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The map label for this gene is pgcA [H]

Identifier: 148381065

GI number: 148381065

Start: 3309550

End: 3311277

Strand: Reverse

Name: pgcA [H]

Synonym: CBO3114

Alternate gene names: 148381065

Gene position: 3311277-3309550 (Counterclockwise)

Preceding gene: 148381066

Following gene: 148381064

Centisome position: 85.19

GC content: 25.93

Gene sequence:

>1728_bases
ATGAACTATAAATATGCTTACAATTCATGGATGAATTCTTGTTTTTTAGAAGAAAGAGAAAAAGAACAATTAAAAAACAT
AGATGATGAACAAGAGATAAAAGATAGATTTTACAAAGACTTAAGCTTTGGAACAGGTGGAATAAGGGGGATAGTTGGCT
TAGGTACAAATAGAATAAATAAATATACTATAGCTAAAGCTACAGAAGGGTTATCAAATTATCTAATTCATAATTTTAAA
GAAAAAGCTATATCTGTTGCAATAGCCTATGATTGTAGAAATGATTCTTTAGATTTTGCTAAAAAAGCTAGTGAAGTACT
ATGTTCACATGGTATAAGAGTATATATATTTAGTGATATAATGTGCACACCTATACTATCCTATGCTGTTAGAGAACTAA
AATGTAAAGCTGGAATAGTTATAACTGCATCACATAATAGTAAAGAGTATAATGGGTACAAAGTATATAATCATAATGGA
AATCAAATAACAGATAAAGAAGCACAAGAGATAGCTGAGTATATAAAACAAGTAGAGGACTTAGGTTGTATAAAGTATAT
GGATATAAACGATGCAAAGGGAAAAAATTTATACGAATTTGTACCAATAGAGATATTAAATAAATATTTTTATAATGTAA
AAAATTTAACTTTAAGAAAAGATATTGTAAAAAATTATGAAAAGGATTTTAAAATATTATATACACCACTACATGGAACT
GGAAATGTTCCAGTGAGAAGAGCTTTATGTGAAATTGGATATAATAATGTTTTTGTAGTTAAGGATCAAGAAAAACCTAA
TGGAAATTTCCCAACAGTAAAATATCCTAATCCAGAGGATAATAAAGCTTTCTATGCTTCTTTAAAAGAGGCAGAAAATA
TAAATCCTGATGTAATAATAGCTACCGATCCTGATTGTGATAGAGTAGGGATTATGGTTAGGGATCATAGTACAAGATAT
GTAGCTTTAAATGGAAATGAATTAGGTGTAATTCTTACTAATTATATATTAAGTTCCTTAGAAGAAGAAAAAAAAATACC
CGAAAATTCAGTGCTTTTAAAAACCATAGTAACTACAGATATGGTTAAAAATATATGTAAAGACTATGGAGTTAAGGTAG
AAGAAGTTTTAACAGGTTTTAAATATATAGGAGAGAAAATAGAGGAATTTAAGAAGGATGGACAAAATAAATTTATATTT
GGATTTGAGGAAAGCTATGGATATTTATTTGGAGACTTTGTTAGGGAGAAGGACGGAATAATAAGTTCCGCATTAATATG
TGAAATGGCTTTATATTATAAGAGTCAAAATAAAAATTTATTTGATGTTTTAACAGAACTTTATGATAAATATGGATATT
ACAAGGAAAAATTAATATCCATGGAGTTTAAAGGAGAAGAGGGCAAAAATAAAATAGAAAATATAATCAATAATTTAAGA
ATTCATGATTCTAAAACTATATTTAATGAAGAAATACTACTAAAAGAAGACTATAAAACAGGTTTGAAAATAAATATTAA
TAAAAAGAAAGAATATATTAATAAATTTCCTAAATCTAATGTTATAAAATTTCATTTAAATAACGGTACTAATTTTGTAA
TTAGACCATCTGGAACAGAACCTAAAATAAAAATATATTTATCATCAGTACACACAACAGCTGAAGGGGCTGAAATGAAT
ATAAATAAGCTAGAAAAAAATATAAAGAATATGATAAATAAATTTTAA

Upstream 100 bases:

>100_bases
TATAGATTTTATAAAATAAAATTGGGTGAAATTTTATTTAGAGTACAATTATTTATGTTTTTTAATATAATGTAGTATGA
AATTTTATTGGAGGTAGTAA

Downstream 100 bases:

>100_bases
AACTACAAATATTTAAATTATGCATAGGATAACTTTAAAAATTATCCTATGCATAATTTAAATATTTTTGTATTTTCATT
GTTTAATCATTTATATTATT

Product: phosphoglucomutase/phosphomannomutase family protein

Products: NA

Alternate protein names: PGM; Alpha-phosphoglucomutase; Glucose phosphomutase [H]

Number of amino acids: Translated: 575; Mature: 575

Protein sequence:

>575_residues
MNYKYAYNSWMNSCFLEEREKEQLKNIDDEQEIKDRFYKDLSFGTGGIRGIVGLGTNRINKYTIAKATEGLSNYLIHNFK
EKAISVAIAYDCRNDSLDFAKKASEVLCSHGIRVYIFSDIMCTPILSYAVRELKCKAGIVITASHNSKEYNGYKVYNHNG
NQITDKEAQEIAEYIKQVEDLGCIKYMDINDAKGKNLYEFVPIEILNKYFYNVKNLTLRKDIVKNYEKDFKILYTPLHGT
GNVPVRRALCEIGYNNVFVVKDQEKPNGNFPTVKYPNPEDNKAFYASLKEAENINPDVIIATDPDCDRVGIMVRDHSTRY
VALNGNELGVILTNYILSSLEEEKKIPENSVLLKTIVTTDMVKNICKDYGVKVEEVLTGFKYIGEKIEEFKKDGQNKFIF
GFEESYGYLFGDFVREKDGIISSALICEMALYYKSQNKNLFDVLTELYDKYGYYKEKLISMEFKGEEGKNKIENIINNLR
IHDSKTIFNEEILLKEDYKTGLKININKKKEYINKFPKSNVIKFHLNNGTNFVIRPSGTEPKIKIYLSSVHTTAEGAEMN
INKLEKNIKNMINKF

Sequences:

>Translated_575_residues
MNYKYAYNSWMNSCFLEEREKEQLKNIDDEQEIKDRFYKDLSFGTGGIRGIVGLGTNRINKYTIAKATEGLSNYLIHNFK
EKAISVAIAYDCRNDSLDFAKKASEVLCSHGIRVYIFSDIMCTPILSYAVRELKCKAGIVITASHNSKEYNGYKVYNHNG
NQITDKEAQEIAEYIKQVEDLGCIKYMDINDAKGKNLYEFVPIEILNKYFYNVKNLTLRKDIVKNYEKDFKILYTPLHGT
GNVPVRRALCEIGYNNVFVVKDQEKPNGNFPTVKYPNPEDNKAFYASLKEAENINPDVIIATDPDCDRVGIMVRDHSTRY
VALNGNELGVILTNYILSSLEEEKKIPENSVLLKTIVTTDMVKNICKDYGVKVEEVLTGFKYIGEKIEEFKKDGQNKFIF
GFEESYGYLFGDFVREKDGIISSALICEMALYYKSQNKNLFDVLTELYDKYGYYKEKLISMEFKGEEGKNKIENIINNLR
IHDSKTIFNEEILLKEDYKTGLKININKKKEYINKFPKSNVIKFHLNNGTNFVIRPSGTEPKIKIYLSSVHTTAEGAEMN
INKLEKNIKNMINKF
>Mature_575_residues
MNYKYAYNSWMNSCFLEEREKEQLKNIDDEQEIKDRFYKDLSFGTGGIRGIVGLGTNRINKYTIAKATEGLSNYLIHNFK
EKAISVAIAYDCRNDSLDFAKKASEVLCSHGIRVYIFSDIMCTPILSYAVRELKCKAGIVITASHNSKEYNGYKVYNHNG
NQITDKEAQEIAEYIKQVEDLGCIKYMDINDAKGKNLYEFVPIEILNKYFYNVKNLTLRKDIVKNYEKDFKILYTPLHGT
GNVPVRRALCEIGYNNVFVVKDQEKPNGNFPTVKYPNPEDNKAFYASLKEAENINPDVIIATDPDCDRVGIMVRDHSTRY
VALNGNELGVILTNYILSSLEEEKKIPENSVLLKTIVTTDMVKNICKDYGVKVEEVLTGFKYIGEKIEEFKKDGQNKFIF
GFEESYGYLFGDFVREKDGIISSALICEMALYYKSQNKNLFDVLTELYDKYGYYKEKLISMEFKGEEGKNKIENIINNLR
IHDSKTIFNEEILLKEDYKTGLKININKKKEYINKFPKSNVIKFHLNNGTNFVIRPSGTEPKIKIYLSSVHTTAEGAEMN
INKLEKNIKNMINKF

Specific function: Catalyzes the interconversion between glucose-6- phosphate and alpha-glucose-1-phosphate. This is the first step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the predominant glycolipid found in B.subtilis membrane, which is also used

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI63055049, Length=562, Percent_Identity=31.4946619217082, Blast_Score=272, Evalue=6e-73,
Organism=Homo sapiens, GI31377548, Length=582, Percent_Identity=32.3024054982818, Blast_Score=271, Evalue=1e-72,
Organism=Caenorhabditis elegans, GI71993870, Length=559, Percent_Identity=31.6636851520572, Blast_Score=273, Evalue=2e-73,
Organism=Caenorhabditis elegans, GI71993878, Length=311, Percent_Identity=34.0836012861736, Blast_Score=178, Evalue=8e-45,
Organism=Saccharomyces cerevisiae, GI6323934, Length=582, Percent_Identity=29.2096219931272, Blast_Score=235, Evalue=2e-62,
Organism=Drosophila melanogaster, GI20129809, Length=562, Percent_Identity=28.4697508896797, Blast_Score=236, Evalue=3e-62,
Organism=Drosophila melanogaster, GI24653722, Length=532, Percent_Identity=28.5714285714286, Blast_Score=228, Evalue=1e-59,
Organism=Drosophila melanogaster, GI24651977, Length=519, Percent_Identity=28.131021194605, Blast_Score=217, Evalue=2e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2 [H]

Molecular weight: Translated: 66260; Mature: 66260

Theoretical pI: Translated: 7.88; Mature: 7.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYKYAYNSWMNSCFLEEREKEQLKNIDDEQEIKDRFYKDLSFGTGGIRGIVGLGTNRIN
CCCEEHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCEEEECCCCCCC
KYTIAKATEGLSNYLIHNFKEKAISVAIAYDCRNDSLDFAKKASEVLCSHGIRVYIFSDI
EEEEHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCHHHHHHHHHHHHHCCCEEEEEHHH
MCTPILSYAVRELKCKAGIVITASHNSKEYNGYKVYNHNGNQITDKEAQEIAEYIKQVED
HHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHH
LGCIKYMDINDAKGKNLYEFVPIEILNKYFYNVKNLTLRKDIVKNYEKDFKILYTPLHGT
CCCEEEEECCCCCCCCCCEEHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEEECCCC
GNVPVRRALCEIGYNNVFVVKDQEKPNGNFPTVKYPNPEDNKAFYASLKEAENINPDVII
CCCHHHHHHHHCCCCCEEEEECCCCCCCCCCEEECCCCCCCCHHHHHHHHHCCCCCCEEE
ATDPDCDRVGIMVRDHSTRYVALNGNELGVILTNYILSSLEEEKKIPENSVLLKTIVTTD
EECCCCCEEEEEEEECCEEEEEECCCCEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
MVKNICKDYGVKVEEVLTGFKYIGEKIEEFKKDGQNKFIFGFEESYGYLFGDFVREKDGI
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHCCH
ISSALICEMALYYKSQNKNLFDVLTELYDKYGYYKEKLISMEFKGEEGKNKIENIINNLR
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCHHHHHHEEEEECCCCCHHHHHHHHHHCE
IHDSKTIFNEEILLKEDYKTGLKININKKKEYINKFPKSNVIKFHLNNGTNFVIRPSGTE
ECCCCCEECCCEEEECCCCCCCEEEECHHHHHHHHCCCCCEEEEEECCCCEEEEECCCCC
PKIKIYLSSVHTTAEGAEMNINKLEKNIKNMINKF
CEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNYKYAYNSWMNSCFLEEREKEQLKNIDDEQEIKDRFYKDLSFGTGGIRGIVGLGTNRIN
CCCEEHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCEEEECCCCCCC
KYTIAKATEGLSNYLIHNFKEKAISVAIAYDCRNDSLDFAKKASEVLCSHGIRVYIFSDI
EEEEHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCHHHHHHHHHHHHHCCCEEEEEHHH
MCTPILSYAVRELKCKAGIVITASHNSKEYNGYKVYNHNGNQITDKEAQEIAEYIKQVED
HHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHH
LGCIKYMDINDAKGKNLYEFVPIEILNKYFYNVKNLTLRKDIVKNYEKDFKILYTPLHGT
CCCEEEEECCCCCCCCCCEEHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEEECCCC
GNVPVRRALCEIGYNNVFVVKDQEKPNGNFPTVKYPNPEDNKAFYASLKEAENINPDVII
CCCHHHHHHHHCCCCCEEEEECCCCCCCCCCEEECCCCCCCCHHHHHHHHHCCCCCCEEE
ATDPDCDRVGIMVRDHSTRYVALNGNELGVILTNYILSSLEEEKKIPENSVLLKTIVTTD
EECCCCCEEEEEEEECCEEEEEECCCCEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
MVKNICKDYGVKVEEVLTGFKYIGEKIEEFKKDGQNKFIFGFEESYGYLFGDFVREKDGI
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHCCH
ISSALICEMALYYKSQNKNLFDVLTELYDKYGYYKEKLISMEFKGEEGKNKIENIINNLR
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCHHHHHHEEEEECCCCCHHHHHHHHHHCE
IHDSKTIFNEEILLKEDYKTGLKININKKKEYINKFPKSNVIKFHLNNGTNFVIRPSGTE
ECCCCCEECCCEEEECCCCCCCEEEECHHHHHHHHCCCCCEEEEEECCCCEEEEECCCCC
PKIKIYLSSVHTTAEGAEMNINKLEKNIKNMINKF
CEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 2127799 [H]