| Definition | Legionella pneumophila str. Corby chromosome, complete genome. |
|---|---|
| Accession | NC_009494 |
| Length | 3,576,470 |
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The map label for this gene is fabL [H]
Identifier: 148361026
GI number: 148361026
Start: 452429
End: 453187
Strand: Direct
Name: fabL [H]
Synonym: LPC_2986
Alternate gene names: 148361026
Gene position: 452429-453187 (Clockwise)
Preceding gene: 148361029
Following gene: 148361025
Centisome position: 12.65
GC content: 41.5
Gene sequence:
>759_bases ATGAGTTCATTAGTTTTTTCAGGAAAAGTGGGATTGATAACGGGTGGTGCTCGAGGAATAGGTAAAGCAACCGCATTAAA GTTAGCGCATTCAGGCTGCGATATTGCTATCGTGTATTATAATAGCTCTGATGAGGCTCAAAGCTTGGTCAATGAAATAA CAAGCATGGGTAGAAAAGCAATTGCTTTACAAGCCGATGTAGCAGATTGTCAATCTGTCAAGGAAATGTTCTCTCAATTT AGAGAACACTTTAAGCACTTAAATTTTCTAGTGAGCAATGCAGCGAGTGGAGTATTAAAACCCGCTTTGAAAATGTCGAC CAAGCATTGGCGCTGGTGCTTGGAAACAAATGCTTTGGCTTTGAACCACTTGGTTACGGAAGGTCTTGATTTAATGCCTA AAAATAGCCGAGTTATTGCGCTATCCAGCTTAGGTGCATCAAGGGCAATTCCAAATTATGCTTTTATTGGCGCCTCTAAA GCAGCTCTGGAAGCTTTGGTTCGTTCGCTAAGCTTGGAGCTGGCTAGTTATGGTATTACTGTGAATACTGTTTCTGCAGG TGTTGTCGATACGGACGCTTTAAAGCATTTTCCAAACAGAGAACAGTTACTCGATGAATATCAAGCTCATGCTTTGGCAG ATAGAGCGTTAACACCTGAAGATGTGGCTAATGCTATCTATTTACTTTGTTTACCTGAAGCGGCCATGATTAATGCCCAT ACATTATATGTTGACGCAGGCTATAGTCAGGTTGGGTAG
Upstream 100 bases:
>100_bases ATAAATTATTAAATTCCGCTTGATGGAGCCCCGATATTTCCATTGACAGCACAGCAGAATAACGGTAGTTTGGTGGGATT TTATACTGTAGGGTTATTGT
Downstream 100 bases:
>100_bases TAGATGATAAAAGTAAATTTTATGATATAATTTCAAGCTTTGCGAGCTTTGTTGGTTCAGAGGATAAAATATGAATGTAG CTGAAGTTTACCCTAAGGTT
Product: enoyl-(acyl carrier protein) reductase
Products: NA
Alternate protein names: Enoyl-acyl carrier protein reductase III; NADPH-dependent enoyl-ACP reductase [H]
Number of amino acids: Translated: 252; Mature: 251
Protein sequence:
>252_residues MSSLVFSGKVGLITGGARGIGKATALKLAHSGCDIAIVYYNSSDEAQSLVNEITSMGRKAIALQADVADCQSVKEMFSQF REHFKHLNFLVSNAASGVLKPALKMSTKHWRWCLETNALALNHLVTEGLDLMPKNSRVIALSSLGASRAIPNYAFIGASK AALEALVRSLSLELASYGITVNTVSAGVVDTDALKHFPNREQLLDEYQAHALADRALTPEDVANAIYLLCLPEAAMINAH TLYVDAGYSQVG
Sequences:
>Translated_252_residues MSSLVFSGKVGLITGGARGIGKATALKLAHSGCDIAIVYYNSSDEAQSLVNEITSMGRKAIALQADVADCQSVKEMFSQF REHFKHLNFLVSNAASGVLKPALKMSTKHWRWCLETNALALNHLVTEGLDLMPKNSRVIALSSLGASRAIPNYAFIGASK AALEALVRSLSLELASYGITVNTVSAGVVDTDALKHFPNREQLLDEYQAHALADRALTPEDVANAIYLLCLPEAAMINAH TLYVDAGYSQVG >Mature_251_residues SSLVFSGKVGLITGGARGIGKATALKLAHSGCDIAIVYYNSSDEAQSLVNEITSMGRKAIALQADVADCQSVKEMFSQFR EHFKHLNFLVSNAASGVLKPALKMSTKHWRWCLETNALALNHLVTEGLDLMPKNSRVIALSSLGASRAIPNYAFIGASKA ALEALVRSLSLELASYGITVNTVSAGVVDTDALKHFPNREQLLDEYQAHALADRALTPEDVANAIYLLCLPEAAMINAHT LYVDAGYSQVG
Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]
COG id: COG1028
COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI5031737, Length=251, Percent_Identity=30.2788844621514, Blast_Score=94, Evalue=8e-20, Organism=Homo sapiens, GI19923817, Length=254, Percent_Identity=27.9527559055118, Blast_Score=93, Evalue=2e-19, Organism=Homo sapiens, GI31542939, Length=244, Percent_Identity=28.6885245901639, Blast_Score=82, Evalue=5e-16, Organism=Homo sapiens, GI7705925, Length=255, Percent_Identity=25.8823529411765, Blast_Score=75, Evalue=5e-14, Organism=Homo sapiens, GI40254992, Length=243, Percent_Identity=27.5720164609054, Blast_Score=70, Evalue=2e-12, Organism=Homo sapiens, GI109715829, Length=242, Percent_Identity=28.9256198347107, Blast_Score=69, Evalue=3e-12, Organism=Homo sapiens, GI224922801, Length=170, Percent_Identity=30, Blast_Score=69, Evalue=5e-12, Organism=Homo sapiens, GI209862901, Length=217, Percent_Identity=26.7281105990783, Blast_Score=69, Evalue=5e-12, Organism=Homo sapiens, GI19923983, Length=217, Percent_Identity=26.7281105990783, Blast_Score=69, Evalue=5e-12, Organism=Homo sapiens, GI32483357, Length=250, Percent_Identity=25.2, Blast_Score=67, Evalue=2e-11, Organism=Homo sapiens, GI33667109, Length=194, Percent_Identity=29.3814432989691, Blast_Score=64, Evalue=1e-10, Organism=Escherichia coli, GI1787335, Length=252, Percent_Identity=31.7460317460317, Blast_Score=107, Evalue=9e-25, Organism=Escherichia coli, GI2367365, Length=248, Percent_Identity=30.6451612903226, Blast_Score=102, Evalue=2e-23, Organism=Escherichia coli, GI1787905, Length=252, Percent_Identity=30.952380952381, Blast_Score=100, Evalue=1e-22, Organism=Escherichia coli, GI2367175, Length=239, Percent_Identity=33.8912133891213, Blast_Score=100, Evalue=1e-22, Organism=Escherichia coli, GI1789208, Length=260, Percent_Identity=26.5384615384615, Blast_Score=97, Evalue=8e-22, Organism=Escherichia coli, GI1787545, Length=258, Percent_Identity=29.0697674418605, Blast_Score=93, Evalue=2e-20, Organism=Escherichia coli, GI1789378, Length=231, Percent_Identity=27.7056277056277, Blast_Score=90, Evalue=1e-19, Organism=Escherichia coli, GI1788459, Length=248, Percent_Identity=25.8064516129032, Blast_Score=85, Evalue=4e-18, Organism=Escherichia coli, GI87082160, Length=258, Percent_Identity=27.1317829457364, Blast_Score=80, Evalue=9e-17, Organism=Escherichia coli, GI87082100, Length=253, Percent_Identity=27.6679841897233, Blast_Score=77, Evalue=9e-16, Organism=Escherichia coli, GI1786812, Length=254, Percent_Identity=25.9842519685039, Blast_Score=74, Evalue=8e-15, Organism=Escherichia coli, GI1790717, Length=245, Percent_Identity=25.3061224489796, Blast_Score=71, Evalue=6e-14, Organism=Caenorhabditis elegans, GI193204405, Length=217, Percent_Identity=29.4930875576037, Blast_Score=89, Evalue=3e-18, Organism=Caenorhabditis elegans, GI17562910, Length=263, Percent_Identity=27.3764258555133, Blast_Score=86, Evalue=3e-17, Organism=Caenorhabditis elegans, GI17562906, Length=264, Percent_Identity=27.2727272727273, Blast_Score=82, Evalue=2e-16, Organism=Caenorhabditis elegans, GI115534694, Length=254, Percent_Identity=30.3149606299213, Blast_Score=82, Evalue=4e-16, Organism=Caenorhabditis elegans, GI17560220, Length=263, Percent_Identity=27.7566539923954, Blast_Score=81, Evalue=4e-16, Organism=Caenorhabditis elegans, GI17536025, Length=249, Percent_Identity=26.5060240963855, Blast_Score=78, Evalue=4e-15, Organism=Caenorhabditis elegans, GI72000259, Length=260, Percent_Identity=25.7692307692308, Blast_Score=78, Evalue=4e-15, Organism=Caenorhabditis elegans, GI17536651, Length=249, Percent_Identity=25.7028112449799, Blast_Score=72, Evalue=2e-13, Organism=Caenorhabditis elegans, GI17531453, Length=266, Percent_Identity=27.8195488721804, Blast_Score=72, Evalue=3e-13, Organism=Caenorhabditis elegans, GI17560332, Length=269, Percent_Identity=26.7657992565056, Blast_Score=70, Evalue=7e-13, Organism=Caenorhabditis elegans, GI17565030, Length=194, Percent_Identity=27.8350515463918, Blast_Score=70, Evalue=8e-13, Organism=Caenorhabditis elegans, GI17562904, Length=240, Percent_Identity=24.5833333333333, Blast_Score=70, Evalue=1e-12, Organism=Caenorhabditis elegans, GI71994604, Length=253, Percent_Identity=26.0869565217391, Blast_Score=69, Evalue=2e-12, Organism=Caenorhabditis elegans, GI17559104, Length=264, Percent_Identity=25, Blast_Score=69, Evalue=2e-12, Organism=Caenorhabditis elegans, GI17563726, Length=258, Percent_Identity=24.8062015503876, Blast_Score=69, Evalue=3e-12, Organism=Caenorhabditis elegans, GI71997099, Length=254, Percent_Identity=26.7716535433071, Blast_Score=68, Evalue=3e-12, Organism=Caenorhabditis elegans, GI17562908, Length=263, Percent_Identity=23.9543726235741, Blast_Score=68, Evalue=5e-12, Organism=Caenorhabditis elegans, GI17544670, Length=271, Percent_Identity=26.5682656826568, Blast_Score=67, Evalue=6e-12, Organism=Caenorhabditis elegans, GI17561402, Length=261, Percent_Identity=26.4367816091954, Blast_Score=67, Evalue=8e-12, Organism=Caenorhabditis elegans, GI17555612, Length=208, Percent_Identity=27.8846153846154, Blast_Score=67, Evalue=1e-11, Organism=Caenorhabditis elegans, GI17538480, Length=198, Percent_Identity=29.2929292929293, Blast_Score=66, Evalue=2e-11, Organism=Caenorhabditis elegans, GI25147288, Length=261, Percent_Identity=27.9693486590038, Blast_Score=65, Evalue=3e-11, Organism=Caenorhabditis elegans, GI17560676, Length=248, Percent_Identity=23.7903225806452, Blast_Score=65, Evalue=3e-11, Organism=Caenorhabditis elegans, GI17551412, Length=198, Percent_Identity=27.7777777777778, Blast_Score=64, Evalue=6e-11, Organism=Caenorhabditis elegans, GI17538486, Length=194, Percent_Identity=26.2886597938144, Blast_Score=64, Evalue=1e-10, Organism=Saccharomyces cerevisiae, GI6324126, Length=258, Percent_Identity=24.8062015503876, Blast_Score=76, Evalue=4e-15, Organism=Saccharomyces cerevisiae, GI6323882, Length=228, Percent_Identity=27.6315789473684, Blast_Score=64, Evalue=2e-11, Organism=Drosophila melanogaster, GI24639444, Length=254, Percent_Identity=29.1338582677165, Blast_Score=84, Evalue=1e-16, Organism=Drosophila melanogaster, GI21357041, Length=249, Percent_Identity=28.5140562248996, Blast_Score=81, Evalue=6e-16, Organism=Drosophila melanogaster, GI24644339, Length=250, Percent_Identity=28.8, Blast_Score=81, Evalue=6e-16, Organism=Drosophila melanogaster, GI28571526, Length=254, Percent_Identity=29.5275590551181, Blast_Score=81, Evalue=8e-16, Organism=Drosophila melanogaster, GI24643142, Length=253, Percent_Identity=28.4584980237154, Blast_Score=80, Evalue=1e-15, Organism=Drosophila melanogaster, GI21355319, Length=250, Percent_Identity=26.8, Blast_Score=77, Evalue=1e-14, Organism=Drosophila melanogaster, GI24648944, Length=236, Percent_Identity=26.271186440678, Blast_Score=72, Evalue=5e-13,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: =1.3.1.10 [H]
Molecular weight: Translated: 26981; Mature: 26850
Theoretical pI: Translated: 6.95; Mature: 6.95
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.6 %Cys (Translated Protein) 2.4 %Met (Translated Protein) 4.0 %Cys+Met (Translated Protein) 1.6 %Cys (Mature Protein) 2.0 %Met (Mature Protein) 3.6 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSSLVFSGKVGLITGGARGIGKATALKLAHSGCDIAIVYYNSSDEAQSLVNEITSMGRKA CCCEEECCCEEEEECCCCCCCHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHCCCCE IALQADVADCQSVKEMFSQFREHFKHLNFLVSNAASGVLKPALKMSTKHWRWCLETNALA EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHEEHHCCHHH LNHLVTEGLDLMPKNSRVIALSSLGASRAIPNYAFIGASKAALEALVRSLSLELASYGIT HHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCEE VNTVSAGVVDTDALKHFPNREQLLDEYQAHALADRALTPEDVANAIYLLCLPEAAMINAH EEEEECCCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHEEEEEECCCHHHEEEE TLYVDAGYSQVG EEEEECCCCCCC >Mature Secondary Structure SSLVFSGKVGLITGGARGIGKATALKLAHSGCDIAIVYYNSSDEAQSLVNEITSMGRKA CCEEECCCEEEEECCCCCCCHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHCCCCE IALQADVADCQSVKEMFSQFREHFKHLNFLVSNAASGVLKPALKMSTKHWRWCLETNALA EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHEEHHCCHHH LNHLVTEGLDLMPKNSRVIALSSLGASRAIPNYAFIGASKAALEALVRSLSLELASYGIT HHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCEE VNTVSAGVVDTDALKHFPNREQLLDEYQAHALADRALTPEDVANAIYLLCLPEAAMINAH EEEEECCCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHEEEEEECCCHHHEEEE TLYVDAGYSQVG EEEEECCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 8946165; 9202460; 9384377 [H]