, Length=487, Percent_Identity=26.694045174538, Blast_Score=100, Evalue=5e-21,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR020568
- InterPro:   IPR014251 [H]

Pfam domain/function: PF00004 AAA; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 71860; Mature: 71860

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: PS50045 SIGMA54_INTERACT_4 ; PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSHKLDELQEDIINEIEQDISKDMSIELQTEVLFEIVKKIIKDSNIRARVVKYKLEKYI
CCCCHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
NSNNPYERLYALNKIISDGKGIQTVPTDKNVIEVLTETNRLIVEVLAKRYVENNIEREVE
CCCCHHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QVLMEKQDKYIEEVKLNILKKQKGPENAKTLKKYANIQVLESKKLTNNIQHLLRPASFSE
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCEEEEHHHHHHHHHHHHHCCCCHHH
IIGQERPIKSLLSKIASPYPQHIILYGPPGVGKTSAARLALEEVKKLKYTPFYQESKFVE
HHCCCCCHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEE
VDGTTLRWDPREITNPLLGSVHDPIYQGSKRDLAETGIPEPKLGLVTEAHGGVLFIDEIG
ECCCEEEECHHHHCCHHHHHHCCHHHCCCCCCHHHCCCCCCCCCEEEECCCCEEEEHHHH
ELDDMLQNKLLKVLEDKRVEFSSSYYDPDDENTPKYIKHLFENGAPADFVLIGATTREPS
HHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCC
EINPALRSRCAEVFFEPLSSKDIEKIVINAADKLNIILEDGVAQTISRYTIEGRKAVNIL
CCCHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCEEEEEECCHHHHHHHHHCCCHHHHHHH
SDVYGYALYKDKEYKEGTKLNITMDDLEQVISISRLIPYDRIENKEELEIGHVYGLGVSG
HHHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHHHHCCHHHCCCCCCEEEEEEEECCCCC
YIGSTIEIEATVFNAKDKGKGFIRFNDTAGSMAKDSVFNATSVIRKITKEDIKDYDVHVN
CCCCEEEEEEEEECCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
AIGGGKIDGPSAGAAITICIISALLNKPIKQDIAITGEISLKGKIKPVGGIFEKIYGARR
EECCCCCCCCCCCHHHHHHHHHHHHCCCCHHCEEEEEEEEECCCCCCHHHHHHHHHHHHH
KGIKRVIIPKDNMKDAPSDIKDIEIICIDTIEELMNIVF
CCCEEEEECCCCCCCCCCCCCCEEEEEHHHHHHHHHHCC
>Mature Secondary Structure
MNSHKLDELQEDIINEIEQDISKDMSIELQTEVLFEIVKKIIKDSNIRARVVKYKLEKYI
CCCCHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
NSNNPYERLYALNKIISDGKGIQTVPTDKNVIEVLTETNRLIVEVLAKRYVENNIEREVE
CCCCHHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QVLMEKQDKYIEEVKLNILKKQKGPENAKTLKKYANIQVLESKKLTNNIQHLLRPASFSE
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCEEEEHHHHHHHHHHHHHCCCCHHH
IIGQERPIKSLLSKIASPYPQHIILYGPPGVGKTSAARLALEEVKKLKYTPFYQESKFVE
HHCCCCCHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEE
VDGTTLRWDPREITNPLLGSVHDPIYQGSKRDLAETGIPEPKLGLVTEAHGGVLFIDEIG
ECCCEEEECHHHHCCHHHHHHCCHHHCCCCCCHHHCCCCCCCCCEEEECCCCEEEEHHHH
ELDDMLQNKLLKVLEDKRVEFSSSYYDPDDENTPKYIKHLFENGAPADFVLIGATTREPS
HHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCC
EINPALRSRCAEVFFEPLSSKDIEKIVINAADKLNIILEDGVAQTISRYTIEGRKAVNIL
CCCHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCEEEEEECCHHHHHHHHHCCCHHHHHHH
SDVYGYALYKDKEYKEGTKLNITMDDLEQVISISRLIPYDRIENKEELEIGHVYGLGVSG
HHHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHHHHCCHHHCCCCCCEEEEEEEECCCCC
YIGSTIEIEATVFNAKDKGKGFIRFNDTAGSMAKDSVFNATSVIRKITKEDIKDYDVHVN
CCCCEEEEEEEEECCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
AIGGGKIDGPSAGAAITICIISALLNKPIKQDIAITGEISLKGKIKPVGGIFEKIYGARR
EECCCCCCCCCCCHHHHHHHHHHHHCCCCHHCEEEEEEEEECCCCCCHHHHHHHHHHHHH
KGIKRVIIPKDNMKDAPSDIKDIEIICIDTIEELMNIVF
CCCEEEEECCCCCCCCCCCCCCEEEEEHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377; 7961402; 11325926 [H]