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The map label for this gene is csrD [H]

Identifier: 148360526

GI number: 148360526

Start: 1013082

End: 1015001

Strand: Direct

Name: csrD [H]

Synonym: LPC_2467

Alternate gene names: 148360526

Gene position: 1013082-1015001 (Clockwise)

Preceding gene: 148360527

Following gene: 148360525

Centisome position: 28.33

GC content: 37.03

Gene sequence:

>1920_bases
ATGACATTAACTAAGAAAATGGCTGTAGGCGTGTTGATTATGTTGTTATTCGTTTTTATCGGAACTTATTTCATCACTAT
GAATAATGCGCGTAATTTTTTTATCCAACAACTTGAAAGCAATGCTCAAGATACTGCGACATCATTAGGCTTGTCTCTAT
CTCAGTCTTTAATCAATCATGATGTACCTACCATGGATTCTATGGTTAAAGCTGTTTTTGACAGGGGATATTTTTCATCA
ATTAAGGTAAAAGACATAAAAGGGAAAGTGATCATTTTAAAGAAACAATTGCCACAAGAAAGCGATATACCACAATGGTT
TGTGAACTTGATAAAATGGCCATCAACTGAGAAGTCATCCTTAATTATGGATGGGTGGATGCAAGCAGGAGTTGTTTTAG
TCGCTAGTGATCCGAGCTATGTTTACGCCTCTTTGTGGCGTAATGCTGTAGAAATGGTAAACGCTTATCTGATTTTTGCG
TTAGTTGCTTTGGTTCTAAGCTATTGCTTTATAAAATATTTATTGCAACCTTTAAAACGAGTCACAGCACAGGCTTTGGC
AATTTCAGAACATGAGTTTCCTGTAGAAACAAAGATTCCTAAAACCCCTGAATTGAGGCAAGTTACCTTGGCTATGAATC
AAATGGTTACTAAAGTCAAATCCTTATTTCAAGACCAGTTAAAACAAACAGAATCACTTAGAACACAGGTTTACCAAGAT
TCATTAACAGGGATGAGTAATCGTCGTTATTTTTTACAGCATTTGGCTCTGATCCTGGATAATGAAGATGAATTTATACC
TGGTTATGTCATGATGCTGGTCATAGATGGTCTGGATGAGTTAAATCAGAAGCAAGGGTATCAGCAAGGGGATCAATTGG
TATTAACTGTAGCCAAAATATGTAAAAGCTATTGGAAGCAATCGTCTGTTAGTACATTGGCAAGAATTAACGGGACGACC
TTTGCCTTGATTAGTCATGAAAGGGATCCCTTGGTGTTTGAAAAGGAATGTAAGGAGTTTGAACAAATTTTGAGCCAAGG
TATCACTGATATTAAAATTTGCGAAACACACATGGGGGCTGCGAGTTATTTTCTCCACCAACCTGTCTCCAATCTGTTGT
CTATAGTAGATCAAGCGGTTAAAAAAGCTCGTGAAACTGGCGTATTTTATTGCCAGAAGGAGCATGATACTTATAAATAT
CCCCAGTTAATCAGTGGCGATGAAATTAGAAAATCATTGGAACAGAAAAAAATAAGTTTGTATGCGCAGGCAGTTACAGA
TGGTAAGAATTGTTTTCATAAAGAAGTCTTCGTTCGAATTCGCAACCAGGAAGGGGAGGAGTTAGGCGCTGGTTATTTTA
TACCAGTTGCTGAGAAATTAGGGTTGGCCTATCTTATTGATCAGTATGTTCTCAATGAATTAACCGTCATGGACATTGCA
ACGCATACCCATTTTGCTCTTAATATTTCAGAAGATACTTTAACAAATAAAGTCAATAGCACTGGTTATTTGCGGCAATT
GGAAGCTACTCCTGCAGCTGTCTTGAGAAATCTCTCACTGGAAATCAATGAAGCTCACGTTTTGTCACATTTTTCAAACT
CCAAGTTCTTTATCAAGCAAGCCAAAAAATTGGGGGTGACAGTTGGAATAGATCGTGTGGGTATTAAATTTTCTCCGTTG
CATTATTTGAGTGATTTAAACATAGATTATTTAAAACTGCATGGAAGTTTGGTGACAGATATTGATGAAAACGAAAGCAA
GCAGTTTTTCATACATTATTTTAATGAAATGGCTAAAACGATGGATATTGCGGTGGTAGCAACTCAAGTGGAAAGCGAGG
CTCAATGGCAAGCATTACAAATAGTCCACATACCTTGGGGGCAGGGACGCTTTTTATCTTCTGTAGAATTAATAAAATAA

Upstream 100 bases:

>100_bases
TGCGAAAACAAGGGGAGAGAGTTCATTGATGGGGGATTCAAAAAGTTTGGGCAAGTGGGATGCTCTAATGAAACGTATGG
AATAAAAAAGGTGATAGACC

Downstream 100 bases:

>100_bases
CGAGATGAAAAACAGATTATTCTCAATGCATTAAAATGAATTCGTGAATAGCCCTAAACCCGCTTGGTGCCTCTGTAAAA
TGGTATAAGAATAAGGTATG

Product: two component histidine kinase

Products: NA

Alternate protein names: Regulator of CsrB and CsrC decay CsrD [H]

Number of amino acids: Translated: 639; Mature: 638

Protein sequence:

>639_residues
MTLTKKMAVGVLIMLLFVFIGTYFITMNNARNFFIQQLESNAQDTATSLGLSLSQSLINHDVPTMDSMVKAVFDRGYFSS
IKVKDIKGKVIILKKQLPQESDIPQWFVNLIKWPSTEKSSLIMDGWMQAGVVLVASDPSYVYASLWRNAVEMVNAYLIFA
LVALVLSYCFIKYLLQPLKRVTAQALAISEHEFPVETKIPKTPELRQVTLAMNQMVTKVKSLFQDQLKQTESLRTQVYQD
SLTGMSNRRYFLQHLALILDNEDEFIPGYVMMLVIDGLDELNQKQGYQQGDQLVLTVAKICKSYWKQSSVSTLARINGTT
FALISHERDPLVFEKECKEFEQILSQGITDIKICETHMGAASYFLHQPVSNLLSIVDQAVKKARETGVFYCQKEHDTYKY
PQLISGDEIRKSLEQKKISLYAQAVTDGKNCFHKEVFVRIRNQEGEELGAGYFIPVAEKLGLAYLIDQYVLNELTVMDIA
THTHFALNISEDTLTNKVNSTGYLRQLEATPAAVLRNLSLEINEAHVLSHFSNSKFFIKQAKKLGVTVGIDRVGIKFSPL
HYLSDLNIDYLKLHGSLVTDIDENESKQFFIHYFNEMAKTMDIAVVATQVESEAQWQALQIVHIPWGQGRFLSSVELIK

Sequences:

>Translated_639_residues
MTLTKKMAVGVLIMLLFVFIGTYFITMNNARNFFIQQLESNAQDTATSLGLSLSQSLINHDVPTMDSMVKAVFDRGYFSS
IKVKDIKGKVIILKKQLPQESDIPQWFVNLIKWPSTEKSSLIMDGWMQAGVVLVASDPSYVYASLWRNAVEMVNAYLIFA
LVALVLSYCFIKYLLQPLKRVTAQALAISEHEFPVETKIPKTPELRQVTLAMNQMVTKVKSLFQDQLKQTESLRTQVYQD
SLTGMSNRRYFLQHLALILDNEDEFIPGYVMMLVIDGLDELNQKQGYQQGDQLVLTVAKICKSYWKQSSVSTLARINGTT
FALISHERDPLVFEKECKEFEQILSQGITDIKICETHMGAASYFLHQPVSNLLSIVDQAVKKARETGVFYCQKEHDTYKY
PQLISGDEIRKSLEQKKISLYAQAVTDGKNCFHKEVFVRIRNQEGEELGAGYFIPVAEKLGLAYLIDQYVLNELTVMDIA
THTHFALNISEDTLTNKVNSTGYLRQLEATPAAVLRNLSLEINEAHVLSHFSNSKFFIKQAKKLGVTVGIDRVGIKFSPL
HYLSDLNIDYLKLHGSLVTDIDENESKQFFIHYFNEMAKTMDIAVVATQVESEAQWQALQIVHIPWGQGRFLSSVELIK
>Mature_638_residues
TLTKKMAVGVLIMLLFVFIGTYFITMNNARNFFIQQLESNAQDTATSLGLSLSQSLINHDVPTMDSMVKAVFDRGYFSSI
KVKDIKGKVIILKKQLPQESDIPQWFVNLIKWPSTEKSSLIMDGWMQAGVVLVASDPSYVYASLWRNAVEMVNAYLIFAL
VALVLSYCFIKYLLQPLKRVTAQALAISEHEFPVETKIPKTPELRQVTLAMNQMVTKVKSLFQDQLKQTESLRTQVYQDS
LTGMSNRRYFLQHLALILDNEDEFIPGYVMMLVIDGLDELNQKQGYQQGDQLVLTVAKICKSYWKQSSVSTLARINGTTF
ALISHERDPLVFEKECKEFEQILSQGITDIKICETHMGAASYFLHQPVSNLLSIVDQAVKKARETGVFYCQKEHDTYKYP
QLISGDEIRKSLEQKKISLYAQAVTDGKNCFHKEVFVRIRNQEGEELGAGYFIPVAEKLGLAYLIDQYVLNELTVMDIAT
HTHFALNISEDTLTNKVNSTGYLRQLEATPAAVLRNLSLEINEAHVLSHFSNSKFFIKQAKKLGVTVGIDRVGIKFSPLH
YLSDLNIDYLKLHGSLVTDIDENESKQFFIHYFNEMAKTMDIAVVATQVESEAQWQALQIVHIPWGQGRFLSSVELIK

Specific function: Serves as a specificity factor required for RNase E- mediated decay of the small global regulatory RNAs CsrB and CsrC, it is probably not a nuclease. Nor does its activity involve c-di- GMP, despite its domain composition. Positively modulates motility ge

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GGDEF domain [H]

Homologues:

Organism=Escherichia coli, GI1789650, Length=442, Percent_Identity=22.1719457013575, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1788849, Length=293, Percent_Identity=23.5494880546075, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1790496, Length=234, Percent_Identity=26.9230769230769, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI87081921, Length=435, Percent_Identity=22.5287356321839, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI87082096, Length=238, Percent_Identity=27.7310924369748, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI87081845, Length=242, Percent_Identity=23.9669421487603, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1787541, Length=412, Percent_Identity=24.0291262135922, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1788956, Length=294, Percent_Identity=22.7891156462585, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF [H]

EC number: NA

Molecular weight: Translated: 72536; Mature: 72405

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: PS50885 HAMP ; PS50883 EAL ; PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLTKKMAVGVLIMLLFVFIGTYFITMNNARNFFIQQLESNAQDTATSLGLSLSQSLINH
CCCHHHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHC
DVPTMDSMVKAVFDRGYFSSIKVKDIKGKVIILKKQLPQESDIPQWFVNLIKWPSTEKSS
CCCCHHHHHHHHHCCCCCCCEEEEECCCCEEEEECCCCCCCCCHHHHHHHHCCCCCCCCH
LIMDGWMQAGVVLVASDPSYVYASLWRNAVEMVNAYLIFALVALVLSYCFIKYLLQPLKR
HHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VTAQALAISEHEFPVETKIPKTPELRQVTLAMNQMVTKVKSLFQDQLKQTESLRTQVYQD
HHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLTGMSNRRYFLQHLALILDNEDEFIPGYVMMLVIDGLDELNQKQGYQQGDQLVLTVAKI
HHCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCHHHHHHHCCCCCCHHHHHHHHHH
CKSYWKQSSVSTLARINGTTFALISHERDPLVFEKECKEFEQILSQGITDIKICETHMGA
HHHHHCCHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEHHHHCCH
ASYFLHQPVSNLLSIVDQAVKKARETGVFYCQKEHDTYKYPQLISGDEIRKSLEQKKISL
HHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHH
YAQAVTDGKNCFHKEVFVRIRNQEGEELGAGYFIPVAEKLGLAYLIDQYVLNELTVMDIA
HHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHEEEE
THTHFALNISEDTLTNKVNSTGYLRQLEATPAAVLRNLSLEINEAHVLSHFSNSKFFIKQ
CCCEEEEEECHHHHHHCCCCCHHHHHHHCCHHHHHHHCCCEECHHHHHHHCCCCHHHHHH
AKKLGVTVGIDRVGIKFSPLHYLSDLNIDYLKLHGSLVTDIDENESKQFFIHYFNEMAKT
HHHCCEEEEEECCCCEECCHHHHHCCCEEEEEECCCEEECCCCCCCHHHHHHHHHHHHHH
MDIAVVATQVESEAQWQALQIVHIPWGQGRFLSSVELIK
HHHHHEEHHHHCCCCEEEEEEEECCCCCCCHHCCHHHCC
>Mature Secondary Structure 
TLTKKMAVGVLIMLLFVFIGTYFITMNNARNFFIQQLESNAQDTATSLGLSLSQSLINH
CCHHHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHC
DVPTMDSMVKAVFDRGYFSSIKVKDIKGKVIILKKQLPQESDIPQWFVNLIKWPSTEKSS
CCCCHHHHHHHHHCCCCCCCEEEEECCCCEEEEECCCCCCCCCHHHHHHHHCCCCCCCCH
LIMDGWMQAGVVLVASDPSYVYASLWRNAVEMVNAYLIFALVALVLSYCFIKYLLQPLKR
HHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VTAQALAISEHEFPVETKIPKTPELRQVTLAMNQMVTKVKSLFQDQLKQTESLRTQVYQD
HHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLTGMSNRRYFLQHLALILDNEDEFIPGYVMMLVIDGLDELNQKQGYQQGDQLVLTVAKI
HHCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCHHHHHHHCCCCCCHHHHHHHHHH
CKSYWKQSSVSTLARINGTTFALISHERDPLVFEKECKEFEQILSQGITDIKICETHMGA
HHHHHCCHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEHHHHCCH
ASYFLHQPVSNLLSIVDQAVKKARETGVFYCQKEHDTYKYPQLISGDEIRKSLEQKKISL
HHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHH
YAQAVTDGKNCFHKEVFVRIRNQEGEELGAGYFIPVAEKLGLAYLIDQYVLNELTVMDIA
HHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHEEEE
THTHFALNISEDTLTNKVNSTGYLRQLEATPAAVLRNLSLEINEAHVLSHFSNSKFFIKQ
CCCEEEEEECHHHHHHCCCCCHHHHHHHCCHHHHHHHCCCEECHHHHHHHCCCCHHHHHH
AKKLGVTVGIDRVGIKFSPLHYLSDLNIDYLKLHGSLVTDIDENESKQFFIHYFNEMAKT
HHHCCEEEEEECCCCEECCHHHHHCCCEEEEEECCCEEECCCCCCCHHHHHHHHHHHHHH
MDIAVVATQVESEAQWQALQIVHIPWGQGRFLSSVELIK
HHHHHEEHHHHCCCCEEEEEEEECCCCCCCHHCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503; 3049542 [H]