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The map label for this gene is mleN [H]

Identifier: 148381343

GI number: 148381343

Start: 3642525

End: 3643850

Strand: Reverse

Name: mleN [H]

Synonym: CBO3402

Alternate gene names: 148381343

Gene position: 3643850-3642525 (Counterclockwise)

Preceding gene: 148381344

Following gene: 148381342

Centisome position: 93.75

GC content: 31.37

Gene sequence:

>1326_bases
TTGGAAAGAAGAGAAATTGGTAAAGGAAATCCAATAGCACTGTTGCCATTATTAATATTTTTAGTAGTTTATGTTTTCAT
TGGAGTTATATCAAGGGATTTTTATGCTGTACCTATGAGTGTACCGTTTTTAATAGCAGCTATGAGTGCATTAGCAATGA
ACAGAAAAGAAACTTTATCAAAAAAAATAGATGTATTTTGTGAAGGATCAGGTAATTCAAATATAATTTTGATGTGTTTA
ATATTTATATTAGCAGGTGCTTTTGCACAGGTTGCCAAAGATATAGGCGCTGTGGACTCAACAGTTAATTTAGGACTTAG
CATACTTCCAAGTAATATATTAATAACAGGAGTTTTTATTATAGCTTGCTTTATATCATTGTCCATAGGAAGCTCTATGG
GAACTATAGTGGCTCTAGCACCTATGGCCGTAGGAATATCACAAAAGACAGGAATAATTTTAGGATTAACATTAGGAGCC
GTTATAAGTGGAGCTATGTTTGGAGATAACTTATCTATGATATCTGATACCACTATAGCAGCATCTAGAACTCAAGGTTG
TGATTTAAAGGATAAATTTAGAACAAATTTCTTTATTGTATTACCAGCAGCTATAATAACAGCAATAATATTTAGTATAA
TAACAGCTAATAAAGGTACTGTACTAGATGGAAATTATTCTTATTCATTGATAAAAGTTTTACCCTATGTATCTGTTTTA
GTAGCAGCATTGCTTGGTGGTAACGTAATAATTGTATTATGTGGAGGAATTGTTTTTTCAGCGGTGATAGGTCTATATTT
TGGAACATTTAATATAATAGGTTTATTTCAATCTATGGGTAAAGGCATTGGTGGAATGACAGAGTTAGTTATAATATCCT
TAATAATAGGTGGAATGGTAGAAGTAATAAAATATAATGGAGGAATAGACTTCCTATTAAATTTAATAAAAAGTAAAGTA
AAGAGCAAAAAGGGAGCAGAATTAGGGATTGCTTTGTTAGTTAGTGTTGTTGATATATGTACAGCTAATAATACCATAGC
TATAGTAATGGCTGGACCAATAGCTAAAGATATAGCAGATAAATATGATGTAGATCCAAGAAAAAGTGCCAGTTTACTAG
ATACATTTTCATGTTTTTGCCAAGGAATAATTCCTTATGGTGCTCAATTGTTAGCAGCAGCAGGGATTGCTAAGATTTCA
CCTTTTGCCATAATGCAGTATCTTTACTATCCATATTTAATGGGTATATGTGCATTAATAGCTATAATTGTAGGATTGCC
AAAATTCAAAAATGTTACAAAAGTAGTTGAGGAAAATGTAGGCTAA

Upstream 100 bases:

>100_bases
GTTTTTTTATTATATAGAAATAAAAAACTTTAGAGGATAAGAACAAAATAGAATATATGGGAAATAATATATTTGTTATA
TAAAAATAGGAGGGATAATA

Downstream 100 bases:

>100_bases
TAATTAAATATAATAAGTAATATAATAACACAAAATAACTTTTATAGAAATAAAGTAAATTTGTGTTATTATTTTTTATT
AGATGTAATAATAATTAATC

Product: Na+/H+ antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MERREIGKGNPIALLPLLIFLVVYVFIGVISRDFYAVPMSVPFLIAAMSALAMNRKETLSKKIDVFCEGSGNSNIILMCL
IFILAGAFAQVAKDIGAVDSTVNLGLSILPSNILITGVFIIACFISLSIGSSMGTIVALAPMAVGISQKTGIILGLTLGA
VISGAMFGDNLSMISDTTIAASRTQGCDLKDKFRTNFFIVLPAAIITAIIFSIITANKGTVLDGNYSYSLIKVLPYVSVL
VAALLGGNVIIVLCGGIVFSAVIGLYFGTFNIIGLFQSMGKGIGGMTELVIISLIIGGMVEVIKYNGGIDFLLNLIKSKV
KSKKGAELGIALLVSVVDICTANNTIAIVMAGPIAKDIADKYDVDPRKSASLLDTFSCFCQGIIPYGAQLLAAAGIAKIS
PFAIMQYLYYPYLMGICALIAIIVGLPKFKNVTKVVEENVG

Sequences:

>Translated_441_residues
MERREIGKGNPIALLPLLIFLVVYVFIGVISRDFYAVPMSVPFLIAAMSALAMNRKETLSKKIDVFCEGSGNSNIILMCL
IFILAGAFAQVAKDIGAVDSTVNLGLSILPSNILITGVFIIACFISLSIGSSMGTIVALAPMAVGISQKTGIILGLTLGA
VISGAMFGDNLSMISDTTIAASRTQGCDLKDKFRTNFFIVLPAAIITAIIFSIITANKGTVLDGNYSYSLIKVLPYVSVL
VAALLGGNVIIVLCGGIVFSAVIGLYFGTFNIIGLFQSMGKGIGGMTELVIISLIIGGMVEVIKYNGGIDFLLNLIKSKV
KSKKGAELGIALLVSVVDICTANNTIAIVMAGPIAKDIADKYDVDPRKSASLLDTFSCFCQGIIPYGAQLLAAAGIAKIS
PFAIMQYLYYPYLMGICALIAIIVGLPKFKNVTKVVEENVG
>Mature_441_residues
MERREIGKGNPIALLPLLIFLVVYVFIGVISRDFYAVPMSVPFLIAAMSALAMNRKETLSKKIDVFCEGSGNSNIILMCL
IFILAGAFAQVAKDIGAVDSTVNLGLSILPSNILITGVFIIACFISLSIGSSMGTIVALAPMAVGISQKTGIILGLTLGA
VISGAMFGDNLSMISDTTIAASRTQGCDLKDKFRTNFFIVLPAAIITAIIFSIITANKGTVLDGNYSYSLIKVLPYVSVL
VAALLGGNVIIVLCGGIVFSAVIGLYFGTFNIIGLFQSMGKGIGGMTELVIISLIIGGMVEVIKYNGGIDFLLNLIKSKV
KSKKGAELGIALLVSVVDICTANNTIAIVMAGPIAKDIADKYDVDPRKSASLLDTFSCFCQGIIPYGAQLLAAAGIAKIS
PFAIMQYLYYPYLMGICALIAIIVGLPKFKNVTKVVEENVG

Specific function: Couples proton uptake and Na(+) efflux to the substrate- product malate/lactate antiport, in an electroneutral malate- 2H(+)/Na(+)-lactate exchange. Plays a role in supporting growth to high density on malate at reduced protonmotive force [H]

COG id: COG1757

COG function: function code C; Na+/H+ antiporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaC Na(+)/H(+) antiporter family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004770
- InterPro:   IPR018461 [H]

Pfam domain/function: PF03553 Na_H_antiporter [H]

EC number: NA

Molecular weight: Translated: 46435; Mature: 46435

Theoretical pI: Translated: 8.59; Mature: 8.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERREIGKGNPIALLPLLIFLVVYVFIGVISRDFYAVPMSVPFLIAAMSALAMNRKETLS
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHCCHHHHHH
KKIDVFCEGSGNSNIILMCLIFILAGAFAQVAKDIGAVDSTVNLGLSILPSNILITGVFI
HHCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHCCHHHHHHHHHH
IACFISLSIGSSMGTIVALAPMAVGISQKTGIILGLTLGAVISGAMFGDNLSMISDTTIA
HHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHCCCCCHHHCCCHHC
ASRTQGCDLKDKFRTNFFIVLPAAIITAIIFSIITANKGTVLDGNYSYSLIKVLPYVSVL
CCCCCCCCCHHHHCCCEEEEEHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHH
VAALLGGNVIIVLCGGIVFSAVIGLYFGTFNIIGLFQSMGKGIGGMTELVIISLIIGGMV
HHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
EVIKYNGGIDFLLNLIKSKVKSKKGAELGIALLVSVVDICTANNTIAIVMAGPIAKDIAD
HHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHH
KYDVDPRKSASLLDTFSCFCQGIIPYGAQLLAAAGIAKISPFAIMQYLYYPYLMGICALI
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
AIIVGLPKFKNVTKVVEENVG
HHHHCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MERREIGKGNPIALLPLLIFLVVYVFIGVISRDFYAVPMSVPFLIAAMSALAMNRKETLS
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHCCHHHHHH
KKIDVFCEGSGNSNIILMCLIFILAGAFAQVAKDIGAVDSTVNLGLSILPSNILITGVFI
HHCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHCCHHHHHHHHHH
IACFISLSIGSSMGTIVALAPMAVGISQKTGIILGLTLGAVISGAMFGDNLSMISDTTIA
HHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHCCCCCHHHCCCHHC
ASRTQGCDLKDKFRTNFFIVLPAAIITAIIFSIITANKGTVLDGNYSYSLIKVLPYVSVL
CCCCCCCCCHHHHCCCEEEEEHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHH
VAALLGGNVIIVLCGGIVFSAVIGLYFGTFNIIGLFQSMGKGIGGMTELVIISLIIGGMV
HHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
EVIKYNGGIDFLLNLIKSKVKSKKGAELGIALLVSVVDICTANNTIAIVMAGPIAKDIAD
HHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHH
KYDVDPRKSASLLDTFSCFCQGIIPYGAQLLAAAGIAKISPFAIMQYLYYPYLMGICALI
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
AIIVGLPKFKNVTKVVEENVG
HHHHCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377; 10903309 [H]