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The map label for this gene is selB [H]

Identifier: 148380926

GI number: 148380926

Start: 3168726

End: 3170633

Strand: Reverse

Name: selB [H]

Synonym: CBO2975

Alternate gene names: 148380926

Gene position: 3170633-3168726 (Counterclockwise)

Preceding gene: 148380927

Following gene: 148380925

Centisome position: 81.57

GC content: 29.4

Gene sequence:

>1908_bases
ATGAAGAACGTAATAATAGGAACAGCTGGACATATAGATCATGGTAAAACCACTTTAATAAAAGCATTAACAGGAAGAGA
AACAGATACTCTTAGAGAAGAAAAAGATAGAGGTATATCTATTAATTTAGGTTTTACATTTTTTGATCTACCTTCAGGGA
AAAGGGCAGGGATTGTAGATGTACCAGGACATGAAAAGTTTGTTAAGAATATGTTAGCTGGAGTAAGTGGTATAGATGTA
GTTCTTATGGTTATTGCTTCAGATGAAGGCATTATGCCTCAAACTAAAGAGCATTTAGAAATACTCCAATTACTTAATGT
TAATAAAGGTATAATTGTTCTTACGAAAACTGATATGGTGGAGCCAGAGTGGTTAGACATGGTTAAAGAAGACTTAAGGG
AAGAGCTAAAAGATACTTTTTTAGAAAATGCGGATATATATCCAGTATCTTCTAAGACTAAAGAAGGAATAGATGAATTA
ATAAAAGCTATAGATAACATGACAGAACATATAGAAACGAAAGATATACAGGGTCACTTTAGGTTACCTGTAGATAGAGT
TTTCTCTATAATGGGTTTTGGAACTGTAGTAACAGGTACAGTAATTAGTGGTTCTATAAAAGAAGGACAAACCGTTCAGA
TTTATCCTTCAAAGGTTGTTACAAAGGTTAGGGGAATTCAAGTACATGATGAGCCAACTAAAATAGCAGAGGCAGGACAA
AGATGTGCAATAAACTTATCTAATATAAAAAAGACAGATGTAGATAGGGGAGATATAGTATCTATAGAAAATCTAATGGA
ACCATCTATGATGATAGATTGTAAGTTATATTATTTAAAAAGTGCATCAAAGCCACTGGAAAATAGGCAAAGAGTTAGAT
TATATCATGGAACTAGTGAAATAATATGTAGAGTTGTTATATTAGACAAAGAATATCTAAATCCAGGGGAGGAAGGATAT
GTTCAATTAAGATTAGAAAAACCTATAACTTGTCAGAGAAATGATAGATATGTTATGAGATCCTATTCTCCAATGGTAAC
TATAGCAGGAGGTTCTATAATAGATCCATTGCCTAAAAAGGCAAAACGATTTAATGAAAAATATATAGAAGAACTAAAAC
TAAAAGAAAGTGGAGATACTTCTAATATAATAGAAAAAATTATAGAAAAATTAAGCTCTAAATTCCCAAATGAGGATGAA
ATATTAAAAGCATTAGGAAAAAATGAAGAGAATATATCAGATGAAATAGAAGAATTAATAAAGTTACAAAAGATAGTATC
TTTTAGTAATGGAGATAAAAAAGTATATACCCATATAAACTATATAGATAAAAAAGTAAAAGAAATGACATCTATATTAA
AAGAGTTTCACCAAAAAAATCCTCTTAAATGGGGAGTTTCTAAAGAAGAGTTAAGAATAAGAGCTTTAGGTAAAGATATA
AAACAAAAAACTTATGATAAACTTTTAGAGCTTTTAGAGAGCAAGGAACTAATAAAAATTCATGGAAAATATATTTCAGA
GCATGATTTTAATGTAGAGTTTAACAAAGAACAAAAGGCTATTTATGATAGAATAATAGTTAACTATAAAAAAGAAAAAT
ACAGTCCACCTAAATATGAAGAACTTATTTCCCGGGAACAAAATGAAATAGAATTTAAAAGAGTTTATGAAGCTGTATTA
GAAGAGGGGACCTTGTTTAAAGTAAATGAGGACTGCATACTTTTAACATCAGATTATAATGAAGCAAAAGAAAAGGTAAA
GAAATATATAGAGGATAATGGGAAAATAACAGTAGCAGAGTTTAGAGATATGATGGATACTAGTAGAAAGTATTCTTTAG
CCATATTAGAACATTTTGATGGAATAAAATTTACAAAGAGAAATGGAGACGAAAGAGTCTTATATTAA

Upstream 100 bases:

>100_bases
TGAAGTAATATTAGACGTGAGAACTTTATTTGAGAGAGATTTTAATATAATAGTAGAAGAATTTAAAAAATTATTAAAAT
AATTGAGAATGGTGATGTTT

Downstream 100 bases:

>100_bases
GGAAATTGCGACTTAAAAGGAAGTTATACTACCCGTGATTTAAAAAAGGGATATGTGGTTAGAAAGGCAGCTCACTTCAA
TAAGAGATTCTAACTTGTTT

Product: selenocysteine-specific translation elongation factor

Products: NA

Alternate protein names: SelB translation factor [H]

Number of amino acids: Translated: 635; Mature: 635

Protein sequence:

>635_residues
MKNVIIGTAGHIDHGKTTLIKALTGRETDTLREEKDRGISINLGFTFFDLPSGKRAGIVDVPGHEKFVKNMLAGVSGIDV
VLMVIASDEGIMPQTKEHLEILQLLNVNKGIIVLTKTDMVEPEWLDMVKEDLREELKDTFLENADIYPVSSKTKEGIDEL
IKAIDNMTEHIETKDIQGHFRLPVDRVFSIMGFGTVVTGTVISGSIKEGQTVQIYPSKVVTKVRGIQVHDEPTKIAEAGQ
RCAINLSNIKKTDVDRGDIVSIENLMEPSMMIDCKLYYLKSASKPLENRQRVRLYHGTSEIICRVVILDKEYLNPGEEGY
VQLRLEKPITCQRNDRYVMRSYSPMVTIAGGSIIDPLPKKAKRFNEKYIEELKLKESGDTSNIIEKIIEKLSSKFPNEDE
ILKALGKNEENISDEIEELIKLQKIVSFSNGDKKVYTHINYIDKKVKEMTSILKEFHQKNPLKWGVSKEELRIRALGKDI
KQKTYDKLLELLESKELIKIHGKYISEHDFNVEFNKEQKAIYDRIIVNYKKEKYSPPKYEELISREQNEIEFKRVYEAVL
EEGTLFKVNEDCILLTSDYNEAKEKVKKYIEDNGKITVAEFRDMMDTSRKYSLAILEHFDGIKFTKRNGDERVLY

Sequences:

>Translated_635_residues
MKNVIIGTAGHIDHGKTTLIKALTGRETDTLREEKDRGISINLGFTFFDLPSGKRAGIVDVPGHEKFVKNMLAGVSGIDV
VLMVIASDEGIMPQTKEHLEILQLLNVNKGIIVLTKTDMVEPEWLDMVKEDLREELKDTFLENADIYPVSSKTKEGIDEL
IKAIDNMTEHIETKDIQGHFRLPVDRVFSIMGFGTVVTGTVISGSIKEGQTVQIYPSKVVTKVRGIQVHDEPTKIAEAGQ
RCAINLSNIKKTDVDRGDIVSIENLMEPSMMIDCKLYYLKSASKPLENRQRVRLYHGTSEIICRVVILDKEYLNPGEEGY
VQLRLEKPITCQRNDRYVMRSYSPMVTIAGGSIIDPLPKKAKRFNEKYIEELKLKESGDTSNIIEKIIEKLSSKFPNEDE
ILKALGKNEENISDEIEELIKLQKIVSFSNGDKKVYTHINYIDKKVKEMTSILKEFHQKNPLKWGVSKEELRIRALGKDI
KQKTYDKLLELLESKELIKIHGKYISEHDFNVEFNKEQKAIYDRIIVNYKKEKYSPPKYEELISREQNEIEFKRVYEAVL
EEGTLFKVNEDCILLTSDYNEAKEKVKKYIEDNGKITVAEFRDMMDTSRKYSLAILEHFDGIKFTKRNGDERVLY
>Mature_635_residues
MKNVIIGTAGHIDHGKTTLIKALTGRETDTLREEKDRGISINLGFTFFDLPSGKRAGIVDVPGHEKFVKNMLAGVSGIDV
VLMVIASDEGIMPQTKEHLEILQLLNVNKGIIVLTKTDMVEPEWLDMVKEDLREELKDTFLENADIYPVSSKTKEGIDEL
IKAIDNMTEHIETKDIQGHFRLPVDRVFSIMGFGTVVTGTVISGSIKEGQTVQIYPSKVVTKVRGIQVHDEPTKIAEAGQ
RCAINLSNIKKTDVDRGDIVSIENLMEPSMMIDCKLYYLKSASKPLENRQRVRLYHGTSEIICRVVILDKEYLNPGEEGY
VQLRLEKPITCQRNDRYVMRSYSPMVTIAGGSIIDPLPKKAKRFNEKYIEELKLKESGDTSNIIEKIIEKLSSKFPNEDE
ILKALGKNEENISDEIEELIKLQKIVSFSNGDKKVYTHINYIDKKVKEMTSILKEFHQKNPLKWGVSKEELRIRALGKDI
KQKTYDKLLELLESKELIKIHGKYISEHDFNVEFNKEQKAIYDRIIVNYKKEKYSPPKYEELISREQNEIEFKRVYEAVL
EEGTLFKVNEDCILLTSDYNEAKEKVKKYIEDNGKITVAEFRDMMDTSRKYSLAILEHFDGIKFTKRNGDERVLY

Specific function: Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP [H]

COG id: COG3276

COG function: function code J; Selenocysteine-specific translation elongation factor

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. SelB subfamily [H]

Homologues:

Organism=Homo sapiens, GI34147630, Length=371, Percent_Identity=29.6495956873315, Blast_Score=158, Evalue=2e-38,
Organism=Homo sapiens, GI54607086, Length=398, Percent_Identity=28.391959798995, Blast_Score=149, Evalue=1e-35,
Organism=Homo sapiens, GI194097354, Length=309, Percent_Identity=29.126213592233, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI194018520, Length=309, Percent_Identity=29.126213592233, Blast_Score=97, Evalue=5e-20,
Organism=Homo sapiens, GI194018522, Length=329, Percent_Identity=28.2674772036474, Blast_Score=97, Evalue=7e-20,
Organism=Homo sapiens, GI46094014, Length=329, Percent_Identity=28.8753799392097, Blast_Score=96, Evalue=9e-20,
Organism=Homo sapiens, GI5729864, Length=392, Percent_Identity=24.4897959183673, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI223555963, Length=392, Percent_Identity=24.4897959183673, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI4503507, Length=259, Percent_Identity=27.4131274131274, Blast_Score=93, Evalue=6e-19,
Organism=Homo sapiens, GI53729339, Length=232, Percent_Identity=29.7413793103448, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI53729337, Length=232, Percent_Identity=29.7413793103448, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI82546879, Length=404, Percent_Identity=25, Blast_Score=83, Evalue=8e-16,
Organism=Escherichia coli, GI2367247, Length=637, Percent_Identity=30.1412872841444, Blast_Score=291, Evalue=1e-79,
Organism=Escherichia coli, GI1790412, Length=369, Percent_Identity=30.8943089430894, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI1789737, Length=369, Percent_Identity=30.8943089430894, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI1789108, Length=282, Percent_Identity=28.0141843971631, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1789559, Length=212, Percent_Identity=30.6603773584906, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI25141371, Length=384, Percent_Identity=32.5520833333333, Blast_Score=159, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI17556456, Length=448, Percent_Identity=27.0089285714286, Blast_Score=137, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17506081, Length=259, Percent_Identity=28.957528957529, Blast_Score=106, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17509919, Length=272, Percent_Identity=26.1029411764706, Blast_Score=97, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI32566303, Length=240, Percent_Identity=28.3333333333333, Blast_Score=90, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI32566629, Length=331, Percent_Identity=25.0755287009063, Blast_Score=77, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI115532067, Length=279, Percent_Identity=25.8064516129032, Blast_Score=75, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI115532065, Length=273, Percent_Identity=26.007326007326, Blast_Score=75, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI71994658, Length=266, Percent_Identity=25.187969924812, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324761, Length=305, Percent_Identity=31.4754098360656, Blast_Score=138, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6325337, Length=268, Percent_Identity=29.1044776119403, Blast_Score=100, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6319594, Length=268, Percent_Identity=29.1044776119403, Blast_Score=100, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6320863, Length=262, Percent_Identity=27.4809160305344, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6324550, Length=175, Percent_Identity=29.1428571428571, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6320377, Length=309, Percent_Identity=25.2427184466019, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI281363316, Length=384, Percent_Identity=27.8645833333333, Blast_Score=165, Evalue=7e-41,
Organism=Drosophila melanogaster, GI17864358, Length=384, Percent_Identity=27.8645833333333, Blast_Score=165, Evalue=7e-41,
Organism=Drosophila melanogaster, GI19921738, Length=388, Percent_Identity=29.1237113402062, Blast_Score=157, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24647046, Length=262, Percent_Identity=29.7709923664122, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24647048, Length=262, Percent_Identity=29.7709923664122, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI19922690, Length=367, Percent_Identity=26.9754768392371, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI45553807, Length=270, Percent_Identity=28.5185185185185, Blast_Score=102, Evalue=1e-21,
Organism=Drosophila melanogaster, GI45553816, Length=270, Percent_Identity=28.5185185185185, Blast_Score=102, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24651721, Length=270, Percent_Identity=28.5185185185185, Blast_Score=102, Evalue=1e-21,
Organism=Drosophila melanogaster, GI17864154, Length=270, Percent_Identity=28.5185185185185, Blast_Score=102, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24652838, Length=282, Percent_Identity=26.5957446808511, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI17137572, Length=282, Percent_Identity=26.5957446808511, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI17137380, Length=359, Percent_Identity=24.7910863509749, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI45550900, Length=307, Percent_Identity=23.7785016286645, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28572034, Length=117, Percent_Identity=33.3333333333333, Blast_Score=71, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015189
- InterPro:   IPR015190
- InterPro:   IPR015191
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR009001
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR004535
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2; PF09105 SelB-wing_1; PF09106 SelB-wing_2; PF09107 SelB-wing_3 [H]

EC number: NA

Molecular weight: Translated: 72860; Mature: 72860

Theoretical pI: Translated: 6.48; Mature: 6.48

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNVIIGTAGHIDHGKTTLIKALTGRETDTLREEKDRGISINLGFTFFDLPSGKRAGIVD
CCCEEEECCCCCCCCHHHHHHHHCCCCHHHHHHHHCCCEEEEECEEEEECCCCCCCCEEE
VPGHEKFVKNMLAGVSGIDVVLMVIASDEGIMPQTKEHLEILQLLNVNKGIIVLTKTDMV
CCCHHHHHHHHHHCCCCHHEEEEEEECCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCC
EPEWLDMVKEDLREELKDTFLENADIYPVSSKTKEGIDELIKAIDNMTEHIETKDIQGHF
CHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
RLPVDRVFSIMGFGTVVTGTVISGSIKEGQTVQIYPSKVVTKVRGIQVHDEPTKIAEAGQ
CCCHHHHHHHHHCCHHHCCCEEECCCCCCCEEEEECHHHHHHHHCEEECCCCHHHHHCCC
RCAINLSNIKKTDVDRGDIVSIENLMEPSMMIDCKLYYLKSASKPLENRQRVRLYHGTSE
EEEEECCCCCCCCCCCCCEEEHHHHCCCCEEEEEEEEEECCCCCCCCCCCEEEEEECCHH
IICRVVILDKEYLNPGEEGYVQLRLEKPITCQRNDRYVMRSYSPMVTIAGGSIIDPLPKK
HEEEEEEEEHHHCCCCCCCEEEEEECCCCCCCCCCCEEEECCCCEEEECCCCCCCCCCHH
AKRFNEKYIEELKLKESGDTSNIIEKIIEKLSSKFPNEDEILKALGKNEENISDEIEELI
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHH
KLQKIVSFSNGDKKVYTHINYIDKKVKEMTSILKEFHQKNPLKWGVSKEELRIRALGKDI
HHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
KQKTYDKLLELLESKELIKIHGKYISEHDFNVEFNKEQKAIYDRIIVNYKKEKYSPPKYE
HHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEECCHHHHHHHHHHHHHHHHCCCCCHHH
ELISREQNEIEFKRVYEAVLEEGTLFKVNEDCILLTSDYNEAKEKVKKYIEDNGKITVAE
HHHCCCCHHHHHHHHHHHHHCCCCEEEECCCEEEEECCCHHHHHHHHHHHHCCCCEEHHH
FRDMMDTSRKYSLAILEHFDGIKFTKRNGDERVLY
HHHHHHCCCHHEEHHHHHCCCCEEECCCCCCCCCC
>Mature Secondary Structure
MKNVIIGTAGHIDHGKTTLIKALTGRETDTLREEKDRGISINLGFTFFDLPSGKRAGIVD
CCCEEEECCCCCCCCHHHHHHHHCCCCHHHHHHHHCCCEEEEECEEEEECCCCCCCCEEE
VPGHEKFVKNMLAGVSGIDVVLMVIASDEGIMPQTKEHLEILQLLNVNKGIIVLTKTDMV
CCCHHHHHHHHHHCCCCHHEEEEEEECCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCC
EPEWLDMVKEDLREELKDTFLENADIYPVSSKTKEGIDELIKAIDNMTEHIETKDIQGHF
CHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
RLPVDRVFSIMGFGTVVTGTVISGSIKEGQTVQIYPSKVVTKVRGIQVHDEPTKIAEAGQ
CCCHHHHHHHHHCCHHHCCCEEECCCCCCCEEEEECHHHHHHHHCEEECCCCHHHHHCCC
RCAINLSNIKKTDVDRGDIVSIENLMEPSMMIDCKLYYLKSASKPLENRQRVRLYHGTSE
EEEEECCCCCCCCCCCCCEEEHHHHCCCCEEEEEEEEEECCCCCCCCCCCEEEEEECCHH
IICRVVILDKEYLNPGEEGYVQLRLEKPITCQRNDRYVMRSYSPMVTIAGGSIIDPLPKK
HEEEEEEEEHHHCCCCCCCEEEEEECCCCCCCCCCCEEEECCCCEEEECCCCCCCCCCHH
AKRFNEKYIEELKLKESGDTSNIIEKIIEKLSSKFPNEDEILKALGKNEENISDEIEELI
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHH
KLQKIVSFSNGDKKVYTHINYIDKKVKEMTSILKEFHQKNPLKWGVSKEELRIRALGKDI
HHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
KQKTYDKLLELLESKELIKIHGKYISEHDFNVEFNKEQKAIYDRIIVNYKKEKYSPPKYE
HHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEECCHHHHHHHHHHHHHHHHCCCCCHHH
ELISREQNEIEFKRVYEAVLEEGTLFKVNEDCILLTSDYNEAKEKVKKYIEDNGKITVAE
HHHCCCCHHHHHHHHHHHHHCCCCEEEECCCEEEEECCCHHHHHHHHHHHHCCCCEEHHH
FRDMMDTSRKYSLAILEHFDGIKFTKRNGDERVLY
HHHHHHCCCHHEEHHHHHCCCCEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8893853 [H]