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The map label for this gene is hgdC [H]

Identifier: 148380156

GI number: 148380156

Start: 2354400

End: 2356094

Strand: Direct

Name: hgdC [H]

Synonym: CBO2202

Alternate gene names: 148380156

Gene position: 2354400-2356094 (Clockwise)

Preceding gene: 148380155

Following gene: 148380165

Centisome position: 60.57

GC content: 30.68

Gene sequence:

>1695_bases
ATGATTGCATATACTTGTAAATATACCCCCCTTTCCATACTTGAAGCTTTTGATGAGGTTCCCATAAAAATAAATCCTAT
AGCATATACCTTTGATAGAGCTGATGTACTTATGCACCCAAATATATGTACATATTGTAAGTCTCTACTTGAAAATCTTA
TTGATTGTAATAGTGATCAGTTAATATTGATGAACTGCTGTGACAGCATGAGGAGACTATATGATGTTTTAAAATCCAAA
TCAAGTATTAAATATTTATATATGATGGACTTACCTCACAAAAACAATTGTTGTTCACGTATTTTACTTAAAGAATCCTT
TATTAAATTTATAAATAATTATGAGAAATTTAGTGGAAAAAAGTTTAATATTGAAAAGTTTAAACTATCTATTAAAAATC
ATATCGTTAGTAACAGTAGCTATAAAAATAATTTTAATAATAATAGAATTGCCATTCTAGGTGGTAGATGTGATGATTCT
CTTGTAAACATGATAGAAAACTGTACTGGATCATCAGTATTAAACCTTGCATGTACAGGAGAAAATTTCATATTAGACAA
ATCCCCGGATTTTTCTTCTATGAATGAACTGATTTTATGGTATGCTGAAGCTATTTTATCTCAAGCTCCTTGCATGAGAA
TGTCTGATATTTCTTACAGGAAAAAACTTATTCTTTCTAATAATATATCAGGAATTATCTATAACACAGTAAAATTCTGC
GATTATTATTCCTTTGAATATGCATCAATTAAAAAGAAAATTAATATTCCCATACTAAAGATTGAAACTGATTATACTAA
TCAAAGTAGAGGACAACTTAAAACCAGAATAGAGGCTTTTATTGAAAGACTAAAAGATAAAAGAAAAATAAGCTACAAAA
CTTTGTCCAATCTAGAAGATAACTACTATGTGGCAGGCATTGATAGTGGATCCACTTCCACAAATATAGTAATTTTAGAT
AAAGATAAAAATATAATCAGCTACTCCATAGTAAGCACTGGTGCTAAAAGTATTTATGGTGCCGAAGCTGCACTAGATAC
TGCTTTAGAAAAGGCTGATCTTTCAAAGGATAACCTTAAATATATTGTTTCCACTGGGTATGGTAGGGTAAATATTCCTT
TTGCCAATGAAAATGTTACTGAAATAACCTGTCATGGTATTGCAGCTCATCATTTAAATCCTAGTATAAGAACAGTTATG
GATATTGGAGGTCAAGACAGTAAAGTAATAAAATTAGATGAAAAGGGTAATATTAAAGACTTTGCAATGAATGACAAATG
CGCTGCAGGTACAGGCCGCTTTCTTGACATGATGGCCAGAACCCTACAAATAAGCATTGATGAAATGAGTAAGGAAGGAC
TTCATTGGGAGGAAGAACTTAAAATAACCAATATGTGTACCGTATTTGCAGAATCAGAAGTAGTTTCACTTATAGCTGAA
AACAAGGAAAAATGTGATATAATCCATGGACTTAATGATTCCATAGCTTCAAAAATGTTATCATTATTAAATAGAGTAGG
TAAAGAAGATGCCTACATGATGACTGGAGGAGTTGCAAAAAATCTAGGAGTGGTAAAGTCCTTAGAAAAAAAACTTAAAA
ACAAAATCTTCATATGTGAGGAACCTCAAATATGTGGTTCTCTAGGTGCTGCTTTAATAGCCCTTAAAAAGTATGAAGAG
GCTTTTTCAATATAA

Upstream 100 bases:

>100_bases
GAGATGGGGTTGATAGGCGAAATTCTCAGGATGGTCAGCTTCGTACCAGATTGGAAGCATTTTTTGAAATTTTAGAAAAT
AATAAAGGAGGTATTTAAAT

Downstream 100 bases:

>100_bases
AATATCTTAATTTTAAATATAGAGCAAAGATAAAAAATACATGTAATAAATGGAACCAATTGGTTTATATATTTTTTATC
TTTGCCTTTTTAAAATTAGA

Product: bifunctional 2-hydroxyacyl-CoA dehydratase/activator domain-containing protein

Products: NA

Alternate protein names: 2-hydroxyglutaryl-CoA dehydratase component A [H]

Number of amino acids: Translated: 564; Mature: 564

Protein sequence:

>564_residues
MIAYTCKYTPLSILEAFDEVPIKINPIAYTFDRADVLMHPNICTYCKSLLENLIDCNSDQLILMNCCDSMRRLYDVLKSK
SSIKYLYMMDLPHKNNCCSRILLKESFIKFINNYEKFSGKKFNIEKFKLSIKNHIVSNSSYKNNFNNNRIAILGGRCDDS
LVNMIENCTGSSVLNLACTGENFILDKSPDFSSMNELILWYAEAILSQAPCMRMSDISYRKKLILSNNISGIIYNTVKFC
DYYSFEYASIKKKINIPILKIETDYTNQSRGQLKTRIEAFIERLKDKRKISYKTLSNLEDNYYVAGIDSGSTSTNIVILD
KDKNIISYSIVSTGAKSIYGAEAALDTALEKADLSKDNLKYIVSTGYGRVNIPFANENVTEITCHGIAAHHLNPSIRTVM
DIGGQDSKVIKLDEKGNIKDFAMNDKCAAGTGRFLDMMARTLQISIDEMSKEGLHWEEELKITNMCTVFAESEVVSLIAE
NKEKCDIIHGLNDSIASKMLSLLNRVGKEDAYMMTGGVAKNLGVVKSLEKKLKNKIFICEEPQICGSLGAALIALKKYEE
AFSI

Sequences:

>Translated_564_residues
MIAYTCKYTPLSILEAFDEVPIKINPIAYTFDRADVLMHPNICTYCKSLLENLIDCNSDQLILMNCCDSMRRLYDVLKSK
SSIKYLYMMDLPHKNNCCSRILLKESFIKFINNYEKFSGKKFNIEKFKLSIKNHIVSNSSYKNNFNNNRIAILGGRCDDS
LVNMIENCTGSSVLNLACTGENFILDKSPDFSSMNELILWYAEAILSQAPCMRMSDISYRKKLILSNNISGIIYNTVKFC
DYYSFEYASIKKKINIPILKIETDYTNQSRGQLKTRIEAFIERLKDKRKISYKTLSNLEDNYYVAGIDSGSTSTNIVILD
KDKNIISYSIVSTGAKSIYGAEAALDTALEKADLSKDNLKYIVSTGYGRVNIPFANENVTEITCHGIAAHHLNPSIRTVM
DIGGQDSKVIKLDEKGNIKDFAMNDKCAAGTGRFLDMMARTLQISIDEMSKEGLHWEEELKITNMCTVFAESEVVSLIAE
NKEKCDIIHGLNDSIASKMLSLLNRVGKEDAYMMTGGVAKNLGVVKSLEKKLKNKIFICEEPQICGSLGAALIALKKYEE
AFSI
>Mature_564_residues
MIAYTCKYTPLSILEAFDEVPIKINPIAYTFDRADVLMHPNICTYCKSLLENLIDCNSDQLILMNCCDSMRRLYDVLKSK
SSIKYLYMMDLPHKNNCCSRILLKESFIKFINNYEKFSGKKFNIEKFKLSIKNHIVSNSSYKNNFNNNRIAILGGRCDDS
LVNMIENCTGSSVLNLACTGENFILDKSPDFSSMNELILWYAEAILSQAPCMRMSDISYRKKLILSNNISGIIYNTVKFC
DYYSFEYASIKKKINIPILKIETDYTNQSRGQLKTRIEAFIERLKDKRKISYKTLSNLEDNYYVAGIDSGSTSTNIVILD
KDKNIISYSIVSTGAKSIYGAEAALDTALEKADLSKDNLKYIVSTGYGRVNIPFANENVTEITCHGIAAHHLNPSIRTVM
DIGGQDSKVIKLDEKGNIKDFAMNDKCAAGTGRFLDMMARTLQISIDEMSKEGLHWEEELKITNMCTVFAESEVVSLIAE
NKEKCDIIHGLNDSIASKMLSLLNRVGKEDAYMMTGGVAKNLGVVKSLEKKLKNKIFICEEPQICGSLGAALIALKKYEE
AFSI

Specific function: Required for the activation of (R)-2-hydroxyglutaryl-CoA dehydratase. This protein is extremely sensitive towards oxygen [H]

COG id: COG1924

COG function: function code I; Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To E.coli yjiL and M.jannaschii MJ0004 and MJ0800 [H]

Homologues:

Organism=Escherichia coli, GI87082426, Length=254, Percent_Identity=39.3700787401575, Blast_Score=177, Evalue=2e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002731
- InterPro:   IPR008275 [H]

Pfam domain/function: PF01869 BcrAD_BadFG [H]

EC number: NA

Molecular weight: Translated: 63488; Mature: 63488

Theoretical pI: Translated: 7.79; Mature: 7.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAYTCKYTPLSILEAFDEVPIKINPIAYTFDRADVLMHPNICTYCKSLLENLIDCNSDQ
CEEEEECCCHHHHHHHHCCCCEEECCEEEEECCCCEEECCCHHHHHHHHHHHHHCCCCCC
LILMNCCDSMRRLYDVLKSKSSIKYLYMMDLPHKNNCCSRILLKESFIKFINNYEKFSGK
EEHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
KFNIEKFKLSIKNHIVSNSSYKNNFNNNRIAILGGRCDDSLVNMIENCTGSSVLNLACTG
EECHHHEEEEHHHHHCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHCCCCCCEEEEEECC
ENFILDKSPDFSSMNELILWYAEAILSQAPCMRMSDISYRKKLILSNNISGIIYNTVKFC
CCEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHEEECCCCCEEEEHHHHHH
DYYSFEYASIKKKINIPILKIETDYTNQSRGQLKTRIEAFIERLKDKRKISYKTLSNLED
HCCCCHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
NYYVAGIDSGSTSTNIVILDKDKNIISYSIVSTGAKSIYGAEAALDTALEKADLSKDNLK
CEEEEEECCCCCCEEEEEEECCCCEEEEEEHHCCCHHHHHHHHHHHHHHHHHCCCCCCCE
YIVSTGYGRVNIPFANENVTEITCHGIAAHHLNPSIRTVMDIGGQDSKVIKLDEKGNIKD
EEEECCCCEEEEEECCCCCEEEEECCEEEECCCCHHHHHHHCCCCCCEEEEECCCCCCCE
FAMNDKCAAGTGRFLDMMARTLQISIDEMSKEGLHWEEELKITNMCTVFAESEVVSLIAE
ECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHEEHHHHEEEHHHHHHHHHHHC
NKEKCDIIHGLNDSIASKMLSLLNRVGKEDAYMMTGGVAKNLGVVKSLEKKLKNKIFICE
CCHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHCCEEEEC
EPQICGSLGAALIALKKYEEAFSI
CCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIAYTCKYTPLSILEAFDEVPIKINPIAYTFDRADVLMHPNICTYCKSLLENLIDCNSDQ
CEEEEECCCHHHHHHHHCCCCEEECCEEEEECCCCEEECCCHHHHHHHHHHHHHCCCCCC
LILMNCCDSMRRLYDVLKSKSSIKYLYMMDLPHKNNCCSRILLKESFIKFINNYEKFSGK
EEHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
KFNIEKFKLSIKNHIVSNSSYKNNFNNNRIAILGGRCDDSLVNMIENCTGSSVLNLACTG
EECHHHEEEEHHHHHCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHCCCCCCEEEEEECC
ENFILDKSPDFSSMNELILWYAEAILSQAPCMRMSDISYRKKLILSNNISGIIYNTVKFC
CCEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHEEECCCCCEEEEHHHHHH
DYYSFEYASIKKKINIPILKIETDYTNQSRGQLKTRIEAFIERLKDKRKISYKTLSNLED
HCCCCHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
NYYVAGIDSGSTSTNIVILDKDKNIISYSIVSTGAKSIYGAEAALDTALEKADLSKDNLK
CEEEEEECCCCCCEEEEEEECCCCEEEEEEHHCCCHHHHHHHHHHHHHHHHHCCCCCCCE
YIVSTGYGRVNIPFANENVTEITCHGIAAHHLNPSIRTVMDIGGQDSKVIKLDEKGNIKD
EEEECCCCEEEEEECCCCCEEEEECCEEEECCCCHHHHHHHCCCCCCEEEEECCCCCCCE
FAMNDKCAAGTGRFLDMMARTLQISIDEMSKEGLHWEEELKITNMCTVFAESEVVSLIAE
ECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHEEHHHHEEEHHHHHHHHHHHC
NKEKCDIIHGLNDSIASKMLSLLNRVGKEDAYMMTGGVAKNLGVVKSLEKKLKNKIFICE
CCHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHCCEEEEC
EPQICGSLGAALIALKKYEEAFSI
CCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8365476; 2659350; 7607244; 11106419; 11243821 [H]