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The map label for this gene is degP [H]

Identifier: 148360449

GI number: 148360449

Start: 1085718

End: 1086803

Strand: Direct

Name: degP [H]

Synonym: LPC_2388

Alternate gene names: 148360449

Gene position: 1085718-1086803 (Clockwise)

Preceding gene: 148360450

Following gene: 148360448

Centisome position: 30.36

GC content: 39.32

Gene sequence:

>1086_bases
ATGATGAGACAACAACGTAACTTATTACTTATCCCTTTTATTTTATGTTTTATTCTGGCAAGACCTGTTTTTAGTTTAAA
CCTGGATGCTCTCCTTCCAGATGAACGAAATACAGTTGAAGTATTTCAAAAAGCCTCATCCAAAGTTGTTTATGTTCATC
GATTGGCAAATGCTACTGTTCAGCGTCGTTACTCATTACAAAAAACACATATTCCTGATGGGGCAGGCTCCGGTATTATT
TGGGATAACAAAGGCCATGTTGTAACCAATTTTCATGTCATTAACGGTGCTGATGACATAGCAATTACTTTGGGAAATAT
GACTGTCCCTGCCAAAGTGATTGGTTCAGAGCCTCGCAAGGACATTGCAGTCCTTGAAATTAAATCACCTAAGGCTCTGA
ATTATTTGAAATCATTTCAGCCCTTTGAAATAGTCTCTCTTAATGATCTGATCGTTGGGCAAAAAGCGATTGCGATTGGG
AATCCTTTTGGGTTGGATCATAGTTTATCAAAGGGAGTGATTTCTGCTTTAGGTAGAAAAGTACCAGGTATAGGTGGGGT
AACAATTTATGATATGATTCAGACAGATACCCCTATCAATCCGGGTAATTCAGGAGGTCCTCTATTAAATAGCGCAGGCC
AATTAATTGGTATGAACACCATGATTTATTCACGATCTGGTTCTTCTGCAGGTATTGGTTTCGCAGTTCCCGCGGAAGAT
ATTCAGAAAATTGCATCTCAAATTATTAATCATGGTCGAGTGGTATTGTCTGGTATCGGTATTCAACGAGTTGAGCCACA
TCTTGCGGAAAGGCTGGGAGTTAAAAAGGGTATTTTGATTGCTGATGTGGTGCCTGGAACTCCTGCAGACAAATTGAAGT
TACGAGGTACTCACAGAGATCAATGGGGGCGTATTGTTTTAGGGGATGTTATTGTAGGTGTGAATGCACATCCTGTCCCA
AATTATGATGCCCTGTATAATTTGCTCACGGAAATTAAGGTGGGAGAGCAAATTACTGTTTCAATAATAAGGCATGGTAA
GAAAATGGATGTCAAAATGAAAACAATTGATATTGCAGCGCTTTAA

Upstream 100 bases:

>100_bases
ACTATTACAGATTTTCCACAATCAGTAATTGATAAATTATTAGCGCGACAGGCATTTCGCAAGAGATTTGCAAGCCGTGC
AGGTATGGAGTTAAATGGAG

Downstream 100 bases:

>100_bases
CTCTCTTCATTTTTTCTAACTATTATTTCCCCGGAAAAGAATTATGCCTCAATCCGGGGTTCACTCACTTTTCTTAATGC
TATATGATATAGATCAATAA

Product: DegP protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 361; Mature: 361

Protein sequence:

>361_residues
MMRQQRNLLLIPFILCFILARPVFSLNLDALLPDERNTVEVFQKASSKVVYVHRLANATVQRRYSLQKTHIPDGAGSGII
WDNKGHVVTNFHVINGADDIAITLGNMTVPAKVIGSEPRKDIAVLEIKSPKALNYLKSFQPFEIVSLNDLIVGQKAIAIG
NPFGLDHSLSKGVISALGRKVPGIGGVTIYDMIQTDTPINPGNSGGPLLNSAGQLIGMNTMIYSRSGSSAGIGFAVPAED
IQKIASQIINHGRVVLSGIGIQRVEPHLAERLGVKKGILIADVVPGTPADKLKLRGTHRDQWGRIVLGDVIVGVNAHPVP
NYDALYNLLTEIKVGEQITVSIIRHGKKMDVKMKTIDIAAL

Sequences:

>Translated_361_residues
MMRQQRNLLLIPFILCFILARPVFSLNLDALLPDERNTVEVFQKASSKVVYVHRLANATVQRRYSLQKTHIPDGAGSGII
WDNKGHVVTNFHVINGADDIAITLGNMTVPAKVIGSEPRKDIAVLEIKSPKALNYLKSFQPFEIVSLNDLIVGQKAIAIG
NPFGLDHSLSKGVISALGRKVPGIGGVTIYDMIQTDTPINPGNSGGPLLNSAGQLIGMNTMIYSRSGSSAGIGFAVPAED
IQKIASQIINHGRVVLSGIGIQRVEPHLAERLGVKKGILIADVVPGTPADKLKLRGTHRDQWGRIVLGDVIVGVNAHPVP
NYDALYNLLTEIKVGEQITVSIIRHGKKMDVKMKTIDIAAL
>Mature_361_residues
MMRQQRNLLLIPFILCFILARPVFSLNLDALLPDERNTVEVFQKASSKVVYVHRLANATVQRRYSLQKTHIPDGAGSGII
WDNKGHVVTNFHVINGADDIAITLGNMTVPAKVIGSEPRKDIAVLEIKSPKALNYLKSFQPFEIVSLNDLIVGQKAIAIG
NPFGLDHSLSKGVISALGRKVPGIGGVTIYDMIQTDTPINPGNSGGPLLNSAGQLIGMNTMIYSRSGSSAGIGFAVPAED
IQKIASQIINHGRVVLSGIGIQRVEPHLAERLGVKKGILIADVVPGTPADKLKLRGTHRDQWGRIVLGDVIVGVNAHPVP
NYDALYNLLTEIKVGEQITVSIIRHGKKMDVKMKTIDIAAL

Specific function: A putative protease, its function overlaps that of the related putative proteases HhoA and HhoB [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential). Cell outer membrane (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI22129776, Length=334, Percent_Identity=29.0419161676647, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI4506141, Length=297, Percent_Identity=29.2929292929293, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI7019477, Length=327, Percent_Identity=28.4403669724771, Blast_Score=98, Evalue=9e-21,
Organism=Homo sapiens, GI24308541, Length=266, Percent_Identity=28.1954887218045, Blast_Score=86, Evalue=4e-17,
Organism=Escherichia coli, GI1786356, Length=285, Percent_Identity=36.4912280701754, Blast_Score=174, Evalue=1e-44,
Organism=Escherichia coli, GI1789629, Length=291, Percent_Identity=36.426116838488, Blast_Score=167, Evalue=9e-43,
Organism=Escherichia coli, GI1789630, Length=286, Percent_Identity=32.8671328671329, Blast_Score=132, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24646839, Length=306, Percent_Identity=24.8366013071895, Blast_Score=78, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 38977; Mature: 38977

Theoretical pI: Translated: 10.17; Mature: 10.17

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMRQQRNLLLIPFILCFILARPVFSLNLDALLPDERNTVEVFQKASSKVVYVHRLANATV
CCCCCCCEEEHHHHHHHHHHCCHHEECCCEECCCCCCHHHHHHHCCCCEEEEEEHHHHHH
QRRYSLQKTHIPDGAGSGIIWDNKGHVVTNFHVINGADDIAITLGNMTVPAKVIGSEPRK
HHHHHHHHCCCCCCCCCCEEECCCCCEEEEEEEECCCCCEEEEECCEECCHHHCCCCCCC
DIAVLEIKSPKALNYLKSFQPFEIVSLNDLIVGQKAIAIGNPFGLDHSLSKGVISALGRK
CEEEEEECCCHHHHHHHCCCCEEEEEECCEEECCEEEEECCCCCCCCHHHHHHHHHHHHC
VPGIGGVTIYDMIQTDTPINPGNSGGPLLNSAGQLIGMNTMIYSRSGSSAGIGFAVPAED
CCCCCCEEEEEEECCCCCCCCCCCCCCCHHCCCCEEEEEEEEEECCCCCCCCEEECCHHH
IQKIASQIINHGRVVLSGIGIQRVEPHLAERLGVKKGILIADVVPGTPADKLKLRGTHRD
HHHHHHHHHHCCEEEEEECCCHHCCHHHHHHCCCCCCEEEEEECCCCCCCCEEECCCCCC
QWGRIVLGDVIVGVNAHPVPNYDALYNLLTEIKVGEQITVSIIRHGKKMDVKMKTIDIAA
CCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCEEEEHHHCCCCCEEEEEEEEEEE
L
C
>Mature Secondary Structure
MMRQQRNLLLIPFILCFILARPVFSLNLDALLPDERNTVEVFQKASSKVVYVHRLANATV
CCCCCCCEEEHHHHHHHHHHCCHHEECCCEECCCCCCHHHHHHHCCCCEEEEEEHHHHHH
QRRYSLQKTHIPDGAGSGIIWDNKGHVVTNFHVINGADDIAITLGNMTVPAKVIGSEPRK
HHHHHHHHCCCCCCCCCCEEECCCCCEEEEEEEECCCCCEEEEECCEECCHHHCCCCCCC
DIAVLEIKSPKALNYLKSFQPFEIVSLNDLIVGQKAIAIGNPFGLDHSLSKGVISALGRK
CEEEEEECCCHHHHHHHCCCCEEEEEECCEEECCEEEEECCCCCCCCHHHHHHHHHHHHC
VPGIGGVTIYDMIQTDTPINPGNSGGPLLNSAGQLIGMNTMIYSRSGSSAGIGFAVPAED
CCCCCCEEEEEEECCCCCCCCCCCCCCCHHCCCCEEEEEEEEEECCCCCCCCEEECCHHH
IQKIASQIINHGRVVLSGIGIQRVEPHLAERLGVKKGILIADVVPGTPADKLKLRGTHRD
HHHHHHHHHHCCEEEEEECCCHHCCHHHHHHCCCCCCEEEEEECCCCCCCCEEECCCCCC
QWGRIVLGDVIVGVNAHPVPNYDALYNLLTEIKVGEQITVSIIRHGKKMDVKMKTIDIAA
CCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCEEEEHHHCCCCCEEEEEEEEEEE
L
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]