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The map label for this gene is yclK [H]

Identifier: 148378609

GI number: 148378609

Start: 706189

End: 707610

Strand: Direct

Name: yclK [H]

Synonym: CBO0608

Alternate gene names: 148378609

Gene position: 706189-707610 (Clockwise)

Preceding gene: 148378608

Following gene: 148378610

Centisome position: 18.17

GC content: 24.47

Gene sequence:

>1422_bases
ATGAAAATAAGAGATAAATTTATAACTGGTTTAATATTTATACTGATAGTTTCTATGATAGTAATGAATGTGGCAATAAC
ACATGTTTTAAAGTCTAATATGGAAAATAGTATAAATAATTTTTTAAAACAAGTAATGAATAGCACTCACGAGTATGTAA
AGTACAACCTTGTAACTAATAGTTTTAAGGATAAAAAAGAATCATTGGTTGAAGAAGGAAATTACATAATAAAACATATA
TCTTTAAATTATGAATGCAAATGTGATATAAGAGATATAAATTATATATTGATAGAAGGAAATGTTCCAGAGGAATTCAG
AAGCATAACAAAAAAAAGTAAAAAAGTAGCAATGGATGGTAAAGCCGTAGTAGATTTGAAATATAGATATAATGGAGTAG
ATGCAATACTAACTTATCCTATATATATAGATAATGAATATGTGGGGATCATAAGCATAGTAAAGAATTATGACTCGAAA
TATAGGGATTATAAAAATACTATAAATATTATAAATATTATAGAACTTGGAACATTTATAGTTATATTTATATTTTTATT
TTTAAGAACAAATAAAATTACTAAACCAATTACAGAATTAACAGATGCAATAAAAAAACTAGGATATGGTGATTATAATA
TTTCAATTGCTGAACATGGAAAAGATGAGGTAGCAATATTAGCAAGAGAATTTATAAATATGAGAGATAAAATAAAAGAA
CAAATAGAAACTATTGAATCAGAAAAGAACAAAGTTTATAAATTAGAAAAAGGAAGAAAGGAATTTTTTAATAGTGTAAC
CCATGAATTAAAAACACCATTGACAGCTATATCAGGATATGCTGAGTTACTACTTACAGGAATGGTCAAGGATAAAGACT
TTGATAAAAGAGCTATTGAAAGAATATATTCAGAAAGTGACAGGCTTCATAAGTTAGTATTAGATCTTATAGAGGTATCT
AAAGGTATGTGTGTTATCAAAGAAGAACTTAATTATGTTGACATGAAAGAGCTTATTATTCAAAGTTGTAGTGATATGAA
TATAAAGGCTAATAAATATTCCTTAAAAATAATACAAAATATAAGTGAAGGAACAGTTAAGGTACAACAGGATAAAATTA
GGCAAGTACTAATCAATATAATTGATAATGCAATAAAATATTCCTATGGGGGAAATGAGATATATGTTAATTCTTACGTA
TCAGACAATAAATATATTATTGAAGTAATAAATAATAGTAATCCAATCCCAGATGAAATATTTAATAGTATATTTGAACC
TTTTATAAAATCTAATAATGATAATAAAGATAGTAGAGGACTTGGTTTATATTTATGTAATGAAATAGTTAAAGAGCATG
ACGGTGAAATAACCATAGAAAATGGCTCTCTAATAAAAGTAAAAATTCATTTAATAATTTAA

Upstream 100 bases:

>100_bases
GACGTTCATGTTAGAAGATTAAGAAGTAAGCTTGATAAGGAGAATGCAACATCTATTATAGACACTGTTTTTGGAATAGG
ATATGTAATGAGGTAGCCTT

Downstream 100 bases:

>100_bases
AAATATGAAAAGCGCACTAATCTTCATGATATAGGTGCTTTTTATTTTTATTATTAATTTCTATATTAATTTGAAAAAAT
TTAATTTTAATAATTAATTT

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 473; Mature: 473

Protein sequence:

>473_residues
MKIRDKFITGLIFILIVSMIVMNVAITHVLKSNMENSINNFLKQVMNSTHEYVKYNLVTNSFKDKKESLVEEGNYIIKHI
SLNYECKCDIRDINYILIEGNVPEEFRSITKKSKKVAMDGKAVVDLKYRYNGVDAILTYPIYIDNEYVGIISIVKNYDSK
YRDYKNTINIINIIELGTFIVIFIFLFLRTNKITKPITELTDAIKKLGYGDYNISIAEHGKDEVAILAREFINMRDKIKE
QIETIESEKNKVYKLEKGRKEFFNSVTHELKTPLTAISGYAELLLTGMVKDKDFDKRAIERIYSESDRLHKLVLDLIEVS
KGMCVIKEELNYVDMKELIIQSCSDMNIKANKYSLKIIQNISEGTVKVQQDKIRQVLINIIDNAIKYSYGGNEIYVNSYV
SDNKYIIEVINNSNPIPDEIFNSIFEPFIKSNNDNKDSRGLGLYLCNEIVKEHDGEITIENGSLIKVKIHLII

Sequences:

>Translated_473_residues
MKIRDKFITGLIFILIVSMIVMNVAITHVLKSNMENSINNFLKQVMNSTHEYVKYNLVTNSFKDKKESLVEEGNYIIKHI
SLNYECKCDIRDINYILIEGNVPEEFRSITKKSKKVAMDGKAVVDLKYRYNGVDAILTYPIYIDNEYVGIISIVKNYDSK
YRDYKNTINIINIIELGTFIVIFIFLFLRTNKITKPITELTDAIKKLGYGDYNISIAEHGKDEVAILAREFINMRDKIKE
QIETIESEKNKVYKLEKGRKEFFNSVTHELKTPLTAISGYAELLLTGMVKDKDFDKRAIERIYSESDRLHKLVLDLIEVS
KGMCVIKEELNYVDMKELIIQSCSDMNIKANKYSLKIIQNISEGTVKVQQDKIRQVLINIIDNAIKYSYGGNEIYVNSYV
SDNKYIIEVINNSNPIPDEIFNSIFEPFIKSNNDNKDSRGLGLYLCNEIVKEHDGEITIENGSLIKVKIHLII
>Mature_473_residues
MKIRDKFITGLIFILIVSMIVMNVAITHVLKSNMENSINNFLKQVMNSTHEYVKYNLVTNSFKDKKESLVEEGNYIIKHI
SLNYECKCDIRDINYILIEGNVPEEFRSITKKSKKVAMDGKAVVDLKYRYNGVDAILTYPIYIDNEYVGIISIVKNYDSK
YRDYKNTINIINIIELGTFIVIFIFLFLRTNKITKPITELTDAIKKLGYGDYNISIAEHGKDEVAILAREFINMRDKIKE
QIETIESEKNKVYKLEKGRKEFFNSVTHELKTPLTAISGYAELLLTGMVKDKDFDKRAIERIYSESDRLHKLVLDLIEVS
KGMCVIKEELNYVDMKELIIQSCSDMNIKANKYSLKIIQNISEGTVKVQQDKIRQVLINIIDNAIKYSYGGNEIYVNSYV
SDNKYIIEVINNSNPIPDEIFNSIFEPFIKSNNDNKDSRGLGLYLCNEIVKEHDGEITIENGSLIKVKIHLII

Specific function: Could be member of the two-component regulatory system yclK/yclJ. Potentially phosphorylates yclJ [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=284, Percent_Identity=24.2957746478873, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI87082128, Length=300, Percent_Identity=24.3333333333333, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1790861, Length=340, Percent_Identity=24.1176470588235, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1788713, Length=237, Percent_Identity=25.7383966244726, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1786912, Length=234, Percent_Identity=25.6410256410256, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1786600, Length=307, Percent_Identity=22.1498371335505, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1789808, Length=285, Percent_Identity=24.9122807017544, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI87081816, Length=335, Percent_Identity=21.7910447761194, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1790346, Length=283, Percent_Identity=20.4946996466431, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1790436, Length=235, Percent_Identity=24.6808510638298, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI145693157, Length=267, Percent_Identity=26.2172284644195, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI1788549, Length=204, Percent_Identity=23.5294117647059, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 54602; Mature: 54602

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIRDKFITGLIFILIVSMIVMNVAITHVLKSNMENSINNFLKQVMNSTHEYVKYNLVTN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHEEEEEHHC
SFKDKKESLVEEGNYIIKHISLNYECKCDIRDINYILIEGNVPEEFRSITKKSKKVAMDG
CHHHHHHHHHHCCCEEEEEEEECEEEEEEEEECEEEEEECCCCHHHHHHHHHHHHEECCC
KAVVDLKYRYNGVDAILTYPIYIDNEYVGIISIVKNYDSKYRDYKNTINIINIIELGTFI
CEEEEEEEEECCEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VIFIFLFLRTNKITKPITELTDAIKKLGYGDYNISIAEHGKDEVAILAREFINMRDKIKE
HHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHH
QIETIESEKNKVYKLEKGRKEFFNSVTHELKTPLTAISGYAELLLTGMVKDKDFDKRAIE
HHHHHHHHCHHEEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHH
RIYSESDRLHKLVLDLIEVSKGMCVIKEELNYVDMKELIIQSCSDMNIKANKYSLKIIQN
HHHCCHHHHHHHHHHHHHHCCCCEEEHHHCCCCCHHHHHHHCCCCCCEECCCEEEHHHHC
ISEGTVKVQQDKIRQVLINIIDNAIKYSYGGNEIYVNSYVSDNKYIIEVINNSNPIPDEI
CCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCEEEEEECCCCCCHHHH
FNSIFEPFIKSNNDNKDSRGLGLYLCNEIVKEHDGEITIENGSLIKVKIHLII
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCEEEEEEEEEC
>Mature Secondary Structure
MKIRDKFITGLIFILIVSMIVMNVAITHVLKSNMENSINNFLKQVMNSTHEYVKYNLVTN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHEEEEEHHC
SFKDKKESLVEEGNYIIKHISLNYECKCDIRDINYILIEGNVPEEFRSITKKSKKVAMDG
CHHHHHHHHHHCCCEEEEEEEECEEEEEEEEECEEEEEECCCCHHHHHHHHHHHHEECCC
KAVVDLKYRYNGVDAILTYPIYIDNEYVGIISIVKNYDSKYRDYKNTINIINIIELGTFI
CEEEEEEEEECCEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VIFIFLFLRTNKITKPITELTDAIKKLGYGDYNISIAEHGKDEVAILAREFINMRDKIKE
HHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHH
QIETIESEKNKVYKLEKGRKEFFNSVTHELKTPLTAISGYAELLLTGMVKDKDFDKRAIE
HHHHHHHHCHHEEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHH
RIYSESDRLHKLVLDLIEVSKGMCVIKEELNYVDMKELIIQSCSDMNIKANKYSLKIIQN
HHHCCHHHHHHHHHHHHHHCCCCEEEHHHCCCCCHHHHHHHCCCCCCEECCCEEEHHHHC
ISEGTVKVQQDKIRQVLINIIDNAIKYSYGGNEIYVNSYVSDNKYIIEVINNSNPIPDEI
CCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCEEEEEECCCCCCHHHH
FNSIFEPFIKSNNDNKDSRGLGLYLCNEIVKEHDGEITIENGSLIKVKIHLII
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]