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The map label for this gene is thyX [H]

Identifier: 148381441

GI number: 148381441

Start: 3727383

End: 3728141

Strand: Reverse

Name: thyX [H]

Synonym: CBO3500

Alternate gene names: 148381441

Gene position: 3728141-3727383 (Counterclockwise)

Preceding gene: 148381442

Following gene: 148381440

Centisome position: 95.92

GC content: 28.72

Gene sequence:

>759_bases
TTGATAATGAAAGTTAAATTATTAGAATATACACCAAATGCAGAAAAATTAATAGCTTCCGCAGCAAAATTATGTTATAG
TTCATCTGGAATTGAAAATTTACAAAATAATTTAGACAAAGAAAAAGTGGATAAATTTTTAAATATGTTAATGTCCTATG
GACATGAATCACCAATAGAACATGTTTCTTTTACTTTTGGTATAGAGGGAGTATCAAGAAGTTTAACACATCAACTTGTA
AGACATAGAATAGGATCTTATTCACAACAAAGCCAAAGGTATGTTAGGTTAGATCAATTTGAATATGTTATTCCACCTTC
TGTAGAAAAGGATGAAGAGGCAAAAAATATATATATAAAAACTATGAAAAATTGTCAAAAGTCCTACGATGATATTGCGA
GTATTTTAAAAGAAAAATATATTAATAATGGATTAAGGGATATAGATGCAGAAAAAAAGGCTATAGAAGATGCAAGATAT
GTATTTCCAAATGCTTGTACAAGTAAAATTATAGTTACAATGAATGCTAGAAGTTTAATGAATTTCTTTAGACATAGATG
CTGCAATAGAGCGCAATGGGAAATAAGAGAACTAGCTGAAATTATGTTGTTTGAAGTTAAAGATGTTGCACCAACATTAT
TTAAATATTGTGGACCAGGTTGCGTAAATGGACCTTGTCCAGAAGGAAAAATGTCCTGTGGTAAAATAAAAGAAGTTAGA
GAAAAGTACAATGTAAAATTATACAAGGAGAGTAAGTAA

Upstream 100 bases:

>100_bases
TTTGAAGCCCTTATAGGTTTTTTATATATAACAGATCAACAGGAAAGATTAAATTATTTATTAAATAATATAGTTACTTT
AAATGGAAAAAAAGGAGCAC

Downstream 100 bases:

>100_bases
TAATGAAAAATAGAGTTGGTCAACAGGAAGAAATAAGAGAAGATATAATAGAGGGCAGAAATGCGGTAATAGAAGCATTA
AAATCAAATAAAACTATAGA

Product: FAD-dependent thymidylate synthase

Products: NA

Alternate protein names: TS; TSase [H]

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MIMKVKLLEYTPNAEKLIASAAKLCYSSSGIENLQNNLDKEKVDKFLNMLMSYGHESPIEHVSFTFGIEGVSRSLTHQLV
RHRIGSYSQQSQRYVRLDQFEYVIPPSVEKDEEAKNIYIKTMKNCQKSYDDIASILKEKYINNGLRDIDAEKKAIEDARY
VFPNACTSKIIVTMNARSLMNFFRHRCCNRAQWEIRELAEIMLFEVKDVAPTLFKYCGPGCVNGPCPEGKMSCGKIKEVR
EKYNVKLYKESK

Sequences:

>Translated_252_residues
MIMKVKLLEYTPNAEKLIASAAKLCYSSSGIENLQNNLDKEKVDKFLNMLMSYGHESPIEHVSFTFGIEGVSRSLTHQLV
RHRIGSYSQQSQRYVRLDQFEYVIPPSVEKDEEAKNIYIKTMKNCQKSYDDIASILKEKYINNGLRDIDAEKKAIEDARY
VFPNACTSKIIVTMNARSLMNFFRHRCCNRAQWEIRELAEIMLFEVKDVAPTLFKYCGPGCVNGPCPEGKMSCGKIKEVR
EKYNVKLYKESK
>Mature_252_residues
MIMKVKLLEYTPNAEKLIASAAKLCYSSSGIENLQNNLDKEKVDKFLNMLMSYGHESPIEHVSFTFGIEGVSRSLTHQLV
RHRIGSYSQQSQRYVRLDQFEYVIPPSVEKDEEAKNIYIKTMKNCQKSYDDIASILKEKYINNGLRDIDAEKKAIEDARY
VFPNACTSKIIVTMNARSLMNFFRHRCCNRAQWEIRELAEIMLFEVKDVAPTLFKYCGPGCVNGPCPEGKMSCGKIKEVR
EKYNVKLYKESK

Specific function: Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate [H]

COG id: COG1351

COG function: function code F; Predicted alternative thymidylate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thyX (flavin-dependent thymidylate synthase) domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003669 [H]

Pfam domain/function: PF02511 Thy1 [H]

EC number: =2.1.1.148 [H]

Molecular weight: Translated: 29069; Mature: 29069

Theoretical pI: Translated: 8.74; Mature: 8.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
3.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
7.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIMKVKLLEYTPNAEKLIASAAKLCYSSSGIENLQNNLDKEKVDKFLNMLMSYGHESPIE
CCEEEEEEECCCCHHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHHHCCCCCCHH
HVSFTFGIEGVSRSLTHQLVRHRIGSYSQQSQRYVRLDQFEYVIPPSVEKDEEAKNIYIK
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHH
TMKNCQKSYDDIASILKEKYINNGLRDIDAEKKAIEDARYVFPNACTSKIIVTMNARSLM
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECHHHHH
NFFRHRCCNRAQWEIRELAEIMLFEVKDVAPTLFKYCGPGCVNGPCPEGKMSCGKIKEVR
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHH
EKYNVKLYKESK
HHHCCCEEECCC
>Mature Secondary Structure
MIMKVKLLEYTPNAEKLIASAAKLCYSSSGIENLQNNLDKEKVDKFLNMLMSYGHESPIE
CCEEEEEEECCCCHHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHHHCCCCCCHH
HVSFTFGIEGVSRSLTHQLVRHRIGSYSQQSQRYVRLDQFEYVIPPSVEKDEEAKNIYIK
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHH
TMKNCQKSYDDIASILKEKYINNGLRDIDAEKKAIEDARYVFPNACTSKIIVTMNARSLM
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECHHHHH
NFFRHRCCNRAQWEIRELAEIMLFEVKDVAPTLFKYCGPGCVNGPCPEGKMSCGKIKEVR
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHH
EKYNVKLYKESK
HHHCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12552129 [H]