Click here to switch to the map view.

The map label for this gene is pdxH

Identifier: 148360808

GI number: 148360808

Start: 669711

End: 670358

Strand: Direct

Name: pdxH

Synonym: LPC_2766

Alternate gene names: 148360808

Gene position: 669711-670358 (Clockwise)

Preceding gene: 148360809

Following gene: 148360807

Centisome position: 18.73

GC content: 38.73

Gene sequence:

>648_bases
ATGAGCAAATTTAGAAGTCTTGCGGATATTAGACGAGATTATGGTGAGTTGCAGCTCAGTGAAGAATCCGCTGAAAATGA
TCCCATTTCTCAATTCAAACTATGGTTTGATGATGTATTACTAAATGAAAAAAATGATCCCACGGCAATGGTTCTGTCTA
CAGTAGATGAAAAGGGCTATCCAGATTCCAGAGTTGTCTTATTAAAAGGATTAGAGAACGGTAATTTTATCTTTTATACC
AATTATCAAAGTGCCAAGGCAATGCAAATCCAAAAGAATCCTTATGCCGCACTTAATTTTTATTGGCCTCAAATGGCAAG
ACAAGTACGTGTTCGTGGTCGAGTAAAAAAAATCAGTAGCGAGCAATCCGATGCTTATTTCTCCTCCAGACCTTTAAAAA
GTCAGTTTAGTGCGATTGTTTCTCCCCAAAGCCAAGAAATTCTGGATAGGATTTCTTTAGAAGATGCTTTAAATCAGTTG
ATTGAAGAATATGGCCAAAAACCCGTAGTCAGACCGGAAAACTGGGGTGGATATATGATAATCCCGGATGAGATTGAGTT
TTGGCAGGGTAGAGATAACAGATTACATGATCGAATTCATTATTACCGGCATGGTCATGAATGGACGCACCGTAGATTGG
CACCTTGA

Upstream 100 bases:

>100_bases
ATGCAAGAAGTCGATTGAAAAATTTTAACTGTAAAATGTGTCGCAAATTATAAATTTTAGAGAGTATAATTATTTACATT
TTTTTTAGTGAAGGTTTGCT

Downstream 100 bases:

>100_bases
CCGGCAGTTTTTGTCATCATTCCTGCCGGCATCATTTTACTATTGAGATATAGAAGGATGAGTTTTCATGGCAGGTTAGT
TAATGGTTGAATTCTTTTGA

Product: pyridoxamine 5'-phosphate oxidase

Products: NA

Alternate protein names: PNP/PMP oxidase; PNPOx; Pyridoxal 5'-phosphate synthase

Number of amino acids: Translated: 215; Mature: 214

Protein sequence:

>215_residues
MSKFRSLADIRRDYGELQLSEESAENDPISQFKLWFDDVLLNEKNDPTAMVLSTVDEKGYPDSRVVLLKGLENGNFIFYT
NYQSAKAMQIQKNPYAALNFYWPQMARQVRVRGRVKKISSEQSDAYFSSRPLKSQFSAIVSPQSQEILDRISLEDALNQL
IEEYGQKPVVRPENWGGYMIIPDEIEFWQGRDNRLHDRIHYYRHGHEWTHRRLAP

Sequences:

>Translated_215_residues
MSKFRSLADIRRDYGELQLSEESAENDPISQFKLWFDDVLLNEKNDPTAMVLSTVDEKGYPDSRVVLLKGLENGNFIFYT
NYQSAKAMQIQKNPYAALNFYWPQMARQVRVRGRVKKISSEQSDAYFSSRPLKSQFSAIVSPQSQEILDRISLEDALNQL
IEEYGQKPVVRPENWGGYMIIPDEIEFWQGRDNRLHDRIHYYRHGHEWTHRRLAP
>Mature_214_residues
SKFRSLADIRRDYGELQLSEESAENDPISQFKLWFDDVLLNEKNDPTAMVLSTVDEKGYPDSRVVLLKGLENGNFIFYTN
YQSAKAMQIQKNPYAALNFYWPQMARQVRVRGRVKKISSEQSDAYFSSRPLKSQFSAIVSPQSQEILDRISLEDALNQLI
EEYGQKPVVRPENWGGYMIIPDEIEFWQGRDNRLHDRIHYYRHGHEWTHRRLAP

Specific function: Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)

COG id: COG0259

COG function: function code H; Pyridoxamine-phosphate oxidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyridoxamine 5'-phosphate oxidase family

Homologues:

Organism=Homo sapiens, GI8922498, Length=228, Percent_Identity=39.4736842105263, Blast_Score=167, Evalue=7e-42,
Organism=Escherichia coli, GI1787926, Length=213, Percent_Identity=40.8450704225352, Blast_Score=162, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17553712, Length=199, Percent_Identity=42.713567839196, Blast_Score=155, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6319509, Length=208, Percent_Identity=37.5, Blast_Score=131, Evalue=1e-31,
Organism=Drosophila melanogaster, GI45551845, Length=228, Percent_Identity=40.3508771929825, Blast_Score=154, Evalue=6e-38,
Organism=Drosophila melanogaster, GI24644901, Length=228, Percent_Identity=40.3508771929825, Blast_Score=153, Evalue=6e-38,
Organism=Drosophila melanogaster, GI24644903, Length=146, Percent_Identity=28.7671232876712, Blast_Score=75, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXH_LEGPA (Q5X7K4)

Other databases:

- EMBL:   CR628336
- RefSeq:   YP_122939.1
- ProteinModelPortal:   Q5X7K4
- SMR:   Q5X7K4
- STRING:   Q5X7K4
- GeneID:   3119633
- GenomeReviews:   CR628336_GR
- KEGG:   lpp:lpp0601
- LegioList:   lpp0601
- eggNOG:   COG0259
- HOGENOM:   HBG327559
- OMA:   FTFFTNY
- ProtClustDB:   CLSK832243
- BioCyc:   LPNE297246:LPP0601-MONOMER
- HAMAP:   MF_01629
- InterPro:   IPR000659
- InterPro:   IPR019740
- InterPro:   IPR019576
- InterPro:   IPR011576
- InterPro:   IPR012349
- InterPro:   IPR009002
- Gene3D:   G3DSA:2.30.110.10
- PANTHER:   PTHR10851
- PIRSF:   PIRSF000190
- TIGRFAMs:   TIGR00558

Pfam domain/function: PF10590 PNPOx_C; PF01243 Pyridox_oxidase; SSF50475 FMN_binding

EC number: =1.4.3.5

Molecular weight: Translated: 25264; Mature: 25132

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS01064 PYRIDOX_OXIDASE

Important sites: BINDING 64-64 BINDING 67-67 BINDING 69-69 BINDING 86-86 BINDING 126-126 BINDING 130-130 BINDING 134-134

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKFRSLADIRRDYGELQLSEESAENDPISQFKLWFDDVLLNEKNDPTAMVLSTVDEKGY
CCHHHHHHHHHHHHHCEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEHHCCCC
PDSRVVLLKGLENGNFIFYTNYQSAKAMQIQKNPYAALNFYWPQMARQVRVRGRVKKISS
CCCEEEEEEECCCCCEEEEECCCCCEEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHCC
EQSDAYFSSRPLKSQFSAIVSPQSQEILDRISLEDALNQLIEEYGQKPVVRPENWGGYMI
CCCCCHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEE
IPDEIEFWQGRDNRLHDRIHYYRHGHEWTHRRLAP
ECCCCCCCCCCCCHHHHHHHHHHCCCHHHHCCCCC
>Mature Secondary Structure 
SKFRSLADIRRDYGELQLSEESAENDPISQFKLWFDDVLLNEKNDPTAMVLSTVDEKGY
CHHHHHHHHHHHHHCEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEHHCCCC
PDSRVVLLKGLENGNFIFYTNYQSAKAMQIQKNPYAALNFYWPQMARQVRVRGRVKKISS
CCCEEEEEEECCCCCEEEEECCCCCEEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHCC
EQSDAYFSSRPLKSQFSAIVSPQSQEILDRISLEDALNQLIEEYGQKPVVRPENWGGYMI
CCCCCHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEE
IPDEIEFWQGRDNRLHDRIHYYRHGHEWTHRRLAP
ECCCCCCCCCCCCHHHHHHHHHHCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA