Click here to switch to the map view.

The map label for this gene is yfnA [H]

Identifier: 148378392

GI number: 148378392

Start: 459448

End: 460899

Strand: Direct

Name: yfnA [H]

Synonym: CBO0389

Alternate gene names: 148378392

Gene position: 459448-460899 (Clockwise)

Preceding gene: 148378391

Following gene: 148378394

Centisome position: 11.82

GC content: 33.95

Gene sequence:

>1452_bases
ATGTCTAAGGAAAATGACGTCAGTAGCAGTGATCAAAATTTTGAAAGGGTTTTATCGAAAAAGGATATTATGGCCTTAGC
CTTTGGAGCTATGATTGGTTGGGGTTGGGTTGTATTAACAGGTCCATGGATACAGAAAGCAGGAAGCATGGGTGCTATAT
TAGCCTTTATAATAGGCGGAATCGTGGTATTATTTGTAGGACTCACCTATGCAGAACTTACATCAGCTATGCCAAAGTGT
GGTGGGGACTTGGTATTTAGCTATAGAGCACTAGGGAAAAAAGCAGCTTTTATATGTACTTGGGGCATAATTTTAGGATA
TATTTCCGTTGTAGCCTTTGAAGCAGTTGCATTCCCTTCAGTATTAGAAAATTTATTTTCTTTTTCTTATTTAAAAGGTT
ATATGTACACCATTGCAGGCTATGATATATATGCTTCTTGGGCATTAATAGGTTCTATAAGTGCTATAATTATAACAATA
GTAAATTATTTTGGAGCAAAACCAGCAGCTTTTATGCAAACTGTAGTAACAGTTATGATTGCTTGCGTAGGAATTGCATT
GTTTACAGGAAGCTTATTTAATGGAAGTGTACAAAACATGTCGCCTATGTTTGTTACAGGGACTTCAGGAAAAGGTATTT
TAGCAGTAGCTATAATGACTCCTTTTATGTATGTGGGCTTTGATGTAATACCACAGGCAGCAGAAGAAATAAATGTACCT
TTTAAGAAAATAGGAAAAATACTAATTTTATCAGTAATTATGGCAGTAGTTTGGTATGCTATGATAATATACAGTACATC
AGTAGCACTAAATTCTAACGAAATAAATAGTTCAAGCTTAGTAGCTGCAGATGCTATGAAAAAGATGTTCGGAAATAGTG
TGGCAGCATCTAAGATATTGATATTAGCTGGAATAGGTGGAATTTTAACTAGTTGGAATTCTTTTTTTATGGGTGGAAGC
AGAGCTATATATTCTATGGCAGAGGCTGGAATGTTACCAAAATTTTTAGCTAAAATACACCCTAAATATAAAACACCAAC
TAACGCTATAGTATTAATAGGATTAGTATCAAGCATTGCACCATTCTTTGGAGAGAAGATGCTAGTATGGCTTAGTAATG
CAGGTGGATTTGGTATATTGATATCCTATTTACTTGTATCTATATCTTTCTTAGTATTAAGAAAGAAGGAACCTAATATG
GAAAGACCTTATAAAGTAAAACATCCTAAGTTTGTAGGCACTATGGCTATAGTTTTATGTATAGGAATGCTTTTAATGTT
TATGCCAGGTTTACCATCAGGACTTAGCTGGCCTTATGAATGGGGAATAATATTAGCATGGTTCTTACTTGGAGGTATAT
TCTATTTAGCTGCAGCTAATAAAGACTTTAATGAATCCAAGCGCACTAAATATAAAGATGATTATTATACAAATAAAAAA
GTTAGTGTATAG

Upstream 100 bases:

>100_bases
ATAGTTAAGTTGCAAGTTGTAACTTATACCTTATAATATTATTAAATAATCTTAATATTAAAATATTAAAAAATTAACTA
TAAATTGAAGGGGGATCATT

Downstream 100 bases:

>100_bases
TTAATTTATAAATTGAAGAAAACAAATAAAAACGTAATAAAAGGAAAGTGCTATGCACTTTCCTTTTATTGTGGAATTAT
TCTATTGAATAATTCTTTAA

Product: amino acid permease

Products: Proton [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 483; Mature: 482

Protein sequence:

>483_residues
MSKENDVSSSDQNFERVLSKKDIMALAFGAMIGWGWVVLTGPWIQKAGSMGAILAFIIGGIVVLFVGLTYAELTSAMPKC
GGDLVFSYRALGKKAAFICTWGIILGYISVVAFEAVAFPSVLENLFSFSYLKGYMYTIAGYDIYASWALIGSISAIIITI
VNYFGAKPAAFMQTVVTVMIACVGIALFTGSLFNGSVQNMSPMFVTGTSGKGILAVAIMTPFMYVGFDVIPQAAEEINVP
FKKIGKILILSVIMAVVWYAMIIYSTSVALNSNEINSSSLVAADAMKKMFGNSVAASKILILAGIGGILTSWNSFFMGGS
RAIYSMAEAGMLPKFLAKIHPKYKTPTNAIVLIGLVSSIAPFFGEKMLVWLSNAGGFGILISYLLVSISFLVLRKKEPNM
ERPYKVKHPKFVGTMAIVLCIGMLLMFMPGLPSGLSWPYEWGIILAWFLLGGIFYLAAANKDFNESKRTKYKDDYYTNKK
VSV

Sequences:

>Translated_483_residues
MSKENDVSSSDQNFERVLSKKDIMALAFGAMIGWGWVVLTGPWIQKAGSMGAILAFIIGGIVVLFVGLTYAELTSAMPKC
GGDLVFSYRALGKKAAFICTWGIILGYISVVAFEAVAFPSVLENLFSFSYLKGYMYTIAGYDIYASWALIGSISAIIITI
VNYFGAKPAAFMQTVVTVMIACVGIALFTGSLFNGSVQNMSPMFVTGTSGKGILAVAIMTPFMYVGFDVIPQAAEEINVP
FKKIGKILILSVIMAVVWYAMIIYSTSVALNSNEINSSSLVAADAMKKMFGNSVAASKILILAGIGGILTSWNSFFMGGS
RAIYSMAEAGMLPKFLAKIHPKYKTPTNAIVLIGLVSSIAPFFGEKMLVWLSNAGGFGILISYLLVSISFLVLRKKEPNM
ERPYKVKHPKFVGTMAIVLCIGMLLMFMPGLPSGLSWPYEWGIILAWFLLGGIFYLAAANKDFNESKRTKYKDDYYTNKK
VSV
>Mature_482_residues
SKENDVSSSDQNFERVLSKKDIMALAFGAMIGWGWVVLTGPWIQKAGSMGAILAFIIGGIVVLFVGLTYAELTSAMPKCG
GDLVFSYRALGKKAAFICTWGIILGYISVVAFEAVAFPSVLENLFSFSYLKGYMYTIAGYDIYASWALIGSISAIIITIV
NYFGAKPAAFMQTVVTVMIACVGIALFTGSLFNGSVQNMSPMFVTGTSGKGILAVAIMTPFMYVGFDVIPQAAEEINVPF
KKIGKILILSVIMAVVWYAMIIYSTSVALNSNEINSSSLVAADAMKKMFGNSVAASKILILAGIGGILTSWNSFFMGGSR
AIYSMAEAGMLPKFLAKIHPKYKTPTNAIVLIGLVSSIAPFFGEKMLVWLSNAGGFGILISYLLVSISFLVLRKKEPNME
RPYKVKHPKFVGTMAIVLCIGMLLMFMPGLPSGLSWPYEWGIILAWFLLGGIFYLAAANKDFNESKRTKYKDDYYTNKKV
SV

Specific function: Permease That Is Involved In The Transport Across The Cytoplasmic Membrane Of Lysine. [C]

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI4507047, Length=445, Percent_Identity=26.0674157303371, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI258614003, Length=425, Percent_Identity=26.8235294117647, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI114326544, Length=419, Percent_Identity=24.8210023866348, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI114326550, Length=419, Percent_Identity=24.8210023866348, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI258614005, Length=425, Percent_Identity=26.8235294117647, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI181337167, Length=392, Percent_Identity=25.2551020408163, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI258645169, Length=425, Percent_Identity=25.4117647058824, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI7657683, Length=388, Percent_Identity=25, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI110347453, Length=416, Percent_Identity=24.2788461538462, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI33286428, Length=389, Percent_Identity=25.4498714652956, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI71979932, Length=421, Percent_Identity=25.1781472684086, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI9790235, Length=322, Percent_Identity=24.5341614906832, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI186910308, Length=407, Percent_Identity=24.0786240786241, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI186910306, Length=407, Percent_Identity=24.0786240786241, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI186910304, Length=407, Percent_Identity=24.0786240786241, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI115648063, Length=427, Percent_Identity=24.824355971897, Blast_Score=67, Evalue=5e-11,
Organism=Homo sapiens, GI115648022, Length=427, Percent_Identity=24.824355971897, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI1788480, Length=438, Percent_Identity=22.8310502283105, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI87082250, Length=354, Percent_Identity=25.7062146892655, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1786789, Length=450, Percent_Identity=22.6666666666667, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17532491, Length=414, Percent_Identity=28.2608695652174, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17531343, Length=421, Percent_Identity=26.8408551068884, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17533459, Length=406, Percent_Identity=27.0935960591133, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17540018, Length=445, Percent_Identity=25.3932584269663, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI32566699, Length=359, Percent_Identity=22.8412256267409, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71993915, Length=365, Percent_Identity=25.7534246575342, Blast_Score=66, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI193208714, Length=419, Percent_Identity=22.673031026253, Blast_Score=65, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI32566695, Length=419, Percent_Identity=22.673031026253, Blast_Score=65, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6321629, Length=448, Percent_Identity=23.4375, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6321053, Length=414, Percent_Identity=23.1884057971014, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24668806, Length=435, Percent_Identity=27.816091954023, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI21356285, Length=435, Percent_Identity=27.816091954023, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24668802, Length=435, Percent_Identity=27.816091954023, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI221512776, Length=423, Percent_Identity=26.4775413711584, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24666159, Length=425, Percent_Identity=26.8235294117647, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24667468, Length=424, Percent_Identity=26.4150943396226, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI281366235, Length=411, Percent_Identity=26.7639902676399, Blast_Score=96, Evalue=8e-20,
Organism=Drosophila melanogaster, GI116007820, Length=411, Percent_Identity=26.7639902676399, Blast_Score=96, Evalue=8e-20,
Organism=Drosophila melanogaster, GI116007818, Length=409, Percent_Identity=26.8948655256724, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI85725152, Length=409, Percent_Identity=26.8948655256724, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21357367, Length=462, Percent_Identity=24.4588744588745, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI221331183, Length=420, Percent_Identity=25.2380952380952, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI17647653, Length=420, Percent_Identity=25.2380952380952, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24664379, Length=420, Percent_Identity=25.2380952380952, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24641993, Length=429, Percent_Identity=23.7762237762238, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24641995, Length=429, Percent_Identity=23.7762237762238, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI161077963, Length=445, Percent_Identity=25.8426966292135, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24651635, Length=386, Percent_Identity=23.5751295336788, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24651633, Length=386, Percent_Identity=23.5751295336788, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI45550968, Length=410, Percent_Identity=22.6829268292683, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI19921172, Length=410, Percent_Identity=22.6829268292683, Blast_Score=66, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR015606 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 52410; Mature: 52279

Theoretical pI: Translated: 9.76; Mature: 9.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCC
>Mature Secondary Structure 
SKENDVSSSDQNFERVLSKKDIMALAFGAMIGWGWVVLTGPWIQKAGSMGAILAFIIGG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHEEECHHHHHCCCHHHHHHHHHHH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CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-lysine [Periplasm] = Proton [Cytoplasm] + L-lysine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9141694; 9384377 [H]