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The map label for this gene is napA [H]

Identifier: 148380811

GI number: 148380811

Start: 3031592

End: 3032809

Strand: Reverse

Name: napA [H]

Synonym: CBO2853

Alternate gene names: 148380811

Gene position: 3032809-3031592 (Counterclockwise)

Preceding gene: 148380812

Following gene: 148380810

Centisome position: 78.03

GC content: 31.28

Gene sequence:

>1218_bases
TTGTTATCTTATGAATTCTTATTAGATCTTGCGATTATATTGTTAAGTACAAAAGTCTTAGGTATGGTTACTAAAAAATT
ACACATGCCTAAGGTTGTAGGTGCATTATTAGCGGGTCTTATACTAGGACCATGTGTACTGAATATAGTACATGAAACTG
ACTTTCTAGCGAAAATGGCCCAACTAGGAGTAATTATTTTAATGTTTTCAGCAGGCTTACAAACAGATCTTAAGGAATTA
AAAAAATGTGGTAGGGCTTCCTTGATTATTGCTATATTAGGAACAGTTGTCCCTTTATTAGGAGGATACTTTGTATCAGC
ACTATTCTTTGATTCTAATGGGATCTTTGATATAACTTCAAAAGCATTTATTAAGAATTTTTTTATTGGGGTAATATTAA
CTGCTACTTCTGTTAGTATTACTGTTGAAACTTTACAAGAACTAGGCAGATTGAAAACACGTTCTGGAACAGCTATATTA
GGGGCAGCAATTATTGATGATATTTTAGGAATAATCATTTTAACTATGGTTACAAGTTCTACAAATAATTCAACAAGTAT
TAATTTAGTGCTTCTAAAAATTGTAGCATTCTTTATATTATCTACTATCTGTGGAGTAGTGTTGCATCACATTTTCAATA
GAATTTATAAACGTTATGGTAATATAAGTGGAATTTCAGCTGTTACATTTTCTTTTTGTCTAATTATGGCCTTTATTGCA
GAGCACTTTTTTGGTGTAGCAGATATAACAGGTGCTTTTATAGCTGGAGTTATTATTTCAAATACGTCTTTTCGTGAGCA
TGTAGAAAAAAATTTCGAAGTAATTTCCTATATGCTTTTATCTCCCGTATTTTTTGCCAGTATAGGTTTAAATACAACAA
TGAAACATATGAATAATAAAATGAGGCTGTTTACAATTGCATTATTACTAATGGCGATATTAGCAAAAGTCATAGGGTGT
TTTATAGGAGGAAGAATTTGCAAATACACATATGCTGAATCTCTTAGAATCGGAATTGGAATGATATCACGTGGAGAAGT
TGCCCTAATAATTGCAAAGAAAGGTGCCGCATTAGGTTTGATAGAAGCACAATTCTTCGGATCGATAGTTTTTGTAGTTA
TAGCAACTACCCTTATAACACCTATATTATTAAAGATGGTGTATAGTACTAAATTCAATGATATTAAAGCATATGATTCC
TTGCATAGTGCTGCTTAA

Upstream 100 bases:

>100_bases
TTTTGAAAAAAGGTATCTATAAAATTTAATTAAACTTAGTGTTACAATTTTGCTTAACTAAGTCAAAACCTATAATAATA
CTTTAAAGGAGGAGTTAAAT

Downstream 100 bases:

>100_bases
TATTCATGAATAAGATAAATTTTATCCTAGAAACTTTATAAATACTTTCAAAGGCAGAACTTAATTTATATATATATCTT
AACCTTTCAATGATTCAACT

Product: transporter, monovalent cation:proton antiporter-2 (CPA2) family

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MLSYEFLLDLAIILLSTKVLGMVTKKLHMPKVVGALLAGLILGPCVLNIVHETDFLAKMAQLGVIILMFSAGLQTDLKEL
KKCGRASLIIAILGTVVPLLGGYFVSALFFDSNGIFDITSKAFIKNFFIGVILTATSVSITVETLQELGRLKTRSGTAIL
GAAIIDDILGIIILTMVTSSTNNSTSINLVLLKIVAFFILSTICGVVLHHIFNRIYKRYGNISGISAVTFSFCLIMAFIA
EHFFGVADITGAFIAGVIISNTSFREHVEKNFEVISYMLLSPVFFASIGLNTTMKHMNNKMRLFTIALLLMAILAKVIGC
FIGGRICKYTYAESLRIGIGMISRGEVALIIAKKGAALGLIEAQFFGSIVFVVIATTLITPILLKMVYSTKFNDIKAYDS
LHSAA

Sequences:

>Translated_405_residues
MLSYEFLLDLAIILLSTKVLGMVTKKLHMPKVVGALLAGLILGPCVLNIVHETDFLAKMAQLGVIILMFSAGLQTDLKEL
KKCGRASLIIAILGTVVPLLGGYFVSALFFDSNGIFDITSKAFIKNFFIGVILTATSVSITVETLQELGRLKTRSGTAIL
GAAIIDDILGIIILTMVTSSTNNSTSINLVLLKIVAFFILSTICGVVLHHIFNRIYKRYGNISGISAVTFSFCLIMAFIA
EHFFGVADITGAFIAGVIISNTSFREHVEKNFEVISYMLLSPVFFASIGLNTTMKHMNNKMRLFTIALLLMAILAKVIGC
FIGGRICKYTYAESLRIGIGMISRGEVALIIAKKGAALGLIEAQFFGSIVFVVIATTLITPILLKMVYSTKFNDIKAYDS
LHSAA
>Mature_405_residues
MLSYEFLLDLAIILLSTKVLGMVTKKLHMPKVVGALLAGLILGPCVLNIVHETDFLAKMAQLGVIILMFSAGLQTDLKEL
KKCGRASLIIAILGTVVPLLGGYFVSALFFDSNGIFDITSKAFIKNFFIGVILTATSVSITVETLQELGRLKTRSGTAIL
GAAIIDDILGIIILTMVTSSTNNSTSINLVLLKIVAFFILSTICGVVLHHIFNRIYKRYGNISGISAVTFSFCLIMAFIA
EHFFGVADITGAFIAGVIISNTSFREHVEKNFEVISYMLLSPVFFASIGLNTTMKHMNNKMRLFTIALLLMAILAKVIGC
FIGGRICKYTYAESLRIGIGMISRGEVALIIAKKGAALGLIEAQFFGSIVFVVIATTLITPILLKMVYSTKFNDIKAYDS
LHSAA

Specific function: This is a Na(+)/H(+) antiporter. It can mediate sodium uptake when a transmembrane pH gradient is applied [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family [H]

Homologues:

Organism=Escherichia coli, GI1786232, Length=379, Percent_Identity=23.7467018469657, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1786685, Length=388, Percent_Identity=23.9690721649485, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1789749, Length=410, Percent_Identity=21.9512195121951, Blast_Score=65, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6322367, Length=413, Percent_Identity=26.3922518159806, Blast_Score=119, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 43866; Mature: 43866

Theoretical pI: Translated: 9.72; Mature: 9.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSYEFLLDLAIILLSTKVLGMVTKKLHMPKVVGALLAGLILGPCVLNIVHETDFLAKMA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QLGVIILMFSAGLQTDLKELKKCGRASLIIAILGTVVPLLGGYFVSALFFDSNGIFDITS
HHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHH
KAFIKNFFIGVILTATSVSITVETLQELGRLKTRSGTAILGAAIIDDILGIIILTMVTSS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
TNNSTSINLVLLKIVAFFILSTICGVVLHHIFNRIYKRYGNISGISAVTFSFCLIMAFIA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
EHFFGVADITGAFIAGVIISNTSFREHVEKNFEVISYMLLSPVFFASIGLNTTMKHMNNK
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCH
MRLFTIALLLMAILAKVIGCFIGGRICKYTYAESLRIGIGMISRGEVALIIAKKGAALGL
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCEECCCCEEEEEEECCCEEHH
IEAQFFGSIVFVVIATTLITPILLKMVYSTKFNDIKAYDSLHSAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MLSYEFLLDLAIILLSTKVLGMVTKKLHMPKVVGALLAGLILGPCVLNIVHETDFLAKMA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QLGVIILMFSAGLQTDLKELKKCGRASLIIAILGTVVPLLGGYFVSALFFDSNGIFDITS
HHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHH
KAFIKNFFIGVILTATSVSITVETLQELGRLKTRSGTAILGAAIIDDILGIIILTMVTSS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
TNNSTSINLVLLKIVAFFILSTICGVVLHHIFNRIYKRYGNISGISAVTFSFCLIMAFIA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
EHFFGVADITGAFIAGVIISNTSFREHVEKNFEVISYMLLSPVFFASIGLNTTMKHMNNK
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCH
MRLFTIALLLMAILAKVIGCFIGGRICKYTYAESLRIGIGMISRGEVALIIAKKGAALGL
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCEECCCCEEEEEEECCCEEHH
IEAQFFGSIVFVVIATTLITPILLKMVYSTKFNDIKAYDSLHSAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1312090; 1325937 [H]