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The map label for this gene is lytS [H]

Identifier: 148381252

GI number: 148381252

Start: 3521232

End: 3522866

Strand: Reverse

Name: lytS [H]

Synonym: CBO3309

Alternate gene names: 148381252

Gene position: 3522866-3521232 (Counterclockwise)

Preceding gene: 148381254

Following gene: 148381251

Centisome position: 90.63

GC content: 26.97

Gene sequence:

>1635_bases
ATGATATATATACAATTATTAGAAAGTATGTCTTTAATTGGTATAGCGGCTTATTTATATAGTCAAACTAAAACTTTTAA
TAAATTTATTAAAAACAAATCTGATTATAAATATAAGTTAATAATTATAACTTTTTTTAGTGTGTTATCTATATTAGGAA
CTTATACTGGAGTTAATATAGAACCTTATGCATTAGCTAACGCAAGACCTATAGGGGCTATAGTAGCTGGGTATATAGGG
GGACCATTAGTAGGAATTATGGTTGGAATCATAGGGGGAACTCATAGGTATTTTTTAGGTGGGTTTACAGCTCTTTCTTG
CGCTATATCTACCATATTAGAAGGTATAGTAGGAGGCATAGCTAATGTAATTACAAAGGATGAAGGCTTAGATGTTTCAA
CGGGTGTTACAGCAGCAATAATAGCAGAAGTATTACAGATGATAATAATTTTATTAATAGCAAAACCTTATGAGGCTGCT
TTGGAATTAGAAAGGGTTATAGCATTACCAATGATAATAACAAATTCTATTGGAGTGGGTATATTTATAAATATTATAAA
TAATACTCAAGAACATTATAAAAAAATTGGCGCTATACAATCTCAAAAAGCTCTTAATATAGCCAAAAAAACTTCTATTT
ACTTAAGAAGTGGATTTAATCAAGAAATTTTAGATAAAGTATGTTCAATAATATATGAATCAATAAATTTAAAAAGTATA
TTTATTGCTGAAAATGGGGGAATATTTTCTTATAATGGAGAAGAATTAAATAAGGAAAAATTAAAATATAGAGTAAAGGA
ATATTTTGATTTCAAAGATTATAAGTTAATAAAATTTGAAGATAATAATAAACAAAAATTATTCTATTGTATACCGATAT
ATACAGATAAGGATAAGTTTAAGTTTGTAATAGGAATACAAGTTAAGTCCTATAAAAGTATAGATAAATATTTTAGTGAT
TTTGCTAAAGAATTAAGTGCTCTTTTGGCTACTCAAATAGAATTATATGAATTAGATCAATTAGCTCAAGAAGTTTCAAA
GGCAGAATTAAAAATGTTAAGAAATCAAATACATCCACATTTTTTATTTAATACACTAAATACCATAGCATCTTTTTGTA
GAACTGATCCTATAAAAGCCAGGGAGCTTATATTGAACCTTTCAAATTATTTTAGACAAACCCTAAAAAGACAAGATGAA
AAAATTATATTGAAAGATGAAATAGAGTTTTTAGAGTCTTATTTAGCTATAGAAAAGGCTAGATTTGGAGAAAGGCTGAA
TATAGATATTAATATACCAGAAGAGCTTTTAGATGCTAAAGTTCCAATATTTGTACTTCAACCTATAATAGAAAATTCTA
TGAAACATGGTATACTAATAAAACCACAGGGGGGAGAAGTAATAATTACTGCAATAGATGAAAAAGATAAAATTAAATTT
GTAATAAAAGATACAGGAGTAGGTATGGATAAAAATACACTTAGCTATGTAGTGGAAAGTTGGCCAGGGATAGGACTTTC
AAATGTTAATAAAAGATTAAAATTACTCTATGGGGAAAAAAGTTTCATACGCATAGAAAGTAAACTAAATGAAGGAACAA
AAGTTATGTTTTGTATACCTAAGGAGGTGTTTTAG

Upstream 100 bases:

>100_bases
TTTAGCAAATTACCATAGAAAAAATATTTATTTATTGTATAATTTATTAAAGAATATTTAATAAATTATTTATAATAATG
TAATTTAACAGGAGAAATTT

Downstream 100 bases:

>100_bases
ATGAAAGAAATTAGAGCTATTATAATAGAGGATGAGAAGCCAGCTATAGAAGAACTTAAGTATGTTTTATCTAAATATAA
TTTTTTAAATATAGTAGATG

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 544; Mature: 544

Protein sequence:

>544_residues
MIYIQLLESMSLIGIAAYLYSQTKTFNKFIKNKSDYKYKLIIITFFSVLSILGTYTGVNIEPYALANARPIGAIVAGYIG
GPLVGIMVGIIGGTHRYFLGGFTALSCAISTILEGIVGGIANVITKDEGLDVSTGVTAAIIAEVLQMIIILLIAKPYEAA
LELERVIALPMIITNSIGVGIFINIINNTQEHYKKIGAIQSQKALNIAKKTSIYLRSGFNQEILDKVCSIIYESINLKSI
FIAENGGIFSYNGEELNKEKLKYRVKEYFDFKDYKLIKFEDNNKQKLFYCIPIYTDKDKFKFVIGIQVKSYKSIDKYFSD
FAKELSALLATQIELYELDQLAQEVSKAELKMLRNQIHPHFLFNTLNTIASFCRTDPIKARELILNLSNYFRQTLKRQDE
KIILKDEIEFLESYLAIEKARFGERLNIDINIPEELLDAKVPIFVLQPIIENSMKHGILIKPQGGEVIITAIDEKDKIKF
VIKDTGVGMDKNTLSYVVESWPGIGLSNVNKRLKLLYGEKSFIRIESKLNEGTKVMFCIPKEVF

Sequences:

>Translated_544_residues
MIYIQLLESMSLIGIAAYLYSQTKTFNKFIKNKSDYKYKLIIITFFSVLSILGTYTGVNIEPYALANARPIGAIVAGYIG
GPLVGIMVGIIGGTHRYFLGGFTALSCAISTILEGIVGGIANVITKDEGLDVSTGVTAAIIAEVLQMIIILLIAKPYEAA
LELERVIALPMIITNSIGVGIFINIINNTQEHYKKIGAIQSQKALNIAKKTSIYLRSGFNQEILDKVCSIIYESINLKSI
FIAENGGIFSYNGEELNKEKLKYRVKEYFDFKDYKLIKFEDNNKQKLFYCIPIYTDKDKFKFVIGIQVKSYKSIDKYFSD
FAKELSALLATQIELYELDQLAQEVSKAELKMLRNQIHPHFLFNTLNTIASFCRTDPIKARELILNLSNYFRQTLKRQDE
KIILKDEIEFLESYLAIEKARFGERLNIDINIPEELLDAKVPIFVLQPIIENSMKHGILIKPQGGEVIITAIDEKDKIKF
VIKDTGVGMDKNTLSYVVESWPGIGLSNVNKRLKLLYGEKSFIRIESKLNEGTKVMFCIPKEVF
>Mature_544_residues
MIYIQLLESMSLIGIAAYLYSQTKTFNKFIKNKSDYKYKLIIITFFSVLSILGTYTGVNIEPYALANARPIGAIVAGYIG
GPLVGIMVGIIGGTHRYFLGGFTALSCAISTILEGIVGGIANVITKDEGLDVSTGVTAAIIAEVLQMIIILLIAKPYEAA
LELERVIALPMIITNSIGVGIFINIINNTQEHYKKIGAIQSQKALNIAKKTSIYLRSGFNQEILDKVCSIIYESINLKSI
FIAENGGIFSYNGEELNKEKLKYRVKEYFDFKDYKLIKFEDNNKQKLFYCIPIYTDKDKFKFVIGIQVKSYKSIDKYFSD
FAKELSALLATQIELYELDQLAQEVSKAELKMLRNQIHPHFLFNTLNTIASFCRTDPIKARELILNLSNYFRQTLKRQDE
KIILKDEIEFLESYLAIEKARFGERLNIDINIPEELLDAKVPIFVLQPIIENSMKHGILIKPQGGEVIITAIDEKDKIKF
VIKDTGVGMDKNTLSYVVESWPGIGLSNVNKRLKLLYGEKSFIRIESKLNEGTKVMFCIPKEVF

Specific function: Member of the two-component regulatory system lytS/lytT that probably regulates genes involved in cell wall metabolism [H]

COG id: COG3275

COG function: function code T; Putative regulator of cell autolysis

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788446, Length=559, Percent_Identity=33.0948121645796, Blast_Score=279, Evalue=3e-76,
Organism=Escherichia coli, GI1788723, Length=557, Percent_Identity=31.2387791741472, Blast_Score=264, Evalue=1e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003018
- InterPro:   IPR010559
- InterPro:   IPR005467
- InterPro:   IPR011620 [H]

Pfam domain/function: PF07694 5TM-5TMR_LYT; PF01590 GAF; PF02518 HATPase_c; PF06580 His_kinase [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 61430; Mature: 61430

Theoretical pI: Translated: 8.85; Mature: 8.85

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIYIQLLESMSLIGIAAYLYSQTKTFNKFIKNKSDYKYKLIIITFFSVLSILGTYTGVNI
CEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHCCCCC
EPYALANARPIGAIVAGYIGGPLVGIMVGIIGGTHRYFLGGFTALSCAISTILEGIVGGI
CCEEECCCCCHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ANVITKDEGLDVSTGVTAAIIAEVLQMIIILLIAKPYEAALELERVIALPMIITNSIGVG
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCE
IFINIINNTQEHYKKIGAIQSQKALNIAKKTSIYLRSGFNQEILDKVCSIIYESINLKSI
EEEEECCCCHHHHHHHCCHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHCCCEEE
FIAENGGIFSYNGEELNKEKLKYRVKEYFDFKDYKLIKFEDNNKQKLFYCIPIYTDKDKF
EEEECCCEEEECCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEEEEEECCCCE
KFVIGIQVKSYKSIDKYFSDFAKELSALLATQIELYELDQLAQEVSKAELKMLRNQIHPH
EEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
FLFNTLNTIASFCRTDPIKARELILNLSNYFRQTLKRQDEKIILKDEIEFLESYLAIEKA
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHH
RFGERLNIDINIPEELLDAKVPIFVLQPIIENSMKHGILIKPQGGEVIITAIDEKDKIKF
HCCCEEEEEECCCHHHHCCCCCHHHHHHHHHCCCCCCEEEECCCCEEEEEEECCCCCEEE
VIKDTGVGMDKNTLSYVVESWPGIGLSNVNKRLKLLYGEKSFIRIESKLNEGTKVMFCIP
EEEECCCCCCCHHHHHHHHCCCCCCHHHHCHHHEEEECCCCEEEEECCCCCCCEEEEEEC
KEVF
CCCC
>Mature Secondary Structure
MIYIQLLESMSLIGIAAYLYSQTKTFNKFIKNKSDYKYKLIIITFFSVLSILGTYTGVNI
CEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHCCCCC
EPYALANARPIGAIVAGYIGGPLVGIMVGIIGGTHRYFLGGFTALSCAISTILEGIVGGI
CCEEECCCCCHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ANVITKDEGLDVSTGVTAAIIAEVLQMIIILLIAKPYEAALELERVIALPMIITNSIGVG
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCE
IFINIINNTQEHYKKIGAIQSQKALNIAKKTSIYLRSGFNQEILDKVCSIIYESINLKSI
EEEEECCCCHHHHHHHCCHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHCCCEEE
FIAENGGIFSYNGEELNKEKLKYRVKEYFDFKDYKLIKFEDNNKQKLFYCIPIYTDKDKF
EEEECCCEEEECCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEEEEEECCCCE
KFVIGIQVKSYKSIDKYFSDFAKELSALLATQIELYELDQLAQEVSKAELKMLRNQIHPH
EEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
FLFNTLNTIASFCRTDPIKARELILNLSNYFRQTLKRQDEKIILKDEIEFLESYLAIEKA
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHH
RFGERLNIDINIPEELLDAKVPIFVLQPIIENSMKHGILIKPQGGEVIITAIDEKDKIKF
HCCCEEEEEECCCHHHHCCCCCHHHHHHHHHCCCCCCEEEECCCCEEEEEEECCCCCEEE
VIKDTGVGMDKNTLSYVVESWPGIGLSNVNKRLKLLYGEKSFIRIESKLNEGTKVMFCIP
EEEECCCCCCCHHHHHHHHCCCCCCHHHHCHHHEEEECCCCEEEEECCCCCCCEEEEEEC
KEVF
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]