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The map label for this gene is mraW [H]

Identifier: 148360438

GI number: 148360438

Start: 1093359

End: 1094285

Strand: Direct

Name: mraW [H]

Synonym: LPC_2377

Alternate gene names: 148360438

Gene position: 1093359-1094285 (Clockwise)

Preceding gene: 148360439

Following gene: 148360437

Centisome position: 30.57

GC content: 40.56

Gene sequence:

>927_bases
ATGGCAAAGCATCAATCTGTTTTATTACATGAGTCAATCAAAGGTTTGGCTATAAAAGCTGACGGCATCTATTTTGATGG
AACTTTTGGCCGAGGAGGCCACAGCCGCGAGATTTTAAATCATTTAAGCGATAAAGGAAGACTGTTTGCAATAGATAAGG
ACCTTGATGCGGTGCAATATGCCAAGGATTATTTTGGTTTGGATAAACGATTTCAAATTTTTCACGGTTCATTCGCGCAA
ATCAAGGAATTTGCGTCACAAGCGGGAGTAATTGGGGCCGTTGATGGTATTTTGCTTGATCTGGGAGTGTCTTCACCTCA
GTTGGACAATCCAGAAAGAGGTTTTAGTTTTATGCTGCAAGGCCCTCTTGATATGCGAATGGATTTAACTCAATCAATTA
ATGCTGCGAATTTTGTCAATGAAGCAGAAGTCAACGAGCTGGCTCATGTATTCAGGGCTTATGGTGAGGAACGATTTGCA
GGCAGGATTGCAAAAGCTATTGTTGATGCAAGAAAACTAAAACCAATAACAACTACTTTGGAGTTAGCAGAAATTGTTAA
AGAAGCAAACCCCAAATGGGAAAAACACAAACATCCTGCAACCCGGGTATTTCAAGCGATTCGAATACATGTCAATCAGG
AATTAACCGATTTGAGTAATTGTCTAGAGCAATGTCTGGACGTATTGGGGCCAAGAGGACGCTTGGCCGTTATCAGTTTC
CACTCTTTGGAAGACCGAATAGTCAAACAATTTATGAGAGATAAAGAGCAAGGTAACAGGCCGCCTGTTGAAGTCCCAAT
CAAATACGAAGAACTAAAGACCAATTTTAAAAGAGTAGGTAAAGCAGTGAAACCACAGAGTAGCGAAATAAAGGAAAATG
TTAGATCTCGAAGTGCAGTACTTAGGATAGGGGAGAAATTAGCATGA

Upstream 100 bases:

>100_bases
TATGGGAATCCAAGCGTGAGCAATGGCTAGCAGAAGAAGCGTCCATGACGGATGGGTTACCCGAGGAAATGAAAACGTTT
TCTTTATAACGGAAAGAGAA

Downstream 100 bases:

>100_bases
ACGCTGCAGCGAAAGTCATTAATCAAGGTAATTTATTTAATGGTCAATTGGCAGATATGCAAATGTCAAAATCACTCTAT
ATGTTGATAGTATTGTTAGC

Product: S-adenosyl-methyltransferase MraW

Products: NA

Alternate protein names: 16S rRNA m(4)C1402 methyltransferase; rRNA (cytosine-N(4)-)-methyltransferase RsmH [H]

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MAKHQSVLLHESIKGLAIKADGIYFDGTFGRGGHSREILNHLSDKGRLFAIDKDLDAVQYAKDYFGLDKRFQIFHGSFAQ
IKEFASQAGVIGAVDGILLDLGVSSPQLDNPERGFSFMLQGPLDMRMDLTQSINAANFVNEAEVNELAHVFRAYGEERFA
GRIAKAIVDARKLKPITTTLELAEIVKEANPKWEKHKHPATRVFQAIRIHVNQELTDLSNCLEQCLDVLGPRGRLAVISF
HSLEDRIVKQFMRDKEQGNRPPVEVPIKYEELKTNFKRVGKAVKPQSSEIKENVRSRSAVLRIGEKLA

Sequences:

>Translated_308_residues
MAKHQSVLLHESIKGLAIKADGIYFDGTFGRGGHSREILNHLSDKGRLFAIDKDLDAVQYAKDYFGLDKRFQIFHGSFAQ
IKEFASQAGVIGAVDGILLDLGVSSPQLDNPERGFSFMLQGPLDMRMDLTQSINAANFVNEAEVNELAHVFRAYGEERFA
GRIAKAIVDARKLKPITTTLELAEIVKEANPKWEKHKHPATRVFQAIRIHVNQELTDLSNCLEQCLDVLGPRGRLAVISF
HSLEDRIVKQFMRDKEQGNRPPVEVPIKYEELKTNFKRVGKAVKPQSSEIKENVRSRSAVLRIGEKLA
>Mature_307_residues
AKHQSVLLHESIKGLAIKADGIYFDGTFGRGGHSREILNHLSDKGRLFAIDKDLDAVQYAKDYFGLDKRFQIFHGSFAQI
KEFASQAGVIGAVDGILLDLGVSSPQLDNPERGFSFMLQGPLDMRMDLTQSINAANFVNEAEVNELAHVFRAYGEERFAG
RIAKAIVDARKLKPITTTLELAEIVKEANPKWEKHKHPATRVFQAIRIHVNQELTDLSNCLEQCLDVLGPRGRLAVISFH
SLEDRIVKQFMRDKEQGNRPPVEVPIKYEELKTNFKRVGKAVKPQSSEIKENVRSRSAVLRIGEKLA

Specific function: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA [H]

COG id: COG0275

COG function: function code M; Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. RsmH family [H]

Homologues:

Organism=Homo sapiens, GI165377209, Length=343, Percent_Identity=39.6501457725948, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI165377202, Length=199, Percent_Identity=43.7185929648241, Blast_Score=140, Evalue=2e-33,
Organism=Escherichia coli, GI1786270, Length=308, Percent_Identity=53.8961038961039, Blast_Score=328, Evalue=3e-91,
Organism=Drosophila melanogaster, GI62472493, Length=332, Percent_Identity=35.8433734939759, Blast_Score=170, Evalue=1e-42,
Organism=Drosophila melanogaster, GI28571637, Length=332, Percent_Identity=35.8433734939759, Blast_Score=170, Evalue=1e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002903 [H]

Pfam domain/function: PF01795 Methyltransf_5 [H]

EC number: NA

Molecular weight: Translated: 34588; Mature: 34457

Theoretical pI: Translated: 9.31; Mature: 9.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKHQSVLLHESIKGLAIKADGIYFDGTFGRGGHSREILNHLSDKGRLFAIDKDLDAVQY
CCCCHHHHHHHHCCCEEEEECCEEEECCCCCCCCHHHHHHHHCCCCCEEEECCCCHHHHH
AKDYFGLDKRFQIFHGSFAQIKEFASQAGVIGAVDGILLDLGVSSPQLDNPERGFSFMLQ
HHHHHCCCCHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEC
GPLDMRMDLTQSINAANFVNEAEVNELAHVFRAYGEERFAGRIAKAIVDARKLKPITTTL
CCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCHHHHH
ELAEIVKEANPKWEKHKHPATRVFQAIRIHVNQELTDLSNCLEQCLDVLGPRGRLAVISF
HHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCEEEEEH
HSLEDRIVKQFMRDKEQGNRPPVEVPIKYEELKTNFKRVGKAVKPQSSEIKENVRSRSAV
HHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHCHHCCCCHHHHHHHHHHHHHH
LRIGEKLA
HHHHHHCC
>Mature Secondary Structure 
AKHQSVLLHESIKGLAIKADGIYFDGTFGRGGHSREILNHLSDKGRLFAIDKDLDAVQY
CCCHHHHHHHHCCCEEEEECCEEEECCCCCCCCHHHHHHHHCCCCCEEEECCCCHHHHH
AKDYFGLDKRFQIFHGSFAQIKEFASQAGVIGAVDGILLDLGVSSPQLDNPERGFSFMLQ
HHHHHCCCCHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEC
GPLDMRMDLTQSINAANFVNEAEVNELAHVFRAYGEERFAGRIAKAIVDARKLKPITTTL
CCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCHHHHH
ELAEIVKEANPKWEKHKHPATRVFQAIRIHVNQELTDLSNCLEQCLDVLGPRGRLAVISF
HHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCEEEEEH
HSLEDRIVKQFMRDKEQGNRPPVEVPIKYEELKTNFKRVGKAVKPQSSEIKENVRSRSAV
HHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHCHHCCCCHHHHHHHHHHHHHH
LRIGEKLA
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA