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The map label for this gene is prsA

Identifier: 148381478

GI number: 148381478

Start: 3780871

End: 3781881

Strand: Reverse

Name: prsA

Synonym: CBO3538

Alternate gene names: 148381478

Gene position: 3781881-3780871 (Counterclockwise)

Preceding gene: 148381479

Following gene: 148381477

Centisome position: 97.3

GC content: 27.5

Gene sequence:

>1011_bases
GTGAAAAGTGCAAAAAAATTATTAAGCGTATTGTGTTTAGGAATATTTATTTTAACATTTACAGCATGCGATATGGTGGA
AAAGACTCCAGAAGCTAAAGCCAAAAGTACCATAGCCAAAGTAAATGGTGAAAAGATTCAAAGGAAAGATTTAGATGAAA
GCCCTAGTATGCAACAAGTGCTTAGTCAAATAAAAACACAGTATGGTGAAGAATTTGAAAAAAGTGAACAAGGAAAAGAA
GTTATAAAAGAACAAAAGAAGCAAATATTAGAAAATCTTATAACAGAAAAAGTTTTATTACAAAAGGGGAAAGAATTAAA
AGTTATTCCAAAGGATGAGGAATTAAACAAAGAAGCAGATAAAAAAGTTAATGAAATAAAGGCAGTATATAATAATGATG
AAAAGAAATTTGAAGAAACTTTAAAATCTACAGGATTTACTAAAGAAACTCTAAAAGAATACTTAAGAGATCAGATAGTA
ATAGAAAAAGTTATAAATGAAGTTACAAAAGATGTAAAAGTTGAAGATAAGGATGCCCAGAAGTATTATAATGAAAATCA
AAGTATGTTCACAGAAAAACCAAATACTATGAATGTATCACATATATTAGTTAAAACAGAAGATGAAGCTAAAAAAGTTA
AAAAGAGATTAGATGCAAAAGAAGATTTTGCAAAGGTGGCAAAGGAAGTATCACAGGATCCAGGTTCTAAAGATAAGGGT
GGATTATTAGGAGATATAAGTTATAGTGATTCTAACTATGATCCTACATTTATGAAAGCGGCTATAGCTCTTAAAGAGGG
TACAATTTCTAACCCAGTTCATACTCAATGGGGATATCATATTATAAAAGTTAATAGTAAAAAAGAATATCCAGTTAAAA
AATTTGATTCTGTAAAAGAAGATATTAAAAAACAATTAAAACAAGAAAAACAACAAGAAGCTTATACCAAAAAAATAGAA
GAATGGAAAAAAGCTTCTAAGATAAAAACTTACGAAAAAAATCTATTATAA

Upstream 100 bases:

>100_bases
TAAACAACAATCAATAAGTAGATATTTTGTAGTATTATTAATTATGTGGTAAAATTACTTTAATTACGTAAAAAAAATGT
TAAGAGTGGAGGAATATAGG

Downstream 100 bases:

>100_bases
TGAATAAAAATCATGTGTATTAATTACACATGATTTTTATTTGGAAGAAAATTTTAAAAAGTTAGTTTATTTTACAATTA
AATGAAAAAATATAAAATGT

Product: peptidylprolyl isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MKSAKKLLSVLCLGIFILTFTACDMVEKTPEAKAKSTIAKVNGEKIQRKDLDESPSMQQVLSQIKTQYGEEFEKSEQGKE
VIKEQKKQILENLITEKVLLQKGKELKVIPKDEELNKEADKKVNEIKAVYNNDEKKFEETLKSTGFTKETLKEYLRDQIV
IEKVINEVTKDVKVEDKDAQKYYNENQSMFTEKPNTMNVSHILVKTEDEAKKVKKRLDAKEDFAKVAKEVSQDPGSKDKG
GLLGDISYSDSNYDPTFMKAAIALKEGTISNPVHTQWGYHIIKVNSKKEYPVKKFDSVKEDIKKQLKQEKQQEAYTKKIE
EWKKASKIKTYEKNLL

Sequences:

>Translated_336_residues
MKSAKKLLSVLCLGIFILTFTACDMVEKTPEAKAKSTIAKVNGEKIQRKDLDESPSMQQVLSQIKTQYGEEFEKSEQGKE
VIKEQKKQILENLITEKVLLQKGKELKVIPKDEELNKEADKKVNEIKAVYNNDEKKFEETLKSTGFTKETLKEYLRDQIV
IEKVINEVTKDVKVEDKDAQKYYNENQSMFTEKPNTMNVSHILVKTEDEAKKVKKRLDAKEDFAKVAKEVSQDPGSKDKG
GLLGDISYSDSNYDPTFMKAAIALKEGTISNPVHTQWGYHIIKVNSKKEYPVKKFDSVKEDIKKQLKQEKQQEAYTKKIE
EWKKASKIKTYEKNLL
>Mature_336_residues
MKSAKKLLSVLCLGIFILTFTACDMVEKTPEAKAKSTIAKVNGEKIQRKDLDESPSMQQVLSQIKTQYGEEFEKSEQGKE
VIKEQKKQILENLITEKVLLQKGKELKVIPKDEELNKEADKKVNEIKAVYNNDEKKFEETLKSTGFTKETLKEYLRDQIV
IEKVINEVTKDVKVEDKDAQKYYNENQSMFTEKPNTMNVSHILVKTEDEAKKVKKRLDAKEDFAKVAKEVSQDPGSKDKG
GLLGDISYSDSNYDPTFMKAAIALKEGTISNPVHTQWGYHIIKVNSKKEYPVKKFDSVKEDIKKQLKQEKQQEAYTKKIE
EWKKASKIKTYEKNLL

Specific function: Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain

Homologues:

Organism=Escherichia coli, GI1786645, Length=386, Percent_Identity=25.1295336787565, Blast_Score=88, Evalue=7e-19,
Organism=Escherichia coli, GI1786238, Length=150, Percent_Identity=30, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PRSA_CLOB1 (A7FPK5)

Other databases:

- EMBL:   CP000726
- RefSeq:   YP_001385853.1
- ProteinModelPortal:   A7FPK5
- STRING:   A7FPK5
- GeneID:   5396506
- GenomeReviews:   CP000726_GR
- KEGG:   cba:CLB_3619
- eggNOG:   COG0760
- HOGENOM:   HBG712792
- OMA:   YHIIKIN
- ProtClustDB:   PRK00059
- BioCyc:   CBOT441770:CLB_3619-MONOMER
- HAMAP:   MF_01145
- InterPro:   IPR023059
- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR015391
- InterPro:   IPR008880

Pfam domain/function: PF00639 Rotamase; PF09312 SurA_N; SSF109998 Trigger_fac_C_bac

EC number: =5.2.1.8

Molecular weight: Translated: 38673; Mature: 38673

Theoretical pI: Translated: 9.50; Mature: 9.50

Prosite motif: PS01096 PPIC_PPIASE_1; PS50198 PPIC_PPIASE_2; PS51257 PROKAR_LIPOPROTEIN; PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSAKKLLSVLCLGIFILTFTACDMVEKTPEAKAKSTIAKVNGEKIQRKDLDESPSMQQV
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHCCCCCCCHHHH
LSQIKTQYGEEFEKSEQGKEVIKEQKKQILENLITEKVLLQKGKELKVIPKDEELNKEAD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHCHHHH
KKVNEIKAVYNNDEKKFEETLKSTGFTKETLKEYLRDQIVIEKVINEVTKDVKVEDKDAQ
HHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
KYYNENQSMFTEKPNTMNVSHILVKTEDEAKKVKKRLDAKEDFAKVAKEVSQDPGSKDKG
HHHCCCCHHCCCCCCCCCHHEEEEECCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCC
GLLGDISYSDSNYDPTFMKAAIALKEGTISNPVHTQWGYHIIKVNSKKEYPVKKFDSVKE
CEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHH
DIKKQLKQEKQQEAYTKKIEEWKKASKIKTYEKNLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKSAKKLLSVLCLGIFILTFTACDMVEKTPEAKAKSTIAKVNGEKIQRKDLDESPSMQQV
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHCCCCCCCHHHH
LSQIKTQYGEEFEKSEQGKEVIKEQKKQILENLITEKVLLQKGKELKVIPKDEELNKEAD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHCHHHH
KKVNEIKAVYNNDEKKFEETLKSTGFTKETLKEYLRDQIVIEKVINEVTKDVKVEDKDAQ
HHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
KYYNENQSMFTEKPNTMNVSHILVKTEDEAKKVKKRLDAKEDFAKVAKEVSQDPGSKDKG
HHHCCCCHHCCCCCCCCCHHEEEEECCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCC
GLLGDISYSDSNYDPTFMKAAIALKEGTISNPVHTQWGYHIIKVNSKKEYPVKKFDSVKE
CEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHH
DIKKQLKQEKQQEAYTKKIEEWKKASKIKTYEKNLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA