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The map label for this gene is ispA [C]

Identifier: 148379844

GI number: 148379844

Start: 2011766

End: 2012650

Strand: Reverse

Name: ispA [C]

Synonym: CBO1883

Alternate gene names: 148379844

Gene position: 2012650-2011766 (Counterclockwise)

Preceding gene: 148379845

Following gene: 148379843

Centisome position: 51.78

GC content: 29.6

Gene sequence:

>885_bases
TTGGTGAACTTTATGGATAGAATAAAAAAAATGGGAGAAGAAATAGAGTTATGGTTAAAGGAATATTTAGATAATAAAGG
TAATTATGATAAAAACATATATGAAGCTATGGCCTATAGTTTAGAGGCTGGTGGAAAAAGAATAAGACCAGTACTATTTT
TAAATACGTATAGTTTATATAAAGAAGATTATAAAAAGGCTATGCCTATAGCTGCTGCCATAGAAATGATACATACCTAT
TCTTTAATACATGATGATCTGCCAGCTATGGATAATGATGACTTAAGGAGAGGAAAACCTACCAATCATAAAATCTTTGG
AGAAGCTATAGCTATACTGGCAGGAGATGCACTTTTAAATGAAGCTATGAATATAATGTTTGAGTATTCATTAAAAAATG
GAGAAAAGGCATTAGAGGCGTGTTATGCCATAGCTAAAGCAGCAGGAGTAGATGGGATGATTGGGGGCCAGGTAGTAGAT
ATATTAAGTGAAGATAAATCTATACCTCTCGATGAGTTATATTATATGCACAAAAAAAAGACTGGTGCTTTAATAAAAGC
ATCTATATTGGCTGGAGCTATTTTAGGATCTGATACATATACAGATATAGAACTTTTAGGGGAATATGGAGATAATTTAG
GATTGGCATTTCAAATAAAAGACGATATATTAGATGTGGAAGGTGATACTACTACTTTAGGAAAAAAGACAAAGAGTGAT
GAAGATAATCATAAAACTACTTTTGTTAAAGTTTATGGTATAGAAAAATGTAATGAACTTTGTACTGAAATGACAAATAA
ATGTTTTGATATATTAAATAAAATAAAGAAAAACACAGATAAGTTAAAAGAAATTACTATGTTTTTATTAAACAGAAACT
ATTAA

Upstream 100 bases:

>100_bases
TTTTTACTAAAGACTTTGAATTAATTAAAAGAAAGTTCAGATAGAGTAATAATCTAATCTGAATTAGGATTTACTTTACA
GCTAAAATTAATATTAAGGA

Downstream 100 bases:

>100_bases
TATTAATAAAGCTTTAAATTAATTTAAATAAAAAAATAATTCTATGCAATAAATATTTTTCTGTGATATAATAGAAAATG
CTTTATACACAAAATGAATA

Product: geranyltranstransferase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MVNFMDRIKKMGEEIELWLKEYLDNKGNYDKNIYEAMAYSLEAGGKRIRPVLFLNTYSLYKEDYKKAMPIAAAIEMIHTY
SLIHDDLPAMDNDDLRRGKPTNHKIFGEAIAILAGDALLNEAMNIMFEYSLKNGEKALEACYAIAKAAGVDGMIGGQVVD
ILSEDKSIPLDELYYMHKKKTGALIKASILAGAILGSDTYTDIELLGEYGDNLGLAFQIKDDILDVEGDTTTLGKKTKSD
EDNHKTTFVKVYGIEKCNELCTEMTNKCFDILNKIKKNTDKLKEITMFLLNRNY

Sequences:

>Translated_294_residues
MVNFMDRIKKMGEEIELWLKEYLDNKGNYDKNIYEAMAYSLEAGGKRIRPVLFLNTYSLYKEDYKKAMPIAAAIEMIHTY
SLIHDDLPAMDNDDLRRGKPTNHKIFGEAIAILAGDALLNEAMNIMFEYSLKNGEKALEACYAIAKAAGVDGMIGGQVVD
ILSEDKSIPLDELYYMHKKKTGALIKASILAGAILGSDTYTDIELLGEYGDNLGLAFQIKDDILDVEGDTTTLGKKTKSD
EDNHKTTFVKVYGIEKCNELCTEMTNKCFDILNKIKKNTDKLKEITMFLLNRNY
>Mature_294_residues
MVNFMDRIKKMGEEIELWLKEYLDNKGNYDKNIYEAMAYSLEAGGKRIRPVLFLNTYSLYKEDYKKAMPIAAAIEMIHTY
SLIHDDLPAMDNDDLRRGKPTNHKIFGEAIAILAGDALLNEAMNIMFEYSLKNGEKALEACYAIAKAAGVDGMIGGQVVD
ILSEDKSIPLDELYYMHKKKTGALIKASILAGAILGSDTYTDIELLGEYGDNLGLAFQIKDDILDVEGDTTTLGKKTKSD
EDNHKTTFVKVYGIEKCNELCTEMTNKCFDILNKIKKNTDKLKEITMFLLNRNY

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=217, Percent_Identity=31.3364055299539, Blast_Score=86, Evalue=5e-17,
Organism=Escherichia coli, GI1786623, Length=298, Percent_Identity=36.9127516778523, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI1789578, Length=218, Percent_Identity=33.4862385321101, Blast_Score=99, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17505681, Length=276, Percent_Identity=28.2608695652174, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24651612, Length=252, Percent_Identity=28.5714285714286, Blast_Score=84, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 33140; Mature: 33140

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVNFMDRIKKMGEEIELWLKEYLDNKGNYDKNIYEAMAYSLEAGGKRIRPVLFLNTYSLY
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEHHHHHH
KEDYKKAMPIAAAIEMIHTYSLIHDDLPAMDNDDLRRGKPTNHKIFGEAIAILAGDALLN
HHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
EAMNIMFEYSLKNGEKALEACYAIAKAAGVDGMIGGQVVDILSEDKSIPLDELYYMHKKK
HHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHC
TGALIKASILAGAILGSDTYTDIELLGEYGDNLGLAFQIKDDILDVEGDTTTLGKKTKSD
CCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEEEEECCEEECCCCCCCCCCCCCCC
EDNHKTTFVKVYGIEKCNELCTEMTNKCFDILNKIKKNTDKLKEITMFLLNRNY
CCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MVNFMDRIKKMGEEIELWLKEYLDNKGNYDKNIYEAMAYSLEAGGKRIRPVLFLNTYSLY
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEHHHHHH
KEDYKKAMPIAAAIEMIHTYSLIHDDLPAMDNDDLRRGKPTNHKIFGEAIAILAGDALLN
HHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
EAMNIMFEYSLKNGEKALEACYAIAKAAGVDGMIGGQVVDILSEDKSIPLDELYYMHKKK
HHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHC
TGALIKASILAGAILGSDTYTDIELLGEYGDNLGLAFQIKDDILDVEGDTTTLGKKTKSD
CCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEEEEECCEEECCCCCCCCCCCCCCC
EDNHKTTFVKVYGIEKCNELCTEMTNKCFDILNKIKKNTDKLKEITMFLLNRNY
CCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8486607; 7918490 [H]