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The map label for this gene is ccmA [H]

Identifier: 148360498

GI number: 148360498

Start: 1037588

End: 1038190

Strand: Direct

Name: ccmA [H]

Synonym: LPC_2439

Alternate gene names: 148360498

Gene position: 1037588-1038190 (Clockwise)

Preceding gene: 148360501

Following gene: 148360497

Centisome position: 29.01

GC content: 35.49

Gene sequence:

>603_bases
ATGCTTGATGTGATTGAACTTAATTTTGACTATCATGACCAGCCATTGTTGCAACAAATTTCTTTTCATCTTCCTGCTGG
AGGCTTATTGCATTTAAAAGGCTCCAATGGCGCAGGAAAAACGACTTTACTTAAATTAATCGCAGGTTTGCTTAATCCTG
AAAAGGGAGAAATTTTCTTCGAAAGGCAATCTATAAAAAAAGATCTATGCACCTATCAAAAGCAATTATGTTTTGTGGGG
CATAGATCAGGGATTAATCCCTATCTTACGCTAAGAGAAAATTGTTTATATGACATACATTTTTCTTCTGGTGCAATGGG
CATTACAGAATTATGCAGATTATTCAGTTTAGAACACCTTATTGATTATCCATGTGGATTACTATCATCAGGACAAAAAA
GGCAAGTTGCTTTATTAAGATTATGGATGTCAAAAGCAAAATTATGGTTGCTTGATGAACCTTTGGTTGCTCTTGATGAG
TTATCATTGCTTACAATTATCACAAAAATCCAGGAGCACAGGGCAAAAGGTGGTGCTGTATTATTGACCTCTCATCAGGA
TTTGCCTTTAAACAAGGCAGATTATGAGGAGTATCATCTATGA

Upstream 100 bases:

>100_bases
ACTTCGCAAGCAAAAATTAAATAACTTTTAACGAAGGCATTGGGGATTTTTCTTATGTCCTGTTATAGTTAGCCGAGTTT
ATCTAAAAATAAAGTGTTTT

Downstream 100 bases:

>100_bases
ATTCCCCATTTCAATTATTCGGAAAACAGTTCAGGCGTGAAATATTAATCCAGGTGCGGCAAATCAGATATTTAGTTAAT
TCGTGTTTATTTTTTTTAAT

Product: cytochrome c biogenesis protein CcmA

Products: NA

Alternate protein names: Heme exporter protein A [H]

Number of amino acids: Translated: 200; Mature: 200

Protein sequence:

>200_residues
MLDVIELNFDYHDQPLLQQISFHLPAGGLLHLKGSNGAGKTTLLKLIAGLLNPEKGEIFFERQSIKKDLCTYQKQLCFVG
HRSGINPYLTLRENCLYDIHFSSGAMGITELCRLFSLEHLIDYPCGLLSSGQKRQVALLRLWMSKAKLWLLDEPLVALDE
LSLLTIITKIQEHRAKGGAVLLTSHQDLPLNKADYEEYHL

Sequences:

>Translated_200_residues
MLDVIELNFDYHDQPLLQQISFHLPAGGLLHLKGSNGAGKTTLLKLIAGLLNPEKGEIFFERQSIKKDLCTYQKQLCFVG
HRSGINPYLTLRENCLYDIHFSSGAMGITELCRLFSLEHLIDYPCGLLSSGQKRQVALLRLWMSKAKLWLLDEPLVALDE
LSLLTIITKIQEHRAKGGAVLLTSHQDLPLNKADYEEYHL
>Mature_200_residues
MLDVIELNFDYHDQPLLQQISFHLPAGGLLHLKGSNGAGKTTLLKLIAGLLNPEKGEIFFERQSIKKDLCTYQKQLCFVG
HRSGINPYLTLRENCLYDIHFSSGAMGITELCRLFSLEHLIDYPCGLLSSGQKRQVALLRLWMSKAKLWLLDEPLVALDE
LSLLTIITKIQEHRAKGGAVLLTSHQDLPLNKADYEEYHL

Specific function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system [H]

COG id: COG4133

COG function: function code O; ABC-type transport system involved in cytochrome c biogenesis, ATPase component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI90421313, Length=197, Percent_Identity=30.4568527918782, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI153792144, Length=179, Percent_Identity=26.2569832402235, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI11967969, Length=186, Percent_Identity=26.3440860215054, Blast_Score=64, Evalue=6e-11,
Organism=Escherichia coli, GI87082064, Length=194, Percent_Identity=39.1752577319588, Blast_Score=120, Evalue=5e-29,
Organism=Escherichia coli, GI87081709, Length=162, Percent_Identity=30.8641975308642, Blast_Score=81, Evalue=4e-17,
Organism=Escherichia coli, GI1788761, Length=167, Percent_Identity=29.3413173652695, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1786563, Length=198, Percent_Identity=30.8080808080808, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI87081834, Length=192, Percent_Identity=29.6875, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1789593, Length=184, Percent_Identity=26.6304347826087, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI87081791, Length=165, Percent_Identity=26.6666666666667, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1786319, Length=174, Percent_Identity=25.8620689655172, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1790467, Length=177, Percent_Identity=24.8587570621469, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1787370, Length=154, Percent_Identity=31.1688311688312, Blast_Score=68, Evalue=3e-13,
Organism=Escherichia coli, GI87081782, Length=204, Percent_Identity=25, Blast_Score=67, Evalue=9e-13,
Organism=Escherichia coli, GI1788897, Length=207, Percent_Identity=28.9855072463768, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1786698, Length=191, Percent_Identity=28.2722513089005, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1786398, Length=181, Percent_Identity=28.1767955801105, Blast_Score=65, Evalue=2e-12,
Organism=Escherichia coli, GI1789873, Length=193, Percent_Identity=27.4611398963731, Blast_Score=64, Evalue=5e-12,
Organism=Escherichia coli, GI1788165, Length=195, Percent_Identity=27.1794871794872, Blast_Score=64, Evalue=6e-12,
Organism=Escherichia coli, GI1789891, Length=200, Percent_Identity=27, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI87082268, Length=209, Percent_Identity=26.7942583732057, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI1789586, Length=216, Percent_Identity=24.537037037037, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1787792, Length=179, Percent_Identity=26.8156424581006, Blast_Score=62, Evalue=2e-11,
Organism=Escherichia coli, GI1786345, Length=182, Percent_Identity=25.2747252747253, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1787547, Length=172, Percent_Identity=27.906976744186, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI48995001, Length=181, Percent_Identity=25.414364640884, Blast_Score=61, Evalue=6e-11,
Organism=Drosophila melanogaster, GI19920532, Length=170, Percent_Identity=27.0588235294118, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24580930, Length=170, Percent_Identity=27.0588235294118, Blast_Score=67, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR005895
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: =3.6.3.41 [H]

Molecular weight: Translated: 22613; Mature: 22613

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDVIELNFDYHDQPLLQQISFHLPAGGLLHLKGSNGAGKTTLLKLIAGLLNPEKGEIFF
CCEEEEECCCCCCCHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCEEE
ERQSIKKDLCTYQKQLCFVGHRSGINPYLTLRENCLYDIHFSSGAMGITELCRLFSLEHL
EHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCEEEEEEECCCCCCHHHHHHHHHHHHH
IDYPCGLLSSGQKRQVALLRLWMSKAKLWLLDEPLVALDELSLLTIITKIQEHRAKGGAV
HHCCCCCCCCCCHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCEE
LLTSHQDLPLNKADYEEYHL
EEECCCCCCCCCCCCHHCCC
>Mature Secondary Structure
MLDVIELNFDYHDQPLLQQISFHLPAGGLLHLKGSNGAGKTTLLKLIAGLLNPEKGEIFF
CCEEEEECCCCCCCHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCEEE
ERQSIKKDLCTYQKQLCFVGHRSGINPYLTLRENCLYDIHFSSGAMGITELCRLFSLEHL
EHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCEEEEEEECCCCCCHHHHHHHHHHHHH
IDYPCGLLSSGQKRQVALLRLWMSKAKLWLLDEPLVALDELSLLTIITKIQEHRAKGGAV
HHCCCCCCCCCCHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCEE
LLTSHQDLPLNKADYEEYHL
EEECCCCCCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA