The gene/protein map for NC_009495 is currently unavailable.
Definition Clostridium botulinum A str. ATCC 3502, complete genome.
Accession NC_009495
Length 3,886,916

Click here to switch to the map view.

The map label for this gene is gutD [H]

Identifier: 148381353

GI number: 148381353

Start: 3654628

End: 3655413

Strand: Reverse

Name: gutD [H]

Synonym: CBO3413

Alternate gene names: 148381353

Gene position: 3655413-3654628 (Counterclockwise)

Preceding gene: 148381354

Following gene: 148381352

Centisome position: 94.04

GC content: 28.88

Gene sequence:

>786_bases
GTGAATTTTAAAGAAAAAACTGTTATAATAACAGGAGGAGCTCAAAGTTTAGGAGAATATATTGCTTATAGCTTTGCTGA
AAAAGGTGCTAATATAGTAATTGCAGATATAAATTATGAACAGGCTAATAAAGTATCTCAAAATATAATAAACAAATATA
AAGTAAGATCTATAGCAGTTAAAGTTGATGTTTGTAAAGAAGAGGAAGTTAAAAATCTTATAAAAAATACAATAGATAAT
TTTAGTAAAATAGATATTTTAATTTGTAATGCTGGAGTAGTTTATAGTACAAAGGTTACTGAGCTGCCTAAAGAAAAATG
GGACAATATATTAAATGTAAATTTAACAGGATATTTTTTATGTGCAAAAGAGGCTGCAAAGGAGATGGTGAAGAGAAAAC
AAGGAGTTATTATCGATATAAATTCTAAATCAGGTAAAAAAGGAAGTTTGCATAACTGTGCTTATTCTGCATCAAAATTT
GGAGCTATAGGTTTAACTCAAAGTTTAGCATTGGATTTAGCGGAGGATGGAATAAGAGTTAATGCAGTTTGTTCAGGTAA
TTTATTAGACTCGCCTATGTGGAAAAATGGCTTATATGAACAATATGCTAAAAAATTAAATATACCTAAAGAAAAAGTTA
GACAAGCATATATAGATAAGGTACCTTTAAAAAGAGGCTGTACTTATGAGGATGTAAGTAATCTAGTATTATTTTTAAGT
TCAAAAGAAGCTTCATATATGACTGGACAGGCTGTAAACGTTACGGGTGGTCAAGAAATGAGATAA

Upstream 100 bases:

>100_bases
TTACCAGGAAGCTTATATTTAGAAGATAAAGAAATAAAAGAAATAAAAGAAGGAACTGTAATAGAAGTTGAAAGACCTTA
GTTAGAAAAGGAGGGATACT

Downstream 100 bases:

>100_bases
AATATATTTTTAGGAGATAAATTATGTTAGATACAATAATTTTTGATATGGATGGGGTAATAATAGACACAGAACCTTTA
TCCTTTGAAACTAGTAAAAT

Product: sorbitol-6-phosphate dehydrogenase

Products: NA

Alternate protein names: Glucitol-6-phosphate dehydrogenase; Ketosephosphate reductase [H]

Number of amino acids: Translated: 261; Mature: 261

Protein sequence:

>261_residues
MNFKEKTVIITGGAQSLGEYIAYSFAEKGANIVIADINYEQANKVSQNIINKYKVRSIAVKVDVCKEEEVKNLIKNTIDN
FSKIDILICNAGVVYSTKVTELPKEKWDNILNVNLTGYFLCAKEAAKEMVKRKQGVIIDINSKSGKKGSLHNCAYSASKF
GAIGLTQSLALDLAEDGIRVNAVCSGNLLDSPMWKNGLYEQYAKKLNIPKEKVRQAYIDKVPLKRGCTYEDVSNLVLFLS
SKEASYMTGQAVNVTGGQEMR

Sequences:

>Translated_261_residues
MNFKEKTVIITGGAQSLGEYIAYSFAEKGANIVIADINYEQANKVSQNIINKYKVRSIAVKVDVCKEEEVKNLIKNTIDN
FSKIDILICNAGVVYSTKVTELPKEKWDNILNVNLTGYFLCAKEAAKEMVKRKQGVIIDINSKSGKKGSLHNCAYSASKF
GAIGLTQSLALDLAEDGIRVNAVCSGNLLDSPMWKNGLYEQYAKKLNIPKEKVRQAYIDKVPLKRGCTYEDVSNLVLFLS
SKEASYMTGQAVNVTGGQEMR
>Mature_261_residues
MNFKEKTVIITGGAQSLGEYIAYSFAEKGANIVIADINYEQANKVSQNIINKYKVRSIAVKVDVCKEEEVKNLIKNTIDN
FSKIDILICNAGVVYSTKVTELPKEKWDNILNVNLTGYFLCAKEAAKEMVKRKQGVIIDINSKSGKKGSLHNCAYSASKF
GAIGLTQSLALDLAEDGIRVNAVCSGNLLDSPMWKNGLYEQYAKKLNIPKEKVRQAYIDKVPLKRGCTYEDVSNLVLFLS
SKEASYMTGQAVNVTGGQEMR

Specific function: Sorbitol metabolism. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI19923817, Length=264, Percent_Identity=32.1969696969697, Blast_Score=135, Evalue=4e-32,
Organism=Homo sapiens, GI15277342, Length=270, Percent_Identity=28.5185185185185, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI66933014, Length=261, Percent_Identity=32.183908045977, Blast_Score=111, Evalue=8e-25,
Organism=Homo sapiens, GI59889578, Length=238, Percent_Identity=29.4117647058824, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI32483357, Length=260, Percent_Identity=28.0769230769231, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI40254992, Length=256, Percent_Identity=28.125, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI4504505, Length=189, Percent_Identity=29.6296296296296, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI31542939, Length=193, Percent_Identity=27.979274611399, Blast_Score=88, Evalue=8e-18,
Organism=Homo sapiens, GI5031737, Length=257, Percent_Identity=28.0155642023346, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI10190704, Length=256, Percent_Identity=24.21875, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI4758504, Length=209, Percent_Identity=30.622009569378, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI210032110, Length=181, Percent_Identity=27.0718232044199, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI126723750, Length=264, Percent_Identity=26.1363636363636, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI83715985, Length=191, Percent_Identity=30.3664921465969, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI109715829, Length=267, Percent_Identity=26.5917602996255, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI33667109, Length=190, Percent_Identity=29.4736842105263, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI4503817, Length=171, Percent_Identity=29.2397660818713, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI40807363, Length=203, Percent_Identity=27.5862068965517, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI226371731, Length=180, Percent_Identity=28.3333333333333, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI224922801, Length=175, Percent_Identity=26.2857142857143, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI25282469, Length=224, Percent_Identity=26.3392857142857, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI142976729, Length=197, Percent_Identity=26.3959390862944, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI4503301, Length=264, Percent_Identity=25.7575757575758, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI40254986, Length=163, Percent_Identity=30.0613496932515, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI7705925, Length=253, Percent_Identity=24.1106719367589, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI126723191, Length=180, Percent_Identity=26.6666666666667, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI7706318, Length=188, Percent_Identity=23.4042553191489, Blast_Score=64, Evalue=1e-10,
Organism=Escherichia coli, GI1789057, Length=257, Percent_Identity=46.3035019455253, Blast_Score=236, Evalue=1e-63,
Organism=Escherichia coli, GI87082100, Length=258, Percent_Identity=33.7209302325581, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1787335, Length=260, Percent_Identity=28.8461538461538, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI87082160, Length=264, Percent_Identity=29.9242424242424, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1787905, Length=262, Percent_Identity=30.9160305343511, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1790717, Length=252, Percent_Identity=26.984126984127, Blast_Score=114, Evalue=4e-27,
Organism=Escherichia coli, GI1788459, Length=254, Percent_Identity=31.8897637795276, Blast_Score=114, Evalue=6e-27,
Organism=Escherichia coli, GI1789208, Length=263, Percent_Identity=26.9961977186312, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI2367175, Length=258, Percent_Identity=28.2945736434109, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1786812, Length=273, Percent_Identity=26.007326007326, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI1789378, Length=261, Percent_Identity=24.1379310344828, Blast_Score=88, Evalue=5e-19,
Organism=Escherichia coli, GI2367365, Length=255, Percent_Identity=25.8823529411765, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1787526, Length=212, Percent_Identity=23.1132075471698, Blast_Score=77, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17555706, Length=260, Percent_Identity=31.9230769230769, Blast_Score=125, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI25147288, Length=257, Percent_Identity=30.7392996108949, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17561402, Length=263, Percent_Identity=27.7566539923954, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71994600, Length=254, Percent_Identity=29.1338582677165, Blast_Score=100, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI17562904, Length=268, Percent_Identity=28.3582089552239, Blast_Score=97, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17560676, Length=260, Percent_Identity=24.6153846153846, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI115534694, Length=260, Percent_Identity=29.6153846153846, Blast_Score=95, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17564282, Length=192, Percent_Identity=31.7708333333333, Blast_Score=94, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17562908, Length=270, Percent_Identity=25.9259259259259, Blast_Score=94, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI193203115, Length=249, Percent_Identity=29.3172690763052, Blast_Score=94, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI193203117, Length=248, Percent_Identity=30.241935483871, Blast_Score=94, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17562910, Length=267, Percent_Identity=27.7153558052434, Blast_Score=94, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI17560150, Length=268, Percent_Identity=27.6119402985075, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17544670, Length=282, Percent_Identity=27.6595744680851, Blast_Score=91, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17559104, Length=268, Percent_Identity=28.3582089552239, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71994604, Length=253, Percent_Identity=26.0869565217391, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17536025, Length=259, Percent_Identity=26.2548262548263, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17560332, Length=281, Percent_Identity=27.4021352313167, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17508895, Length=184, Percent_Identity=27.7173913043478, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17531453, Length=276, Percent_Identity=26.0869565217391, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI193204405, Length=273, Percent_Identity=24.9084249084249, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17538182, Length=200, Percent_Identity=30, Blast_Score=88, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17562906, Length=270, Percent_Identity=23.7037037037037, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17536651, Length=262, Percent_Identity=26.7175572519084, Blast_Score=87, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17562990, Length=264, Percent_Identity=25.7575757575758, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17563726, Length=271, Percent_Identity=28.4132841328413, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI72000259, Length=264, Percent_Identity=26.8939393939394, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17560220, Length=273, Percent_Identity=25.2747252747253, Blast_Score=84, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17568967, Length=189, Percent_Identity=29.6296296296296, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17567345, Length=270, Percent_Identity=25.5555555555556, Blast_Score=77, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17561272, Length=242, Percent_Identity=24.7933884297521, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17508651, Length=261, Percent_Identity=26.8199233716475, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI71982365, Length=189, Percent_Identity=27.5132275132275, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17538480, Length=273, Percent_Identity=24.9084249084249, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71997099, Length=191, Percent_Identity=28.2722513089005, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17538486, Length=278, Percent_Identity=25.1798561151079, Blast_Score=64, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17555612, Length=203, Percent_Identity=28.0788177339901, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=252, Percent_Identity=30.1587301587302, Blast_Score=95, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6324126, Length=259, Percent_Identity=29.3436293436293, Blast_Score=89, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6323882, Length=244, Percent_Identity=24.1803278688525, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320089, Length=193, Percent_Identity=27.979274611399, Blast_Score=65, Evalue=8e-12,
Organism=Drosophila melanogaster, GI28571526, Length=259, Percent_Identity=30.1158301158301, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI21355319, Length=257, Percent_Identity=31.5175097276265, Blast_Score=116, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24639444, Length=255, Percent_Identity=27.4509803921569, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24644339, Length=259, Percent_Identity=30.1158301158301, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI21357041, Length=259, Percent_Identity=28.1853281853282, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI23397609, Length=260, Percent_Identity=27.6923076923077, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI17737361, Length=270, Percent_Identity=26.6666666666667, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI18859837, Length=189, Percent_Identity=26.4550264550265, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24581726, Length=184, Percent_Identity=29.8913043478261, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI21357673, Length=186, Percent_Identity=28.494623655914, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI21355631, Length=178, Percent_Identity=26.9662921348315, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24649181, Length=165, Percent_Identity=27.2727272727273, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24644337, Length=262, Percent_Identity=26.7175572519084, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI21358495, Length=184, Percent_Identity=26.0869565217391, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI28571387, Length=168, Percent_Identity=27.9761904761905, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24584744, Length=180, Percent_Identity=26.6666666666667, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI28574402, Length=180, Percent_Identity=26.6666666666667, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24643142, Length=254, Percent_Identity=24.4094488188976, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24647946, Length=227, Percent_Identity=27.3127753303965, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45553409, Length=227, Percent_Identity=27.3127753303965, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24647948, Length=227, Percent_Identity=27.3127753303965, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221510726, Length=167, Percent_Identity=29.940119760479, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI161076933, Length=180, Percent_Identity=25, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24584748, Length=180, Percent_Identity=25, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.140 [H]

Molecular weight: Translated: 28857; Mature: 28857

Theoretical pI: Translated: 9.22; Mature: 9.22

Prosite motif: PS00061 ADH_SHORT ; PS00189 LIPOYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MNFKEKTVIITGGAQSLGEYIAYSFAEKGANIVIADINYEQANKVSQNIINKYKVRSIAV
CCCCCEEEEEECCHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHEEEEEE
KVDVCKEEEVKNLIKNTIDNFSKIDILICNAGVVYSTKVTELPKEKWDNILNVNLTGYFL
EEECCCHHHHHHHHHHHHCCCCEEEEEEECCCEEEECHHHHCCHHHCCCEEEEEEEEEEE
CAKEAAKEMVKRKQGVIIDINSKSGKKGSLHNCAYSASKFGAIGLTQSLALDLAEDGIRV
EHHHHHHHHHHHHCCEEEEEECCCCCCCCCHHHHHCHHHCCCCCCHHHHHHHHHCCCEEE
NAVCSGNLLDSPMWKNGLYEQYAKKLNIPKEKVRQAYIDKVPLKRGCTYEDVSNLVLFLS
EEEEECCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHCCEEEEEE
SKEASYMTGQAVNVTGGQEMR
CCCCCEECCCEEEECCCCCCC
>Mature Secondary Structure
MNFKEKTVIITGGAQSLGEYIAYSFAEKGANIVIADINYEQANKVSQNIINKYKVRSIAV
CCCCCEEEEEECCHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHEEEEEE
KVDVCKEEEVKNLIKNTIDNFSKIDILICNAGVVYSTKVTELPKEKWDNILNVNLTGYFL
EEECCCHHHHHHHHHHHHCCCCEEEEEEECCCEEEECHHHHCCHHHCCCEEEEEEEEEEE
CAKEAAKEMVKRKQGVIIDINSKSGKKGSLHNCAYSASKFGAIGLTQSLALDLAEDGIRV
EHHHHHHHHHHHHCCEEEEEECCCCCCCCCHHHHHCHHHCCCCCCHHHHHHHHHCCCEEE
NAVCSGNLLDSPMWKNGLYEQYAKKLNIPKEKVRQAYIDKVPLKRGCTYEDVSNLVLFLS
EEEEECCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHCCEEEEEE
SKEASYMTGQAVNVTGGQEMR
CCCCCEECCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3553176; 9205837; 9278503; 6384188 [H]