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The map label for this gene is obgE

Identifier: 148380937

GI number: 148380937

Start: 3180173

End: 3181447

Strand: Reverse

Name: obgE

Synonym: CBO2986

Alternate gene names: 148380937

Gene position: 3181447-3180173 (Counterclockwise)

Preceding gene: 148380938

Following gene: 148380936

Centisome position: 81.85

GC content: 31.61

Gene sequence:

>1275_bases
TTGTTTATAGATACAGCCAAAATATTTGTAAAATCAGGAAAGGGAGGAGATGGATCCATCTCTTTTAGAAGAGAAAAATA
TATAGCCTTTGGAGGACCAGATGGTGGAGATGGTGGTAAAGGCGGTAATGTAGTACTAGTAGTAGATCCTAATATGACAA
CTCTATTAGATTTTACTTATAAAAGAAAATATAAAGCAGAACCAGGTGGAAATGGCGCAGGATCAAAATGTTTTGGTAAA
AACGGTAAAGATCTACATATAAAAGTACCTATGGGAACTATAGTTAAAGATGCAGAAACAGACAAAATAATGGCAGATTT
ATCAAAGCCAGAGGATTCTTATGTGGTTGCTAAAGGTGGAAGAGGTGGTAAAGGTAATTGCAGATTTACAACACCTACAA
GACAGGCACCAGATTTTGCAGAACCAGGTATGCCAGAGGAAGAAAGATGGATTAAGCTTGAATTAAAGCTTTTAGCAGAT
GTGGGTCTTATAGGATTTCCTAACGTGGGAAAATCTACTTTATTATCAGTCGTATCTAAAGCTAGACCTAAAATAGCTAA
CTATCATTTTACTACATTAAAACCTAATTTAGGCGTGGTAAGTATTGAAGGTGTAAATAATTTTGTAATTGCAGATATAC
CAGGAATAATTGAAGGTGCTTCAGAAGGAGTAGGATTAGGTTTAGATTTTTTAAGACATGTAGAGAGAACAAGAGTATTA
ATTCATGTAATAGATATATCTTCTGTAGAAGGAAGAGACCCTTATGATGATTTTTTAAAGATAAACGAAGAACTAAAAAG
ATATAGTGTAAAACTTTATGATAGACCTCAAATAATAGCTGCTAATAAATCTGATATGTTATTTGATGAAGAAAAGTTTG
AAGAATTTAAAACAAAAGTAGAAAAACATGGTTATAATAAGGTGTTTAAGATATCAGCAGCTACAAAGCAAGGTGTAGAT
GATCTTATGAAAGAAGCTGCAAGACTTTTAAGTACTATACTTGTTACAGATCTAGAAATATCAGAAGAAGATAGATTTAT
AGAGGAAGAAAAGAGATTTACATACTCTATAAGAAAAGAAGATAACACTTATATTGTGGAAGGAAGTTTTGTAGATAGAC
TTTTGAATGCAGTTAATGTAAATGATCCAGATGATTTAAGATATTTCCATAAAGTACTTAAAAATAAAGGGGTAATGGAA
GAATTAATGGAAATGGGTATTGAAGATGGTGATGTTGTACGATTAAATGACTTTGAATTTGATTTTTTATTATAA

Upstream 100 bases:

>100_bases
TATAGAATTAACGCAATTGAATATACATTTAAATTATTATAGCTAGATTTTATAAAAAACATTATATATTAATTATCGAA
ATAAAGAGGAGTGAAAAACT

Downstream 100 bases:

>100_bases
TATATGACTTTAGGAGGAATACAATAATGATAACAACAAAACAGAGAAGTTATTTAAGATCTTTAGCTAATAAGATGGAT
GCTATATTTCAAATAGGTAA

Product: GTPase ObgE

Products: NA

Alternate protein names: GTP-binding protein obg

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MFIDTAKIFVKSGKGGDGSISFRREKYIAFGGPDGGDGGKGGNVVLVVDPNMTTLLDFTYKRKYKAEPGGNGAGSKCFGK
NGKDLHIKVPMGTIVKDAETDKIMADLSKPEDSYVVAKGGRGGKGNCRFTTPTRQAPDFAEPGMPEEERWIKLELKLLAD
VGLIGFPNVGKSTLLSVVSKARPKIANYHFTTLKPNLGVVSIEGVNNFVIADIPGIIEGASEGVGLGLDFLRHVERTRVL
IHVIDISSVEGRDPYDDFLKINEELKRYSVKLYDRPQIIAANKSDMLFDEEKFEEFKTKVEKHGYNKVFKISAATKQGVD
DLMKEAARLLSTILVTDLEISEEDRFIEEEKRFTYSIRKEDNTYIVEGSFVDRLLNAVNVNDPDDLRYFHKVLKNKGVME
ELMEMGIEDGDVVRLNDFEFDFLL

Sequences:

>Translated_424_residues
MFIDTAKIFVKSGKGGDGSISFRREKYIAFGGPDGGDGGKGGNVVLVVDPNMTTLLDFTYKRKYKAEPGGNGAGSKCFGK
NGKDLHIKVPMGTIVKDAETDKIMADLSKPEDSYVVAKGGRGGKGNCRFTTPTRQAPDFAEPGMPEEERWIKLELKLLAD
VGLIGFPNVGKSTLLSVVSKARPKIANYHFTTLKPNLGVVSIEGVNNFVIADIPGIIEGASEGVGLGLDFLRHVERTRVL
IHVIDISSVEGRDPYDDFLKINEELKRYSVKLYDRPQIIAANKSDMLFDEEKFEEFKTKVEKHGYNKVFKISAATKQGVD
DLMKEAARLLSTILVTDLEISEEDRFIEEEKRFTYSIRKEDNTYIVEGSFVDRLLNAVNVNDPDDLRYFHKVLKNKGVME
ELMEMGIEDGDVVRLNDFEFDFLL
>Mature_424_residues
MFIDTAKIFVKSGKGGDGSISFRREKYIAFGGPDGGDGGKGGNVVLVVDPNMTTLLDFTYKRKYKAEPGGNGAGSKCFGK
NGKDLHIKVPMGTIVKDAETDKIMADLSKPEDSYVVAKGGRGGKGNCRFTTPTRQAPDFAEPGMPEEERWIKLELKLLAD
VGLIGFPNVGKSTLLSVVSKARPKIANYHFTTLKPNLGVVSIEGVNNFVIADIPGIIEGASEGVGLGLDFLRHVERTRVL
IHVIDISSVEGRDPYDDFLKINEELKRYSVKLYDRPQIIAANKSDMLFDEEKFEEFKTKVEKHGYNKVFKISAATKQGVD
DLMKEAARLLSTILVTDLEISEEDRFIEEEKRFTYSIRKEDNTYIVEGSFVDRLLNAVNVNDPDDLRYFHKVLKNKGVME
ELMEMGIEDGDVVRLNDFEFDFLL

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain

Homologues:

Organism=Homo sapiens, GI24308117, Length=322, Percent_Identity=42.2360248447205, Blast_Score=205, Evalue=7e-53,
Organism=Homo sapiens, GI111955139, Length=347, Percent_Identity=36.8876080691643, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI111955063, Length=246, Percent_Identity=32.9268292682927, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI4557537, Length=89, Percent_Identity=42.6966292134831, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI4758796, Length=127, Percent_Identity=34.6456692913386, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI58761500, Length=129, Percent_Identity=32.5581395348837, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1789574, Length=323, Percent_Identity=49.5356037151703, Blast_Score=269, Evalue=2e-73,
Organism=Escherichia coli, GI1787454, Length=140, Percent_Identity=35, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1790615, Length=172, Percent_Identity=29.6511627906977, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17508313, Length=324, Percent_Identity=37.962962962963, Blast_Score=148, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI17552324, Length=309, Percent_Identity=32.3624595469256, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17509631, Length=139, Percent_Identity=35.2517985611511, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71981008, Length=118, Percent_Identity=36.4406779661017, Blast_Score=72, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6321962, Length=183, Percent_Identity=41.5300546448087, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6321612, Length=254, Percent_Identity=26.3779527559055, Blast_Score=67, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6319281, Length=128, Percent_Identity=33.59375, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI20129375, Length=328, Percent_Identity=39.9390243902439, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI24585318, Length=308, Percent_Identity=35.3896103896104, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24640873, Length=129, Percent_Identity=34.8837209302326, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24640877, Length=129, Percent_Identity=34.8837209302326, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24640875, Length=129, Percent_Identity=34.8837209302326, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI21356473, Length=89, Percent_Identity=42.6966292134831, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17981711, Length=127, Percent_Identity=35.4330708661417, Blast_Score=66, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OBG_CLOB1 (A7FXU6)

Other databases:

- EMBL:   CP000726
- RefSeq:   YP_001385306.1
- ProteinModelPortal:   A7FXU6
- SMR:   A7FXU6
- STRING:   A7FXU6
- GeneID:   5396751
- GenomeReviews:   CP000726_GR
- KEGG:   cba:CLB_3011
- eggNOG:   COG0536
- HOGENOM:   HBG716038
- OMA:   HFTTLVP
- ProtClustDB:   PRK12297
- BioCyc:   CBOT441770:CLB_3011-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01454
- InterPro:   IPR014100
- InterPro:   IPR015349
- InterPro:   IPR006074
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917
- InterPro:   IPR005225
- Gene3D:   G3DSA:2.70.210.12
- PANTHER:   PTHR11702:SF3
- PIRSF:   PIRSF002401
- PRINTS:   PR00326
- TIGRFAMs:   TIGR02729
- TIGRFAMs:   TIGR03595
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF09269 DUF1967; PF01018 GTP1_OBG; PF01926 MMR_HSR1; SSF102741 GTP-bd_prot_GTP1/OBG_C; SSF82051 GTP1_OBG_sub

EC number: NA

Molecular weight: Translated: 47247; Mature: 47247

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFIDTAKIFVKSGKGGDGSISFRREKYIAFGGPDGGDGGKGGNVVLVVDPNMTTLLDFTY
CEECCEEEEEECCCCCCCCEEEEEEEEEEECCCCCCCCCCCCCEEEEECCCCCEEEEEHH
KRKYKAEPGGNGAGSKCFGKNGKDLHIKVPMGTIVKDAETDKIMADLSKPEDSYVVAKGG
HHEEECCCCCCCCCCCCCCCCCCEEEEEECCCHHCCCCCHHHHHHHCCCCCCCEEEEECC
RGGKGNCRFTTPTRQAPDFAEPGMPEEERWIKLELKLLADVGLIGFPNVGKSTLLSVVSK
CCCCCCEEECCCCCCCCCCCCCCCCCCHHEEEEEEEEECCCCCCCCCCCCHHHHHHHHHH
ARPKIANYHFTTLKPNLGVVSIEGVNNFVIADIPGIIEGASEGVGLGLDFLRHVERTRVL
CCCCCCCEEEEEECCCCCEEEECCCCCEEEECCCHHHCCCCCCCCCCHHHHHHHHHCEEE
IHVIDISSVEGRDPYDDFLKINEELKRYSVKLYDRPQIIAANKSDMLFDEEKFEEFKTKV
EEEEEECCCCCCCCHHHHHHHHHHHHHEEEEEECCCEEEEECCCCCCCCHHHHHHHHHHH
EKHGYNKVFKISAATKQGVDDLMKEAARLLSTILVTDLEISEEDRFIEEEKRFTYSIRKE
HHCCCCEEEEEECHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCEEEEEEEC
DNTYIVEGSFVDRLLNAVNVNDPDDLRYFHKVLKNKGVMEELMEMGIEDGDVVRLNDFEF
CCEEEEECHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCCCEEEEECCCE
DFLL
EEEC
>Mature Secondary Structure
MFIDTAKIFVKSGKGGDGSISFRREKYIAFGGPDGGDGGKGGNVVLVVDPNMTTLLDFTY
CEECCEEEEEECCCCCCCCEEEEEEEEEEECCCCCCCCCCCCCEEEEECCCCCEEEEEHH
KRKYKAEPGGNGAGSKCFGKNGKDLHIKVPMGTIVKDAETDKIMADLSKPEDSYVVAKGG
HHEEECCCCCCCCCCCCCCCCCCEEEEEECCCHHCCCCCHHHHHHHCCCCCCCEEEEECC
RGGKGNCRFTTPTRQAPDFAEPGMPEEERWIKLELKLLADVGLIGFPNVGKSTLLSVVSK
CCCCCCEEECCCCCCCCCCCCCCCCCCHHEEEEEEEEECCCCCCCCCCCCHHHHHHHHHH
ARPKIANYHFTTLKPNLGVVSIEGVNNFVIADIPGIIEGASEGVGLGLDFLRHVERTRVL
CCCCCCCEEEEEECCCCCEEEECCCCCEEEECCCHHHCCCCCCCCCCHHHHHHHHHCEEE
IHVIDISSVEGRDPYDDFLKINEELKRYSVKLYDRPQIIAANKSDMLFDEEKFEEFKTKV
EEEEEECCCCCCCCHHHHHHHHHHHHHEEEEEECCCEEEEECCCCCCCCHHHHHHHHHHH
EKHGYNKVFKISAATKQGVDDLMKEAARLLSTILVTDLEISEEDRFIEEEKRFTYSIRKE
HHCCCCEEEEEECHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCEEEEEEEC
DNTYIVEGSFVDRLLNAVNVNDPDDLRYFHKVLKNKGVMEELMEMGIEDGDVVRLNDFEF
CCEEEEECHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCCCEEEEECCCE
DFLL
EEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA