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The map label for this gene is murB

Identifier: 148381319

GI number: 148381319

Start: 3615635

End: 3616555

Strand: Reverse

Name: murB

Synonym: CBO3378

Alternate gene names: 148381319

Gene position: 3616555-3615635 (Counterclockwise)

Preceding gene: 148381320

Following gene: 148381318

Centisome position: 93.04

GC content: 29.53

Gene sequence:

>921_bases
ATGAACCAATATAAAAATTTTATCATGCAGTTTGAAGATATAGTTGGAAATAATAATGTTTTAATAGATGAGCCAATGAA
AAAACATACTTCATTTAAAGTTGGAGGACCAGCAGATTTATTAATTACACCTACAACTTTAGAACAAGTAAAGGATAGTA
TTATATTATGTAGAAATAATAGTATCCCTTATTATATAATAGGAAATGGATCAAATTTATTAGTAAGAGATGGTGGAATA
AGAGGAGTAGTAATTAAGTTTTTAAAATTAGGTGATATAAAAGTAGAAGGAGATAGAGTAATAGCTCAAAGTGGAGCTCC
TTTAACTAATATTTGTAATGAAGCCTTAAAAAGTAATTTAGGTGGACTAGAGTTTGCTTGTGGTATACCAGGTAGCGTAG
GCGGAGCAGTTACAATGAATGCTGGTGCTTATAATGGAGAAATATCTCAAGTTATAGAAAGTGCTAAAGTTATAGACAAG
GATGGAAATGTATTTTTATTAAACAAAGAACAATTAGATTTGGGATATAGAATGAGTGCTATTCAAAAGTATCACTATAT
TGTTTTAGAAGTAACCTTTAAATTACATAATAGTGAATATGATACTATAAAAAATAGAATAATGGATTTAAATAGAAGAA
GAACGGAAAAACAGCCTTTAGAATATCCATCAGCAGGTAGTACTTTTAAAAGACCAGAAGGACATTTCGCAGCAAAACTT
ATAGAAGATACAGGTTTAAAAGGTGAATCTATAGGAGGGGCTCAAGTTTCAGAAAAACATTCTGGCTTTATAATAAATAA
GGGAGGAGCTACTGCAGGAGATATATTAAATCTTATAGAATTTGTACAAAATAAGGTTATGGAAAAGTTTGAAGTAGATC
TTCATACAGAAGTTAGAATAATTGGAGAGGAAAACAATTAG

Upstream 100 bases:

>100_bases
AAGGAAAGTTAAAGGATTTAAATCTTGATTAAGGGTTAAGCATACATTATACTAATAAGGGTATTTAATTTAGTAATAAA
AAAATCAAGGAGAATGTGTT

Downstream 100 bases:

>100_bases
AATATAACAAATAAGGGAAGTCTTAACAAATGACTTCCCTAGTTTATTGTTAAATAGGTATATGATATAATTAAATAAAA
CATAAAATAATATTCCTTAA

Product: UDP-N-acetylenolpyruvoylglucosamine reductase

Products: NA

Alternate protein names: UDP-N-acetylmuramate dehydrogenase

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MNQYKNFIMQFEDIVGNNNVLIDEPMKKHTSFKVGGPADLLITPTTLEQVKDSIILCRNNSIPYYIIGNGSNLLVRDGGI
RGVVIKFLKLGDIKVEGDRVIAQSGAPLTNICNEALKSNLGGLEFACGIPGSVGGAVTMNAGAYNGEISQVIESAKVIDK
DGNVFLLNKEQLDLGYRMSAIQKYHYIVLEVTFKLHNSEYDTIKNRIMDLNRRRTEKQPLEYPSAGSTFKRPEGHFAAKL
IEDTGLKGESIGGAQVSEKHSGFIINKGGATAGDILNLIEFVQNKVMEKFEVDLHTEVRIIGEENN

Sequences:

>Translated_306_residues
MNQYKNFIMQFEDIVGNNNVLIDEPMKKHTSFKVGGPADLLITPTTLEQVKDSIILCRNNSIPYYIIGNGSNLLVRDGGI
RGVVIKFLKLGDIKVEGDRVIAQSGAPLTNICNEALKSNLGGLEFACGIPGSVGGAVTMNAGAYNGEISQVIESAKVIDK
DGNVFLLNKEQLDLGYRMSAIQKYHYIVLEVTFKLHNSEYDTIKNRIMDLNRRRTEKQPLEYPSAGSTFKRPEGHFAAKL
IEDTGLKGESIGGAQVSEKHSGFIINKGGATAGDILNLIEFVQNKVMEKFEVDLHTEVRIIGEENN
>Mature_306_residues
MNQYKNFIMQFEDIVGNNNVLIDEPMKKHTSFKVGGPADLLITPTTLEQVKDSIILCRNNSIPYYIIGNGSNLLVRDGGI
RGVVIKFLKLGDIKVEGDRVIAQSGAPLTNICNEALKSNLGGLEFACGIPGSVGGAVTMNAGAYNGEISQVIESAKVIDK
DGNVFLLNKEQLDLGYRMSAIQKYHYIVLEVTFKLHNSEYDTIKNRIMDLNRRRTEKQPLEYPSAGSTFKRPEGHFAAKL
IEDTGLKGESIGGAQVSEKHSGFIINKGGATAGDILNLIEFVQNKVMEKFEVDLHTEVRIIGEENN

Specific function: Cell wall formation

COG id: COG0812

COG function: function code M; UDP-N-acetylmuramate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURB_CLOB1 (A7FYX2)

Other databases:

- EMBL:   CP000726
- RefSeq:   YP_001385695.1
- ProteinModelPortal:   A7FYX2
- SMR:   A7FYX2
- STRING:   A7FYX2
- GeneID:   5394557
- GenomeReviews:   CP000726_GR
- KEGG:   cba:CLB_3434
- eggNOG:   COG0812
- HOGENOM:   HBG686573
- OMA:   SKKHAGF
- ProtClustDB:   PRK13905
- BioCyc:   CBOT441770:CLB_3434-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00037
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR003170
- InterPro:   IPR011601
- InterPro:   IPR006094
- Gene3D:   G3DSA:3.30.465.10
- Gene3D:   G3DSA:3.30.43.10
- Gene3D:   G3DSA:3.90.78.10
- PANTHER:   PTHR21071
- TIGRFAMs:   TIGR00179

Pfam domain/function: PF01565 FAD_binding_4; PF02873 MurB_C; SSF56176 FAD-binding_2; SSF56194 MurB_C

EC number: =1.1.1.158

Molecular weight: Translated: 33649; Mature: 33649

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS51387 FAD_PCMH

Important sites: ACT_SITE 177-177 ACT_SITE 227-227 ACT_SITE 297-297

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQYKNFIMQFEDIVGNNNVLIDEPMKKHTSFKVGGPADLLITPTTLEQVKDSIILCRNN
CCHHHHHHHHHHHHCCCCCEEECCCHHHCCCEECCCCCEEEEECHHHHHHCCCEEEEECC
SIPYYIIGNGSNLLVRDGGIRGVVIKFLKLGDIKVEGDRVIAQSGAPLTNICNEALKSNL
CCCEEEEECCCEEEEECCCCHHHHHHHHHHCCEEECCCEEEECCCCCHHHHHHHHHHCCC
GGLEFACGIPGSVGGAVTMNAGAYNGEISQVIESAKVIDKDGNVFLLNKEQLDLGYRMSA
CCEEEECCCCCCCCCEEEECCCCCCCHHHHHHHHHHHEECCCCEEEEEHHCCCCCHHHHH
IQKYHYIVLEVTFKLHNSEYDTIKNRIMDLNRRRTEKQPLEYPSAGSTFKRPEGHFAAKL
HHHEEEEEEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHH
IEDTGLKGESIGGAQVSEKHSGFIINKGGATAGDILNLIEFVQNKVMEKFEVDLHTEVRI
HHHCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEE
IGEENN
EECCCC
>Mature Secondary Structure
MNQYKNFIMQFEDIVGNNNVLIDEPMKKHTSFKVGGPADLLITPTTLEQVKDSIILCRNN
CCHHHHHHHHHHHHCCCCCEEECCCHHHCCCEECCCCCEEEEECHHHHHHCCCEEEEECC
SIPYYIIGNGSNLLVRDGGIRGVVIKFLKLGDIKVEGDRVIAQSGAPLTNICNEALKSNL
CCCEEEEECCCEEEEECCCCHHHHHHHHHHCCEEECCCEEEECCCCCHHHHHHHHHHCCC
GGLEFACGIPGSVGGAVTMNAGAYNGEISQVIESAKVIDKDGNVFLLNKEQLDLGYRMSA
CCEEEECCCCCCCCCEEEECCCCCCCHHHHHHHHHHHEECCCCEEEEEHHCCCCCHHHHH
IQKYHYIVLEVTFKLHNSEYDTIKNRIMDLNRRRTEKQPLEYPSAGSTFKRPEGHFAAKL
HHHEEEEEEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHH
IEDTGLKGESIGGAQVSEKHSGFIINKGGATAGDILNLIEFVQNKVMEKFEVDLHTEVRI
HHHCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEE
IGEENN
EECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA