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The map label for this gene is comEC [H]

Identifier: 148380921

GI number: 148380921

Start: 3160254

End: 3162041

Strand: Reverse

Name: comEC [H]

Synonym: CBO2969

Alternate gene names: 148380921

Gene position: 3162041-3160254 (Counterclockwise)

Preceding gene: 148380922

Following gene: 148380920

Centisome position: 81.35

GC content: 22.37

Gene sequence:

>1788_bases
ATGGAAAAACCACTGATTTATTATGCTATTTCAGTTTTTTTGGGATGTATTTCTATCTTGTTATTATTTAATAATATATT
ATTAGGTGCAGTATTTACTGCATCTTTTTTAATAATTATTTTTATAAATGAGGATAGCAAAAATTTTATTATAATTTTAT
TATTTTTTATCTTGGCTATGTTTAGTTTTTACAGTTATTTCACTATAGATGTTCCAGATAATATTAAAGTTAGGATTGTA
AAAAAAGAAAAATATTATTGTTTTGGAGACTATAAGGGAAGAAATATTTTTATAATAGGGAAGACTAAAGATTTAAAAGA
AGGGCTGAAAACTACAATAGAGGGCGAATTTACAAGAGATATTAGATATAGGGGTGGATCTTTGGGAAGTTTTAAAGTAA
AAAAAGTAAAAGGAAAAGAAGAAGATATAGTATATAATATATATAATTTTAAATCTATAGCCTATAATAAATTTAAAGAA
CAGTTAGGAGAAAATAAGACTGCTATGGTAATGTCTTTATGCTTTGGAGAAACTAAATATATATCTAATAGTGATAAAGA
TATATTAAAGAAATTAGGTGTTATACATGCAGTTAGTGTATCTGGTTTTCATATGGCTATAATATATAAGCTCCTAGAGA
GGGTATTAGGTCTTGCCTTAGCTATCCCAGTATCTTTTTTATATGTAATCTTAACAGGAATGAAATCATCCGCTATAAGA
GCTTTTATAATGATTATAATATTAAAGCTTTCTAAAAAGGTTTTTAGAAAGTATGATAGTTTATCTTCTATAAGTTTAGC
AGCTATAATAATATTATTAAATAAGCCATATTACATATTGGATATAGGATTTATGTTATCTTTTTTATCTACCCTAGGTA
TATTATTATATAATAAAAAAATATCTAGGACTCTTTATAAATTGCCACAGAGAATTAATTCTTGTCTAAGTCTTACGTTG
AGTTCTCAGATATATACATTTCCCTATATGTGTTTTACCATTCAAAGCTTTGGATTAGGTTTTATAATAGGAAATTTAGT
GTTAGTACCTCTTTATGCTCCTATAGTATTATTAGGAAATTTAGCAATGCTTTTAATAAAAATACCTTTTGTATTTAAGA
TTATAAATAAAATTATATATATTTTTTTAATAATGATAGAAGGAGCTCAGTATTTACTCTCTAATATAACTCCAGATTGT
ATTTATATAAGAGAGTTTGAGGGGATATGTTTTGTGATTATATATATGAGTTATGTGTTATACAAGCATGGTTATAAAAA
TGTAAAATATATTCCATTAAGTTGTATAATGTTTTTGATTCTATTCAACTATACTTTTTTCCCAAGTATAGATTTTTATA
GAGAAAAAGATTATAATATTACAGTTGTAAGATATAAGTTTGATACAATCATGCTTTGTAATTATGAAAGTAATGCAAGT
AAAGACATATTAAAAATAAAACATCAGGTAAAACCAGATAAAGTAGTTACAAATATAAAAAATAATACAAAGATAAATTT
AGATAGAAATTTAAAAATCTATATTTTAAGTTGTAAAAAAGAACCTAATTTTTATAATGAAAGGTCAATAGAAAATAAGG
GGAAATATAGTAATGTAAATATTTTATTAAAAAATAAAAACAAAAATATAATTTTTACAGAAAAACCTATTAGATTAAAA
AGTCCTAAAAATAAATATGTTATAATAAATTTAAAAGAAAAAAATTATACAGATATTTTAAGTAAAAGATATATAGTAGT
TTTTAATAAAATTTTATGTTTAAAATAA

Upstream 100 bases:

>100_bases
AAGGAAATAAAAAATATGCTGAAGTTATGAATATAGAATATAATGAATATACGAAAAGTGTTCAAATAGTAGCAAAACTT
CAAAGTTAAGGAGATAGTTT

Downstream 100 bases:

>100_bases
AGGAAATGTTAAATAAGGAGTGAACATTTTGTTAGATATACTAGAGTTTGAACAAAATACAAAGAAATATATAAATAATA
ATTGTTATATTTTTTGTGGA

Product: ComEC/Rec2 family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 595; Mature: 595

Protein sequence:

>595_residues
MEKPLIYYAISVFLGCISILLLFNNILLGAVFTASFLIIIFINEDSKNFIIILLFFILAMFSFYSYFTIDVPDNIKVRIV
KKEKYYCFGDYKGRNIFIIGKTKDLKEGLKTTIEGEFTRDIRYRGGSLGSFKVKKVKGKEEDIVYNIYNFKSIAYNKFKE
QLGENKTAMVMSLCFGETKYISNSDKDILKKLGVIHAVSVSGFHMAIIYKLLERVLGLALAIPVSFLYVILTGMKSSAIR
AFIMIIILKLSKKVFRKYDSLSSISLAAIIILLNKPYYILDIGFMLSFLSTLGILLYNKKISRTLYKLPQRINSCLSLTL
SSQIYTFPYMCFTIQSFGLGFIIGNLVLVPLYAPIVLLGNLAMLLIKIPFVFKIINKIIYIFLIMIEGAQYLLSNITPDC
IYIREFEGICFVIIYMSYVLYKHGYKNVKYIPLSCIMFLILFNYTFFPSIDFYREKDYNITVVRYKFDTIMLCNYESNAS
KDILKIKHQVKPDKVVTNIKNNTKINLDRNLKIYILSCKKEPNFYNERSIENKGKYSNVNILLKNKNKNIIFTEKPIRLK
SPKNKYVIINLKEKNYTDILSKRYIVVFNKILCLK

Sequences:

>Translated_595_residues
MEKPLIYYAISVFLGCISILLLFNNILLGAVFTASFLIIIFINEDSKNFIIILLFFILAMFSFYSYFTIDVPDNIKVRIV
KKEKYYCFGDYKGRNIFIIGKTKDLKEGLKTTIEGEFTRDIRYRGGSLGSFKVKKVKGKEEDIVYNIYNFKSIAYNKFKE
QLGENKTAMVMSLCFGETKYISNSDKDILKKLGVIHAVSVSGFHMAIIYKLLERVLGLALAIPVSFLYVILTGMKSSAIR
AFIMIIILKLSKKVFRKYDSLSSISLAAIIILLNKPYYILDIGFMLSFLSTLGILLYNKKISRTLYKLPQRINSCLSLTL
SSQIYTFPYMCFTIQSFGLGFIIGNLVLVPLYAPIVLLGNLAMLLIKIPFVFKIINKIIYIFLIMIEGAQYLLSNITPDC
IYIREFEGICFVIIYMSYVLYKHGYKNVKYIPLSCIMFLILFNYTFFPSIDFYREKDYNITVVRYKFDTIMLCNYESNAS
KDILKIKHQVKPDKVVTNIKNNTKINLDRNLKIYILSCKKEPNFYNERSIENKGKYSNVNILLKNKNKNIIFTEKPIRLK
SPKNKYVIINLKEKNYTDILSKRYIVVFNKILCLK
>Mature_595_residues
MEKPLIYYAISVFLGCISILLLFNNILLGAVFTASFLIIIFINEDSKNFIIILLFFILAMFSFYSYFTIDVPDNIKVRIV
KKEKYYCFGDYKGRNIFIIGKTKDLKEGLKTTIEGEFTRDIRYRGGSLGSFKVKKVKGKEEDIVYNIYNFKSIAYNKFKE
QLGENKTAMVMSLCFGETKYISNSDKDILKKLGVIHAVSVSGFHMAIIYKLLERVLGLALAIPVSFLYVILTGMKSSAIR
AFIMIIILKLSKKVFRKYDSLSSISLAAIIILLNKPYYILDIGFMLSFLSTLGILLYNKKISRTLYKLPQRINSCLSLTL
SSQIYTFPYMCFTIQSFGLGFIIGNLVLVPLYAPIVLLGNLAMLLIKIPFVFKIINKIIYIFLIMIEGAQYLLSNITPDC
IYIREFEGICFVIIYMSYVLYKHGYKNVKYIPLSCIMFLILFNYTFFPSIDFYREKDYNITVVRYKFDTIMLCNYESNAS
KDILKIKHQVKPDKVVTNIKNNTKINLDRNLKIYILSCKKEPNFYNERSIENKGKYSNVNILLKNKNKNIIFTEKPIRLK
SPKNKYVIINLKEKNYTDILSKRYIVVFNKILCLK

Specific function: The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding [H]

COG id: COG0658

COG function: function code R; Predicted membrane metal-binding protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 68992; Mature: 68992

Theoretical pI: Translated: 10.07; Mature: 10.07

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKPLIYYAISVFLGCISILLLFNNILLGAVFTASFLIIIFINEDSKNFIIILLFFILAM
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEECCCCCHHHHHHHHHHHH
FSFYSYFTIDVPDNIKVRIVKKEKYYCFGDYKGRNIFIIGKTKDLKEGLKTTIEGEFTRD
HHHHCEEEEECCCCCEEEEEEECCEEEEECCCCCEEEEEECCHHHHHHHHHCCCCCEEEH
IRYRGGSLGSFKVKKVKGKEEDIVYNIYNFKSIAYNKFKEQLGENKTAMVMSLCFGETKY
HHCCCCCCCCEEEEEECCCCCCEEEEEECHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCC
ISNSDKDILKKLGVIHAVSVSGFHMAIIYKLLERVLGLALAIPVSFLYVILTGMKSSAIR
CCCCCHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
AFIMIIILKLSKKVFRKYDSLSSISLAAIIILLNKPYYILDIGFMLSFLSTLGILLYNKK
HHHHHHHHHHHHHHHHHHCCCCHHHHEEEEEEECCCEEEEEHHHHHHHHHHHHHHHHHHH
ISRTLYKLPQRINSCLSLTLSSQIYTFPYMCFTIQSFGLGFIIGNLVLVPLYAPIVLLGN
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
LAMLLIKIPFVFKIINKIIYIFLIMIEGAQYLLSNITPDCIYIREFEGICFVIIYMSYVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHH
YKHGYKNVKYIPLSCIMFLILFNYTFFPSIDFYREKDYNITVVRYKFDTIMLCNYESNAS
HHCCCCCCEEEHHHHHHHHHHHCCHHCCCCCCEECCCCEEEEEEEEEEEEEEEECCCCCC
KDILKIKHQVKPDKVVTNIKNNTKINLDRNLKIYILSCKKEPNFYNERSIENKGKYSNVN
HHHHHHHHHCCCCHHHHCCCCCCEEEECCCEEEEEEEECCCCCCCCCCCCCCCCCCCEEE
ILLKNKNKNIIFTEKPIRLKSPKNKYVIINLKEKNYTDILSKRYIVVFNKILCLK
EEEEECCCCEEEECCCEEECCCCCCEEEEEECCCCHHHHHHCCHHEEEHHHHHCC
>Mature Secondary Structure
MEKPLIYYAISVFLGCISILLLFNNILLGAVFTASFLIIIFINEDSKNFIIILLFFILAM
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEECCCCCHHHHHHHHHHHH
FSFYSYFTIDVPDNIKVRIVKKEKYYCFGDYKGRNIFIIGKTKDLKEGLKTTIEGEFTRD
HHHHCEEEEECCCCCEEEEEEECCEEEEECCCCCEEEEEECCHHHHHHHHHCCCCCEEEH
IRYRGGSLGSFKVKKVKGKEEDIVYNIYNFKSIAYNKFKEQLGENKTAMVMSLCFGETKY
HHCCCCCCCCEEEEEECCCCCCEEEEEECHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCC
ISNSDKDILKKLGVIHAVSVSGFHMAIIYKLLERVLGLALAIPVSFLYVILTGMKSSAIR
CCCCCHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
AFIMIIILKLSKKVFRKYDSLSSISLAAIIILLNKPYYILDIGFMLSFLSTLGILLYNKK
HHHHHHHHHHHHHHHHHHCCCCHHHHEEEEEEECCCEEEEEHHHHHHHHHHHHHHHHHHH
ISRTLYKLPQRINSCLSLTLSSQIYTFPYMCFTIQSFGLGFIIGNLVLVPLYAPIVLLGN
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
LAMLLIKIPFVFKIINKIIYIFLIMIEGAQYLLSNITPDCIYIREFEGICFVIIYMSYVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHH
YKHGYKNVKYIPLSCIMFLILFNYTFFPSIDFYREKDYNITVVRYKFDTIMLCNYESNAS
HHCCCCCCEEEHHHHHHHHHHHCCHHCCCCCCEECCCCEEEEEEEEEEEEEEEECCCCCC
KDILKIKHQVKPDKVVTNIKNNTKINLDRNLKIYILSCKKEPNFYNERSIENKGKYSNVN
HHHHHHHHHCCCCHHHHCCCCCCEEEECCCEEEEEEEECCCCCCCCCCCCCCCCCCCEEE
ILLKNKNKNIIFTEKPIRLKSPKNKYVIINLKEKNYTDILSKRYIVVFNKILCLK
EEEEECCCCEEEECCCEEECCCCCCEEEEEECCCCHHHHHHCCHHEEEHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]