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The map label for this gene is glmS [H]

Identifier: 148381350

GI number: 148381350

Start: 3650832

End: 3652658

Strand: Reverse

Name: glmS [H]

Synonym: CBO3410

Alternate gene names: 148381350

Gene position: 3652658-3650832 (Counterclockwise)

Preceding gene: 148381351

Following gene: 148381348

Centisome position: 93.97

GC content: 31.25

Gene sequence:

>1827_bases
ATGTGCGGAATAGTAGGTTACGTAGGATTTAGGAAGGCAAGCGATGTAATCGTGGATGGATTATCAAAACTAGAGTATAG
AGGATATGACTCTGCAGGAATCGCTGTTAATGATGGAAAGGAAATAGAGTTCCAAAAATATAAAGGTAGACTAAATGTTT
TAAGTGAAAATTTGGAAAGTAAGCCTATGGAGGGAACTATAGGAATAGGTCATACAAGATGGGCTACTCACGGAGTGCCA
TCTGATGTGAATTCACATCCACATTTAAATATGGATGAAACAATTGCAGTAGTTCACAATGGTATAATTGAAAATTATAT
GGAAATAAAAGACTGGTTGTCTTCTGAAGGTGTAAAATTTAAATCAGAAACAGATACTGAAGTAATAGCTCATTTAGTTG
ACCATTATTATGAAGGTGATTTATTACAAGCAGTATTTAAGGCTATAAAAAAATTAAGAGGAGCTTATGCTCTAGGAGTA
GTTTGTAAAGATAACCCAGAACAATTAGTAGCTGTAAGAAAAGATAGTCCATTAATAGTAGGAATTGGAGAGAATGAAAA
CTTCATTGCATCTGATGTACCAGCTATTTTAAAATATACTAGAGATGTATATTTCTTAGATAATGGAGAAGTAGTTACTT
TAGAAAAAGACAAAATAAAAATTTACAACGAAAAGGAAGAAGGAATCACAAAAGAACCTTTCCATGTAATGTGGGATGTG
GAAGCAGCATCTAAGGGTGGATATGACCACTTCATGATAAAAGAAATAAATGAACAACCAAATGGTATAAAAGAAACTTT
AGTTAGAAGATTAGATGAAAATGGTAAAATAAAATTAGATGATATAAAACTAACAAAAGAAGACTTAGATGAAATAAATA
AAGTTTATATAGTTGCTTGTGGAACTGCATACAATGCAGGAATAACAGGAAGATATGCTATTGAAAGATTTGCAAAAATA
GCTGTAGAAACAGATGTAGCTTCAGAGTTTAGATATAGAAATCCATTTATAGACGACAAAACATTAATTATTGTTGTAAG
TCAATCTGGAGAAACAGCAGATACTTTAGCAGTTGTAAGAGAAGGAAAAGAAAAAGGAGCGAGAGTTTTAGCTATTACTA
ATGTTGTAGGATCTTCTATAGCTAGAGAAGCAGATGATGTATTTTATACTTGGGCGGGGCCTGAAGTAGCAGTTGCATCA
ACTAAAGCATATACAACTCAACTTGTAGCATTGTATATGATCGCATTAGATATGGGTATAAAAAGAGGAACAATAACTGA
AGAATTTTATAATGATATAATAAGTGAATTAAAACTTATACCTGAAAAAGTACAAAAAATACTTTATCAACATGATGATA
TAAAAGAAATAGCAAAAGAAATAAAAGACAATGAACATGCATTTTATATAGGAAGAGGATTAGATTATAATCTTTCATTA
GAAGGTTCATTAAAGATAAAAGAAATATCTTATATGCATGCAGAAGCTTTTGCTGCTGGTGAATTAAAGCATGGAACTAT
AGCTCTTATTGAAGAAAATACACCAGTAGTAGCTACAATGACTCAAACAGATTTATTTGAAAAGAGTATTTCTAATATAA
AAGAAGTTAAATCAAGAGGAGCACATGTTATTGCTATAACTCAGGAAGGAAATAAAGAAGCAGAGCAAGTAGCGGATAAA
GTAATTTATATACCAAGAACAAATGATATATTACAAAGTATTATTGCAGTAGTGCCTCATCAATTATTAGCATACTATGT
AGCAATACTAAAAGACCGTGATGTAGATAAGCCAAGAAACTTAGCTAAATCCGTTACAGTTGAATAG

Upstream 100 bases:

>100_bases
TAAAAGCTATAATAAAAGTTAGAAGTGATTCTGATTACAAAAAAGCTTTAGTGAGGACTTTCTTCTTAAATTATTAATAT
AATCTAAGGAGGATTTTTTT

Downstream 100 bases:

>100_bases
AGTATGGTTTGTCCCTCGATTACTGTTAACTATATAAAAATTCGTTTAAATATAAGAAAACATTTTAAAAATAAAAAGAA
AATCAGGATTATTCCTGGTT

Product: glucosamine--fructose-6-phosphate aminotransferase, isomerizing

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 608; Mature: 608

Protein sequence:

>608_residues
MCGIVGYVGFRKASDVIVDGLSKLEYRGYDSAGIAVNDGKEIEFQKYKGRLNVLSENLESKPMEGTIGIGHTRWATHGVP
SDVNSHPHLNMDETIAVVHNGIIENYMEIKDWLSSEGVKFKSETDTEVIAHLVDHYYEGDLLQAVFKAIKKLRGAYALGV
VCKDNPEQLVAVRKDSPLIVGIGENENFIASDVPAILKYTRDVYFLDNGEVVTLEKDKIKIYNEKEEGITKEPFHVMWDV
EAASKGGYDHFMIKEINEQPNGIKETLVRRLDENGKIKLDDIKLTKEDLDEINKVYIVACGTAYNAGITGRYAIERFAKI
AVETDVASEFRYRNPFIDDKTLIIVVSQSGETADTLAVVREGKEKGARVLAITNVVGSSIAREADDVFYTWAGPEVAVAS
TKAYTTQLVALYMIALDMGIKRGTITEEFYNDIISELKLIPEKVQKILYQHDDIKEIAKEIKDNEHAFYIGRGLDYNLSL
EGSLKIKEISYMHAEAFAAGELKHGTIALIEENTPVVATMTQTDLFEKSISNIKEVKSRGAHVIAITQEGNKEAEQVADK
VIYIPRTNDILQSIIAVVPHQLLAYYVAILKDRDVDKPRNLAKSVTVE

Sequences:

>Translated_608_residues
MCGIVGYVGFRKASDVIVDGLSKLEYRGYDSAGIAVNDGKEIEFQKYKGRLNVLSENLESKPMEGTIGIGHTRWATHGVP
SDVNSHPHLNMDETIAVVHNGIIENYMEIKDWLSSEGVKFKSETDTEVIAHLVDHYYEGDLLQAVFKAIKKLRGAYALGV
VCKDNPEQLVAVRKDSPLIVGIGENENFIASDVPAILKYTRDVYFLDNGEVVTLEKDKIKIYNEKEEGITKEPFHVMWDV
EAASKGGYDHFMIKEINEQPNGIKETLVRRLDENGKIKLDDIKLTKEDLDEINKVYIVACGTAYNAGITGRYAIERFAKI
AVETDVASEFRYRNPFIDDKTLIIVVSQSGETADTLAVVREGKEKGARVLAITNVVGSSIAREADDVFYTWAGPEVAVAS
TKAYTTQLVALYMIALDMGIKRGTITEEFYNDIISELKLIPEKVQKILYQHDDIKEIAKEIKDNEHAFYIGRGLDYNLSL
EGSLKIKEISYMHAEAFAAGELKHGTIALIEENTPVVATMTQTDLFEKSISNIKEVKSRGAHVIAITQEGNKEAEQVADK
VIYIPRTNDILQSIIAVVPHQLLAYYVAILKDRDVDKPRNLAKSVTVE
>Mature_608_residues
MCGIVGYVGFRKASDVIVDGLSKLEYRGYDSAGIAVNDGKEIEFQKYKGRLNVLSENLESKPMEGTIGIGHTRWATHGVP
SDVNSHPHLNMDETIAVVHNGIIENYMEIKDWLSSEGVKFKSETDTEVIAHLVDHYYEGDLLQAVFKAIKKLRGAYALGV
VCKDNPEQLVAVRKDSPLIVGIGENENFIASDVPAILKYTRDVYFLDNGEVVTLEKDKIKIYNEKEEGITKEPFHVMWDV
EAASKGGYDHFMIKEINEQPNGIKETLVRRLDENGKIKLDDIKLTKEDLDEINKVYIVACGTAYNAGITGRYAIERFAKI
AVETDVASEFRYRNPFIDDKTLIIVVSQSGETADTLAVVREGKEKGARVLAITNVVGSSIAREADDVFYTWAGPEVAVAS
TKAYTTQLVALYMIALDMGIKRGTITEEFYNDIISELKLIPEKVQKILYQHDDIKEIAKEIKDNEHAFYIGRGLDYNLSL
EGSLKIKEISYMHAEAFAAGELKHGTIALIEENTPVVATMTQTDLFEKSISNIKEVKSRGAHVIAITQEGNKEAEQVADK
VIYIPRTNDILQSIIAVVPHQLLAYYVAILKDRDVDKPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=684, Percent_Identity=35.233918128655, Blast_Score=414, Evalue=1e-115,
Organism=Homo sapiens, GI205277386, Length=682, Percent_Identity=35.0439882697947, Blast_Score=405, Evalue=1e-113,
Organism=Homo sapiens, GI29570798, Length=201, Percent_Identity=28.8557213930348, Blast_Score=70, Evalue=7e-12,
Organism=Escherichia coli, GI1790167, Length=613, Percent_Identity=44.0456769983687, Blast_Score=519, Evalue=1e-148,
Organism=Escherichia coli, GI87082251, Length=315, Percent_Identity=23.4920634920635, Blast_Score=87, Evalue=4e-18,
Organism=Escherichia coli, GI1788651, Length=249, Percent_Identity=29.3172690763052, Blast_Score=82, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17532899, Length=430, Percent_Identity=36.7441860465116, Blast_Score=285, Evalue=4e-77,
Organism=Caenorhabditis elegans, GI17532897, Length=430, Percent_Identity=36.7441860465116, Blast_Score=285, Evalue=6e-77,
Organism=Caenorhabditis elegans, GI17539970, Length=430, Percent_Identity=37.2093023255814, Blast_Score=283, Evalue=1e-76,
Organism=Caenorhabditis elegans, GI17554892, Length=251, Percent_Identity=28.2868525896414, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322745, Length=432, Percent_Identity=38.8888888888889, Blast_Score=298, Evalue=2e-81,
Organism=Saccharomyces cerevisiae, GI6323731, Length=431, Percent_Identity=31.0904872389791, Blast_Score=204, Evalue=3e-53,
Organism=Saccharomyces cerevisiae, GI6323730, Length=207, Percent_Identity=37.1980676328502, Blast_Score=124, Evalue=6e-29,
Organism=Drosophila melanogaster, GI21357745, Length=687, Percent_Identity=35.8078602620087, Blast_Score=437, Evalue=1e-123,
Organism=Drosophila melanogaster, GI28573187, Length=141, Percent_Identity=31.2056737588652, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 67847; Mature: 67847

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGYVGFRKASDVIVDGLSKLEYRGYDSAGIAVNDGKEIEFQKYKGRLNVLSENLES
CCCEEECCCCCCHHHHHHHHHHHHHCCCCCCCCEEECCCCCEEEHHHCCHHHHHHHHHCC
KPMEGTIGIGHTRWATHGVPSDVNSHPHLNMDETIAVVHNGIIENYMEIKDWLSSEGVKF
CCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEE
KSETDTEVIAHLVDHYYEGDLLQAVFKAIKKLRGAYALGVVCKDNPEQLVAVRKDSPLIV
CCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEEEECCCHHHEEEEECCCCEEE
GIGENENFIASDVPAILKYTRDVYFLDNGEVVTLEKDKIKIYNEKEEGITKEPFHVMWDV
EECCCCCEEHHHHHHHHHHCCEEEEECCCCEEEEECCCEEEEECCCCCCCCCCCEEEEEE
EAASKGGYDHFMIKEINEQPNGIKETLVRRLDENGKIKLDDIKLTKEDLDEINKVYIVAC
ECCCCCCCCEEEHEECCCCCCCHHHHHHHHHCCCCCEEEEEEECCHHHHHCCCEEEEEEE
GTAYNAGITGRYAIERFAKIAVETDVASEFRYRNPFIDDKTLIIVVSQSGETADTLAVVR
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCHHHHHHHH
EGKEKGARVLAITNVVGSSIAREADDVFYTWAGPEVAVASTKAYTTQLVALYMIALDMGI
CCHHCCCEEEEEHHHHHHHHHHCCCCEEEEECCCEEEEECCHHHHHHHHHHHHHHHHCCC
KRGTITEEFYNDIISELKLIPEKVQKILYQHDDIKEIAKEIKDNEHAFYIGRGLDYNLSL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEECCCEEEEEE
EGSLKIKEISYMHAEAFAAGELKHGTIALIEENTPVVATMTQTDLFEKSISNIKEVKSRG
CCCEEEEHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHCC
AHVIAITQEGNKEAEQVADKVIYIPRTNDILQSIIAVVPHQLLAYYVAILKDRDVDKPRN
CEEEEEECCCCCHHHHHHHCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
LAKSVTVE
HHHHCCCC
>Mature Secondary Structure
MCGIVGYVGFRKASDVIVDGLSKLEYRGYDSAGIAVNDGKEIEFQKYKGRLNVLSENLES
CCCEEECCCCCCHHHHHHHHHHHHHCCCCCCCCEEECCCCCEEEHHHCCHHHHHHHHHCC
KPMEGTIGIGHTRWATHGVPSDVNSHPHLNMDETIAVVHNGIIENYMEIKDWLSSEGVKF
CCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEE
KSETDTEVIAHLVDHYYEGDLLQAVFKAIKKLRGAYALGVVCKDNPEQLVAVRKDSPLIV
CCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEEEECCCHHHEEEEECCCCEEE
GIGENENFIASDVPAILKYTRDVYFLDNGEVVTLEKDKIKIYNEKEEGITKEPFHVMWDV
EECCCCCEEHHHHHHHHHHCCEEEEECCCCEEEEECCCEEEEECCCCCCCCCCCEEEEEE
EAASKGGYDHFMIKEINEQPNGIKETLVRRLDENGKIKLDDIKLTKEDLDEINKVYIVAC
ECCCCCCCCEEEHEECCCCCCCHHHHHHHHHCCCCCEEEEEEECCHHHHHCCCEEEEEEE
GTAYNAGITGRYAIERFAKIAVETDVASEFRYRNPFIDDKTLIIVVSQSGETADTLAVVR
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCHHHHHHHH
EGKEKGARVLAITNVVGSSIAREADDVFYTWAGPEVAVASTKAYTTQLVALYMIALDMGI
CCHHCCCEEEEEHHHHHHHHHHCCCCEEEEECCCEEEEECCHHHHHHHHHHHHHHHHCCC
KRGTITEEFYNDIISELKLIPEKVQKILYQHDDIKEIAKEIKDNEHAFYIGRGLDYNLSL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEECCCEEEEEE
EGSLKIKEISYMHAEAFAAGELKHGTIALIEENTPVVATMTQTDLFEKSISNIKEVKSRG
CCCEEEEHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHCC
AHVIAITQEGNKEAEQVADKVIYIPRTNDILQSIIAVVPHQLLAYYVAILKDRDVDKPRN
CEEEEEECCCCCHHHHHHHCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
LAKSVTVE
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]