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The map label for this gene is guaA

Identifier: 148381238

GI number: 148381238

Start: 3503782

End: 3505314

Strand: Reverse

Name: guaA

Synonym: CBO3295

Alternate gene names: 148381238

Gene position: 3505314-3503782 (Counterclockwise)

Preceding gene: 148381239

Following gene: 148381237

Centisome position: 90.18

GC content: 31.77

Gene sequence:

>1533_bases
ATGAATAAAGAATTAGTATTAGTAGTTGACTTTGGAGGTCAATATAATCAGTTAATAGCAAGACGTGTAAGAGAGAATAG
AGTGTATTGTGAAATAGTACCTTATACTACTTCTATAGAAGATATAAAAGAAAAAGCACCAAAGGGAATAATATTTACAG
GTGGTCCTAATAGTGTATATGGAGAAAATGCACCAAGAGTTCAAAAAGAATTATTTGATTTAGGTATTCCAGTCTTAGGT
ATATGTTATGGAGATCAACTTATGGCACATAGCTTAGAAGGTGAAGTAACAAGTCCTGAAAAAAGAGAATATGGTAAAAC
AGATGTAAATTTAGATAATAGTAGTTTATTGTTTAAGGATATGAAAGAGAAAGATCAATGCTGGATGAGTCATACAGATT
ATATTTCAAAGGTTCCAAAGGGATTTAAAATTATAGCAACAACAGATGAGTGCCCTTGTGCAGCTATGGAAAATGCAGAA
AAAAAATTATATGGAGTTCAATTTCATCCAGAGGTAGAGCATACTTTATTTGGCAAAAAAATGCTTAAGAACTTTTTGTT
TAACGTATGTAATTTAAAAGGTGATTGGAGTATGAGTTCTTTTGCAGAGCAGCAAATAAAAGCTATAAAGGAAAAAGTAG
GAGATAAAAAAGTAATATGCGCTCTATCAGGTGGAGTAGATTCATCAGTAGCAGCAGTAATTGTTCATAAAGCTATAGGA
AAACAATTAACTTGTGTATTTGTTGATCATGGTTTACTTAGAAAAGATGAAGGAGACCAAGTAGAAAGAATATTTAAAGA
TCAATTTGATATGAATTTAATAAGAGTTAATGCTCAAGATAGATTTTTAGGAAAATTAAAGGGAGTTTCAGATCCAGAAA
GAAAGAGAAAAATAATTGGAGAAGAATTTATAAGAGTATTTGAAGAAGAAGCTAAAAAATTAGGTGATATAAGTTTCTTA
GTTCAAGGTACTATATATCCTGATATAGTAGAAAGTGGAACAAACACATCAGCTACTATAAAAAGTCATCATAACGTAGG
TGGATTACCTGAAGATATGGAATTCAAATTAATAGAACCTTTAAGAGAATTGTTTAAAGATGAAGTAAGAGCTGTAGGAG
AAGAATTAGGTATACCACATAAATTAGTATGGAGACAGCCATTCCCAGGACCAGGCTTAGCTATAAGAGTATTAGGTGAG
GTTACAGAGGAAAAATTAGCTATTACAAGAGAAGCAGATGCTATATTCAGAGAAGAGATAGCTAAAGCAGGCCTAGAAGA
AAAGATATGGCAATATTTTGCCTGCCTTCCAAATATACAGTCAGTAGGAGTAATGGGAGATGAAAGAACATATTGCCATA
CAATAGCATTAAGAGCTGTTACATCTTCAGATGCAATGACTTCAGATTGGGCAAGAATACCTTATGAAGTATTAGATAAA
GTATCAAGAAGAATAGTAAATGAGGTTAAAGAAGTAAACAGAATTGTTTATGATGTAACTTCAAAACCACCAGCAACTAT
TGAATGGGAATAA

Upstream 100 bases:

>100_bases
AATTCAAACATCTTCAGGGATAAGAGAAAGTCATCCTCATGATATTTCAATAACAAAAGAAGCGCCAAATTATAGCGTTA
ATCAATAAAAGGAGGCACAT

Downstream 100 bases:

>100_bases
AATAAAGTTTAGTAAAGTTAATATTTAGATCATATAAAAAGTGCTTTCAATATTTACTTGTATAAAAGTGAATTGAAAGC
ACTTTGTATTTTTTTGTAAT

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase

Number of amino acids: Translated: 510; Mature: 510

Protein sequence:

>510_residues
MNKELVLVVDFGGQYNQLIARRVRENRVYCEIVPYTTSIEDIKEKAPKGIIFTGGPNSVYGENAPRVQKELFDLGIPVLG
ICYGDQLMAHSLEGEVTSPEKREYGKTDVNLDNSSLLFKDMKEKDQCWMSHTDYISKVPKGFKIIATTDECPCAAMENAE
KKLYGVQFHPEVEHTLFGKKMLKNFLFNVCNLKGDWSMSSFAEQQIKAIKEKVGDKKVICALSGGVDSSVAAVIVHKAIG
KQLTCVFVDHGLLRKDEGDQVERIFKDQFDMNLIRVNAQDRFLGKLKGVSDPERKRKIIGEEFIRVFEEEAKKLGDISFL
VQGTIYPDIVESGTNTSATIKSHHNVGGLPEDMEFKLIEPLRELFKDEVRAVGEELGIPHKLVWRQPFPGPGLAIRVLGE
VTEEKLAITREADAIFREEIAKAGLEEKIWQYFACLPNIQSVGVMGDERTYCHTIALRAVTSSDAMTSDWARIPYEVLDK
VSRRIVNEVKEVNRIVYDVTSKPPATIEWE

Sequences:

>Translated_510_residues
MNKELVLVVDFGGQYNQLIARRVRENRVYCEIVPYTTSIEDIKEKAPKGIIFTGGPNSVYGENAPRVQKELFDLGIPVLG
ICYGDQLMAHSLEGEVTSPEKREYGKTDVNLDNSSLLFKDMKEKDQCWMSHTDYISKVPKGFKIIATTDECPCAAMENAE
KKLYGVQFHPEVEHTLFGKKMLKNFLFNVCNLKGDWSMSSFAEQQIKAIKEKVGDKKVICALSGGVDSSVAAVIVHKAIG
KQLTCVFVDHGLLRKDEGDQVERIFKDQFDMNLIRVNAQDRFLGKLKGVSDPERKRKIIGEEFIRVFEEEAKKLGDISFL
VQGTIYPDIVESGTNTSATIKSHHNVGGLPEDMEFKLIEPLRELFKDEVRAVGEELGIPHKLVWRQPFPGPGLAIRVLGE
VTEEKLAITREADAIFREEIAKAGLEEKIWQYFACLPNIQSVGVMGDERTYCHTIALRAVTSSDAMTSDWARIPYEVLDK
VSRRIVNEVKEVNRIVYDVTSKPPATIEWE
>Mature_510_residues
MNKELVLVVDFGGQYNQLIARRVRENRVYCEIVPYTTSIEDIKEKAPKGIIFTGGPNSVYGENAPRVQKELFDLGIPVLG
ICYGDQLMAHSLEGEVTSPEKREYGKTDVNLDNSSLLFKDMKEKDQCWMSHTDYISKVPKGFKIIATTDECPCAAMENAE
KKLYGVQFHPEVEHTLFGKKMLKNFLFNVCNLKGDWSMSSFAEQQIKAIKEKVGDKKVICALSGGVDSSVAAVIVHKAIG
KQLTCVFVDHGLLRKDEGDQVERIFKDQFDMNLIRVNAQDRFLGKLKGVSDPERKRKIIGEEFIRVFEEEAKKLGDISFL
VQGTIYPDIVESGTNTSATIKSHHNVGGLPEDMEFKLIEPLRELFKDEVRAVGEELGIPHKLVWRQPFPGPGLAIRVLGE
VTEEKLAITREADAIFREEIAKAGLEEKIWQYFACLPNIQSVGVMGDERTYCHTIALRAVTSSDAMTSDWARIPYEVLDK
VSRRIVNEVKEVNRIVYDVTSKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain

Homologues:

Organism=Homo sapiens, GI4504035, Length=547, Percent_Identity=35.6489945155393, Blast_Score=303, Evalue=2e-82,
Organism=Escherichia coli, GI1788854, Length=521, Percent_Identity=50.8637236084453, Blast_Score=553, Evalue=1e-159,
Organism=Caenorhabditis elegans, GI133901714, Length=568, Percent_Identity=35.9154929577465, Blast_Score=311, Evalue=5e-85,
Organism=Caenorhabditis elegans, GI71992717, Length=568, Percent_Identity=35.9154929577465, Blast_Score=311, Evalue=6e-85,
Organism=Caenorhabditis elegans, GI71992710, Length=568, Percent_Identity=35.9154929577465, Blast_Score=311, Evalue=7e-85,
Organism=Saccharomyces cerevisiae, GI6323873, Length=516, Percent_Identity=52.3255813953488, Blast_Score=541, Evalue=1e-154,
Organism=Drosophila melanogaster, GI281365319, Length=544, Percent_Identity=36.0294117647059, Blast_Score=310, Evalue=2e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GUAA_CLOB1 (A7FYP0)

Other databases:

- EMBL:   CP000726
- RefSeq:   YP_001385613.1
- ProteinModelPortal:   A7FYP0
- SMR:   A7FYP0
- STRING:   A7FYP0
- GeneID:   5395242
- GenomeReviews:   CP000726_GR
- KEGG:   cba:CLB_3351
- eggNOG:   COG0519
- HOGENOM:   HBG391775
- OMA:   PSTIEPC
- ProtClustDB:   PRK00074
- BioCyc:   CBOT441770:CLB_3351-MONOMER
- HAMAP:   MF_00344
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PRINTS:   PR00099
- PRINTS:   PR00096
- TIGRFAMs:   TIGR00884
- TIGRFAMs:   TIGR00888

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase

EC number: =6.3.5.2

Molecular weight: Translated: 57514; Mature: 57514

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 82-82 ACT_SITE 169-169 ACT_SITE 171-171

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKELVLVVDFGGQYNQLIARRVRENRVYCEIVPYTTSIEDIKEKAPKGIIFTGGPNSVY
CCCCEEEEEECCCCHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHCCCCEEEECCCCCCC
GENAPRVQKELFDLGIPVLGICYGDQLMAHSLEGEVTSPEKREYGKTDVNLDNSSLLFKD
CCCCHHHHHHHHHCCCCCEEEECCHHHHHHCCCCCCCCCHHHHCCCCCCCCCCCHHHHHH
MKEKDQCWMSHTDYISKVPKGFKIIATTDECPCAAMENAEKKLYGVQFHPEVEHTLFGKK
HHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHCCHHHEEEEEECCCHHHHHHHHH
MLKNFLFNVCNLKGDWSMSSFAEQQIKAIKEKVGDKKVICALSGGVDSSVAAVIVHKAIG
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHC
KQLTCVFVDHGLLRKDEGDQVERIFKDQFDMNLIRVNAQDRFLGKLKGVSDPERKRKIIG
CCEEEEEECCCCCCCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHCCCCCHHHHHHHHH
EEFIRVFEEEAKKLGDISFLVQGTIYPDIVESGTNTSATIKSHHNVGGLPEDMEFKLIEP
HHHHHHHHHHHHHHCCEEEEEECCCCHHHHHCCCCCCEEEECCCCCCCCCCCCHHHHHHH
LRELFKDEVRAVGEELGIPHKLVWRQPFPGPGLAIRVLGEVTEEKLAITREADAIFREEI
HHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHH
AKAGLEEKIWQYFACLPNIQSVGVMGDERTYCHTIALRAVTSSDAMTSDWARIPYEVLDK
HHCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHCCCHHHHHH
VSRRIVNEVKEVNRIVYDVTSKPPATIEWE
HHHHHHHHHHHHHHHHEEECCCCCCCEECC
>Mature Secondary Structure
MNKELVLVVDFGGQYNQLIARRVRENRVYCEIVPYTTSIEDIKEKAPKGIIFTGGPNSVY
CCCCEEEEEECCCCHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHCCCCEEEECCCCCCC
GENAPRVQKELFDLGIPVLGICYGDQLMAHSLEGEVTSPEKREYGKTDVNLDNSSLLFKD
CCCCHHHHHHHHHCCCCCEEEECCHHHHHHCCCCCCCCCHHHHCCCCCCCCCCCHHHHHH
MKEKDQCWMSHTDYISKVPKGFKIIATTDECPCAAMENAEKKLYGVQFHPEVEHTLFGKK
HHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHCCHHHEEEEEECCCHHHHHHHHH
MLKNFLFNVCNLKGDWSMSSFAEQQIKAIKEKVGDKKVICALSGGVDSSVAAVIVHKAIG
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHC
KQLTCVFVDHGLLRKDEGDQVERIFKDQFDMNLIRVNAQDRFLGKLKGVSDPERKRKIIG
CCEEEEEECCCCCCCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHCCCCCHHHHHHHHH
EEFIRVFEEEAKKLGDISFLVQGTIYPDIVESGTNTSATIKSHHNVGGLPEDMEFKLIEP
HHHHHHHHHHHHHHCCEEEEEECCCCHHHHHCCCCCCEEEECCCCCCCCCCCCHHHHHHH
LRELFKDEVRAVGEELGIPHKLVWRQPFPGPGLAIRVLGEVTEEKLAITREADAIFREEI
HHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHH
AKAGLEEKIWQYFACLPNIQSVGVMGDERTYCHTIALRAVTSSDAMTSDWARIPYEVLDK
HHCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHCCCHHHHHH
VSRRIVNEVKEVNRIVYDVTSKPPATIEWE
HHHHHHHHHHHHHHHHEEECCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA