Click here to switch to the map view.

The map label for this gene is icd [H]

Identifier: 148378422

GI number: 148378422

Start: 500453

End: 501454

Strand: Direct

Name: icd [H]

Synonym: CBO0419

Alternate gene names: 148378422

Gene position: 500453-501454 (Clockwise)

Preceding gene: 148378421

Following gene: 148378423

Centisome position: 12.88

GC content: 32.14

Gene sequence:

>1002_bases
ATGATGAAACACAATATAACTTTAATACCAGGAGATGGTATAGGACCAGAAGTAACTGAAGCTGCAAGGAAAGTTATAGA
TGCAGTAGGAGCAGATATTAATTGGCATGTAGTAGAGGCGGGGGAAAAAGTTTTAGACAAATATAAAACCCCCCTTCCAA
ACTATGTTTTAGATAGTATAAAGGAGACTAAAGTAGCATTGAAGGGTCCAGTAACTACTCCTGTAGGAAAGGGATTTAGA
AGTGTTAATGTTACTTTAAGAAAAAGCTTAAATTTATATGCAAATATAAGACCTGTAAAGAGTTATAAAGGAATAAAATC
TAGATATGAAAATGTGGATTTAATAATTGTACGGGAAAACACAGAAGATTTATATGCAGGAATTGAGCATATGATAGGTG
ATGATATAGCAGAAAGTATAAAGGTAATTACTAAAAAGGCTAGTGATAGAATAGTAGATTATGCTTTTGATATGGCAAGA
AAAGAAAATAGAAATAAGGTAACTGCAGTGCATAAAGCTAACATAATGAAATTATCAGATGGATTATTTTTAAATTGTGC
AAAGGAAGTTGCTAGTAAAAATAAGGATATTGATTTTGAAGATGTAATAGTAGATGCTATGGCCATGAAATTAGTTTTAA
ATCCAGAAAAATATGATGTTTTAGTAATGCCTAATTTATATGGTGATATTTTATCAGACATGGCAGCAGGTTTAGTTGGG
GGATTAGGATTACTTCCAGGAGCTAATATAGGATATGAAGGAGCTGTGTTTGAAGCAGCCCATGGTGCAGCACCTGATAT
TGCAGGAAAAAATAAAGCTAATCCAACAGCTTGTATATTAAGTGGTGCCATGATGCTAAACTATATTGGTGAAAATGAAA
AAGCTAAAAAAATAGAAAATGCTATAGAAAAAGTATTTGTAGAAGGAAAATGTCTTACAGAGGATTTAGGCGGAAGTTCT
ACAACAGAAGAATTTACAAAGGCAATTATAGAGAATCTTTAA

Upstream 100 bases:

>100_bases
CAGATAGACAAAAGAAGATGATTTTAAAGGGCGGATTATTAAATTTAATAAAAAGTTCTCAACAATAGCTACAAAAATTT
AGTTAAGTTTTCGGAGGGAT

Downstream 100 bases:

>100_bases
ATTAGTATATAATTTTTAATTTGCTACTACTTTTCAATTAGATGTATAAATTTCAGGTCCCCTTTTATAATTACATTCAA
GTTTTTCTTATGATTTTAAG

Product: dehydrogenase, isocitrate/isopropylmalate family

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MMKHNITLIPGDGIGPEVTEAARKVIDAVGADINWHVVEAGEKVLDKYKTPLPNYVLDSIKETKVALKGPVTTPVGKGFR
SVNVTLRKSLNLYANIRPVKSYKGIKSRYENVDLIIVRENTEDLYAGIEHMIGDDIAESIKVITKKASDRIVDYAFDMAR
KENRNKVTAVHKANIMKLSDGLFLNCAKEVASKNKDIDFEDVIVDAMAMKLVLNPEKYDVLVMPNLYGDILSDMAAGLVG
GLGLLPGANIGYEGAVFEAAHGAAPDIAGKNKANPTACILSGAMMLNYIGENEKAKKIENAIEKVFVEGKCLTEDLGGSS
TTEEFTKAIIENL

Sequences:

>Translated_333_residues
MMKHNITLIPGDGIGPEVTEAARKVIDAVGADINWHVVEAGEKVLDKYKTPLPNYVLDSIKETKVALKGPVTTPVGKGFR
SVNVTLRKSLNLYANIRPVKSYKGIKSRYENVDLIIVRENTEDLYAGIEHMIGDDIAESIKVITKKASDRIVDYAFDMAR
KENRNKVTAVHKANIMKLSDGLFLNCAKEVASKNKDIDFEDVIVDAMAMKLVLNPEKYDVLVMPNLYGDILSDMAAGLVG
GLGLLPGANIGYEGAVFEAAHGAAPDIAGKNKANPTACILSGAMMLNYIGENEKAKKIENAIEKVFVEGKCLTEDLGGSS
TTEEFTKAIIENL
>Mature_333_residues
MMKHNITLIPGDGIGPEVTEAARKVIDAVGADINWHVVEAGEKVLDKYKTPLPNYVLDSIKETKVALKGPVTTPVGKGFR
SVNVTLRKSLNLYANIRPVKSYKGIKSRYENVDLIIVRENTEDLYAGIEHMIGDDIAESIKVITKKASDRIVDYAFDMAR
KENRNKVTAVHKANIMKLSDGLFLNCAKEVASKNKDIDFEDVIVDAMAMKLVLNPEKYDVLVMPNLYGDILSDMAAGLVG
GLGLLPGANIGYEGAVFEAAHGAAPDIAGKNKANPTACILSGAMMLNYIGENEKAKKIENAIEKVFVEGKCLTEDLGGSS
TTEEFTKAIIENL

Specific function: Unknown

COG id: COG0473

COG function: function code CE; Isocitrate/isopropylmalate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=336, Percent_Identity=48.5119047619048, Blast_Score=332, Evalue=3e-91,
Organism=Homo sapiens, GI28178821, Length=339, Percent_Identity=45.1327433628319, Blast_Score=266, Evalue=2e-71,
Organism=Homo sapiens, GI28178816, Length=339, Percent_Identity=44.8377581120944, Blast_Score=265, Evalue=6e-71,
Organism=Homo sapiens, GI4758582, Length=334, Percent_Identity=42.814371257485, Blast_Score=264, Evalue=8e-71,
Organism=Homo sapiens, GI28178838, Length=303, Percent_Identity=44.5544554455446, Blast_Score=253, Evalue=1e-67,
Organism=Homo sapiens, GI28178819, Length=200, Percent_Identity=50.5, Blast_Score=184, Evalue=1e-46,
Organism=Escherichia coli, GI1787381, Length=389, Percent_Identity=38.8174807197943, Blast_Score=229, Evalue=2e-61,
Organism=Escherichia coli, GI87081683, Length=331, Percent_Identity=35.0453172205438, Blast_Score=177, Evalue=7e-46,
Organism=Escherichia coli, GI1788101, Length=364, Percent_Identity=32.967032967033, Blast_Score=173, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI71986051, Length=323, Percent_Identity=49.2260061919505, Blast_Score=331, Evalue=3e-91,
Organism=Caenorhabditis elegans, GI25144293, Length=336, Percent_Identity=41.0714285714286, Blast_Score=256, Evalue=1e-68,
Organism=Caenorhabditis elegans, GI17505779, Length=333, Percent_Identity=40.8408408408408, Blast_Score=250, Evalue=6e-67,
Organism=Caenorhabditis elegans, GI17550882, Length=337, Percent_Identity=40.3560830860534, Blast_Score=249, Evalue=1e-66,
Organism=Saccharomyces cerevisiae, GI6324709, Length=335, Percent_Identity=47.4626865671642, Blast_Score=328, Evalue=7e-91,
Organism=Saccharomyces cerevisiae, GI6324291, Length=334, Percent_Identity=45.8083832335329, Blast_Score=289, Evalue=3e-79,
Organism=Saccharomyces cerevisiae, GI6322097, Length=349, Percent_Identity=42.1203438395415, Blast_Score=249, Evalue=6e-67,
Organism=Saccharomyces cerevisiae, GI6319830, Length=358, Percent_Identity=32.4022346368715, Blast_Score=139, Evalue=6e-34,
Organism=Drosophila melanogaster, GI24643270, Length=328, Percent_Identity=53.6585365853659, Blast_Score=363, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24643268, Length=328, Percent_Identity=53.6585365853659, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24661184, Length=334, Percent_Identity=48.502994011976, Blast_Score=334, Evalue=5e-92,
Organism=Drosophila melanogaster, GI281362242, Length=337, Percent_Identity=44.8071216617211, Blast_Score=255, Evalue=3e-68,
Organism=Drosophila melanogaster, GI24648872, Length=337, Percent_Identity=44.8071216617211, Blast_Score=255, Evalue=3e-68,
Organism=Drosophila melanogaster, GI161078633, Length=338, Percent_Identity=39.6449704142012, Blast_Score=242, Evalue=3e-64,
Organism=Drosophila melanogaster, GI24650122, Length=338, Percent_Identity=39.6449704142012, Blast_Score=242, Evalue=3e-64,
Organism=Drosophila melanogaster, GI161078635, Length=338, Percent_Identity=39.6449704142012, Blast_Score=241, Evalue=3e-64,
Organism=Drosophila melanogaster, GI161078637, Length=338, Percent_Identity=39.6449704142012, Blast_Score=241, Evalue=4e-64,
Organism=Drosophila melanogaster, GI161078639, Length=333, Percent_Identity=39.6396396396396, Blast_Score=235, Evalue=3e-62,
Organism=Drosophila melanogaster, GI20130355, Length=329, Percent_Identity=35.258358662614, Blast_Score=211, Evalue=5e-55,
Organism=Drosophila melanogaster, GI45550436, Length=247, Percent_Identity=25.9109311740891, Blast_Score=95, Evalue=8e-20,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 36172; Mature: 36172

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKHNITLIPGDGIGPEVTEAARKVIDAVGADINWHVVEAGEKVLDKYKTPLPNYVLDSI
CCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHCCCCCHHHHHHH
KETKVALKGPVTTPVGKGFRSVNVTLRKSLNLYANIRPVKSYKGIKSRYENVDLIIVREN
HHHHHEECCCCCCCCCCCCCEEEHHHEECCCEEEECEEHHHHHHHHHHHCCCEEEEEECC
TEDLYAGIEHMIGDDIAESIKVITKKASDRIVDYAFDMARKENRNKVTAVHKANIMKLSD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCEEEECC
GLFLNCAKEVASKNKDIDFEDVIVDAMAMKLVLNPEKYDVLVMPNLYGDILSDMAAGLVG
CHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHEECCCCEEEEECCHHHHHHHHHHHHHHHH
GLGLLPGANIGYEGAVFEAAHGAAPDIAGKNKANPTACILSGAMMLNYIGENEKAKKIEN
HHHCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHH
AIEKVFVEGKCLTEDLGGSSTTEEFTKAIIENL
HHHHHHHCCCEEHHHCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MMKHNITLIPGDGIGPEVTEAARKVIDAVGADINWHVVEAGEKVLDKYKTPLPNYVLDSI
CCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHCCCCCHHHHHHH
KETKVALKGPVTTPVGKGFRSVNVTLRKSLNLYANIRPVKSYKGIKSRYENVDLIIVREN
HHHHHEECCCCCCCCCCCCCEEEHHHEECCCEEEECEEHHHHHHHHHHHCCCEEEEEECC
TEDLYAGIEHMIGDDIAESIKVITKKASDRIVDYAFDMARKENRNKVTAVHKANIMKLSD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCEEEECC
GLFLNCAKEVASKNKDIDFEDVIVDAMAMKLVLNPEKYDVLVMPNLYGDILSDMAAGLVG
CHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHEECCCCEEEEECCHHHHHHHHHHHHHHHH
GLGLLPGANIGYEGAVFEAAHGAAPDIAGKNKANPTACILSGAMMLNYIGENEKAKKIEN
HHHCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHH
AIEKVFVEGKCLTEDLGGSSTTEEFTKAIIENL
HHHHHHHCCCEEHHHCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1539996 [H]