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The map label for this gene is pyrD [H]

Identifier: 148381185

GI number: 148381185

Start: 3446235

End: 3447131

Strand: Reverse

Name: pyrD [H]

Synonym: CBO3236

Alternate gene names: 148381185

Gene position: 3447131-3446235 (Counterclockwise)

Preceding gene: 148381186

Following gene: 148381184

Centisome position: 88.69

GC content: 31.1

Gene sequence:

>897_bases
ATGCTTCAAGTAAATTTATGTGGTAAGATTTTTAAAAATCCTATTATAGCTGCATCAGGAACTTTTGGATTTGGAGAAGA
ATATGGGCAATTTTATGATGTTTCTAAATTAGGAGGAATTTCAAGTAAAGGATTGACCTTAAATCCTAAAGACGGAAATA
ATGGAATAAGAATTCATGAAACTAGTTCCGGTATAATGAACAGTGTAGGACTTCAGAATCCAGGAGTAGATAAATTTATA
AAAGAAGAGTTACCTAAAATGAAAAAAATGGATACAGTAACCATTGCAAATGTTGGTGGAGGATGTATAGAAGATTATAT
TGAAGTCATAGAGAAATTAAATAAAACAGATGTAGATATGATAGAGCTAAATATATCCTGTCCCAATGTAAAGCATGGAG
GTATGGCCTTTGGAATAAAGTCAGAAATAGCTTATGAAATAGTAAAAGAAGTTAAAAAAATATGCCAAAAGCCACTTATG
GTAAAGCTATCTCCTAATGCAGAAGATATAGTAGATATGGCTATAAAATGTGAGAAAGCAGGAGCAGATGCAATTTCATT
AGTAAATACATTTAAGGCTATGGCTATAGATATAAAGAGAAAAACTCCTGTATTTGAAAATATAACTGCAGGTTTATCAG
GCCCATGCATTAAGCCTATAGCATTGAGAATGGTATATGAAGTGTGTAAGCAGGTGAAAATACCGGTTATAGGTATAGGA
GGAATATGTAATTATGAAGATGTAATAGAATTTATTATGGCGGGGGCCACAGCAGTACAAATAGGAACAACTAATTTTAT
GAATCCATATTCAGCTGTAGATATAATAGAGGACTTAGAAAATTATATGAAAAAACAAGGTATTAAAAATTTAGAAGAAA
TAAGGGGAATTATTTAA

Upstream 100 bases:

>100_bases
GTCTTGTGTGTACTTGTAAAACTAAATTTGGTAATAAAAGAACTTGCAAGGATGGTCCCGTATTTAAAGGAGAGGACATT
CTTTTGAAAGGAGATATATA

Downstream 100 bases:

>100_bases
AATAAATTTTGAAAATATAAGGAGAAGATATAAATGAGTAATATAAATGTTATAGATATATTAAAAGAATCAGATGCGTT
ATTAGAAGGACATTTCTTAT

Product: dihydroorotate dehydrogenase 1B

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MLQVNLCGKIFKNPIIAASGTFGFGEEYGQFYDVSKLGGISSKGLTLNPKDGNNGIRIHETSSGIMNSVGLQNPGVDKFI
KEELPKMKKMDTVTIANVGGGCIEDYIEVIEKLNKTDVDMIELNISCPNVKHGGMAFGIKSEIAYEIVKEVKKICQKPLM
VKLSPNAEDIVDMAIKCEKAGADAISLVNTFKAMAIDIKRKTPVFENITAGLSGPCIKPIALRMVYEVCKQVKIPVIGIG
GICNYEDVIEFIMAGATAVQIGTTNFMNPYSAVDIIEDLENYMKKQGIKNLEEIRGII

Sequences:

>Translated_298_residues
MLQVNLCGKIFKNPIIAASGTFGFGEEYGQFYDVSKLGGISSKGLTLNPKDGNNGIRIHETSSGIMNSVGLQNPGVDKFI
KEELPKMKKMDTVTIANVGGGCIEDYIEVIEKLNKTDVDMIELNISCPNVKHGGMAFGIKSEIAYEIVKEVKKICQKPLM
VKLSPNAEDIVDMAIKCEKAGADAISLVNTFKAMAIDIKRKTPVFENITAGLSGPCIKPIALRMVYEVCKQVKIPVIGIG
GICNYEDVIEFIMAGATAVQIGTTNFMNPYSAVDIIEDLENYMKKQGIKNLEEIRGII
>Mature_298_residues
MLQVNLCGKIFKNPIIAASGTFGFGEEYGQFYDVSKLGGISSKGLTLNPKDGNNGIRIHETSSGIMNSVGLQNPGVDKFI
KEELPKMKKMDTVTIANVGGGCIEDYIEVIEKLNKTDVDMIELNISCPNVKHGGMAFGIKSEIAYEIVKEVKKICQKPLM
VKLSPNAEDIVDMAIKCEKAGADAISLVNTFKAMAIDIKRKTPVFENITAGLSGPCIKPIALRMVYEVCKQVKIPVIGIG
GICNYEDVIEFIMAGATAVQIGTTNFMNPYSAVDIIEDLENYMKKQGIKNLEEIRGII

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=211, Percent_Identity=27.9620853080569, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI45006951, Length=312, Percent_Identity=25.3205128205128, Blast_Score=89, Evalue=5e-18,
Organism=Escherichia coli, GI87082059, Length=323, Percent_Identity=27.8637770897833, Blast_Score=116, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI71984108, Length=297, Percent_Identity=25.2525252525253, Blast_Score=87, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6322633, Length=307, Percent_Identity=27.3615635179153, Blast_Score=96, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24640763, Length=175, Percent_Identity=33.7142857142857, Blast_Score=98, Evalue=9e-21,
Organism=Drosophila melanogaster, GI18858217, Length=175, Percent_Identity=33.7142857142857, Blast_Score=98, Evalue=9e-21,
Organism=Drosophila melanogaster, GI281361352, Length=318, Percent_Identity=26.4150943396226, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17137316, Length=318, Percent_Identity=26.4150943396226, Blast_Score=72, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.3.1 [H]

Molecular weight: Translated: 32436; Mature: 32436

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQVNLCGKIFKNPIIAASGTFGFGEEYGQFYDVSKLGGISSKGLTLNPKDGNNGIRIHE
CEEECCHHHHHCCCEEEECCCCCCHHHHHHHCCHHHHCCCCCCCCEECCCCCCCCEEEEE
TSSGIMNSVGLQNPGVDKFIKEELPKMKKMDTVTIANVGGGCIEDYIEVIEKLNKTDVDM
CCCHHHHHCCCCCCCHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHCCCCCCEE
IELNISCPNVKHGGMAFGIKSEIAYEIVKEVKKICQKPLMVKLSPNAEDIVDMAIKCEKA
EEEEECCCCCCCCCEEECHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHC
GADAISLVNTFKAMAIDIKRKTPVFENITAGLSGPCIKPIALRMVYEVCKQVKIPVIGIG
CCHHHHHHHHHHHHHEECCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEC
GICNYEDVIEFIMAGATAVQIGTTNFMNPYSAVDIIEDLENYMKKQGIKNLEEIRGII
CCCCHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCC
>Mature Secondary Structure
MLQVNLCGKIFKNPIIAASGTFGFGEEYGQFYDVSKLGGISSKGLTLNPKDGNNGIRIHE
CEEECCHHHHHCCCEEEECCCCCCHHHHHHHCCHHHHCCCCCCCCEECCCCCCCCEEEEE
TSSGIMNSVGLQNPGVDKFIKEELPKMKKMDTVTIANVGGGCIEDYIEVIEKLNKTDVDM
CCCHHHHHCCCCCCCHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHCCCCCCEE
IELNISCPNVKHGGMAFGIKSEIAYEIVKEVKKICQKPLMVKLSPNAEDIVDMAIKCEKA
EEEEECCCCCCCCCEEECHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHC
GADAISLVNTFKAMAIDIKRKTPVFENITAGLSGPCIKPIALRMVYEVCKQVKIPVIGIG
CCHHHHHHHHHHHHHEECCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEC
GICNYEDVIEFIMAGATAVQIGTTNFMNPYSAVDIIEDLENYMKKQGIKNLEEIRGII
CCCCHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA